{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:25:00Z","timestamp":1790810700406,"version":"4.1.0"},"reference-count":101,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T00:00:00Z","timestamp":1614211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    The human gut microbiota is a diverse and complex ecosystem that is involved in beneficial physiological functions as well as disease pathogenesis.\n                    <jats:italic>Blastocystis<\/jats:italic>\n                    is a common protistan parasite and is increasingly recognized as an important component of the gut microbiota. The correlations between\n                    <jats:italic>Blastocystis<\/jats:italic>\n                    and other communities of intestinal microbiota have been investigated, and, to a lesser extent, the role of this parasite in maintaining the host immunological homeostasis. Despite recent studies suggesting that\n                    <jats:italic>Blastocystis<\/jats:italic>\n                    decreases the abundance of beneficial bacteria, most reports indicate that\n                    <jats:italic>Blastocystis<\/jats:italic>\n                    is a common component of the healthy gut microbiome. This review covers recent finding on the potential interactions between\n                    <jats:italic>Blastocystis<\/jats:italic>\n                    and the gut microbiota communities and its roles in regulating host immune responses.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1009253","type":"journal-article","created":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T13:25:50Z","timestamp":1614259550000},"page":"e1009253","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":157,"title":["New insights into the interactions between Blastocystis, the gut microbiota, and host immunity"],"prefix":"10.1371","volume":"17","author":[{"given":"Lei","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8555-834X","authenticated-orcid":true,"given":"Lukasz","family":"Wojciech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9980-4225","authenticated-orcid":true,"given":"Nicholas R. J.","family":"Gascoigne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangneng","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9022-729X","authenticated-orcid":true,"given":"Kevin S. W.","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,2,25]]},"reference":[{"key":"ppat.1009253.ref001","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.pt.2013.08.006","article-title":"Blastocystis: getting to grips with our guileful guest","volume":"29","author":"PD Scanlan","year":"2013","journal-title":"Trends Parasitol"},{"key":"ppat.1009253.ref002","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.pt.2019.12.009","article-title":"Pre-empting Pandora\u2019s Box: Blastocystis Subtypes Revisited","volume":"36","author":"CR Stensvold","year":"2020","journal-title":"Trends Parasitol"},{"key":"ppat.1009253.ref003","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.pt.2019.12.008","article-title":"Blastocystis","volume":"36","author":"CR Stensvold","year":"2020","journal-title":"Trends 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