{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:26:01Z","timestamp":1793157961541,"version":"4.5.0"},"reference-count":116,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T00:00:00Z","timestamp":1644451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50GM098911"],"award-info":[{"award-number":["P50GM098911"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01GM125576"],"award-info":[{"award-number":["P01GM125576"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01HD22486"],"award-info":[{"award-number":["P01HD22486"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["PF-17-208-01-MPC"],"award-info":[{"award-number":["PF-17-208-01-MPC"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005851","name":"John Simon Guggenheim Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    The enteric nervous system (ENS) controls many aspects of intestinal homeostasis, including parameters that shape the habitat of microbial residents. Previously we showed that zebrafish lacking an ENS, due to deficiency of the\n                    <jats:italic>sox10<\/jats:italic>\n                    gene, develop intestinal inflammation and bacterial dysbiosis, with an expansion of proinflammatory\n                    <jats:italic>Vibrio<\/jats:italic>\n                    strains. To understand the primary defects resulting in dysbiosis in\n                    <jats:italic>sox10<\/jats:italic>\n                    mutants, we investigated how the ENS shapes the intestinal environment in the absence of microbiota and associated inflammatory responses. We found that intestinal transit, intestinal permeability, and luminal pH regulation are all aberrant in\n                    <jats:italic>sox10<\/jats:italic>\n                    mutants, independent of microbially induced inflammation. Treatment with the proton pump inhibitor, omeprazole, corrected the more acidic luminal pH of\n                    <jats:italic>sox10<\/jats:italic>\n                    mutants to wild type levels. Omeprazole treatment also prevented overabundance of\n                    <jats:italic>Vibrio<\/jats:italic>\n                    and ameliorated inflammation in\n                    <jats:italic>sox10<\/jats:italic>\n                    mutant intestines. Treatment with the carbonic anhydrase inhibitor, acetazolamide, caused wild type luminal pH to become more acidic, and increased both\n                    <jats:italic>Vibrio<\/jats:italic>\n                    abundance and intestinal inflammation. We conclude that a primary function of the ENS is to regulate luminal pH, which plays a critical role in shaping the resident microbial community and regulating intestinal inflammation.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1009989","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T13:26:32Z","timestamp":1644499592000},"page":"e1009989","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":36,"title":["Enteric nervous system modulation of luminal pH modifies the microbial environment to promote intestinal health"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0293-7043","authenticated-orcid":true,"given":"M. Kristina","family":"Hamilton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5120-0801","authenticated-orcid":true,"given":"Elena S.","family":"Wall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine D.","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6004-9955","authenticated-orcid":true,"given":"Karen","family":"Guillemin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith S.","family":"Eisen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,2,10]]},"reference":[{"key":"ppat.1009989.ref001","first-page":"651","article-title":"A Dissertation on the Sensible and Irritable Parts of Animals (1755)","volume":"4","author":"A. 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