{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:38:18Z","timestamp":1791725898823,"version":"4.3.4"},"reference-count":130,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T00:00:00Z","timestamp":1644451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1100919"],"award-info":[{"award-number":["APP1100919"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1079086"],"award-info":[{"award-number":["APP1079086"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1154347"],"award-info":[{"award-number":["APP1154347"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1058391"],"award-info":[{"award-number":["APP1058391"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001791","name":"Griffith University","doi-asserted-by":"publisher","award":["Postgraduate Scholarship"],"award-info":[{"award-number":["Postgraduate Scholarship"]}],"id":[{"id":"10.13039\/501100001791","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>Arthritogenic alphaviruses are mosquito-borne viruses that are a major cause of infectious arthropathies worldwide, and recent outbreaks of chikungunya virus and Ross River virus (RRV) infections highlight the need for robust intervention strategies. Alphaviral arthritis can persist for months after the initial acute disease, and is mediated by cellular immune responses. A common strategy to limit inflammation and pathology is to dampen the overwhelming inflammatory responses by modulating proinflammatory cytokine pathways. Here, we investigate the contribution of interleukin-17 (IL-17), a cytokine involved in arthropathies such as rheumatoid arthritis, in the development RRV-induced arthritis and myositis. IL-17 was quantified in serum from RRV-infected patients, and mice were infected with RRV and joints and muscle tissues collected to analyse cellular infiltrates, tissue mRNA, cytokine expression, and joint and muscle histopathology. IL-17 expression was increased in musculoskeletal tissues and serum of RRV-infected mice and humans, respectively. IL-17\u2013producing T cells and neutrophils contributed to the cellular infiltrate in the joint and muscle tissue during acute RRV disease in mice. Blockade of IL-17A\/F using a monoclonal antibody (mAb) reduced disease severity in RRV-infected mice and led to decreased proinflammatory proteins, cellular infiltration in synovial tissues and cartilage damage, without affecting viral titers in inflamed tissues. IL-17A\/F blockade triggered a shift in transcriptional profile of both leukocyte infiltrates and musculoskeletal stromal cells by downregulating proinflammatory genes. This study highlights a previously uncharacterized role for an effector cytokine in alphaviral pathology and points towards potential therapeutic benefit in targeting IL-17 to treat patients presenting with RRV-induced arthropathy.<\/jats:p>","DOI":"10.1371\/journal.ppat.1010185","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T18:26:56Z","timestamp":1644517616000},"page":"e1010185","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["Interleukin-17 contributes to Ross River virus-induced arthritis and myositis"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6051-3268","authenticated-orcid":true,"given":"Helen","family":"Mostafavi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kothila","family":"Tharmarajah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1696-9812","authenticated-orcid":true,"given":"Jelena","family":"Vider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5482-4182","authenticated-orcid":true,"given":"Nicholas P.","family":"West","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3104-6282","authenticated-orcid":true,"given":"Joseph R.","family":"Freitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Cameron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Foster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9969-7335","authenticated-orcid":true,"given":"Linda P.","family":"Hueston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6277-8887","authenticated-orcid":true,"given":"Andrew R.","family":"Lloyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3141-8410","authenticated-orcid":true,"given":"Suresh","family":"Mahalingam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Zaid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,2,10]]},"reference":[{"issue":"4","key":"ppat.1010185.ref001","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1002\/art.40403","article-title":"Review: Chikungunya Arthritis: Implications of Acute and Chronic Inflammation Mechanisms on Disease Management.","volume":"70","author":"A Zaid","year":"2018","journal-title":"Arthritis & Rheumatology"},{"issue":"3","key":"ppat.1010185.ref002","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.pharmthera.2009.09.005","article-title":"The immunobiology of viral arthritides.","volume":"124","author":"A Suhrbier","year":"2009","journal-title":"Pharmacology & Therapeutics"},{"issue":"9","key":"ppat.1010185.ref003","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S1473-3099(14)70869-2","article-title":"Chikungunya virus and arthritic disease","volume":"14","author":"F Burt","year":"2014","journal-title":"The Lancet Infectious Diseases"},{"key":"ppat.1010185.ref004","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.tmaid.2017.01.004","article-title":"Long-term sequelae of chikungunya virus disease: A systematic review.","volume":"15","author":"M van Aalst","year":"2017","journal-title":"Travel Medicine and Infectious Disease"},{"key":"ppat.1010185.ref005","article-title":"Spatial and temporal patterns of Ross River virus in South East Queensland, Australia: identification of hot spots at the rural-urban interface.","author":"AK Murphy","year":"2020","journal-title":"Europe PMC."},{"issue":"5","key":"ppat.1010185.ref006","doi-asserted-by":"crossref","DOI":"10.1016\/S1473-3099(20)30491-6","article-title":"Arthritogenic alphaviruses: epidemiological and clinical perspective on emerging arboviruses.","volume":"21","author":"A Zaid","year":"2020","journal-title":"The Lancet Infectious Diseases"},{"issue":"2","key":"ppat.1010185.ref007","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/1529-0131(200002)43:2<365::AID-ANR16>3.0.CO;2-E","article-title":"Detection of viral ribonucleic acid and histologic analysis of inflamed synovium in Ross River virus infection.","volume":"43","author":"M Soden","year":"2000","journal-title":"Arthritis & Rheumatism"},{"issue":"4","key":"ppat.1010185.ref008","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/art.40383","article-title":"Chikungunya Arthritis Mechanisms in the Americas: A Cross-Sectional Analysis of Chikungunya Arthritis Patients Twenty-Two Months After Infection Demonstrating No Detectable Viral Persistence in Synovi.","volume":"70","author":"AY Chang","year":"2018","journal-title":"Arthritis & Rheumatology"},{"issue":"4","key":"ppat.1010185.ref009","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s11926-021-00987-y","article-title":"Persistent Joint Pain Following Arthropod Virus Infections.","volume":"23","author":"K Suchowiecki","year":"2021","journal-title":"Current Rheumatology Reports"},{"issue":"1","key":"ppat.1010185.ref010","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1186\/s12891-021-04123-w","article-title":"Pentosan polysulfate sodium for Ross River virus-induced arthralgia: a phase 2a, randomized, double-blind, placebo-controlled study.","volume":"22","author":"R Krishnan","year":"2021","journal-title":"BMC Musculoskeletal Disorders"},{"issue":"15","key":"ppat.1010185.ref011","doi-asserted-by":"crossref","first-page":"8063","DOI":"10.1128\/JVI.00224-15","article-title":"Pentosan Polysulfate: a Novel Glycosaminoglycan-Like Molecule for Effective Treatment of Alphavirus-Induced Cartilage Destruction and Inflammatory Disease","volume":"89","author":"LJ Herrero","year":"2015","journal-title":"Journal of Virology"},{"issue":"16","key":"ppat.1010185.ref012","doi-asserted-by":"crossref","first-page":"8021","DOI":"10.1128\/JVI.02603-09","article-title":"Chikungunya Virus Arthritis in Adult Wild-Type Mice","volume":"84","author":"J Gardner","year":"2010","journal-title":"Journal of Virology"},{"issue":"2","key":"ppat.1010185.ref013","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1084\/jem.20090851","article-title":"Type I IFN controls chikungunya virus via its action on nonhematopoietic cells","volume":"207","author":"C Schilte","year":"2010","journal-title":"The Journal of Experimental Medicine"},{"issue":"2","key":"ppat.1010185.ref014","doi-asserted-by":"crossref","first-page":"678","DOI":"10.4049\/jimmunol.1401833","article-title":"CD8+ T cells control Ross River virus infection in musculoskeletal tissues of infected mice","volume":"194","author":"KS Burrack","year":"2014","journal-title":"Journal of immunology (Baltimore, Md: 1950)."},{"issue":"1","key":"ppat.1010185.ref015","doi-asserted-by":"crossref","first-page":"259","DOI":"10.4049\/jimmunol.1202177","article-title":"A Pathogenic Role for CD4+ T Cells during Chikungunya Virus Infection in Mice.","volume":"190","author":"T-H Teo","year":"2013","journal-title":"The Journal of Immunology"},{"issue":"1","key":"ppat.1010185.ref016","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ajpath.2010.11.018","article-title":"A Mouse Model of Chikungunya Virus\u2013Induced Musculoskeletal Inflammatory Disease Evidence of Arthritis, Tenosynovitis, Myositis, and Persistence","volume":"178","author":"TE Morrison","year":"2011","journal-title":"The American Journal of Pathology"},{"issue":"10","key":"ppat.1010185.ref017","doi-asserted-by":"crossref","first-page":"5914","DOI":"10.4049\/jimmunol.0900255","article-title":"Persistent Chronic Inflammation and Infection by Chikungunya Arthritogenic Alphavirus in Spite of a Robust Host Immune Response","volume":"184","author":"J-J Hoarau","year":"2010","journal-title":"The Journal of Immunology"},{"issue":"375","key":"ppat.1010185.ref018","article-title":"Fingolimod treatment abrogates chikungunya virus\u2013induced arthralgia","volume":"9","author":"T-H Teo","year":"2017","journal-title":"Science Translational Medicine"},{"issue":"375","key":"ppat.1010185.ref019","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aah3438","article-title":"Therapy with CTLA4-Ig and an antiviral monoclonal antibody controls chikungunya virus arthritis.","volume":"9","author":"JJ Miner","year":"2017","journal-title":"Science Translational Medicine"},{"issue":"5","key":"ppat.1010185.ref020","doi-asserted-by":"crossref","DOI":"10.1186\/ar4347","article-title":"A phase Ib multiple ascending dose study evaluating safety, pharmacokinetics, and early clinical response of brodalumab, a human anti-IL-17R antibody, in methotrexate-resistant rheumatoid arthritis.","volume":"15","author":"DA Martin","year":"2013","journal-title":"Arthritis Research & Therapy"},{"issue":"2","key":"ppat.1010185.ref021","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1002\/art.20001","article-title":"Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion.","volume":"50","author":"E Lubberts","year":"2004","journal-title":"Arthritis & Rheumatism"},{"issue":"13","key":"ppat.1010185.ref022","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1056\/NEJMoa1109017","article-title":"Brodalumab, an Anti\u2013Interleukin-17\u2013Receptor Antibody for Psoriasis","volume":"366","author":"KA Papp","year":"2012","journal-title":"The New England Journal of Medicine"},{"issue":"6","key":"ppat.1010185.ref023","doi-asserted-by":"crossref","first-page":"912","DOI":"10.3899\/jrheum.141271","article-title":"A study to evaluate the safety, tolerability, and efficacy of brodalumab in subjects with rheumatoid arthritis and an inadequate response to methotrexate","volume":"42","author":"K Pavelka","year":"2015","journal-title":"The Journal of rheumatology"},{"issue":"2","key":"ppat.1010185.ref024","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.cyto.2013.07.022","article-title":"IL-17 family: Cytokines, receptors and signaling","volume":"64","author":"C Gu","year":"2013","journal-title":"Cytokine"},{"issue":"3","key":"ppat.1010185.ref025","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.coi.2007.04.005","article-title":"Differentiation and function of Th17 T cells.","volume":"19","author":"B Stockinger","year":"2007","journal-title":"Current Opinion in Immunology."},{"issue":"4","key":"ppat.1010185.ref026","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.immuni.2019.03.021","article-title":"The IL-17 Family of Cytokines in Health and Disease","volume":"50","author":"MJ McGeachy","year":"2019","journal-title":"Immunity"},{"key":"ppat.1010185.ref027","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.molimm.2017.07.004","article-title":"IL-17B: A new area of study in the IL-17 family","volume":"90","author":"Q Bie","year":"2017","journal-title":"Molecular Immunology"},{"key":"ppat.1010185.ref028","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.canlet.2018.02.037","article-title":"A positive feedback loop of IL-17B-IL-17RB activates ERK\/\u03b2-catenin to promote lung cancer metastasis","volume":"422","author":"Y-F Yang","year":"2018","journal-title":"Cancer Lett"},{"issue":"4","key":"ppat.1010185.ref029","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.immuni.2015.03.008","article-title":"Interleukin-17B Antagonizes Interleukin-25-Mediated Mucosal Inflammation.","volume":"42","author":"M Reynolds Joseph","year":"2015","journal-title":"Immunity"},{"issue":"12","key":"ppat.1010185.ref030","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/ni.2156","article-title":"IL-17C regulates the innate immune function of epithelial cells in an autocrine manner","volume":"12","author":"V Ramirez-Carrozzi","year":"2011","journal-title":"Nature Immunology"},{"issue":"12","key":"ppat.1010185.ref031","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1038\/ni.2155","article-title":"IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens","volume":"12","author":"X Song","year":"2011","journal-title":"Nature Immunology"},{"issue":"9","key":"ppat.1010185.ref032","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1016\/j.celrep.2016.07.075","article-title":"Nrf2 Induces IL-17D to Mediate Tumor and Virus Surveillance","volume":"16","author":"R Saddawi-Konefka","year":"2016","journal-title":"Cell Reports"},{"key":"ppat.1010185.ref033","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cyto.2016.11.017","article-title":"The ancient cytokine IL-17D is regulated by Nrf2 and mediates tumor and virus surveillance","volume":"91","author":"R Seelige","year":"2017","journal-title":"Cytokine"},{"issue":"4","key":"ppat.1010185.ref034","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1084\/jem.20051615","article-title":"Identification of an interleukin (IL)-25\u2013dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion.","volume":"203","author":"PG Fallon","year":"2006","journal-title":"The Journal of Experimental Medicine"},{"key":"ppat.1010185.ref035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/3908061","article-title":"The Role of IL-17 and Related Cytokines in Inflammatory Autoimmune Diseases.","volume":"2017","author":"T Kuwabara","year":"2017","journal-title":"Mediators of Inflammation"},{"issue":"5","key":"ppat.1010185.ref036","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.4049\/jimmunol.0801967","article-title":"Genome-wide comparison between IL-17A- and IL-17F-induced effects in human rheumatoid arthritis synoviocytes","volume":"182","author":"S Zrioual","year":"2009","journal-title":"Journal of immunology (Baltimore, Md: 1950)"},{"issue":"2","key":"ppat.1010185.ref037","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/eji.201344184","article-title":"Interleukin 17 contributes to the chronicity of inflammatory diseases such as rheumatoid arthritis","volume":"44","author":"G Benedetti","year":"2014","journal-title":"European Journal of Immunology"},{"issue":"4","key":"ppat.1010185.ref038","article-title":"Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen","volume":"17","author":"FJ Burt","year":"2017","journal-title":"The Lancet Infectious Diseases"},{"issue":"4","key":"ppat.1010185.ref039","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.4049\/jimmunol.162.4.2347","article-title":"Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways","volume":"162","author":"M Laan","year":"1999","journal-title":"Journal of immunology (Baltimore, Md: 1950)"},{"key":"ppat.1010185.ref040","doi-asserted-by":"crossref","DOI":"10.1016\/S0065-2776(08)00605-6","article-title":"Emergence of the Th17 pathway and its role in host defense","volume":"99","author":"DB O\u2019Quinn","year":"2008","journal-title":"Adv Immunol"},{"issue":"1","key":"ppat.1010185.ref041","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.cyto.2014.11.020","article-title":"Involvement of the IL-23\/IL-17 axis and the Th17\/Treg balance in the pathogenesis and control of autoimmune arthritis","volume":"74","author":"B Astry","year":"2015","journal-title":"Cytokine"},{"issue":"5","key":"ppat.1010185.ref042","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1172\/JCI40891","article-title":"IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice","volume":"120","author":"JS Cho","year":"2010","journal-title":"Journal of Clinical Investigation"},{"issue":"1","key":"ppat.1010185.ref043","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.immuni.2008.11.009","article-title":"Differential Roles of Interleukin-17A and -17F in Host Defense against Mucoepithelial Bacterial Infection and Allergic Responses","volume":"30","author":"H Ishigame","year":"2009","journal-title":"Immunity"},{"issue":"7","key":"ppat.1010185.ref044","doi-asserted-by":"crossref","DOI":"10.1006\/cyto.2000.0681","article-title":"Contribution of interleukin 17 to synovium matrix destruction in rheumatoid arthritis","volume":"12","author":"M Chabaud","year":"2000","journal-title":"Cytokine"},{"issue":"5","key":"ppat.1010185.ref045","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1093\/rheumatology\/40.5.522","article-title":"High in vivo expression of interleukin-17 receptor in synovial endothelial cells and chondrocytes from arthritis patients.","volume":"40","author":"MC Honorati","year":"2001","journal-title":"Rheumatology"},{"issue":"9","key":"ppat.1010185.ref046","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1172\/JCI5703","article-title":"IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis","volume":"103","author":"S Kotake","year":"1999","journal-title":"Journal of Clinical Investigation"},{"issue":"5","key":"ppat.1010185.ref047","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.4049\/jimmunol.164.5.2832","article-title":"High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism","volume":"164","author":"M Ziolkowska","year":"2000","journal-title":"Journal of immunology (Baltimore, Md: 1950)"},{"issue":"11","key":"ppat.1010185.ref048","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1042\/CS20110496","article-title":"IL-17\/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential","volume":"122","author":"S Zhu","year":"2012","journal-title":"Clinical Science"},{"key":"ppat.1010185.ref049","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/751793","article-title":"Altered Immunoregulation in Rheumatoid Arthritis: The Role of Regulatory T Cells and Proinflammatory Th17 Cells and Therapeutic Implications.","volume":"2015","author":"A Alunno","year":"2015","journal-title":"Mediators of Inflammation"},{"issue":"11","key":"ppat.1010185.ref050","doi-asserted-by":"crossref","first-page":"6173","DOI":"10.4049\/jimmunol.171.11.6173","article-title":"Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice.","volume":"171","author":"S Nakae","year":"2003","journal-title":"Journal of immunology (Baltimore, Md: 1950)."},{"issue":"4","key":"ppat.1010185.ref051","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1002\/art.21749","article-title":"Synovial membrane cytokine expression is predictive of joint damage progression in rheumatoid arthritis: A two-year prospective study (the DAMAGE study cohort).","volume":"54","author":"BW Kirkham","year":"2006","journal-title":"Arthritis & Rheumatism"},{"issue":"9","key":"ppat.1010185.ref052","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1007\/s10067-011-1737-y","article-title":"Serum and synovial fluid levels of interleukin-17 in correlation with disease activity in patients with RA.","volume":"30","author":"S Metawi","year":"2011","journal-title":"Clinical Rheumatology"},{"issue":"6","key":"ppat.1010185.ref053","doi-asserted-by":"crossref","first-page":"3884","DOI":"10.4049\/jimmunol.0802246","article-title":"IL-17 Induces Monocyte Migration in Rheumatoid Arthritis","volume":"182","author":"S Shahrara","year":"2009","journal-title":"The Journal of Immunology"},{"issue":"3\u20134","key":"ppat.1010185.ref054","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.vetmic.2012.11.021","article-title":"Production of IL-8, IL-17, IFN-gamma and IP-10 in human astrocytes correlates with alphavirus attenuation","volume":"163","author":"B-H Peng","year":"2013","journal-title":"Veterinary Microbiology"},{"issue":"45","key":"ppat.1010185.ref055","doi-asserted-by":"crossref","first-page":"16053","DOI":"10.1073\/pnas.1418966111","article-title":"Interleukin 10 modulation of pathogenic Th17 cells during fatal alphavirus encephalomyelitis","volume":"111","author":"KA Kulcsar","year":"2014","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"11","key":"ppat.1010185.ref056","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1002\/art.34631","article-title":"Gene profiling of Chikungunya virus arthritis in a mouse model reveals significant overlap with rheumatoid arthritis. Arthritis &","volume":"64","author":"HI Nakaya","year":"2012","journal-title":"Rheumatism"},{"issue":"4","key":"ppat.1010185.ref057","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1089\/vim.2010.0123","article-title":"Role of proinflammatory cytokines and chemokines in chronic arthropathy in CHIKV infection","volume":"24","author":"I Chaaitanya","year":"2011","journal-title":"Viral immunology"},{"issue":"2","key":"ppat.1010185.ref058","article-title":"Role of Pentraxin 3 in Shaping Arthritogenic Alphaviral Disease: From Enhanced Viral Replication to Immunomodulation.","volume":"11","author":"S-S Foo","year":"2015","journal-title":"PLOS Pathogens"},{"issue":"4","key":"ppat.1010185.ref059","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.immuni.2018.03.015","article-title":"KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity.","volume":"48","author":"D Herndler-Brandstetter","year":"2018","journal-title":"Immunity"},{"issue":"6","key":"ppat.1010185.ref060","doi-asserted-by":"crossref","first-page":"e20200940","DOI":"10.1084\/jem.20200940","article-title":"Ptpn2 and KLRG1 regulate the generation and function of tissue-resident memory CD8+ T cells in skin","volume":"218","author":"K Hochheiser","year":"2021","journal-title":"J Exp Med"},{"issue":"11","key":"ppat.1010185.ref061","doi-asserted-by":"crossref","first-page":"6546","DOI":"10.4049\/jimmunol.151.11.6546","article-title":"Role of gamma delta T cells in murine collagen-induced arthritis","volume":"151","author":"GM Peterman","year":"1993","journal-title":"Journal of immunology (Baltimore, Md: 1950)"},{"issue":"1","key":"ppat.1010185.ref062","first-page":"78","article-title":"Elevation of a \u03b3\u03b4 T cell subset in peripheral blood and synovial fluid of patients with rheumatoid arthritis.","volume":"84","author":"EC Keystone","year":"1991","journal-title":"Clinical & Experimental Immunology"},{"issue":"5","key":"ppat.1010185.ref063","first-page":"371","article-title":"Frequency of gamma delta T cells in peripheral blood, synovial fluid, synovial membrane and lungs from patients with rheumatoid arthritis","volume":"46","author":"T Mitogawa","year":"1992","journal-title":"Acta medica Okayama"},{"key":"ppat.1010185.ref064","doi-asserted-by":"crossref","first-page":"588382","DOI":"10.3389\/fimmu.2020.588382","article-title":"Interleukin-17A Facilitates Chikungunya Virus Infection by Inhibiting IFN-\u03b12 Expression.","volume":"11","author":"B Neupane","year":"2020","journal-title":"Frontiers in Immunology"},{"key":"ppat.1010185.ref065","doi-asserted-by":"crossref","DOI":"10.1016\/j.joca.2010.05.025","article-title":"The OARSI histopathology initiative\u2013recommendations for histological assessments of osteoarthritis in the mouse","volume":"18","author":"SS Glasson","year":"2010","journal-title":"Osteoarthritis and Cartilage"},{"issue":"4","key":"ppat.1010185.ref066","doi-asserted-by":"crossref","first-page":"702","DOI":"10.3201\/eid2304.160466","article-title":"Increased Proinflammatory Cytokine Levels in Prolonged Arthralgia in Ross River Virus Infection","volume":"23","author":"D Tappe","year":"2017","journal-title":"Emerging Infectious Diseases"},{"issue":"11","key":"ppat.1010185.ref067","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1086\/587841","article-title":"Macrophage-Derived Proinflammatory Factors Contribute to the Development of Arthritis and Myositis after Infection with an Arthrogenic Alphavirus","volume":"197","author":"BA Lidbury","year":"2008","journal-title":"The Journal of Infectious Diseases"},{"issue":"1","key":"ppat.1010185.ref068","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/infdis\/jiq006","article-title":"The Acute Phase of Chikungunya Virus Infection in Humans Is Associated With Strong Innate Immunity and T CD8 Cell Activation","volume":"204","author":"N Wauquier","year":"2011","journal-title":"The Journal of Infectious Diseases"},{"issue":"2","key":"ppat.1010185.ref069","article-title":"RNA-Seq analysis of chikungunya virus infection and identification of granzyme A as a major promoter of arthritic inflammation","volume":"13","author":"JAC Wilson","year":"2017","journal-title":"PLOS Pathogens"},{"issue":"2","key":"ppat.1010185.ref070","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/infdis\/jiq042","article-title":"Persistent Arthralgia Induced by Chikungunya Virus Infection is Associated with Interleukin-6 and Granulocyte Macrophage Colony-Stimulating Factor","volume":"203","author":"A Chow","year":"2011","journal-title":"The Journal of Infectious Diseases"},{"issue":"8","key":"ppat.1010185.ref071","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001279","article-title":"Inflammatory Cytokine Expression Is Associated with Chikungunya Virus Resolution and Symptom Severity.","volume":"5","author":"AA Kelvin","year":"2011","journal-title":"PLoS Neglected Tropical Diseases"},{"issue":"12","key":"ppat.1010185.ref072","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1093\/infdis\/jiv049","article-title":"A Systematic Meta-analysis of Immune Signatures in Patients With Acute Chikungunya Virus Infection","volume":"211","author":"T-S Teng","year":"2015","journal-title":"The Journal of Infectious Diseases"},{"issue":"7","key":"ppat.1010185.ref073","doi-asserted-by":"crossref","DOI":"10.1038\/nrrheum.2015.53","article-title":"The IL-23\u2013IL-17 axis in inflammatory arthritis","volume":"11","author":"E. Lubberts","year":"2015","journal-title":"Nature Reviews Rheumatology"},{"issue":"3","key":"ppat.1010185.ref074","article-title":"Prominent Bone Loss Mediated by RANKL and IL-17 Produced by CD4+ T Cells in TallyHo\/JngJ Mice.","volume":"6","author":"H Won","year":"2011","journal-title":"PLoS ONE"},{"issue":"6","key":"ppat.1010185.ref075","first-page":"6854","article-title":"IL-17A promotes osteoclast formation via inducing RANKL in synovial cells","volume":"10","author":"J Wang","year":"2017","journal-title":"International Journal of Clinical and Experimental Pathology"},{"issue":"12","key":"ppat.1010185.ref076","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1084\/jem.20071397","article-title":"Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model","volume":"204","author":"K Hirota","year":"2007","journal-title":"The Journal of Experimental Medicine"},{"issue":"1","key":"ppat.1010185.ref077","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13223-019-0359-9","article-title":"Endogenous stimulation is responsible for the high frequency of IL-17A-producing neutrophils in patients with rheumatoid arthritis.","volume":"15","author":"M Gonzalez-Orozco","year":"2019","journal-title":"Allergy, Asthma & Clinical Immunology."},{"issue":"6","key":"ppat.1010185.ref078","first-page":"552","article-title":"IL-17 Expression by macrophages is associated with proliferative inflammatory atrophy lesions in prostate cancer patients","volume":"4","author":"EV Vykhovanets","year":"2011","journal-title":"Int J Clin Exp Patho"},{"issue":"9","key":"ppat.1010185.ref079","doi-asserted-by":"crossref","first-page":"6117","DOI":"10.4049\/jimmunol.181.9.6117","article-title":"IL-17-Producing Alveolar Macrophages Mediate Allergic Lung Inflammation Related to Asthma","volume":"181","author":"C Song","year":"2008","journal-title":"The Journal of Immunology"},{"issue":"7","key":"ppat.1010185.ref080","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1093\/infdis\/jir470","article-title":"Protection From Arthritis and Myositis in a Mouse Model of Acute Chikungunya Virus Disease by Bindarit, an Inhibitor of Monocyte Chemotactic Protein-1 Synthesis","volume":"204","author":"NE Rulli","year":"2011","journal-title":"The Journal of Infectious Diseases"},{"key":"ppat.1010185.ref081","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.3389\/fimmu.2019.02736","article-title":"Exacerbation of Chikungunya Virus Rheumatic Immunopathology by a High Fiber Diet and Butyrate.","volume":"10","author":"NA Prow","year":"2019","journal-title":"Frontiers in Immunology"},{"issue":"12","key":"ppat.1010185.ref082","doi-asserted-by":"crossref","first-page":"6862","DOI":"10.1128\/JVI.03364-13","article-title":"CCR2 Deficiency Promotes Exacerbated Chronic Erosive Neutrophil-Dominated Chikungunya Virus Arthritis","volume":"88","author":"Y Poo","year":"2014","journal-title":"Journal of Virology"},{"issue":"3","key":"ppat.1010185.ref083","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/jid.2013.404","article-title":"IL-6 Regulates Neutrophil Microabscess Formation in IL-17A-Driven Psoriasiform Lesions","volume":"134","author":"AL Croxford","year":"2014","journal-title":"Journal of Investigative Dermatology"},{"issue":"16","key":"ppat.1010185.ref084","doi-asserted-by":"crossref","first-page":"6040","DOI":"10.1073\/pnas.1318859111","article-title":"Arthritogenic alphaviral infection perturbs osteoblast function and triggers pathologic bone loss","volume":"111","author":"W Chen","year":"2014","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"12","key":"ppat.1010185.ref085","doi-asserted-by":"crossref","first-page":"e1006748","DOI":"10.1371\/journal.ppat.1006748","article-title":"Inflammatory monocytes mediate control of acute alphavirus infection in mice.","volume":"13","author":"KC Haist","year":"2017","journal-title":"PLoS Pathogens"},{"issue":"2","key":"ppat.1010185.ref086","doi-asserted-by":"crossref","first-page":"e03353","DOI":"10.1128\/mBio.03353-19","article-title":"Modulation of Monocyte-Driven Myositis in Alphavirus Infection Reveals a Role for CX3CR1+ Macrophages in Tissue Repair.","volume":"11","author":"A Zaid","year":"2020","journal-title":"Mbio"},{"issue":"15","key":"ppat.1010185.ref087","doi-asserted-by":"crossref","first-page":"7955","DOI":"10.1128\/JVI.00909-15","article-title":"Caribbean and La R\u00e9union Chikungunya Virus Isolates Differ in Their Capacity To Induce Proinflammatory Th1 and NK Cell Responses and Acute Joint Pathology","volume":"89","author":"T-H Teo","year":"2015","journal-title":"Journal of Virology"},{"issue":"3","key":"ppat.1010185.ref088","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.coi.2007.04.004","article-title":"Natural killer cells: from CD3\u2212NKp46+ to post-genomics meta-analyses","volume":"19","author":"T Walzer","year":"2007","journal-title":"Current Opinion in Immunology"},{"issue":"4","key":"ppat.1010185.ref089","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1084\/jem.181.4.1267","article-title":"CD8 beta chain influences CD8 alpha chain-associated Lck kinase activity","volume":"181","author":"HY Irie","year":"1995","journal-title":"The Journal of experimental medicine"},{"issue":"1","key":"ppat.1010185.ref090","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.immuni.2009.11.012","article-title":"Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells","volume":"32","author":"ME Pipkin","year":"2010","journal-title":"Immunity"},{"issue":"1","key":"ppat.1010185.ref091","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1128\/JVI.02034-14","article-title":"Bindarit, an Inhibitor of Monocyte Chemotactic Protein Synthesis, Protects against Bone Loss Induced by Chikungunya Virus Infection","volume":"89","author":"W Chen","year":"2015","journal-title":"Journal of Virology"},{"issue":"1","key":"ppat.1010185.ref092","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1186\/1471-2164-10-372","article-title":"Combined genome-wide expression profiling and targeted RNA interference in primary mouse macrophages reveals perturbation of transcriptional networks associated with interferon signalling","volume":"10","author":"P Lacaze","year":"2009","journal-title":"BMC Genomics"},{"issue":"1","key":"ppat.1010185.ref093","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006835","article-title":"Alphavirus-induced hyperactivation of PI3K\/AKT directs pro-viral metabolic changes.","volume":"14","author":"M Mazzon","year":"2018","journal-title":"PLOS Pathogens"},{"key":"ppat.1010185.ref094","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3389\/fimmu.2017.00311","article-title":"Immunometabolic Regulation of Interleukin-17-Producing T Helper Cells: Uncoupling New Targets for Autoimmunity.","volume":"8","author":"KJ Binger","year":"2017","journal-title":"Frontiers in Immunology"},{"issue":"10","key":"ppat.1010185.ref095","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.3390\/cells8101257","article-title":"Where to Stand with Stromal Cells and Chronic Synovitis in Rheumatoid Arthritis?","volume":"8","author":"J-M Brondello","year":"2019","journal-title":"Cells"},{"issue":"7","key":"ppat.1010185.ref096","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.molmet.2016.04.005","article-title":"Metabolic reprogramming through fatty acid transport protein 1 (FATP1) regulates macrophage inflammatory potential and adipose inflammation.","volume":"5","author":"AR Johnson","year":"2016","journal-title":"Molecular Metabolism"},{"issue":"5","key":"ppat.1010185.ref097","doi-asserted-by":"crossref","DOI":"10.1152\/ajpendo.2000.279.5.E1072","article-title":"Fatty acid transport protein-1 mRNA expression in skeletal muscle and in adipose tissue in humans","volume":"279","author":"C Binnert","year":"2000","journal-title":"American Journal of Physiology-Endocrinology and Metabolism"},{"issue":"5","key":"ppat.1010185.ref098","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0098109","article-title":"Fatty Acid Transport Protein 1 (FATP1) Localizes in Mitochondria in Mouse Skeletal Muscle and Regulates Lipid and Ketone Body Disposal.","volume":"9","author":"M Guitart","year":"2014","journal-title":"PLoS ONE"},{"issue":"22","key":"ppat.1010185.ref099","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1152\/physiolgenomics.00108.2013","article-title":"Analyses of synovial tissues from arthritic and protected congenic rat strains reveal a new core set of genes associated with disease severity","volume":"45","author":"M Brenner","year":"2013","journal-title":"Physiological Genomics"},{"issue":"2","key":"ppat.1010185.ref100","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S1079-9796(03)00151-7","article-title":"Myb protein specificity: evidence of a context-specific transcription factor code","volume":"31","author":"SA Ness","year":"2003","journal-title":"Blood Cells Mol Dis"},{"issue":"6","key":"ppat.1010185.ref101","doi-asserted-by":"crossref","first-page":"e2895","DOI":"10.1038\/cddis.2017.244","article-title":"MYBL2 (B-Myb): a central regulator of cell proliferation, cell survival and differentiation involved in tumorigenesis.","volume":"8","author":"J Musa","year":"2017","journal-title":"Cell Death Dis."},{"issue":"10","key":"ppat.1010185.ref102","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1002\/stem.496","article-title":"B-Myb is Critical for Proper DNA Duplication During an Unperturbed S Phase in Mouse Embryonic Stem Cells","volume":"28","author":"M Lorvellec","year":"2010","journal-title":"Stem Cells"},{"issue":"1","key":"ppat.1010185.ref103","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/s41598-018-19573-x","article-title":"PLK1 protects against sepsis-induced intestinal barrier dysfunction.","volume":"8","author":"Y Cao","year":"2018","journal-title":"Sci Rep-uk"},{"issue":"1","key":"ppat.1010185.ref104","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.tranon.2016.10.003","article-title":"PLK1, A Potential Target for Cancer Therapy.","volume":"10","author":"Z Liu","year":"2017","journal-title":"Transl Oncol"},{"issue":"1","key":"ppat.1010185.ref105","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/2162-3619-1-38","article-title":"Polo-like kinase 1 as target for cancer therapy","volume":"1","author":"L Wei\u00df","year":"2012","journal-title":"Exp Hematology Oncol"},{"issue":"1","key":"ppat.1010185.ref106","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1189\/jlb.2VMR1215-582R","article-title":"The RP105\/MD-1 complex: molecular signaling mechanisms and pathophysiological implications","volume":"101","author":"TE Schultz","year":"2017","journal-title":"Journal of Leukocyte Biology"},{"issue":"1","key":"ppat.1010185.ref107","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1084\/jem.192.1.23","article-title":"The Toll-like Receptor Protein Rp105 Regulates Lipopolysaccharide Signaling in B Cells","volume":"192","author":"H Ogata","year":"2000","journal-title":"The Journal of Experimental Medicine"},{"issue":"1","key":"ppat.1010185.ref108","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.chom.2008.12.002","article-title":"RP105 Facilitates Macrophage Activation by Mycobacterium tuberculosis Lipoproteins","volume":"5","author":"A Blumenthal","year":"2009","journal-title":"Cell Host Microbe"},{"issue":"6","key":"ppat.1010185.ref109","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/ni1198","article-title":"Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105","volume":"6","author":"S Divanovic","year":"2005","journal-title":"Nature Immunology"},{"issue":"17","key":"ppat.1010185.ref110","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.1042\/BCJ20210263","article-title":"Lactate cross-talk in host\u2013pathogen interactions","volume":"478","author":"A Llibre","year":"2021","journal-title":"Biochem J"},{"issue":"11","key":"ppat.1010185.ref111","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1369\/jhc.4A6306.2004","article-title":"Presence and Localization of Three Lactic Acid Transporters (MCT1, \u22122, and \u22124) in Separated Human Granulocytes, Lymphocytes, and Monocytes.","volume":"52","author":"N Merezhinskaya","year":"2004","journal-title":"J Histochem Cytochem"},{"issue":"11","key":"ppat.1010185.ref112","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1002\/art.39270","article-title":"Monocarboxylate Transporter 4, Associated With the Acidification of Synovial Fluid, Is a Novel Therapeutic Target for Inflammatory Arthritis.","volume":"67","author":"W Fujii","year":"2015","journal-title":"Arthritis & Rheumatology."},{"issue":"3","key":"ppat.1010185.ref113","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s00109-020-01882-2","article-title":"Synovial fibroblast-derived exosomal microRNA-106b suppresses chondrocyte proliferation and migration in rheumatoid arthritis via down-regulation of PDK4","volume":"98","author":"D Liu","year":"2020","journal-title":"Journal of Molecular Medicine"},{"issue":"11","key":"ppat.1010185.ref114","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1002\/art.22174","article-title":"Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis.","volume":"54","author":"T Aigner","year":"2006","journal-title":"Arthritis & Rheumatism"},{"key":"ppat.1010185.ref115","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3389\/fphys.2020.00347","article-title":"Metabolic Checkpoints in Rheumatoid Arthritis.","volume":"11","author":"V Pucino","year":"2020","journal-title":"Frontiers in Physiology"},{"issue":"8","key":"ppat.1010185.ref116","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1002\/art.38021","article-title":"The Impact of Inflammation on Metabolomic Profiles in Patients With Arthritis. Arthritis &","volume":"65","author":"SP Young","year":"2013","journal-title":"Rheumatism"},{"issue":"3","key":"ppat.1010185.ref117","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/25785826.2018.1531186","article-title":"Immunometabolism in rheumatoid arthritis.","volume":"41","author":"T Okano","year":"2018","journal-title":"Immunological Medicine"},{"issue":"9","key":"ppat.1010185.ref118","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1002\/art.23753","article-title":"Chikungunya virus aches and pains: An emerging challenge.","volume":"58","author":"A Chopra","year":"2008","journal-title":"Arthritis & Rheumatism."},{"key":"ppat.1010185.ref119","first-page":"83","article-title":"Post-chikungunya chronic arthritis\u2014our experience with DMARDs over two year follow up","volume":"59","author":"MA Ganu","year":"2011","journal-title":"The Journal of the Association of Physicians of India"},{"issue":"3","key":"ppat.1010185.ref120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003603","article-title":"Specific Management of Post-Chikungunya Rheumatic Disorders: A Retrospective Study of 159 Cases in Reunion Island from 2006\u20132012.","volume":"9","author":"E Javelle","year":"2015","journal-title":"PLOS Neglected Tropical Diseases"},{"issue":"6","key":"ppat.1010185.ref121","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1007\/s10067-016-3429-0","article-title":"Efficacy of combination DMARD therapy vs. hydroxychloroquine monotherapy in chronic persistent chikungunya arthritis: a 24-week randomized controlled open label study.","volume":"36","author":"V Ravindran","year":"2017","journal-title":"Clinical Rheumatology"},{"issue":"8","key":"ppat.1010185.ref122","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0071146","article-title":"Methotrexate Treatment Causes Early Onset of Disease in a Mouse Model of Ross River Virus-Induced Inflammatory Disease through Increased Monocyte Production.","volume":"8","author":"A Taylor","year":"2013","journal-title":"PLoS ONE"},{"issue":"2","key":"ppat.1010185.ref123","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/0042-6822(91)90584-X","article-title":"Infectious RNA transcripts from ross river virus cDNA clones and the construction and characterization of defined chimeras with sindbis virus","volume":"182","author":"RJ Kuhn","year":"1991","journal-title":"Virology"},{"issue":"1","key":"ppat.1010185.ref124","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1086\/315164","article-title":"Macrophage-Induced Muscle Pathology Results in Morbidity and Mortality for Ross River Virus-Infected Mice","volume":"181","author":"BA Lidbury","year":"2000","journal-title":"The Journal of Infectious Diseases"},{"issue":"7568","key":"ppat.1010185.ref125","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1136\/bmj.38933.585764.AE","article-title":"Post-infective and chronic fatigue syndromes precipitated by viral and non-viral pathogens: prospective cohort study","volume":"333","author":"I Hickie","year":"2006","journal-title":"BMJ"},{"issue":"7","key":"ppat.1010185.ref126","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/cyto.a.22625","article-title":"FlowSOM: Using self-organizing maps for visualization and interpretation of cytometry data.","volume":"87","author":"SV Gassen","year":"2015","journal-title":"Cytom Part A"},{"key":"ppat.1010185.ref127","article-title":"UMAP: Uniform Manifold Approximation and Projection for Dimension Reduction.","author":"L McInnes","year":"2018","journal-title":"Arxiv"},{"issue":"35","key":"ppat.1010185.ref128","article-title":"Multiplex, quantitative cellular analysis in large tissue volumes with clearing-enhanced 3D microscopy (Ce3D).","volume":"114","author":"W Li","year":"2017","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"3","key":"ppat.1010185.ref129","first-page":"71","article-title":"An improvement of the 2\u02c6(-delta delta CT) method for quantitative real-time polymerase chain reaction data analysis.","volume":"3","author":"X Rao","year":"2013","journal-title":"Biostatistics, bioinformatics and biomathematics"},{"issue":"1","key":"ppat.1010185.ref130","doi-asserted-by":"crossref","first-page":"20560","DOI":"10.1038\/s41598-020-76603-3","article-title":"VolcaNoseR is a web app for creating, exploring, labeling and sharing volcano plots.","volume":"10","author":"J Goedhart","year":"2020","journal-title":"Sci Rep-uk."}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1010519","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1010185","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T14:54:00Z","timestamp":1674744840000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1010185"}},"subtitle":[],"editor":[{"given":"Deborah","family":"Lenschow","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,2,10]]},"references-count":130,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,2,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1010185","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.ppat.1010519","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,10]]}}}