{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:33:45Z","timestamp":1790703225604,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1009379","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T00:00:00Z","timestamp":1629936000000}}],"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T00:00:00Z","timestamp":1629072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI132356"],"award-info":[{"award-number":["R01 AI132356"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["T32AI055396"],"award-info":[{"award-number":["T32AI055396"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["5T32AI055396"],"award-info":[{"award-number":["5T32AI055396"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["5P30CA015704-43"],"award-info":[{"award-number":["5P30CA015704-43"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    The Gram-positive bacterium\n                    <jats:italic>Listeria monocytogenes<\/jats:italic>\n                    is the causative agent of the foodborne disease listeriosis, one of the deadliest bacterial infections known. In order to cause disease,\n                    <jats:italic>L<\/jats:italic>\n                    .\n                    <jats:italic>monocytogenes<\/jats:italic>\n                    must properly coordinate its metabolic and virulence programs in response to rapidly changing environments within the host. However, the mechanisms by which\n                    <jats:italic>L<\/jats:italic>\n                    .\n                    <jats:italic>monocytogenes<\/jats:italic>\n                    senses and adapts to the many stressors encountered as it transits through the gastrointestinal (GI) tract and disseminates to peripheral organs are not well understood. In this study, we investigated the role of the redox-responsive transcriptional regulator Rex in\n                    <jats:italic>L<\/jats:italic>\n                    .\n                    <jats:italic>monocytogenes<\/jats:italic>\n                    growth and pathogenesis. Rex is a conserved canonical transcriptional repressor that monitors the intracellular redox state of the cell by sensing the ratio of reduced and oxidized nicotinamide adenine dinucleotides (NADH and NAD\n                    <jats:sup>+<\/jats:sup>\n                    , respectively). Here, we demonstrated that\n                    <jats:italic>L<\/jats:italic>\n                    .\n                    <jats:italic>monocytogenes<\/jats:italic>\n                    Rex represses fermentative metabolism and is therefore required for optimal growth in the presence of oxygen. We also show that\n                    <jats:italic>in vitro<\/jats:italic>\n                    , Rex represses the production of virulence factors required for survival and invasion of the GI tract, as a strain lacking\n                    <jats:italic>rex<\/jats:italic>\n                    was more resistant to acidified bile and invaded host cells better than wild type. Consistent with these results, Rex was dispensable for colonizing the GI tract and disseminating to peripheral organs in an oral listeriosis model of infection. However, Rex-dependent regulation was required for colonizing the spleen and liver, and\n                    <jats:italic>L<\/jats:italic>\n                    .\n                    <jats:italic>monocytogenes<\/jats:italic>\n                    lacking the Rex repressor were nearly sterilized from the gallbladder. Taken together, these results demonstrated that Rex functions as a repressor of fermentative metabolism and suggests a role for Rex-dependent regulation in\n                    <jats:italic>L<\/jats:italic>\n                    .\n                    <jats:italic>monocytogenes<\/jats:italic>\n                    pathogenesis. Importantly, the gallbladder is the bacterial reservoir during listeriosis, and our data suggest redox sensing and Rex-dependent regulation are necessary for bacterial survival and replication in this organ.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1009379","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T14:50:57Z","timestamp":1629125457000},"page":"e1009379","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["The redox-responsive transcriptional regulator Rex represses fermentative metabolism and is required for Listeria monocytogenes pathogenesis"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0062-2171","authenticated-orcid":true,"given":"Cortney R.","family":"Halsey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5699-0184","authenticated-orcid":true,"given":"Rochelle C.","family":"Glover","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen K.","family":"Thomason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0770-7784","authenticated-orcid":true,"given":"Michelle L.","family":"Reniere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,8,16]]},"reference":[{"key":"ppat.1009379.ref001","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1128\/CMR.14.3.584-640.2001","article-title":"Listeria Pathogenesis and Molecular Virulence Determinants.","volume":"14","author":"JA V\u00e1zquez-Boland","year":"2001","journal-title":"Clin Microbiol Rev"},{"key":"ppat.1009379.ref002","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1083\/jcb.109.4.1597","article-title":"Actin filaments and the growth, movement, and spread of the intracellular bacterial parasite, Listeria monocytogenes","volume":"109","author":"Tilney","year":"1989","journal-title":"J Cell Biol"},{"key":"ppat.1009379.ref003","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.micinf.2007.05.005","article-title":"Listeriolysin O: a phagosome-specific lysin","volume":"9","author":"P Schnupf","year":"2007","journal-title":"Microbes and Infection"},{"key":"ppat.1009379.ref004","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nrmicro2171","article-title":"Listeria monocytogenes\u2014from saprophyte to intracellular pathogen","volume":"7","author":"NE Freitag","year":"2009","journal-title":"Nat Rev Microbiol"},{"key":"ppat.1009379.ref005","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/nrmicro.2017.126","article-title":"Listeria monocytogenes: towards a complete picture of its physiology and pathogenesis","volume":"16","author":"L Radoshevich","year":"2018","journal-title":"Nat Rev Microbiol"},{"key":"ppat.1009379.ref006","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1126\/science.1092712","article-title":"Extracellular Replication of Listeria monocytogenes in the Murine Gall Bladder","volume":"303","author":"J Hardy","year":"2004","journal-title":"Science"},{"key":"ppat.1009379.ref007","doi-asserted-by":"crossref","first-page":"6334","DOI":"10.1073\/pnas.1702077114","article-title":"Deciphering the landscape of host barriers to Listeria monocytogenes infection","volume":"114","author":"T Zhang","year":"2017","journal-title":"Proc Natl Acad Sci"},{"key":"ppat.1009379.ref008","first-page":"10","article-title":"A Multiorgan Trafficking Circuit Provides Purifying Selection of Listeria monocytogenes Virulence Genes","author":"A Louie","year":"2019","journal-title":"mBio"},{"key":"ppat.1009379.ref009","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.femsre.2004.09.003","article-title":"The interaction between bacteria and bile","volume":"29","author":"M Begley","year":"2005","journal-title":"FEMS Microbiol Rev"},{"key":"ppat.1009379.ref010","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3390\/pathogens7010013","article-title":"A Comparison of Oral and Intravenous Mouse Models of Listeriosis","volume":"7","author":"MG Pitts","year":"2018","journal-title":"Pathogens"},{"key":"ppat.1009379.ref011","first-page":"4","article-title":"Animal models for oral transmission of Listeria monocytogenes","author":"SEF D\u2019Orazio","year":"2014","journal-title":"Front Cell Infect Microbiol"},{"key":"ppat.1009379.ref012","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1007\/s00018-015-2119-4","article-title":"Exploring NAD+ metabolism in host\u2013pathogen interactions","volume":"73","author":"I Mesquita","year":"2016","journal-title":"Cell Mol Life Sci"},{"key":"ppat.1009379.ref013","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1128\/JB.06412-11","article-title":"Transcriptional Regulation of Central Carbon and Energy Metabolism in Bacteria by Redox-Responsive Repressor Rex","volume":"194","author":"DA Ravcheev","year":"2012","journal-title":"J Bacteriol"},{"key":"ppat.1009379.ref014","first-page":"3","article-title":"Regulating the Intersection of Metabolism and Pathogenesis in Gram-positive Bacteria.","author":"AR Richardson","year":"2015","journal-title":"Microbiol Spectr"},{"key":"ppat.1009379.ref015","doi-asserted-by":"crossref","first-page":"4856","DOI":"10.1093\/emboj\/cdg453","article-title":"A novel sensor of NADH\/NAD+ redox poise in Streptomyces coelicolor A3(2).","volume":"22","author":"D Brekasis","year":"2003","journal-title":"EMBO J"},{"key":"ppat.1009379.ref016","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/j.1365-2958.2008.06295.x","article-title":"Structure and functional properties of the Bacillus subtilis transcriptional repressor Rex","volume":"69","author":"E Wang","year":"2008","journal-title":"Mol Microbiol"},{"key":"ppat.1009379.ref017","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1111\/j.1365-2958.2010.07105.x","article-title":"Redox sensing by a Rex-family repressor is involved in the regulation of anaerobic gene expression in Staphylococcus aureus","volume":"76","author":"M Pagels","year":"2010","journal-title":"Mol Microbiol"},{"key":"ppat.1009379.ref018","doi-asserted-by":"crossref","first-page":"7062","DOI":"10.1128\/JB.00601-06","article-title":"Regulatory Loop between Redox Sensing of the NADH\/NAD+ Ratio by Rex (YdiH) and Oxidation of NADH by NADH Dehydrogenase Ndh in Bacillus subtilis","volume":"188","author":"S Gyan","year":"2006","journal-title":"J Bacteriol"},{"key":"ppat.1009379.ref019","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.mib.2018.10.006","article-title":"Sense and sensor ability: redox-responsive regulators in Listeria monocytogenes","volume":"47","author":"BR Ruhland","year":"2019","journal-title":"Current Opinion in Microbiology"},{"key":"ppat.1009379.ref020","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/msb.2012.11","article-title":"Comparative transcriptomics of pathogenic and non-pathogenic Listeria species","volume":"8","author":"O Wurtzel","year":"2012","journal-title":"Mol Syst Biol"},{"key":"ppat.1009379.ref021","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1046\/j.1365-2958.2002.03080.x","article-title":"Listeria monocytogenes bile salt hydrolase is a PrfA-regulated virulence factor involved in the intestinal and hepatic phases of listeriosis","volume":"45","author":"the European Listeria Genome Consortium, Buchrieser C","year":"2002","journal-title":"Mol Microbiol"},{"key":"ppat.1009379.ref022","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1128\/IAI.73.2.894-904.2005","article-title":"Contribution of Three Bile-Associated Loci, bsh, pva, and btlB, to Gastrointestinal Persistence and Bile Tolerance of Listeria monocytogenes","volume":"73","author":"M Begley","year":"2005","journal-title":"Infect Immun"},{"key":"ppat.1009379.ref023","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1128\/IAI.00330-10","article-title":"Investigation of the Mechanisms by Which Listeria monocytogenes Grows in Porcine Gallbladder Bile","volume":"79","author":"GC Dowd","year":"2011","journal-title":"Infect Immun"},{"key":"ppat.1009379.ref024","doi-asserted-by":"crossref","first-page":"e00335","DOI":"10.1128\/mSphere.00335-18","article-title":"Germinant Synergy Facilitates Clostridium difficile Spore Germination under Physiological Conditions","volume":"3","author":"TJ Kochan","year":"2018","journal-title":"mSphere"},{"key":"ppat.1009379.ref025","first-page":"2","article-title":"Entry of Listeria monocytogenes in Mammalian Epithelial Cells: An Updated View.","author":"J Pizarro-Cerd\u00e1","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"key":"ppat.1009379.ref026","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1128\/iai.58.11.3770-3778.1990","article-title":"Isolation of Listeria monocytogenes small-plaque mutants defective for intracellular growth and cell-to-cell spread","volume":"58","author":"AN Sun","year":"1990","journal-title":"Infect Immun"},{"key":"ppat.1009379.ref027","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1084\/jem.20170495","article-title":"Commensal microbes provide first line defense against Listeria monocytogenes infection","volume":"214","author":"S Becattini","year":"2017","journal-title":"J Exp Med"},{"key":"ppat.1009379.ref028","doi-asserted-by":"crossref","first-page":"e1003015","DOI":"10.1371\/journal.ppat.1003015","article-title":"InlA Promotes Dissemination of Listeria monocytogenes to the Mesenteric Lymph Nodes during Food Borne Infection of Mice","volume":"8","author":"ENB Ghanem","year":"2012","journal-title":"PLoS Pathog"},{"key":"ppat.1009379.ref029","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1128\/aem.62.1.304-307.1996","article-title":"Aerobic and anaerobic metabolism of Listeria monocytogenes in defined glucose medium","volume":"62","author":"TL Romick","year":"1996","journal-title":"Appl Environ Microbiol"},{"key":"ppat.1009379.ref030","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1099\/mic.0.075242-0","article-title":"Identification of genes essential for anaerobic growth of Listeria monocytogenes","volume":"160","author":"S M\u00fcller-Herbst","year":"2014","journal-title":"Microbiology"},{"key":"ppat.1009379.ref031","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1111\/j.1365-2672.2005.02559.x","article-title":"Gastrointestinal phase of Listeria monocytogenes infection","volume":"98","author":"CGM Gahan","year":"2005","journal-title":"Journal of Applied Microbiology"},{"key":"ppat.1009379.ref032","doi-asserted-by":"crossref","first-page":"13580","DOI":"10.1073\/pnas.0804437105","article-title":"Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome","volume":"105","author":"BV Jones","year":"2008","journal-title":"Proc Natl Acad Sci"},{"key":"ppat.1009379.ref033","article-title":"Cardiotropic isolates of Listeria monocytogenes with enhanced vertical transmission dependent upon the bacterial surface protein InlB","author":"NM Lamond","year":"2020","journal-title":"Infect Immun"},{"key":"ppat.1009379.ref034","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.1093\/emboj\/18.14.3956","article-title":"A single amino acid in E-cadherin responsible for host specificity towards the human pathogen Listeria monocytogenes","volume":"18","author":"M Lecuit","year":"1999","journal-title":"EMBO J"},{"key":"ppat.1009379.ref035","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.1128\/iai.64.10.3983-3986.1996","article-title":"Expression of the inlAB operon by Listeria monocytogenes is not required for entry into hepatic cells in vivo","volume":"64","author":"SH Gregory","year":"1996","journal-title":"Infect Immun"},{"key":"ppat.1009379.ref036","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.micpath.2007.01.004","article-title":"A P60 mutant of Listeria monocytogenes is impaired in its ability to cause infection in intragastrically inoculated mice","volume":"42","author":"NG Faith","year":"2007","journal-title":"Microbial Pathogenesis"},{"key":"ppat.1009379.ref037","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1365-2958.2011.07683.x","article-title":"The novel Listeria monocytogenes bile sensor BrtA controls expression of the cholic acid efflux pump MdrT","volume":"81","author":"SJ Quillin","year":"2011","journal-title":"Mol Microbiol"},{"key":"ppat.1009379.ref038","first-page":"10","article-title":"Cyclic di-GMP-dependent Signaling Pathways in the Pathogenic Firmicute Listeria monocytogenes","author":"L-H Chen","year":"2014","journal-title":"PLoS Pathog"},{"key":"ppat.1009379.ref039","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1089\/fpd.2011.1013","article-title":"Purine biosynthesis mutants (purA and purB) of serotype 4b Listeria monocytogenes are severely attenuated for systemic infection in intragastrically inoculated A\/J Mice","volume":"9","author":"NG Faith","year":"2012","journal-title":"Foodborne Pathog Dis"},{"key":"ppat.1009379.ref040","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1128\/IAI.74.3.1819-1827.2006","article-title":"Induced Biliary Excretion of Listeria monocytogenes","volume":"74","author":"J Hardy","year":"2006","journal-title":"Infect Immun"},{"key":"ppat.1009379.ref041","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrmicro2490","article-title":"Chronic and acute infection of the gall bladder by Salmonella Typhi: understanding the carrier state","volume":"9","author":"G Gonzalez-Escobedo","year":"2011","journal-title":"Nat Rev Microbiol"},{"key":"ppat.1009379.ref042","first-page":"200","article-title":"Reduce, Induce, Thrive: Bacterial Redox Sensing during Pathogenesis","author":"ML Reniere","year":"2018","journal-title":"J Bacteriol"},{"key":"ppat.1009379.ref043","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1126\/science.1155207","article-title":"A Nitric Oxide-Inducible Lactate Dehydrogenase Enables Staphylococcus aureus to Resist Innate Immunity","volume":"319","author":"AR Richardson","year":"2008","journal-title":"Science"},{"key":"ppat.1009379.ref044","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1111\/mmi.14245","article-title":"Role of the global regulator Rex in control of NAD+-regeneration in Clostridioides (Clostridium) difficile","volume":"111","author":"L Bouillaut","year":"2019","journal-title":"Mol Microbiol"},{"key":"ppat.1009379.ref045","doi-asserted-by":"crossref","first-page":"5722","DOI":"10.1128\/JB.185.19.5722-5734.2003","article-title":"Listeria monocytogenes \u03c3B Regulates Stress Response and Virulence Functions","volume":"185","author":"MJ Kazmierczak","year":"2003","journal-title":"J Bacteriol"},{"key":"ppat.1009379.ref046","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.micinf.2007.05.007","article-title":"The PrfA virulence regulon","volume":"9","author":"M Scortti","year":"2007","journal-title":"Microbes and Infection"},{"key":"ppat.1009379.ref047","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3389\/fmicb.2018.00120","article-title":"The Listeria monocytogenes Bile Stimulon under Acidic Conditions Is Characterized by Strain-Specific Patterns and the Upregulation of Motility, Cell Wall Modification Functions, and the PrfA Regulon","volume":"9","author":"V Guariglia-Oropeza","year":"2018","journal-title":"Front Microbiol"},{"key":"ppat.1009379.ref048","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.4049\/jimmunol.139.6.2005","article-title":"Adoptive transfer of immunity to Listeria monocytogenes. The influence of in vitro stimulation on lymphocyte subset requirements","volume":"139","author":"DK Bishop","year":"1987","journal-title":"J Immunol"},{"key":"ppat.1009379.ref049","doi-asserted-by":"crossref","first-page":"e00969","DOI":"10.1128\/mBio.00969-14","article-title":"Comparison of Widely Used Listeria monocytogenes Strains EGD, 10403S, and EGD-e Highlights Genomic Differences Underlying Variations in Pathogenicity","volume":"5","author":"C B\u00e9cavin","year":"2014","journal-title":"mBio"},{"key":"ppat.1009379.ref050","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/nbt1183-784","article-title":"A Broad Host Range Mobilization System for in vivo Genetic Engineering: Transposon Mutagenesis in Gram-Negative Bacteria","volume":"1","author":"R Simon","year":"1983","journal-title":"Nat Biotechnol"},{"key":"ppat.1009379.ref051","doi-asserted-by":"crossref","first-page":"e00526","DOI":"10.1128\/mBio.00526-18","article-title":"RECON-Dependent Inflammation in Hepatocytes Enhances Listeria monocytogenes Cell-to-Cell Spread.","volume":"9","author":"AP McFarland","year":"2018","journal-title":"mBio"},{"key":"ppat.1009379.ref052","first-page":"12","article-title":"An In Vivo Selection Identifies Listeria monocytogenes Genes Required to Sense the Intracellular Environment and Activate Virulence Factor Expression.","author":"ML Reniere","year":"2016","journal-title":"PLoS Pathog"},{"key":"ppat.1009379.ref053","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1365-2958.1993.tb01211.x","article-title":"Dual roles of plcA in Listeria monocytogenes pathogenesis","volume":"8","author":"A Camilli","year":"1993","journal-title":"Mol Microbiol"},{"key":"ppat.1009379.ref054","first-page":"85","article-title":"A Redox-Responsive Transcription Factor Is Critical for Pathogenesis and Aerobic Growth of Listeria monocytogenes","author":"AT Whiteley","year":"2017","journal-title":"Infect Immun"},{"key":"ppat.1009379.ref055","doi-asserted-by":"crossref","first-page":"e02927-16","DOI":"10.1128\/AEM.02927-16","article-title":"An Effective Counterselection System for Listeria monocytogenes and Its Use To Characterize the Monocin Genomic Region of Strain 10403S","volume":"83","author":"T Argov","year":"2017","journal-title":"Appl Environ Microbiol"},{"key":"ppat.1009379.ref056","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.1128\/JB.184.15.4177-4186.2002","article-title":"Construction, Characterization, and Use of Two Listeria monocytogenes Site-Specific Phage Integration Vectors","volume":"184","author":"P Lauer","year":"2002","journal-title":"J Bacteriol"},{"key":"ppat.1009379.ref057","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nature14029","article-title":"Glutathione activates virulence gene expression of an intracellular pathogen","volume":"517","author":"ML Reniere","year":"2015","journal-title":"Nature"},{"key":"ppat.1009379.ref058","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/mmi.14508","article-title":"Listeria monocytogenes SpxA1 is a global regulator required to activate genes encoding catalase and heme biosynthesis enzymes for aerobic growth","volume":"114","author":"MR Cesinger","year":"2020","journal-title":"Mol Microbiol"},{"key":"ppat.1009379.ref059","doi-asserted-by":"crossref","first-page":"5062","DOI":"10.1128\/IAI.00516-10","article-title":"Listeria monocytogenes Uses Listeria Adhesion Protein (LAP) To Promote Bacterial Transepithelial Translocation and Induces Expression of LAP Receptor Hsp60","volume":"78","author":"KM Burkholder","year":"2010","journal-title":"Infect Immun"},{"key":"ppat.1009379.ref060","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1128\/IAI.00999-10","article-title":"The N -Ethyl- N -Nitrosourea-Induced Goldenticket Mouse Mutant Reveals an Essential Function of Sting in the In Vivo Interferon Response to Listeria monocytogenes and Cyclic Dinucleotides","volume":"79","author":"J-D Sauer","year":"2011","journal-title":"Infect Immun"},{"key":"ppat.1009379.ref061","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of Image Analysis","volume":"9","author":"CA Schneider","year":"2012","journal-title":"Nat Methods"},{"key":"ppat.1009379.ref062","first-page":"50381","article-title":"Oral Transmission of Listeria monocytogenes in Mice via Ingestion of Contaminated Food","author":"EN Bou Ghanem","year":"2013","journal-title":"JoVE"},{"key":"ppat.1009379.ref063","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1128\/IAI.00503-15","article-title":"Intracellular Listeria monocytogenes Comprises a Minimal but Vital Fraction of the Intestinal Burden following Foodborne Infection","volume":"83","author":"GS Jones","year":"2015","journal-title":"Infect Immun"},{"key":"ppat.1009379.ref064","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.4049\/jimmunol.1602076","article-title":"\u2019Orazio SEF. Monocytes are the predominate cell type associated with Listeria monocytogenes in the gut but they do not serve as an intracellular growth niche","volume":"198","author":"D Jones GS","year":"2017","journal-title":"J Immunol"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1009379","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T00:00:00Z","timestamp":1629936000000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1009379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,7]],"date-time":"2023-01-07T08:09:05Z","timestamp":1673078945000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1009379"}},"subtitle":[],"editor":[{"given":"Mary","family":"O\u2019Riordan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,8,16]]},"references-count":64,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,8,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1009379","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.02.16.431404","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,16]]}}}