{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:49:41Z","timestamp":1792788581387,"version":"4.5.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1009198","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T00:00:00Z","timestamp":1611187200000}}],"reference-count":87,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T00:00:00Z","timestamp":1610064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["14SDG18230012"],"award-info":[{"award-number":["14SDG18230012"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["18PRE34030086"],"award-info":[{"award-number":["18PRE34030086"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"crossref","award":["1R21AI135385-01A1"],"award-info":[{"award-number":["1R21AI135385-01A1"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIH\/NIDDK U54","award":["DK110858-01"],"award-info":[{"award-number":["DK110858-01"]}]},{"name":"NIH\/OD","award":["1S10OD016232-01"],"award-info":[{"award-number":["1S10OD016232-01"]}]},{"name":"NIH\/OD","award":["1S10OD018210-01A1"],"award-info":[{"award-number":["1S10OD018210-01A1"]}]},{"name":"NIH\/OD","award":["1S10OD021505-01"],"award-info":[{"award-number":["1S10OD021505-01"]}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    Macrophages have a defined role in the pathogenesis of metabolic disease and cholesterol metabolism where alternative activation of macrophages is thought to be beneficial to both glucose and cholesterol metabolism during high fat diet induced disease. It is well established that helminth infection protects from metabolic disease, but the mechanisms underlying protection are not well understood. Here, we investigated the effects of\n                    <jats:italic>Schistosoma mansoni<\/jats:italic>\n                    infection and cytokine activation in the metabolic signatures of bone marrow derived macrophages using an approach that integrated transcriptomics, metabolomics, and lipidomics in a metabolic disease prone mouse model. We demonstrate that bone marrow derived macrophages (BMDM) from\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>mansoni<\/jats:italic>\n                    infected male ApoE\n                    <jats:sup>-\/-<\/jats:sup>\n                    mice have dramatically increased mitochondrial respiration compared to those from uninfected mice. This change is associated with increased glucose and palmitate shuttling into TCA cycle intermediates, increased accumulation of free fatty acids, and decreased accumulation of cellular cholesterol esters, tri and diglycerides, and is dependent on mgll activity. Systemic injection of IL-4 complexes is unable to recapitulate either reductions in systemic glucose AUC or the re-programing of BMDM mitochondrial respiration seen in infected males. Importantly, the metabolic reprogramming of male myeloid cells is transferrable via bone marrow transplantation to an uninfected host, indicating maintenance of reprogramming in the absence of sustained antigen exposure. Finally, schistosome induced metabolic and bone marrow modulation is sex-dependent, with infection protecting male, but not female mice from glucose intolerance and obesity. Our findings identify a transferable, long-lasting sex-dependent reprograming of the metabolic signature of macrophages by helminth infection, providing key mechanistic insight into the factors regulating the beneficial roles of helminth infection in metabolic disease.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1009198","type":"journal-article","created":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T15:52:59Z","timestamp":1610121179000},"page":"e1009198","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["Metabolic reprogramming of the myeloid lineage by Schistosoma mansoni infection persists independently of antigen exposure"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9203-2090","authenticated-orcid":true,"given":"Diana","family":"Cortes-Selva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4567-6659","authenticated-orcid":true,"given":"Lisa","family":"Gibbs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3217-2299","authenticated-orcid":true,"given":"J. Alan","family":"Maschek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3940-0135","authenticated-orcid":true,"given":"Marcia","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"Van Ry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5977-2350","authenticated-orcid":true,"given":"James E.","family":"Cox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1578-8705","authenticated-orcid":true,"given":"Eyal","family":"Amiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8382-2960","authenticated-orcid":true,"given":"Keke C.","family":"Fairfax","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,1,8]]},"reference":[{"issue":"1","key":"ppat.1009198.ref001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jacc.2017.04.052","article-title":"Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015","volume":"70","author":"GA Roth","year":"2017","journal-title":"J Am Coll Cardiol"},{"issue":"8","key":"ppat.1009198.ref002","doi-asserted-by":"crossref","first-page":"e020282","DOI":"10.1136\/bmjopen-2017-020282","article-title":"Incidence and prevalence of cardiovascular disease in English primary care: a cross-sectional and follow-up study of the Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC)","volume":"8","author":"W Hinton","year":"2018","journal-title":"BMJ 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