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Alterations in function and regeneration of dendritic cells (DCs) and monocytes may contribute to immunopathology and influence adaptive immune responses in COVID-19 patients. We analyzed circulating DC and monocyte subsets in 65 hospitalized COVID-19 patients with mild\/moderate or severe disease from acute illness to recovery and in healthy controls. Persisting reduction of all DC subpopulations was accompanied by an expansion of proliferating Lineage<jats:sup>\u2212<\/jats:sup>HLADR<jats:sup>+<\/jats:sup> cells lacking DC markers. Increased frequency of CD163<jats:sup>+<\/jats:sup> CD14<jats:sup>+<\/jats:sup> cells within the recently discovered DC3 subpopulation in patients with more severe disease was associated with systemic inflammation, activated T follicular helper cells, and antibody-secreting cells. Persistent downregulation of CD86 and upregulation of programmed death-ligand 1 (PD-L1) in conventional DCs (cDC2 and DC3) and classical monocytes associated with a reduced capacity to stimulate na\u00efve CD4<jats:sup>+<\/jats:sup> T cells correlated with disease severity. 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