{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:28:50Z","timestamp":1790411330298,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1009313","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000}}],"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T00:00:00Z","timestamp":1612483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Universit\u00e9 de Perpignan"},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"crossref","award":["ANR-18-CE35-0001"],"award-info":[{"award-number":["ANR-18-CE35-0001"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["104958\/Z\/14\/Z"],"award-info":[{"award-number":["104958\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>Hybridization is a fascinating evolutionary phenomenon that raises the question of how species maintain their integrity. Inter-species hybridization occurs between certain <jats:italic>Schistosoma<\/jats:italic> species that can cause important public health and veterinary issues. In particular hybrids between <jats:italic>Schistosoma haematobium<\/jats:italic> and <jats:italic>S<\/jats:italic>. <jats:italic>bovis<\/jats:italic> associated with humans and animals respectively are frequently identified in Africa. Recent genomic evidence indicates that some <jats:italic>S<\/jats:italic>. <jats:italic>haematobium<\/jats:italic> populations show signatures of genomic introgression from <jats:italic>S<\/jats:italic>. <jats:italic>bovis<\/jats:italic>. Here, we conducted a genomic comparative study and investigated the genomic relationships between <jats:italic>S<\/jats:italic>. <jats:italic>haematobium<\/jats:italic>, <jats:italic>S<\/jats:italic>. <jats:italic>bovis<\/jats:italic> and their hybrids using 19 isolates originating from a wide geographical range over Africa, including samples initially classified as <jats:italic>S<\/jats:italic>. <jats:italic>haematobium<\/jats:italic> (n = 11), <jats:italic>S<\/jats:italic>. <jats:italic>bovis<\/jats:italic> (n = 6) and <jats:italic>S<\/jats:italic>. <jats:italic>haematobium<\/jats:italic> x <jats:italic>S<\/jats:italic>. <jats:italic>bovis<\/jats:italic> hybrids (n = 2). Based on a whole genomic sequencing approach, we developed 56,181 SNPs that allowed a clear differentiation of <jats:italic>S<\/jats:italic>. <jats:italic>bovis<\/jats:italic> isolates from a genomic cluster including all <jats:italic>S<\/jats:italic>. <jats:italic>haematobium<\/jats:italic> isolates and a natural <jats:italic>S<\/jats:italic>. <jats:italic>haematobium-bovis<\/jats:italic> hybrid. All the isolates from the <jats:italic>S<\/jats:italic>. <jats:italic>haematobium<\/jats:italic> cluster except the isolate from Madagascar harbored signatures of genomic introgression from <jats:italic>S<\/jats:italic>. <jats:italic>bovis<\/jats:italic>. Isolates from Corsica, Mali and Egypt harbored the <jats:italic>S<\/jats:italic>. <jats:italic>bovis<\/jats:italic>-like <jats:italic>Invadolysin<\/jats:italic> gene, an introgressed tract that has been previously detected in some introgressed <jats:italic>S<\/jats:italic>. <jats:italic>haematobium<\/jats:italic> populations from Niger. Together our results highlight the fact that introgression from <jats:italic>S<\/jats:italic>. <jats:italic>bovis<\/jats:italic> is widespread across <jats:italic>S<\/jats:italic>. <jats:italic>haematobium<\/jats:italic> and that the observed introgression is unidirectional.<\/jats:p>","DOI":"10.1371\/journal.ppat.1009313","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T04:34:59Z","timestamp":1612758899000},"page":"e1009313","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":48,"title":["Diverging patterns of introgression from Schistosoma bovis across S. haematobium African lineages"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3699-7204","authenticated-orcid":true,"given":"Olivier","family":"Rey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2049-2279","authenticated-orcid":true,"given":"Eve","family":"Toulza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5162-349X","authenticated-orcid":true,"given":"Cristian","family":"Chaparro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Allienne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Kincaid-Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6846-5491","authenticated-orcid":true,"given":"Eglantine","family":"Mathieu-Begn\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Allan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1999-1716","authenticated-orcid":true,"given":"David","family":"Rollinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0930-9314","authenticated-orcid":true,"given":"Bonnie L.","family":"Webster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0793-3108","authenticated-orcid":true,"given":"J\u00e9r\u00f4me","family":"Boissier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,2,5]]},"reference":[{"key":"ppat.1009313.ref001","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.tree.2005.02.010","article-title":"Hybridization as an invasion of the genome","volume":"20","author":"J. 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