{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:10:53Z","timestamp":1790745053191,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1009211","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T00:00:00Z","timestamp":1613001600000}}],"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research School of Biology","award":["Innovation Grant"],"award-info":[{"award-number":["Innovation Grant"]}]},{"name":"Research School of Biology","award":["Innovation Grant"],"award-info":[{"award-number":["Innovation Grant"]}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["GNT1182369"],"award-info":[{"award-number":["GNT1182369"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Australian Government Research Training Program Scholarship"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    The mitochondrion is critical for the survival of apicomplexan parasites. Several major anti-parasitic drugs, such as atovaquone and endochin-like quinolones, act through inhibition of the mitochondrial electron transport chain at the coenzyme Q:cytochrome\n                    <jats:italic>c<\/jats:italic>\n                    oxidoreductase complex (Complex III). Despite being an important drug target, the protein composition of Complex III of apicomplexan parasites has not been elucidated. Here, we undertake a mass spectrometry-based proteomic analysis of Complex III in the apicomplexan\n                    <jats:italic>Toxoplasma gondii<\/jats:italic>\n                    . Along with canonical subunits that are conserved across eukaryotic evolution, we identify several novel or highly divergent Complex III components that are conserved within the apicomplexan lineage. We demonstrate that one such subunit, which we term\n                    <jats:italic>Tg<\/jats:italic>\n                    QCR11, is critical for parasite proliferation, mitochondrial oxygen consumption and Complex III activity, and establish that loss of this protein leads to defects in Complex III integrity. We conclude that the protein composition of Complex III in apicomplexans differs from that of the mammalian hosts that these parasites infect.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1009211","type":"journal-article","created":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T17:32:38Z","timestamp":1612200758000},"page":"e1009211","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":42,"title":["Divergent features of the coenzyme Q:cytochrome c oxidoreductase complex in Toxoplasma gondii parasites"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8228-8797","authenticated-orcid":true,"given":"Jenni A.","family":"Hayward","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8036-9531","authenticated-orcid":true,"given":"Esther","family":"Rajendran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soraya M.","family":"Zwahlen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3755-7502","authenticated-orcid":true,"given":"Pierre","family":"Faou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2455-9821","authenticated-orcid":true,"given":"Giel G.","family":"van Dooren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,2,1]]},"reference":[{"issue":"3","key":"ppat.1009211.ref001","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.pt.2019.01.005","article-title":"Advances in the Development of Anti-Toxoplasma gondii Vaccines: Challenges, Opportunities, and Perspectives","volume":"35","author":"JL Wang","year":"2019","journal-title":"Trends Parasitol"},{"issue":"7784","key":"ppat.1009211.ref002","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1038\/d41586-019-03639-5","article-title":"Building a better malaria vaccine","volume":"575","author":"A. 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