{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T15:10:19Z","timestamp":1780758619478,"version":"3.54.1"},"update-to":[{"DOI":"10.1371\/journal.ppat.1009035","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T00:00:00Z","timestamp":1604620800000}}],"reference-count":68,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Program of China","award":["No. 2016YFD0500404"],"award-info":[{"award-number":["No. 2016YFD0500404"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science foundation of China","doi-asserted-by":"crossref","award":["No. 31302116"],"award-info":[{"award-number":["No. 31302116"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"publisher","award":["No. 19ZR1469000"],"award-info":[{"award-number":["No. 19ZR1469000"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Project of Shanghai Science and Technology Commission","award":["No. 17391901600"],"award-info":[{"award-number":["No. 17391901600"]}]},{"name":"Central Public-interest Scientific Institution Basal Research Fund","award":["No. Y2020PT40"],"award-info":[{"award-number":["No. Y2020PT40"]}]},{"name":"the Distinguished Talent Projects","award":["ts201511069"],"award-info":[{"award-number":["ts201511069"]}]},{"name":"the Distinguished Talent Projects","award":["W03020496"],"award-info":[{"award-number":["W03020496"]}]},{"name":"Shandong Provincial Modern Agricultural Industry and Technology System","award":["SDAIT-08-06"],"award-info":[{"award-number":["SDAIT-08-06"]}]},{"name":"Shandong Province Major Application of Agricultural Technology Innovation Projects and Shandong Academy of Agricultural Sciences Projects","award":["CXGC2016B14"],"award-info":[{"award-number":["CXGC2016B14"]}]},{"name":"Shandong Province Major Application of Agricultural Technology Innovation Projects and Shandong Academy of Agricultural Sciences Projects","award":["CXGC2018E11"],"award-info":[{"award-number":["CXGC2018E11"]}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>The tumor suppressor p53 as an innate antiviral regulator contributes to restricting Japanese encephalitis virus (JEV) replication, but the mechanism is still unclear. The interferon-induced transmembrane protein 3 (IFITM3) is an intrinsic barrier to a range of virus infection, whether IFITM3 is responsible for the p53-mediated anti-JEV response remains elusive. Here, we found that IFITM3 significantly inhibited JEV replication in a protein-palmitoylation-dependent manner and incorporated into JEV virions to diminish the infectivity of progeny viruses. Palmitoylation was also indispensible for keeping IFITM3 from lysosomal degradation to maintain its protein stability. p53 up-regulated IFITM3 expression at the protein level via enhancing IFITM3 palmitoylation. Screening of palmitoyltransferases revealed that zinc finger DHHC domain-containing protein 1 (ZDHHC1) was transcriptionally up-regulated by p53, and consequently ZDHHC1 interacted with IFITM3 to promote its palmitoylation and stability. Knockdown of IFITM3 significantly impaired the inhibitory role of ZDHHC1 on JEV replication. Meanwhile, knockdown of either ZDHHC1 or IFITM3 expression also compromised the p53-mediated anti-JEV effect. Interestingly, JEV reduced p53 expression to impair ZDHHC1 mediated IFITM3 palmitoylation for viral evasion. Our data suggest the existence of a previously unrecognized p53-ZDHHC1-IFITM3 regulatory pathway with an essential role in restricting JEV infection and provide a novel insight into JEV-host interaction.<\/jats:p>","DOI":"10.1371\/journal.ppat.1009035","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T13:52:13Z","timestamp":1603806733000},"page":"e1009035","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["p53 promotes ZDHHC1-mediated IFITM3 palmitoylation to inhibit Japanese encephalitis virus replication"],"prefix":"10.1371","volume":"16","author":[{"given":"Xin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuanchang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0947-5603","authenticated-orcid":true,"given":"Yifan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changguang","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiqian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianchao","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghua","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7604-3627","authenticated-orcid":true,"given":"Xufang","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9160-9951","authenticated-orcid":true,"given":"Jiaqiang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafeng","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beibei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6723-0113","authenticated-orcid":true,"given":"Zhiyong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,10,27]]},"reference":[{"key":"ppat.1009035.ref001","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1146\/annurev.ento.54.110807.090510","article-title":"Ecology and geographical expansion of Japanese encephalitis virus","volume":"54","author":"AF van den Hurk","year":"2009","journal-title":"Annu Rev Entomol"},{"key":"ppat.1009035.ref002","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/rmv.1738","article-title":"Genome guardian p53 and viral infections","volume":"23","author":"Y Sato","year":"2013","journal-title":"Rev Med Virol."},{"key":"ppat.1009035.ref003","doi-asserted-by":"crossref","first-page":"E5192","DOI":"10.1073\/pnas.1603435113","article-title":"p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLpro via E3 ubiquitin ligase RCHY1","volume":"113","author":"Y Ma-Lauer","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ppat.1009035.ref004","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.cell.2009.04.050","article-title":"Modes of p53 regulation","volume":"137","author":"JP Kruse","year":"2009","journal-title":"Cell"},{"key":"ppat.1009035.ref005","doi-asserted-by":"crossref","first-page":"6557","DOI":"10.1128\/MCB.01202-08","article-title":"p53 regulates Toll-like receptor 3 expression and function in human epithelial cell lines","volume":"28","author":"M Taura","year":"2008","journal-title":"Mol Cell Biol"},{"key":"ppat.1009035.ref006","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1084\/jem.20080383","article-title":"Transcriptional role of p53 in interferon-mediated antiviral immunity","volume":"205","author":"C Munoz-Fontela","year":"2008","journal-title":"J Exp Med"},{"key":"ppat.1009035.ref007","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.1038\/sj.onc.1205459","article-title":"Identification of the interferon regulatory factor 5 gene (IRF-5) as a direct target for p53","volume":"21","author":"T Mori","year":"2002","journal-title":"Oncogene"},{"key":"ppat.1009035.ref008","doi-asserted-by":"crossref","first-page":"7852","DOI":"10.1073\/pnas.0812148106","article-title":"PKR, a p53 target gene, plays a crucial role in the tumor-suppressor function of p53","volume":"106","author":"CH Yoon","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ppat.1009035.ref009","doi-asserted-by":"crossref","first-page":"7774","DOI":"10.1128\/JVI.75.16.7774-7777.2001","article-title":"Role for p53 in gene induction by double-stranded RNA","volume":"75","author":"BT Hummer","year":"2001","journal-title":"J Virol"},{"key":"ppat.1009035.ref010","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.bbrc.2013.05.074","article-title":"Identification of human guanylate-binding protein 1 gene (hGBP1) as a direct transcriptional target gene of p53","volume":"436","author":"Z Zhu","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"ppat.1009035.ref011","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.jgg.2016.07.002","article-title":"Tumor suppressor p53 functions as an essential antiviral molecule against Japanese encephalitis virus","volume":"43","author":"X Deng","year":"2016","journal-title":"J Genet Genomics"},{"key":"ppat.1009035.ref012","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/0092-8674(84)90270-8","article-title":"Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells","volume":"38","author":"RL Friedman","year":"1984","journal-title":"Cell"},{"key":"ppat.1009035.ref013","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1146\/annurev-virology-031413-085537","article-title":"IFITM-Family Proteins: The Cell's First Line of Antiviral Defense","volume":"1","author":"CC Bailey","year":"2014","journal-title":"Annu Rev Virol"},{"key":"ppat.1009035.ref014","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.chom.2014.11.001","article-title":"IFITM Proteins Incorporated into HIV-1 Virions Impair Viral Fusion and Spread.","volume":"16","author":"AA Compton","year":"2014","journal-title":"Cell Host & Microbe"},{"key":"ppat.1009035.ref015","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/nchembio.405","article-title":"Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3","volume":"6","author":"JS Yount","year":"2010","journal-title":"Nat Chem Biol"},{"key":"ppat.1009035.ref016","doi-asserted-by":"crossref","first-page":"19631","DOI":"10.1074\/jbc.M112.362095","article-title":"S-palmitoylation and ubiquitination differentially regulate interferon-induced transmembrane protein 3 (IFITM3)-mediated resistance to influenza virus","volume":"287","author":"JS Yount","year":"2012","journal-title":"J Biol Chem"},{"key":"ppat.1009035.ref017","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.2217\/fmb.14.65","article-title":"Regulation of the trafficking and antiviral activity of IFITM3 by post-translational modifications","volume":"9","author":"NM Chesarino","year":"2014","journal-title":"Future Microbiol"},{"key":"ppat.1009035.ref018","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1194\/jlr.R600007-JLR200","article-title":"Protein palmitoylation by a family of DHHC protein S-acyltransferases","volume":"47","author":"DA Mitchell","year":"2006","journal-title":"J Lipid Res"},{"key":"ppat.1009035.ref019","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1016\/j.bbamem.2011.07.009","article-title":"Protein palmitoylation and subcellular trafficking","volume":"1808","author":"C Aicart-Ramos","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"ppat.1009035.ref020","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1186\/1471-2164-15-841","article-title":"A systematic analysis of protein palmitoylation in Caenorhabditis elegans","volume":"15","author":"MJ Edmonds","year":"2014","journal-title":"BMC Genomics"},{"key":"ppat.1009035.ref021","doi-asserted-by":"crossref","first-page":"21517","DOI":"10.1074\/jbc.M117.800482","article-title":"The palmitoyltransferase ZDHHC20 enhances interferon-induced transmembrane protein 3 (IFITM3) palmitoylation and antiviral activity","volume":"292","author":"TM McMichael","year":"2017","journal-title":"J Biol Chem"},{"key":"ppat.1009035.ref022","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1021\/pr400011k","article-title":"Identification of host proteins involved in Japanese encephalitis virus infection by quantitative proteomics analysis","volume":"12","author":"LK Zhang","year":"2013","journal-title":"J Proteome Res"},{"key":"ppat.1009035.ref023","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3390\/v2010298","article-title":"Dual Role of p53 in Innate Antiviral Immunity","volume":"2","author":"C Rivas","year":"2010","journal-title":"Viruses"},{"key":"ppat.1009035.ref024","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s12920-015-0127-8","article-title":"Transcriptional analysis of immune-related gene expression in p53-deficient mice with increased susceptibility to influenza A virus infection","volume":"8","author":"W Yan","year":"2015","journal-title":"BMC Med Genomics"},{"key":"ppat.1009035.ref025","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/0092-8674(93)90500-P","article-title":"WAF1, a potential mediator of p53 tumor suppression","volume":"75","author":"WS el-Deiry","year":"1993","journal-title":"Cell"},{"key":"ppat.1009035.ref026","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1126\/science.1092472","article-title":"In vivo activation of the p53 pathway by small-molecule antagonists of MDM2","volume":"303","author":"LT Vassilev","year":"2004","journal-title":"Science"},{"key":"ppat.1009035.ref027","article-title":"Antiviral activity of doxycycline against vesicular stomatitis virus in vitro","volume":"362","author":"ZC Wu","year":"2015","journal-title":"FEMS Microbiol Lett"},{"key":"ppat.1009035.ref028","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/nrm2084","article-title":"Palmitoylation: policing protein stability and traffic","volume":"8","author":"ME Linder","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ppat.1009035.ref029","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1194\/jlr.M800270-JLR200","article-title":"2-Bromopalmitate and 2-(2-hydroxy-5-nitro-benzylidene)-benzo[b]thiophen-3-one inhibit DHHC-mediated palmitoylation in vitro","volume":"50","author":"BC Jennings","year":"2009","journal-title":"J Lipid Res"},{"key":"ppat.1009035.ref030","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1432-1033.1979.tb12956.x","article-title":"Inhibition of the lysosomal pathway of protein degradation in isolated rat hepatocytes by ammonia, methylamine, chloroquine and leupeptin","volume":"95","author":"PO Seglen","year":"1979","journal-title":"Eur J Biochem"},{"key":"ppat.1009035.ref031","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1128\/MCB.18.1.30","article-title":"Proteasome inhibitors cause induction of heat shock proteins and trehalose, which together confer thermotolerance in Saccharomyces cerevisiae","volume":"18","author":"DH Lee","year":"1998","journal-title":"Mol Cell Biol"},{"key":"ppat.1009035.ref032","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1101\/gad.190678.112","article-title":"Mutant p53: one name, many proteins","volume":"26","author":"WA Freed-Pastor","year":"2012","journal-title":"Genes Dev"},{"key":"ppat.1009035.ref033","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.tibs.2011.01.003","article-title":"DHHC palmitoyl transferases: substrate interactions and (patho)physiology","volume":"36","author":"J Greaves","year":"2011","journal-title":"Trends Biochem Sci"},{"key":"ppat.1009035.ref034","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1042\/BST20140235","article-title":"Enzymatic protein depalmitoylation by acyl protein thioesterases","volume":"43","author":"DT Lin","year":"2015","journal-title":"Biochem Soc Trans"},{"key":"ppat.1009035.ref035","doi-asserted-by":"crossref","first-page":"14373","DOI":"10.1073\/pnas.0903284106","article-title":"Redefining the p53 response element","volume":"106","author":"B Wang","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ppat.1009035.ref036","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1083\/jcb.200206120","article-title":"The yeast DHHC cysteine-rich domain protein Akr1p is a palmitoyl transferase","volume":"159","author":"AF Roth","year":"2002","journal-title":"J Cell Biol"},{"key":"ppat.1009035.ref037","doi-asserted-by":"crossref","first-page":"4543","DOI":"10.1091\/mbc.e12-05-0336","article-title":"Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system","volume":"23","author":"Y Ohno","year":"2012","journal-title":"Mol Biol Cell"},{"key":"ppat.1009035.ref038","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.chom.2014.09.006","article-title":"The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA\/STING-dependent innate immune signaling","volume":"16","author":"Q Zhou","year":"2014","journal-title":"Cell Host Microbe"},{"key":"ppat.1009035.ref039","doi-asserted-by":"crossref","first-page":"e1002909","DOI":"10.1371\/journal.ppat.1002909","article-title":"Ifitm3 limits the severity of acute influenza in mice","volume":"8","author":"CC Bailey","year":"2012","journal-title":"PLoS Pathog"},{"key":"ppat.1009035.ref040","doi-asserted-by":"crossref","first-page":"e1004048","DOI":"10.1371\/journal.ppat.1004048","article-title":"IFITM3 restricts influenza A virus entry by blocking the formation of fusion pores following virus-endosome hemifusion.","volume":"10","author":"TM Desai","year":"2014","journal-title":"PLoS Pathog"},{"key":"ppat.1009035.ref041","doi-asserted-by":"crossref","first-page":"8802","DOI":"10.1128\/JVI.79.14.8802-8811.2005","article-title":"Influenza virus infection increases p53 activity: role of p53 in cell death and viral replication","volume":"79","author":"E Turpin","year":"2005","journal-title":"J Virol"},{"key":"ppat.1009035.ref042","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.virusres.2008.05.015","article-title":"Interferon antagonist function of Japanese encephalitis virus NS4A and its interaction with DEAD-box RNA helicase DDX42","volume":"137","author":"CW Lin","year":"2008","journal-title":"Virus Res"},{"key":"ppat.1009035.ref043","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.4049\/jimmunol.1900946","article-title":"The Japanese Encephalitis Virus NS1' Protein Inhibits Type I IFN Production by Targeting MAVS","volume":"204","author":"D Zhou","year":"2020","journal-title":"J Immunol"},{"key":"ppat.1009035.ref044","article-title":"Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-kappaB","volume":"91","author":"J Ye","year":"2017","journal-title":"J Virol"},{"key":"ppat.1009035.ref045","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.virusres.2017.02.012","article-title":"Japanese encephalitis virus disrupts blood-brain barrier and modulates apoptosis proteins in THBMEC cells","volume":"233","author":"MMJ Al-Obaidi","year":"2017","journal-title":"Virus Res"},{"key":"ppat.1009035.ref046","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1099\/0022-1317-43-1-247","article-title":"Regulation of the interferon system: evidence that Vero cells have a genetic defect in interferon production","volume":"43","author":"JM Emeny","year":"1979","journal-title":"J Gen Virol"},{"key":"ppat.1009035.ref047","doi-asserted-by":"crossref","first-page":"E10069","DOI":"10.1073\/pnas.1811892115","article-title":"mTOR inhibitors lower an intrinsic barrier to virus infection mediated by IFITM3","volume":"115","author":"G Shi","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ppat.1009035.ref048","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/ni.1645","article-title":"Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway","volume":"9","author":"W Cao","year":"2008","journal-title":"Nat Immunol"},{"key":"ppat.1009035.ref049","doi-asserted-by":"crossref","first-page":"8204","DOI":"10.1073\/pnas.0502857102","article-title":"The coordinate regulation of the p53 and mTOR pathways in cells","volume":"102","author":"Z Feng","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ppat.1009035.ref050","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3389\/fncel.2019.00115","article-title":"mTORC1 Signaling Is Palmitoylation-Dependent in Hippocampal Neurons and Non-neuronal Cells and Involves Dynamic Palmitoylation of LAMTOR1 and mTOR","volume":"13","author":"SS Sanders","year":"2019","journal-title":"Front Cell Neurosci"},{"key":"ppat.1009035.ref051","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/nrm2395","article-title":"Transcriptional control of human p53-regulated genes","volume":"9","author":"T Riley","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ppat.1009035.ref052","doi-asserted-by":"crossref","first-page":"5078","DOI":"10.1158\/0008-5472.CAN-04-1195","article-title":"p53 upregulates death receptor 4 expression through an intronic p53 binding site","volume":"64","author":"X Liu","year":"2004","journal-title":"Cancer Res"},{"key":"ppat.1009035.ref053","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.cell.2009.12.017","article-title":"The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus","volume":"139","author":"AL Brass","year":"2009","journal-title":"Cell"},{"key":"ppat.1009035.ref054","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1016\/j.celrep.2016.05.074","article-title":"The IFITMs Inhibit Zika Virus Replication","volume":"15","author":"G Savidis","year":"2016","journal-title":"Cell Rep"},{"key":"ppat.1009035.ref055","doi-asserted-by":"crossref","first-page":"8212","DOI":"10.1128\/JVI.00581-16","article-title":"The Interferon-Stimulated Gene Ifitm3 Restricts West Nile Virus Infection and Pathogenesis","volume":"90","author":"MJ Gorman","year":"2016","journal-title":"J Virol"},{"key":"ppat.1009035.ref056","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12977-017-0377-y","article-title":"More than meets the I: the diverse antiviral and cellular functions of interferon-induced transmembrane proteins","volume":"14","author":"G Shi","year":"2017","journal-title":"Retrovirology"},{"key":"ppat.1009035.ref057","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.3389\/fimmu.2018.01193","article-title":"Influenza A Virus Facilitates Its Infectivity by Activating p53 to Inhibit the Expression of Interferon-Induced Transmembrane Proteins","volume":"9","author":"B Wang","year":"2018","journal-title":"Front Immunol"},{"key":"ppat.1009035.ref058","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.bbrc.2014.10.067","article-title":"Type I interferon-mediated immune response against influenza A virus is attenuated in the absence of p53","volume":"454","author":"Z Zhu","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"ppat.1009035.ref059","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1002\/hep.22176","article-title":"Potential contribution of tumor suppressor p53 in the host defense against hepatitis C virus","volume":"47","author":"N Dharel","year":"2008","journal-title":"Hepatology"},{"key":"ppat.1009035.ref060","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01022-18","article-title":"Epstein-Barr Virus MicroRNA miR-BART5-3p Inhibits p53 Expression","volume":"92","author":"X Zheng","year":"2018","journal-title":"J Virol"},{"key":"ppat.1009035.ref061","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1038\/s41419-018-1159-8","article-title":"Correction to: ZIKA virus elicits P53 activation and genotoxic stress in human neural progenitors similar to mutations involved in severe forms of genetic microcephaly","volume":"9","author":"V El Ghouzzi","year":"2018","journal-title":"Cell Death Dis"},{"key":"ppat.1009035.ref062","doi-asserted-by":"crossref","first-page":"14707","DOI":"10.1073\/pnas.94.26.14707","article-title":"Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis","volume":"94","author":"LW Elmore","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ppat.1009035.ref063","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.febslet.2013.03.004","article-title":"The HBx protein of hepatitis B virus confers resistance against nucleolar stress and anti-cancer drug-induced p53 expression","volume":"587","author":"NR Kapoor","year":"2013","journal-title":"FEBS Lett"},{"key":"ppat.1009035.ref064","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/1743-422X-8-209","article-title":"Characterization of nonstructural protein 3 of a neurovirulent Japanese encephalitis virus strain isolated from a pig","volume":"8","author":"X Deng","year":"2011","journal-title":"Virol J"},{"key":"ppat.1009035.ref065","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"key":"ppat.1009035.ref066","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.ab.2007.10.021","article-title":"Splicing together different regions of a gene by modified polymerase chain reaction-based site-directed mutagenesis","volume":"373","author":"X Li","year":"2008","journal-title":"Anal Biochem"},{"key":"ppat.1009035.ref067","doi-asserted-by":"crossref","DOI":"10.1002\/0471140864.ps1415s73","article-title":"Nonradioactive analysis of dynamic protein palmitoylation","volume":"73","author":"BR Martin","year":"2013","journal-title":"Curr Protoc Protein Sci"},{"key":"ppat.1009035.ref068","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41467-017-00024-6","article-title":"Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability","volume":"8","author":"X Wang","year":"2017","journal-title":"Nat Commun"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1009035","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T00:00:00Z","timestamp":1604620800000}},{"DOI":"10.1371\/journal.ppat.1012698","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000}},{"DOI":"10.1371\/journal.ppat.1012698","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"record-id":"69796"}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1009035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T18:09:00Z","timestamp":1618078140000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1009035"}},"subtitle":[],"editor":[{"given":"Shan-Lu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,10,27]]},"references-count":68,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,10,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1009035","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.738913619.793579886","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,27]]}}}