{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:24:14Z","timestamp":1785803054657,"version":"3.56.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1010354","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T00:00:00Z","timestamp":1647907200000}}],"reference-count":70,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T00:00:00Z","timestamp":1646611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01NS108796"],"award-info":[{"award-number":["1R01NS108796"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01 NS060632"],"award-info":[{"award-number":["5R01 NS060632"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>Latency is the main obstacle towards an HIV cure, with cure strategies aiming to either elicit or prevent viral reactivation. While these strategies have shown promise, they have only succeeded in modulating latency in a fraction of the latent HIV reservoir, suggesting that the mechanisms controlling HIV latency are not completely understood, and that comprehensive latency modulation will require targeting of multiple latency maintenance pathways. We show here that the transcriptional co-activator and the central mediator of canonical Wnt signaling, \u03b2-catenin, inhibits HIV transcription in CD4+ T cells via TCF-4 LTR binding sites. Further, we show that inhibiting the \u03b2-catenin pathway reactivates HIV in a primary T<jats:sub>CM<\/jats:sub> cell model of HIV latency, primary cells from cART-controlled HIV donors, and in CD4+ latent cell lines. \u03b2-catenin inhibition or activation also enhanced or inhibited the activity of several classes of HIV latency reversing agents, respectively, in these models, with significant synergy of \u03b2-catenin and each LRA class tested. In sum, we identify \u03b2-catenin as a novel regulator of HIV latency <jats:italic>in vitro<\/jats:italic> and <jats:italic>ex vivo<\/jats:italic>, adding new therapeutic targets that may be combined for comprehensive HIV latency modulation in HIV cure efforts.<\/jats:p>","DOI":"10.1371\/journal.ppat.1010354","type":"journal-article","created":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T18:44:15Z","timestamp":1646678655000},"page":"e1010354","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["\u03b2-catenin regulates HIV latency and modulates HIV reactivation"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6513-6828","authenticated-orcid":true,"given":"Hannah J.","family":"Barbian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie S.","family":"Seaton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivas D.","family":"Narasipura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennillee","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reshma","family":"Rajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9659-3554","authenticated-orcid":true,"given":"Beverly 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Han","year":"2008","journal-title":"Cell Host Microbe"},{"issue":"2","key":"ppat.1010354.ref009","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.chom.2008.05.016","article-title":"Transcriptional interference antagonizes proviral gene expression to promote HIV latency","volume":"4","author":"T Lenasi","year":"2008","journal-title":"Cell Host Microbe"},{"issue":"2","key":"ppat.1010354.ref010","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1128\/JVI.02413-12","article-title":"Cyclin T1 and CDK9 T-loop phosphorylation are downregulated during establishment of HIV-1 latency in primary resting memory CD4+ T cells","volume":"87","author":"S Budhiraja","year":"2013","journal-title":"J Virol"},{"issue":"13","key":"ppat.1010354.ref011","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1128\/JVI.01519-09","article-title":"Establishment of HIV Latency in Primary CD4+ Cells Is due to Epigenetic Transcriptional Silencing and P-TEFb 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Cartilage"},{"issue":"5","key":"ppat.1010354.ref037","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1128\/JVI.06157-11","article-title":"Generation of Transmitted\/Founder HIV-1 Infectious Molecular Clones and Characterization of Their Replication Capacity in CD4 T Lymphocytes and Monocyte-Derived Macrophages","volume":"86","author":"C Ochsenbauer","year":"2012","journal-title":"Journal of Virology"},{"issue":"6","key":"ppat.1010354.ref038","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1128\/JVI.02498-07","article-title":"Active \u03b2-Catenin Signaling Is an Inhibitory Pathway for Human Immunodeficiency Virus Replication in Peripheral Blood Mononuclear Cells","volume":"82","author":"A Kumar","year":"2008","journal-title":"Journal of Virology"},{"issue":"4","key":"ppat.1010354.ref039","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1128\/jvi.68.4.2726-2730.1994","article-title":"Human immunodeficiency virus type 1 RNA expression by four chronically infected cell lines indicates multiple mechanisms of latency","volume":"68","author":"ST Butera","year":"1994","journal-title":"Journal of Virology"},{"issue":"8","key":"ppat.1010354.ref040","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1093\/emboj\/cdg188","article-title":"HIV reproducibly establishes a latent infection after acute infection of T cells in vitro","volume":"22","author":"A Jordan","year":"2003","journal-title":"EMBO J"},{"issue":"1","key":"ppat.1010354.ref041","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1182\/blood-2008-07-168393","article-title":"Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells","volume":"113","author":"A Bosque","year":"2009","journal-title":"Blood"},{"issue":"2","key":"ppat.1010354.ref042","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1089\/aid.2015.0106","article-title":"Modeling HIV-1 Latency in Primary T Cells Using a Replication-Competent Virus","volume":"32","author":"LJ Martins","year":"2016","journal-title":"AIDS Res Hum Retroviruses"},{"issue":"1","key":"ppat.1010354.ref043","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ymeth.2010.10.002","article-title":"Studies of HIV-1 latency in an ex vivo model that uses primary central memory T cells","volume":"53","author":"A Bosque","year":"2011","journal-title":"Methods (San Diego, Calif)"},{"issue":"9","key":"ppat.1010354.ref044","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1089\/aid.2018.0098","article-title":"Influence of Biological Sex, Age, and HIV Status in an In Vitro Primary Cell Model of HIV Latency Using a CXCR4 Tropic Virus","volume":"34","author":"AB Macedo","year":"2018","journal-title":"AIDS Res Hum Retroviruses"},{"issue":"12","key":"ppat.1010354.ref045","doi-asserted-by":"crossref","first-page":"e1003834","DOI":"10.1371\/journal.ppat.1003834","article-title":"An In-Depth Comparison of Latent HIV-1 Reactivation in Multiple Cell Model Systems and Resting CD4+ T 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Ohteki","year":"2000","journal-title":"The Journal of Experimental Medicine"},{"issue":"4","key":"ppat.1010354.ref049","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1128\/JVI.06266-11","article-title":"Role of beta-catenin and TCF\/LEF family members in transcriptional activity of HIV in astrocytes","volume":"86","author":"SD Narasipura","year":"2012","journal-title":"J Virol"},{"issue":"2","key":"ppat.1010354.ref050","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S1535-6108(02)00035-1","article-title":"ITF-2, a downstream target of the Wnt\/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation","volume":"1","author":"FT Kolligs","year":"2002","journal-title":"Cancer Cell"},{"issue":"20","key":"ppat.1010354.ref051","doi-asserted-by":"crossref","first-page":"10914","DOI":"10.1128\/JVI.01208-07","article-title":"c-Myc and Sp1 Contribute to Proviral Latency by Recruiting Histone Deacetylase 1 to the Human 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Reuse","year":"2009","journal-title":"PLOS One"},{"issue":"7","key":"ppat.1010354.ref055","doi-asserted-by":"crossref","first-page":"e1005063","DOI":"10.1371\/journal.ppat.1005063","article-title":"An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression","volume":"11","author":"G Darcis","year":"2015","journal-title":"PLOS Pathogens"},{"issue":"8","key":"ppat.1010354.ref056","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1016\/j.yexcr.2007.02.008","article-title":"The activation of beta-catenin by Wnt signaling mediates the effects of histone deacetylase inhibitors","volume":"313","author":"M Bordonaro","year":"2007","journal-title":"Experimental Cell Research"},{"issue":"4","key":"ppat.1010354.ref057","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1073\/pnas.0811902106","article-title":"Activated 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