{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:49:15Z","timestamp":1791557355701,"version":"4.3.4"},"update-to":[{"DOI":"10.1371\/journal.ppat.1010192","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T00:00:00Z","timestamp":1642636800000}}],"reference-count":70,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T00:00:00Z","timestamp":1641513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"crossref","award":["R01GM117111"],"award-info":[{"award-number":["R01GM117111"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI124566"],"award-info":[{"award-number":["R01AI124566"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01DE026600"],"award-info":[{"award-number":["R01DE026600"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"crossref","award":["R01EY18612"],"award-info":[{"award-number":["R01EY18612"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    is a major opportunistic pathogen of humans. It can grow as morphologically distinct yeast, pseudohyphae and hyphae, and the ability to switch reversibly among different forms is critical for its virulence. The relationship between morphogenesis and innate immune recognition is not quite clear. Dectin-1 is a major C-type lectin receptor that recognizes \u03b2-glucan in the fungal cell wall.\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>albicans<\/jats:italic>\n                    \u03b2-glucan is usually masked by the outer mannan layer of the cell wall. Whether and how \u03b2-glucan masking is differentially regulated during hyphal morphogenesis is not fully understood. Here we show that the endo-1,3-glucanase Eng1 is differentially expressed in yeast, and together with Yeast Wall Protein 1 (Ywp1), regulates \u03b2-glucan exposure and Dectin-1-dependent immune activation of macrophage by yeast cells.\n                    <jats:italic>ENG1<\/jats:italic>\n                    deletion results in enhanced Dectin-1 binding at the septa of yeast cells; while\n                    <jats:italic>eng1 ywp1<\/jats:italic>\n                    yeast cells show strong overall Dectin-1 binding similar to hyphae of wild-type and\n                    <jats:italic>eng1<\/jats:italic>\n                    mutants. Correlatively, hyphae of wild-type and\n                    <jats:italic>eng1<\/jats:italic>\n                    induced similar levels of cytokines in macrophage.\n                    <jats:italic>ENG1<\/jats:italic>\n                    expression and Eng1-mediated \u03b2-glucan trimming are also regulated by antifungal drugs, lactate and N-acetylglucosamine. Deletion of\n                    <jats:italic>ENG1<\/jats:italic>\n                    modulates virulence in the mouse model of hematogenously disseminated candidiasis in a Dectin-1-dependent manner. The\n                    <jats:italic>eng1<\/jats:italic>\n                    mutant exhibited attenuated lethality in male mice, but enhanced lethality in female mice, which was associated with a stronger renal immune response and lower fungal burden. Thus, Eng1-regulated \u03b2-glucan exposure in yeast cells modulates the balance between immune protection and immunopathogenesis during disseminated candidiasis.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1010192","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T13:36:04Z","timestamp":1641562564000},"page":"e1010192","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":63,"title":["Control of \u03b2-glucan exposure by the endo-1,3-glucanase Eng1 in Candida albicans modulates virulence"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5108-648X","authenticated-orcid":true,"given":"Mengli","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5163-2110","authenticated-orcid":true,"given":"Norma V.","family":"Solis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9381-780X","authenticated-orcid":true,"given":"Michaela","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Garleb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0566-3017","authenticated-orcid":true,"given":"Daidong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5261-6267","authenticated-orcid":true,"given":"Marc","family":"Swidergall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Pearlman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7278-3700","authenticated-orcid":true,"given":"Scott G.","family":"Filler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3489-7103","authenticated-orcid":true,"given":"Haoping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,1,7]]},"reference":[{"key":"ppat.1010192.ref001","doi-asserted-by":"crossref","first-page":"165rv13","DOI":"10.1126\/scitranslmed.3004404","article-title":"Hidden killers: human fungal infections","volume":"4","author":"GD Brown","year":"2012","journal-title":"Sci Transl Med."},{"key":"ppat.1010192.ref002","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jinf.2012.02.011","article-title":"Emerging trends in candidemia: A higher incidence but a similar outcome","volume":"65","author":"J Fort\u00fan","year":"2012","journal-title":"J Infect."},{"key":"ppat.1010192.ref003","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1159\/000321157","article-title":"Organ-specific innate immune responses in a mouse model of invasive candidiasis","volume":"3","author":"MS Lionakis","year":"2011","journal-title":"J Innate Immun"},{"key":"ppat.1010192.ref004","doi-asserted-by":"crossref","first-page":"e1002865","DOI":"10.1371\/journal.ppat.1002865","article-title":"Chemokine Receptor Ccr1 Drives Neutrophil-Mediated Kidney Immunopathology and Mortality in Invasive Candidiasis","volume":"8","author":"MS Lionakis","year":"2012","journal-title":"PLoS Pathog"},{"key":"ppat.1010192.ref005","doi-asserted-by":"crossref","first-page":"e1003079","DOI":"10.1371\/journal.ppat.1003079","article-title":"Candida and Host Determinants of Susceptibility to Invasive Candidiasis","volume":"9","author":"MS Lionakis","year":"2013","journal-title":"PLoS Pathog"},{"key":"ppat.1010192.ref006","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/ni1408","article-title":"Dectin-1 is required for \u03b2-glucan recognition and control of fungal infection","volume":"8","author":"PR Taylor","year":"2007","journal-title":"Nat Immunol"},{"key":"ppat.1010192.ref007","first-page":"33","volume-title":"Nature Reviews Immunology","author":"GD Brown","year":"2006"},{"key":"ppat.1010192.ref008","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nrmicro2711","article-title":"Candida albicans morphogenesis and host defence: discriminating invasion from colonization","volume":"10","author":"NARR Gow","year":"2012","journal-title":"Nat Rev Microbiol"},{"key":"ppat.1010192.ref009","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1091\/mbc.E15-06-0355","article-title":"Nanoscopic cell-wall architecture of an immunogenic ligand in Candida albicans during antifungal drug treatment","volume":"27","author":"J Lin","year":"2016","journal-title":"Mol Biol Cell"},{"key":"ppat.1010192.ref010","doi-asserted-by":"crossref","first-page":"16238","DOI":"10.1038\/nmicrobiol.2016.238","article-title":"Lactate signalling regulates fungal \u03b2-glucan masking and immune evasion","volume":"2","author":"ER Ballou","year":"2016","journal-title":"Nat Microbiol"},{"key":"ppat.1010192.ref011","first-page":"9","article-title":"Hypoxia promotes immune evasion by triggering \u03b2-glucan masking on the candida albicans cell surface via mitochondrial and cAMP-protein kinase A signaling","author":"A Pradhan","year":"2018","journal-title":"MBio"},{"key":"ppat.1010192.ref012","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-019-13298-9","article-title":"Non-canonical signalling mediates changes in fungal cell wall PAMPs that drive immune evasion","volume":"10","author":"A Pradhan","year":"2019","journal-title":"Nat Commun"},{"key":"ppat.1010192.ref013","doi-asserted-by":"crossref","first-page":"e1006403","DOI":"10.1371\/journal.ppat.1006403","article-title":"Adaptation of Candida albicans to environmental pH induces cell wall remodelling and enhances innate immune recognition","volume":"13","author":"SL Sherrington","year":"2017","journal-title":"PLOS Pathog"},{"key":"ppat.1010192.ref014","first-page":"10","article-title":"Remasking of candida albicans -glucan in response to environmental ph is regulated by quorum sensing","author":"F Cottier","year":"2019","journal-title":"MBio"},{"key":"ppat.1010192.ref015","doi-asserted-by":"crossref","first-page":"e1005617","DOI":"10.1371\/journal.ppat.1005617","article-title":"Mnn10 Maintains Pathogenicity in Candida albicans by Extending \u03b1-1,6-Mannose Backbone to Evade Host Dectin-1 Mediated Antifungal Immunity","volume":"12","author":"SQ Zhang","year":"2016","journal-title":"PLoS Pathog"},{"key":"ppat.1010192.ref016","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1091\/mbc.E15-06-0355","article-title":"Nanoscopic cell-wall architecture of an immunogenic ligand in Candida albicans during antifungal drug treatment","volume":"27","author":"J Lin","year":"2016","journal-title":"Mol Biol Cell"},{"key":"ppat.1010192.ref017","doi-asserted-by":"crossref","first-page":"e1000227","DOI":"10.1371\/journal.ppat.1000227","article-title":"Dynamic, morphotype-specific Candida albicans beta-glucan exposure during infection and drug treatment","volume":"4","author":"RT Wheeler","year":"2008","journal-title":"PLoS Pathog"},{"key":"ppat.1010192.ref018","doi-asserted-by":"crossref","first-page":"e1003315","DOI":"10.1371\/journal.ppat.1003315","article-title":"Differential Adaptation of Candida albicans In Vivo Modulates Immune Recognition by Dectin-1","volume":"9","author":"MJ Marakalala","year":"2013","journal-title":"PLoS Pathog"},{"key":"ppat.1010192.ref019","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1128\/IAI.00989-09","article-title":"Candida albicans \u03b2-glucan exposure is controlled by the fungal CEK1-mediated mitogen-activated protein kinase pathway that modulates immune responses triggered through dectin-1","volume":"78","author":"M Gal\u00e1n-D\u00edez","year":"2010","journal-title":"Infect Immun"},{"key":"ppat.1010192.ref020","doi-asserted-by":"crossref","first-page":"e1007892","DOI":"10.1371\/journal.pgen.1007892","article-title":"Exposure of Candida albicans \u03b2 (1,3)-glucan is promoted by activation of the Cek1 pathway","volume":"15","author":"T Chen","year":"2019","journal-title":"PLOS Genet."},{"key":"ppat.1010192.ref021","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/mBio.00984-20","article-title":"Epitope shaving promotes fungal immune evasion","volume":"11","author":"DS Childers","year":"2020","journal-title":"MBio"},{"key":"ppat.1010192.ref022","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0092-8674(00)80358-X","article-title":"Nonfilamentous C. albicans mutants are avirulent","volume":"90","author":"HJ Lo","year":"1997","journal-title":"Cell"},{"key":"ppat.1010192.ref023","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.4049\/jimmunol.0901323","article-title":"Cutting edge: Candida albicans hyphae formation triggers activation of the Nlrp3 inflammasome","volume":"183","author":"S Joly","year":"2009","journal-title":"J Immunol"},{"key":"ppat.1010192.ref024","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nature07965","article-title":"Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence","volume":"459","author":"O Gross","year":"2009","journal-title":"Nature"},{"key":"ppat.1010192.ref025","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.chom.2009.05.002","article-title":"An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans","volume":"5","author":"AG Hise","year":"2009","journal-title":"Cell Host Microbe"},{"key":"ppat.1010192.ref026","doi-asserted-by":"crossref","first-page":"e00003\u201414","DOI":"10.1128\/mBio.00003-14","article-title":"The Pathogen Candida albicans Hijacks Pyroptosis for Escape from Macrophages","volume":"5","author":"N Uwamahoro","year":"2014","journal-title":"MBio"},{"key":"ppat.1010192.ref027","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nature17625","article-title":"Candidalysin is a fungal peptide toxin critical for mucosal infection","volume":"532","author":"DL Moyes","year":"2016","journal-title":"Nature"},{"key":"ppat.1010192.ref028","first-page":"10","article-title":"Candidalysin crucially contributes to nlrp3 inflammasome activation by Candida albicans hyphae","author":"O Rogiers","year":"2019","journal-title":"MBio"},{"key":"ppat.1010192.ref029","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1189\/jlb.1210702","article-title":"The dectin-1\/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans","volume":"90","author":"S-C Cheng","year":"2011","journal-title":"J Leukoc Biol"},{"key":"ppat.1010192.ref030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2017.00629","article-title":"Candida albicans yeast, pseudohyphal, and hyphal morphogenesis differentially affects immune recognition","volume":"8","author":"L Mukaremera","year":"2017","journal-title":"Front Immunol."},{"key":"ppat.1010192.ref031","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1128\/EC.00336-13","article-title":"Candida albicans Triggers NLRP3-Mediated Pyroptosis in Macrophages","volume":"13","author":"M Wellington","year":"2014","journal-title":"Eukaryot Cell"},{"key":"ppat.1010192.ref032","doi-asserted-by":"crossref","first-page":"6741","DOI":"10.1038\/ncomms7741","article-title":"Global analysis of fungal morphology exposes mechanisms of host cell escape","volume":"6","author":"TR O\u2019Meara","year":"2015","journal-title":"Nat Commun"},{"key":"ppat.1010192.ref033","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1038\/sj.emboj.7600594","article-title":"Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments","volume":"24","author":"BN Gantner","year":"2005","journal-title":"EMBO J"},{"key":"ppat.1010192.ref034","doi-asserted-by":"crossref","first-page":"e0191194","DOI":"10.1371\/journal.pone.0191194","article-title":"Accessibility and contribution to glucan masking of natural and genetically tagged versions of yeast wall protein 1 of Candida albicans","volume":"13","author":"BL Granger","year":"2018","journal-title":"PLoS One"},{"key":"ppat.1010192.ref035","doi-asserted-by":"crossref","first-page":"e1007927","DOI":"10.1371\/journal.ppat.1007927","article-title":"Mannan detecting C-type lectin receptor probes recognise immune epitopes with diverse chemical, spatial and phylogenetic heterogeneity in fungal cell walls","volume":"16","author":"I Vendele","year":"2020","journal-title":"PLoS Pathog"},{"key":"ppat.1010192.ref036","doi-asserted-by":"crossref","first-page":"e6420","DOI":"10.1371\/journal.pone.0006420","article-title":"Early-Expressed Chemokines Predict Kidney Immunopathology in Experimental Disseminated Candida albicans Infections","volume":"4","author":"DM MacCallum","year":"2009","journal-title":"PLoS One"},{"key":"ppat.1010192.ref037","doi-asserted-by":"crossref","first-page":"e01388","DOI":"10.1128\/mBio.01388-15","article-title":"The Eng1 \u03b2-Glucanase Enhances Histoplasma Virulence by Reducing \u03b2-Glucan Exposure","volume":"7","author":"AL Garfoot","year":"2016","journal-title":"MBio"},{"key":"ppat.1010192.ref038","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00284-005-0066-2","article-title":"Characterization of the CaENG1 Gene Encoding an Endo-1,3-\u03b2-Glucanase Involved in Cell Separation in Candida albicans","volume":"51","author":"PF Esteban","year":"2005","journal-title":"Curr Microbiol"},{"key":"ppat.1010192.ref039","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1128\/EC.00155-06","article-title":"Candida albicans transcription factor Ace2 regulates metabolism and is required for filamentation in hypoxic conditions","volume":"5","author":"SM Mulhern","year":"2006","journal-title":"Eukaryot Cell"},{"key":"ppat.1010192.ref040","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1534\/genetics.112.145516","article-title":"Mitotic exit and separation of mother and daughter cells","volume":"192","author":"EL Weiss","year":"2012","journal-title":"Genetics"},{"key":"ppat.1010192.ref041","doi-asserted-by":"crossref","first-page":"4406","DOI":"10.1128\/MCB.01502-08","article-title":"Hyphal chain formation in Candida albicans: Cdc28-Hgc1 phosphorylation of Efg1 represses cell separation genes","volume":"29","author":"A Wang","year":"2009","journal-title":"Mol Cell Biol"},{"key":"ppat.1010192.ref042","article-title":"An Efficient, Rapid, and Recyclable System for CRISPR-Mediated Genome Editing in Candida albicans","volume":"2","author":"N Nguyen","journal-title":"mSphere"},{"key":"ppat.1010192.ref043","doi-asserted-by":"crossref","first-page":"25969","DOI":"10.1074\/jbc.M110.131300","article-title":"CARD9 Mediates Dectin-2-induced I\u03baB\u03b1 Kinase Ubiquitination Leading to Activation of NF-\u03baB in Response to Stimulation by the Hyphal Form of Candida albicans","volume":"285","author":"L Bi","year":"2010","journal-title":"J Biol Chem"},{"key":"ppat.1010192.ref044","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.4049\/jimmunol.1400276","article-title":"Caspase-8 Modulates Dectin-1 and Complement Receptor 3\u2013Driven IL-1\u03b2 Production in Response to \u03b2-Glucans and the Fungal Pathogen, Candida albicans","volume":"193","author":"S Ganesan","year":"2014","journal-title":"J Immunol"},{"key":"ppat.1010192.ref045","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41564-017-0059-5","article-title":"Lionakis MS, Filler SG. EphA2 is an epithelial cell pattern recognition receptor for fungal \u03b2-glucans","volume":"3","author":"M Swidergall","year":"2018","journal-title":"Nat Microbiol"},{"key":"ppat.1010192.ref046","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.tim.2014.09.001","article-title":"Candida albicans hyphal initiation and elongation","volume":"22","author":"Y Lu","year":"2014","journal-title":"Trends Microbiol"},{"key":"ppat.1010192.ref047","doi-asserted-by":"crossref","first-page":"e1001815","DOI":"10.1371\/journal.pbio.1001815","article-title":"A Tetraploid Intermediate Precedes Aneuploid Formation in Yeasts Exposed to Fluconazole","volume":"12","author":"BD Harrison","year":"2014","journal-title":"PLoS Biol"},{"key":"ppat.1010192.ref048","doi-asserted-by":"crossref","first-page":"3460","DOI":"10.1128\/AAC.00214-15","article-title":"Candida albicans Cek1 mitogen-activated protein kinase signaling enhances fungicidal activity of salivary histatin 5","volume":"59","author":"R Li","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"ppat.1010192.ref049","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1534\/genetics.117.201491","article-title":"Regulation of hyphal growth and N-acetylglucosamine catabolism by two transcription factors in Candida albicans","volume":"206","author":"S Naseem","year":"2017","journal-title":"Genetics"},{"key":"ppat.1010192.ref050","first-page":"6","article-title":"RNA enrichment method for quantitative transcriptional analysis of pathogens in vivo applied to the fungus candida albicans","author":"S Amorim-Vaz","year":"2015","journal-title":"MBio"},{"key":"ppat.1010192.ref051","doi-asserted-by":"crossref","first-page":"e04437","DOI":"10.1016\/j.heliyon.2020.e04437","article-title":"Effect of testosterone and estrogen supplementation on the resistance to systemic Candida albicans infection in mice","volume":"6","author":"M Arroyo-Mendoza","year":"2020","journal-title":"Heliyon"},{"key":"ppat.1010192.ref052","doi-asserted-by":"crossref","first-page":"e1000703","DOI":"10.1371\/journal.ppat.1000703","article-title":"Th1-Th17 Cells Mediate Protective Adaptive Immunity against Staphylococcus aureus and Candida albicans Infection in Mice","volume":"5","author":"L Lin","year":"2009","journal-title":"PLoS Pathog"},{"key":"ppat.1010192.ref053","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/0003-9861(62)90321-1","article-title":"Myeloperoxidase of the leucocyte of normal human blood. I. Content and localization","volume":"96","author":"J Schultz","year":"1962","journal-title":"Arch Biochem Biophys"},{"key":"ppat.1010192.ref054","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/S0002-9440(10)64036-9","article-title":"Macrophage myeloperoxidase regulation by granulocyte macrophage colony-stimulating factor in human atherosclerosis and implications in acute coronary syndromes","volume":"158","author":"S Sugiyama","year":"2001","journal-title":"Am J Pathol"},{"key":"ppat.1010192.ref055","first-page":"37","article-title":"Characterization and quantification of the peroxidase in human monocytes","volume":"525","author":"A Bos","year":"1978","journal-title":"BBA\u2014Enzymol."},{"key":"ppat.1010192.ref056","doi-asserted-by":"crossref","first-page":"e1003519","DOI":"10.1371\/journal.ppat.1003519","article-title":"A comprehensive functional portrait of two heat shock factor-type transcriptional regulators involved in Candida albicans morphogenesis and virulence","volume":"9","author":"S Znaidi","year":"2013","journal-title":"PLoS Pathog."},{"key":"ppat.1010192.ref057","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/nm.4141","article-title":"Targeting CBLB as a potential therapeutic approach for disseminated candidiasis","volume":"22","author":"Y Xiao","year":"2016","journal-title":"Nat Med"},{"key":"ppat.1010192.ref058","first-page":"10","article-title":"Lrg1 regulates \u03b2 (1,3)-glucan masking in Candida albicans through the Cek1 MAP kinase pathway","author":"T Chen","year":"2019","journal-title":"MBio"},{"key":"ppat.1010192.ref059","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1073\/pnas.0609848104","article-title":"Histoplasma capsulatum \u03b1-(1,3)-glucan blocks innate immune recognition by the \u03b2-glucan receptor","volume":"104","author":"CA Rappleye","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ppat.1010192.ref060","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/978-0-387-09550-9_11","article-title":"The damage-response framework of microbial pathogenesis and infectious diseases","volume":"635","author":"LA Pirofski","year":"2008","journal-title":"Adv Exp Med Biol"},{"key":"ppat.1010192.ref061","first-page":"15","article-title":"The protective effect of inflammatory monocytes during systemic C. Albicans infection is dependent on collaboration between C-type lectin-like receptors","author":"A Thompson","year":"2019","journal-title":"PLoS Pathog."},{"key":"ppat.1010192.ref062","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1371\/journal.ppat.1002811","article-title":"Type I interferons promote fatal immunopathology by regulating inflammatory monocytes and neutrophils during Candida infections","volume":"8","author":"O Majer","year":"2012","journal-title":"PLoS Pathog."},{"key":"ppat.1010192.ref063","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.immuni.2013.05.010","article-title":"Interferon-\u03b2 Production via Dectin-1-Syk-IRF5 Signaling in Dendritic Cells Is Crucial for Immunity to C.albicans","volume":"38","author":"C delFresno","year":"2013","journal-title":"Immunity"},{"key":"ppat.1010192.ref064","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/ni1425","article-title":"Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans","volume":"8","author":"S Saijo","year":"2007","journal-title":"Nat Immunol"},{"key":"ppat.1010192.ref065","doi-asserted-by":"crossref","first-page":"6339","DOI":"10.1128\/JB.181.20.6339-6346.1999","article-title":"Ras signaling is required for serum-induced hyphal differentiation in Candida albicans","volume":"181","author":"Q Feng","year":"1999","journal-title":"J Bacteriol"},{"key":"ppat.1010192.ref066","first-page":"349","volume-title":"Methods in enzymology","author":"DG Gibson","year":"2011"},{"key":"ppat.1010192.ref067","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jim.2006.05.013","article-title":"Soluble Dectin-1 as a tool to detect \u03b2-glucans","volume":"314","author":"LM Graham","year":"2006","journal-title":"J Immunol Methods"},{"key":"ppat.1010192.ref068","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.4049\/jimmunol.1300748","article-title":"The RodA hydrophobin on Aspergillus fumigatus spores masks Dectin-1 and Dectin-2 dependent responses and enhances fungal survival in vivo","volume":"191","author":"J Carrion S de","year":"2013","journal-title":"J Immunol"},{"key":"ppat.1010192.ref069","doi-asserted-by":"crossref","first-page":"48988","DOI":"10.1074\/jbc.M104484200","article-title":"DNA Array Studies Demonstrate Convergent Regulation of Virulence Factors by Cph1, Cph2, and Efg1 in Candida albicans","volume":"276","author":"S Lane","year":"2001","journal-title":"J Biol Chem"},{"key":"ppat.1010192.ref070","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1086\/430952","article-title":"Mice with Disseminated Candidiasis Die of Progressive Sepsis","volume":"192","author":"B Spellberg","year":"2005","journal-title":"J Infect Dis"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1010192","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T00:00:00Z","timestamp":1642636800000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1010192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T13:41:33Z","timestamp":1642686093000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1010192"}},"subtitle":[],"editor":[{"given":"Gordon D.","family":"Brown","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,1,7]]},"references-count":70,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1010192","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.09.07.285791","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,7]]}}}