{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T04:24:26Z","timestamp":1793075066437,"version":"4.5.0"},"reference-count":134,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T00:00:00Z","timestamp":1639526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FP7 of the European Commission","award":["290002ADVance"],"award-info":[{"award-number":["290002ADVance"]}]},{"name":"FP7 of the European Commission","award":["290002ADVance"],"award-info":[{"award-number":["290002ADVance"]}]},{"name":"FP7 European Commission","award":["290002ADVance"],"award-info":[{"award-number":["290002ADVance"]}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["31003A_146286"],"award-info":[{"award-number":["31003A_146286"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["31003A_179256 \/ 1"],"award-info":[{"award-number":["31003A_179256 \/ 1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004784","name":"Novartis Stiftung\u00a0f\u00fcr\u00a0Medizinisch-Biologische Forschung","doi-asserted-by":"publisher","award":["16C222"],"award-info":[{"award-number":["16C222"]}],"id":[{"id":"10.13039\/501100004784","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>Mammalian adenoviruses (AdVs) comprise more than ~350 types including over 100 human (HAdVs) and just three mouse AdVs (MAdVs). While most HAdVs initiate infection by high affinity\/avidity binding of their fiber knob (FK) protein to either coxsackievirus AdV receptor (CAR), CD46 or desmoglein (DSG)-2, MAdV-1 (M1) infection requires arginine-glycine-aspartate (RGD) binding integrins. To identify the receptors mediating MAdV infection we generated five novel reporter viruses for MAdV-1\/-2\/-3 (M1, M2, M3) transducing permissive murine (m) CMT-93 cells, but not B16 mouse melanoma cells expressing mCAR, human (h) CD46 or hDSG-2. Recombinant M1 or M3 FKs cross-blocked M1 and M3 but not M2 infections. Profiling of murine and human cells expressing RGD-binding integrins suggested that \u03b1v\u03b26 and \u03b1v\u03b28 heterodimers are associated with M1 and M3 infections. Ectopic expression of m\u03b26 in B16 cells strongly enhanced M1 and M3 binding, infection, and progeny production comparable with m\u03b1v\u03b26-positive CMT-93 cells, whereas m\u03b28 expressing cells were more permissive to M1 than M3. Anti-integrin antibodies potently blocked M1 and M3 binding and infection of CMT-93 cells and h\u03b1v\u03b28-positive M000216 cells. Soluble integrin \u03b1v\u03b26, and synthetic peptides containing the RGDLXXL sequence derived from FK-M1, FK-M3 and foot and mouth disease virus coat protein strongly interfered with M1\/M3 infections, in agreement with high affinity interactions of FK-M1\/FK-M3 with \u03b1v\u03b26\/\u03b1v\u03b28, determined by surface plasmon resonance measurements. Molecular docking simulations of ternary complexes revealed a bent conformation of RGDLXXL-containing FK-M3 peptides on the subunit interface of \u03b1v\u03b26\/\u03b28, where the distal leucine residue dips into a hydrophobic pocket of \u03b26\/8, the arginine residue ionically engages \u03b1v aspartate215, and the aspartate residue coordinates a divalent cation in \u03b1v\u03b26\/\u03b28. Together, the RGDLXXL-bearing FKs are part of an essential mechanism for M1\/M3 infection engaging murine and human \u03b1v\u03b26\/8 integrins. These integrins are highly conserved in other mammals, and may favour cross-species virus transmission.<\/jats:p>","DOI":"10.1371\/journal.ppat.1010083","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T18:36:42Z","timestamp":1639593402000},"page":"e1010083","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["The RGD-binding integrins \u03b1v\u03b26 and \u03b1v\u03b28 are receptors for mouse adenovirus-1 and -3 infection"],"prefix":"10.1371","volume":"17","author":[{"given":"Manuela","family":"Bieri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7161-4526","authenticated-orcid":true,"given":"Rodinde","family":"Hendrickx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8156-4603","authenticated-orcid":true,"given":"Michael","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9678-3622","authenticated-orcid":true,"given":"Tania","family":"Jetzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Dreier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peer R. E.","family":"Mittl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Sobek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4191-5306","authenticated-orcid":true,"given":"Andreas","family":"Pl\u00fcckthun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2278-120X","authenticated-orcid":true,"given":"Urs F.","family":"Greber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4238-2217","authenticated-orcid":true,"given":"Silvio","family":"Hemmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,12,15]]},"reference":[{"issue":"Pt 11","key":"ppat.1010083.ref001","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1099\/vir.0.19497-0","article-title":"Genetic content and evolution of adenoviruses","volume":"84","author":"AJ Davison","year":"2003","journal-title":"J Gen Virol"},{"issue":"24","key":"ppat.1010083.ref002","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1002\/1873-3468.13576","article-title":"Adenovirus persistence, reactivation, and clinical management","volume":"593","author":"T. 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