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The presence of non-pathogenic microflora or their components, at the point of infection, dramatically increases\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>aureus<\/jats:italic>\n                    pathogenicity, a process termed augmentation. Augmentation is associated with macrophage interaction but by a hitherto unknown mechanism. Here, we demonstrate a breadth of cross-kingdom microorganisms can augment\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>aureus<\/jats:italic>\n                    disease and that pathogenesis of\n                    <jats:italic>Enterococcus faecalis<\/jats:italic>\n                    can also be augmented. Co-administration of augmenting material also forms an efficacious vaccine model for\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>aureus<\/jats:italic>\n                    .\n                    <jats:italic>In vitro<\/jats:italic>\n                    , augmenting material protects\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>aureus<\/jats:italic>\n                    directly from reactive oxygen species (ROS), which correlates with\n                    <jats:italic>in vivo<\/jats:italic>\n                    studies where augmentation restores full virulence to the ROS-susceptible, attenuated mutant\n                    <jats:italic>katA ahpC<\/jats:italic>\n                    . At the cellular level, augmentation increases bacterial survival within macrophages via amelioration of ROS, leading to proliferation and escape. We have defined the molecular basis for augmentation that represents an important aspect of the initiation of infection.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1009880","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T13:45:03Z","timestamp":1631799903000},"page":"e1009880","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Commensal bacteria augment Staphylococcus aureus infection by inactivation of phagocyte-derived reactive oxygen species"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4299-2488","authenticated-orcid":true,"given":"Josie F.","family":"Gibson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5193-3631","authenticated-orcid":true,"given":"Grace R.","family":"Pidwill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8847-5489","authenticated-orcid":true,"given":"Oliver T.","family":"Carnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6367-3235","authenticated-orcid":true,"given":"Bas G. 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