{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T21:17:25Z","timestamp":1772227045705,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.ppat.1009595","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T00:00:00Z","timestamp":1638144000000}}],"reference-count":141,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T00:00:00Z","timestamp":1636934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["DST ECR\/2015\/000387"],"award-info":[{"award-number":["DST ECR\/2015\/000387"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ramalingaswami Fellowship, Department of Biotechnology","award":["BT\/HRD\/35\/02\/2006"],"award-info":[{"award-number":["BT\/HRD\/35\/02\/2006"]}]},{"name":"University of Potential Excellence-II Jawaharlal Nehru University","award":["245"],"award-info":[{"award-number":["245"]}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    Tail-anchored (TA) proteins are defined by the absence of N-terminus signal sequence and the presence of a single transmembrane domain (TMD) proximal to their C-terminus. They play fundamental roles in cellular processes including vesicular trafficking, protein translocation and quality control. Some of the TA proteins are post-translationally integrated by the Guided Entry of TA (GET) pathway to the cellular membranes; with their N-terminus oriented towards the cytosol and C-terminus facing the organellar lumen. The TA repertoire and the GET machinery have been extensively characterized in the yeast and mammalian systems, however, they remain elusive in the human malaria parasite\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    . In this study, we bioinformatically predicted a total of 63 TA proteins in the\n                    <jats:italic>P<\/jats:italic>\n                    .\n                    <jats:italic>falciparum<\/jats:italic>\n                    proteome and revealed the association of a subset with the\n                    <jats:italic>P<\/jats:italic>\n                    .\n                    <jats:italic>falciparum<\/jats:italic>\n                    homolog of Get3 (PfGet3). In addition, our proximity labelling studies either definitively identified or shortlisted the other eligible GET constituents, and our\n                    <jats:italic>in vitro<\/jats:italic>\n                    association studies validated associations between PfGet3 and the corresponding homologs of Get4 and Get2 in\n                    <jats:italic>P<\/jats:italic>\n                    .\n                    <jats:italic>falciparum<\/jats:italic>\n                    . Collectively, this study reveals the presence of proteins with hallmark TA signatures and the involvement of evolutionary conserved GET trafficking pathway for their targeted delivery within the parasite.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1009595","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T13:45:06Z","timestamp":1636983906000},"page":"e1009595","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["A conserved guided entry of tail-anchored pathway is involved in the trafficking of a subset of membrane proteins in Plasmodium falciparum"],"prefix":"10.1371","volume":"17","author":[{"given":"Tarkeshwar","family":"Kumar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4825-2373","authenticated-orcid":true,"given":"Satarupa","family":"Maitra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdur","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3782-5677","authenticated-orcid":true,"given":"Souvik","family":"Bhattacharjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2021,11,15]]},"reference":[{"key":"ppat.1009595.ref001","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1083\/jcb.95.2.470","article-title":"Protein translocation across the endoplasmic reticulum. 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