{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:53:42Z","timestamp":1792806822185,"version":"4.5.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1010040","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:00:00Z","timestamp":1649203200000}}],"reference-count":73,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T00:00:00Z","timestamp":1648166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"crossref","award":["P20GM109094"],"award-info":[{"award-number":["P20GM109094"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K22AI134677"],"award-info":[{"award-number":["K22AI134677"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    Invasive aspergillosis is a common opportunistic infection, causing &gt;50% mortality in infected immunocompromised patients. The specific molecular mechanisms of the innate immune system that prevent pathogenesis of invasive aspergillosis in immunocompetent individuals are not fully understood. Here, we used a zebrafish larva-\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    infection model to identify cyclooxygenase (COX) enzyme signaling as one mechanism that promotes host survival. Larvae exposed to the pan-COX inhibitor indomethacin succumb to infection at a significantly higher rate than control larvae. COX signaling is both macrophage- and neutrophil-mediated. However, indomethacin treatment has no effect on phagocyte recruitment. Instead, COX signaling promotes phagocyte-mediated inhibition of germination and invasive hyphal growth. Increased germination and invasive hyphal growth is also observed in infected F0 crispant larvae with mutations in genes encoding for COX enzymes (\n                    <jats:italic>ptgs2a\/b<\/jats:italic>\n                    ). Protective COX-mediated signaling requires the receptor EP2 and exogenous prostaglandin E\n                    <jats:sub>2<\/jats:sub>\n                    (PGE\n                    <jats:sub>2<\/jats:sub>\n                    ) rescues indomethacin-induced decreased immune control of fungal growth. Collectively, we find that COX signaling activates the PGE\n                    <jats:sub>2<\/jats:sub>\n                    -EP2 pathway to increase control\n                    <jats:italic>A<\/jats:italic>\n                    .\n                    <jats:italic>fumigatus<\/jats:italic>\n                    hyphal growth by phagocytes in zebrafish larvae.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1010040","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T13:47:45Z","timestamp":1648216065000},"page":"e1010040","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["Cyclooxygenase production of PGE2 promotes phagocyte control of A. fumigatus hyphal growth in larval zebrafish"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4617-7552","authenticated-orcid":true,"given":"Savini","family":"Thrikawala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1647-5003","authenticated-orcid":true,"given":"Mengyao","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4386-9473","authenticated-orcid":true,"given":"Nancy P.","family":"Keller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6761-1098","authenticated-orcid":true,"given":"Emily E.","family":"Rosowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,3,25]]},"reference":[{"issue":"2","key":"ppat.1010040.ref001","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1128\/CMR.12.2.310","article-title":"Aspergillus fumigatus and aspergillosis","volume":"12","author":"JP Latge","year":"1999","journal-title":"Clinical microbiology reviews"},{"issue":"Suppl 1","key":"ppat.1010040.ref002","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.3109\/13693786.2010.505204","article-title":"Clinical risk factors for invasive aspergillosis","volume":"49","author":"JW Baddley","year":"2011","journal-title":"Medical mycology"},{"issue":"4","key":"ppat.1010040.ref003","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1086\/513943","article-title":"Invasive aspergillosis","volume":"26","author":"DW Denning","year":"1998","journal-title":"Clinical infectious 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Harizi","year":"2013","journal-title":"BioMed research international"},{"issue":"1","key":"ppat.1010040.ref037","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4049\/jimmunol.1101029","article-title":"Regulation of immune responses by prostaglandin E2","volume":"188","author":"P. 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