{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:10:29Z","timestamp":1790680229178,"version":"4.1.0"},"reference-count":129,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T00:00:00Z","timestamp":1626307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["OV5-170349"],"award-info":[{"award-number":["OV5-170349"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["OV5-170349"],"award-info":[{"award-number":["OV5-170349"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["OV5-170349"],"award-info":[{"award-number":["OV5-170349"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["VRI-172779"],"award-info":[{"award-number":["VRI-172779"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["OV2 \u2013 170357"],"award-info":[{"award-number":["OV2 \u2013 170357"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["950-231498"],"award-info":[{"award-number":["950-231498"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000194","name":"Nova Scotia Health Research Foundation","doi-asserted-by":"publisher","award":["No grant number"],"award-info":[{"award-number":["No grant number"]}],"id":[{"id":"10.13039\/501100000194","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008762","name":"Genome Canada","doi-asserted-by":"publisher","award":["No grant number"],"award-info":[{"award-number":["No grant number"]}],"id":[{"id":"10.13039\/100008762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","award":["No grant number"],"award-info":[{"award-number":["No grant number"]}],"id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015147","name":"Innovation Saskatchewan","doi-asserted-by":"crossref","award":["No grant number"],"award-info":[{"award-number":["No grant number"]}],"id":[{"id":"10.13039\/100015147","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of Agriculture, Government of Saskatchewan","award":["No grant number"],"award-info":[{"award-number":["No grant number"]}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>COVID-19 (coronavirus disease 2019) caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection is a disease affecting several organ systems. A model that captures all clinical symptoms of COVID-19 as well as long-haulers disease is needed. We investigated the host responses associated with infection in several major organ systems including the respiratory tract, the heart, and the kidneys after SARS-CoV-2 infection in Syrian hamsters. We found significant increases in inflammatory cytokines (IL-6, IL-1beta, and TNF) and type II interferons whereas type I interferons were inhibited. Examination of extrapulmonary tissue indicated inflammation in the kidney, liver, and heart which also lacked type I interferon upregulation. Histologically, the heart had evidence of myocarditis and microthrombi while the kidney had tubular inflammation. These results give insight into the multiorgan disease experienced by people with COVID-19 and possibly the prolonged disease in people with post-acute sequelae of SARS-CoV-2 (PASC).<\/jats:p>","DOI":"10.1371\/journal.ppat.1009705","type":"journal-article","created":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T13:27:20Z","timestamp":1626355640000},"page":"e1009705","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":80,"title":["SARS-CoV-2 infection in the Syrian hamster model causes inflammation as well as type I interferon dysregulation in both respiratory and non-respiratory tissues including the heart and kidney"],"prefix":"10.1371","volume":"17","author":[{"given":"Magen Ellen","family":"Francis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2058-1194","authenticated-orcid":true,"given":"Una","family":"Goncin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Kroeker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9766-1160","authenticated-orcid":true,"given":"Cynthia","family":"Swan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0245-050X","authenticated-orcid":true,"given":"Robyn","family":"Ralph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6725-3668","authenticated-orcid":true,"given":"Yao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1363-8957","authenticated-orcid":true,"given":"Athema Louise","family":"Etzioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8805-8068","authenticated-orcid":true,"given":"Darryl","family":"Falzarano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Gerdts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3761-6864","authenticated-orcid":true,"given":"Steven","family":"Machtaler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3305-7084","authenticated-orcid":true,"given":"Jason","family":"Kindrachuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0940-0847","authenticated-orcid":true,"given":"Alyson Ann","family":"Kelvin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,7,15]]},"reference":[{"key":"ppat.1009705.ref001","unstructured":"Zhuang Pinghui JW. Wuhan pneumonia: how the search for the source of the mystery illness unfolded South China Morning Post2020. Available from: https:\/\/www.scmp.com\/news\/china\/society\/article\/3046233\/wuhan-pneumonia-how-search-source-mystery-illness-unfolded."},{"issue":"1","key":"ppat.1009705.ref002","first-page":"157","article-title":"WHO Declares COVID-19 a Pandemic.","volume":"91","author":"D Cucinotta","year":"2020","journal-title":"Acta Biomed."},{"issue":"6","key":"ppat.1009705.ref003","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.cmi.2020.03.026","article-title":"COVID-19, SARS and MERS: are they closely related?","volume":"26","author":"N Petrosillo","year":"2020","journal-title":"Clin Microbiol Infect"},{"key":"ppat.1009705.ref004","unstructured":"Medicine JHU. Coronavirus Resource Center 2021. Available from: https:\/\/coronavirus.jhu.edu\/."},{"issue":"7825","key":"ppat.1009705.ref005","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/d41586-020-02598-6","article-title":"The lasting misery of coronavirus long-haulers","volume":"585","author":"M. Marshall","year":"2020","journal-title":"Nature"},{"issue":"7","key":"ppat.1009705.ref006","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/s41591-020-0968-3","article-title":"Extrapulmonary manifestations of COVID-19","volume":"26","author":"A Gupta","year":"2020","journal-title":"Nat Med"},{"issue":"2","key":"ppat.1009705.ref007","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s11357-020-00186-0","article-title":"SARS-CoV-2 and COVID-19 in older adults: what we may expect regarding pathogenesis, immune responses, and outcomes.","volume":"42","author":"J Nikolich-Zugich","year":"2020","journal-title":"Geroscience"},{"key":"ppat.1009705.ref008","unstructured":"WHO. 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VetScan Comprehensive Diagnostic Profile. 2015."},{"key":"ppat.1009705.ref028","doi-asserted-by":"crossref","first-page":"108393","DOI":"10.1016\/j.clim.2020.108393","article-title":"The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The Perspectives of clinical immunologists from China.","volume":"214","author":"W Zhang","year":"2020","journal-title":"Clin Immunol"},{"issue":"15","key":"ppat.1009705.ref029","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1093\/cid\/ciaa248","article-title":"Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China.","volume":"71","author":"C Qin","year":"2020","journal-title":"Clin Infect Dis"},{"issue":"1","key":"ppat.1009705.ref030","doi-asserted-by":"crossref","first-page":"e63","DOI":"10.7861\/clinmed.2020-0896","article-title":"Autonomic dysfunction in \u2019long COVID\u2019: rationale, physiology and management 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Konno","year":"2020","journal-title":"Cell Rep."},{"issue":"9","key":"ppat.1009705.ref064","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/s41423-020-0514-8","article-title":"SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70","volume":"17","author":"HW Jiang","year":"2020","journal-title":"Cell Mol Immunol."},{"issue":"5","key":"ppat.1009705.ref065","article-title":"Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis","volume":"55","author":"WJ Guan","year":"2020","journal-title":"Eur Respir J"},{"issue":"1","key":"ppat.1009705.ref066","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jaci.2020.04.029","article-title":"Type I IFN immunoprofiling in COVID-19 patients","volume":"146","author":"S Trouillet-Assant","year":"2020","journal-title":"J Allergy Clin 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Zhou","year":"2020","journal-title":"Viruses"},{"issue":"10238","key":"ppat.1009705.ref074","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1016\/S0140-6736(20)31042-4","article-title":"Triple combination of interferon beta-1b, lopinavir-ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial","volume":"395","author":"IF Hung","year":"2020","journal-title":"Lancet"},{"key":"ppat.1009705.ref075","article-title":"Peginterferon lambda for the treatment of outpatients with COVID-19: a phase 2, placebo-controlled randomised trial","author":"JJ Feld","year":"2021","journal-title":"Lancet Respir Med"},{"key":"ppat.1009705.ref076","doi-asserted-by":"crossref","first-page":"491","DOI":"10.3389\/fimmu.2014.00491","article-title":"Macrophage cytokines: involvement in immunity and infectious diseases","volume":"5","author":"G Arango Duque","year":"2014","journal-title":"Front 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Cardiol."},{"issue":"3","key":"ppat.1009705.ref080","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.pcad.2020.03.001","article-title":"Cardiac troponin I in patients with coronavirus disease 2019 (COVID-19): Evidence from a meta-analysis.","volume":"63","author":"G Lippi","year":"2020","journal-title":"Prog Cardiovasc Dis."},{"issue":"7","key":"ppat.1009705.ref081","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1001\/jamacardio.2020.0950","article-title":"Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China.","volume":"5","author":"S Shi","year":"2020","journal-title":"JAMA Cardiol."},{"issue":"5","key":"ppat.1009705.ref082","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s15010-020-01424-5","article-title":"First case of COVID-19 complicated with fulminant myocarditis: a case report and insights.","volume":"48","author":"JH Zeng","year":"2020","journal-title":"Infection"},{"key":"ppat.1009705.ref083","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ijcard.2020.03.086","article-title":"SARS-CoV-2 inflames the heart. The importance of awareness of myocardial injury in COVID-19 patients.","volume":"311","author":"E Ammirati","year":"2020","journal-title":"Int J Cardiol."},{"issue":"11","key":"ppat.1009705.ref084","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1001\/jamacardio.2020.3557","article-title":"Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19).","volume":"5","author":"VO Puntmann","year":"2020","journal-title":"JAMA Cardiol."},{"key":"ppat.1009705.ref085","doi-asserted-by":"crossref","unstructured":"Barber C. COVID-19 Can Wreck Your Heart, Even if You Haven\u2019t Had Any Symptoms Scientific American2020. 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Immunol."},{"issue":"9","key":"ppat.1009705.ref097","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/s41577-020-0402-6","article-title":"T cell responses in patients with COVID-19","volume":"20","author":"Z Chen","year":"2020","journal-title":"Nat Rev Immunol"},{"issue":"6","key":"ppat.1009705.ref098","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1189\/jlb.0603272","article-title":"The main function of IL-2 is to promote the development of T regulatory cells","volume":"74","author":"TR Malek","year":"2003","journal-title":"J Leukoc Biol"},{"issue":"6","key":"ppat.1009705.ref099","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.4049\/jimmunol.165.6.2982","article-title":"Coordinate regulation of the IL-4, IL-13, and IL-5 cytokine cluster in Th2 clones revealed by allelic expression patterns","volume":"165","author":"BL Kelly","year":"2000","journal-title":"J 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Kaneko","year":"2020","journal-title":"Cell"},{"issue":"33","key":"ppat.1009705.ref107","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aau6085","article-title":"Structure and function of the immune system in the spleen.","volume":"4","author":"SM Lewis","year":"2019","journal-title":"Sci Immunol."},{"key":"ppat.1009705.ref108","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.3389\/fimmu.2018.02469","article-title":"Regulation of the Germinal Center Response.","volume":"9","author":"M Stebegg","year":"2018","journal-title":"Front Immunol."},{"issue":"8","key":"ppat.1009705.ref109","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/nri3865","article-title":"The multifaceted biology of plasmacytoid dendritic cells","volume":"15","author":"M Swiecki","year":"2015","journal-title":"Nat Rev Immunol"},{"issue":"5","key":"ppat.1009705.ref110","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.immuni.2013.10.010","article-title":"The spleen in 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