{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:03:29Z","timestamp":1787022209225,"version":"build-2736575974"},"update-to":[{"DOI":"10.1371\/journal.ppat.1010408","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T00:00:00Z","timestamp":1650844800000}}],"reference-count":75,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T00:00:00Z","timestamp":1649030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Francis Crick Institute \/ Cancer Research UK","award":["FC001143, FC001178"],"award-info":[{"award-number":["FC001143, FC001178"]}]},{"name":"Francis Crick Institute \/ Cancer Research UK","award":["FC001143, FC001178"],"award-info":[{"award-number":["FC001143, FC001178"]}]},{"name":"Francis Crick Institute \/ Wellcome Trust","award":["FC001143, FC001119"],"award-info":[{"award-number":["FC001143, FC001119"]}]},{"name":"Francis Crick Institute \/ Wellcome Trust","award":["FC001143, FC001119"],"award-info":[{"award-number":["FC001143, FC001119"]}]},{"name":"Francis Crick Institute \/ UK Medical Research Council","award":["FC001143, FC001119"],"award-info":[{"award-number":["FC001143, FC001119"]}]},{"name":"Francis Crick Institute \/ UK Medical Research Council","award":["FC001143, FC001119"],"award-info":[{"award-number":["FC001143, FC001119"]}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    Malaria is responsible for half a million deaths annually and poses a huge economic burden on the developing world. The mosquito-borne parasites (\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    spp.) that cause the disease depend upon an unconventional actomyosin motor for both gliding motility and host cell invasion. The motor system, often referred to as the glideosome complex, remains to be understood in molecular terms and is an attractive target for new drugs that might block the infection pathway. Here, we present the high-resolution structure of the actomyosin motor complex from\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    . The complex includes the malaria parasite actin filament (\n                    <jats:italic>Pf<\/jats:italic>\n                    Act1) complexed with the class XIV myosin motor (\n                    <jats:italic>Pf<\/jats:italic>\n                    MyoA) and its two associated light-chains. The high-resolution core structure reveals the\n                    <jats:italic>Pf<\/jats:italic>\n                    Act1:\n                    <jats:italic>Pf<\/jats:italic>\n                    MyoA interface in atomic detail, while at lower-resolution, we visualize the\n                    <jats:italic>Pf<\/jats:italic>\n                    MyoA light-chain binding region, including the essential light chain (\n                    <jats:italic>Pf<\/jats:italic>\n                    ELC) and the myosin tail interacting protein (\n                    <jats:italic>Pf<\/jats:italic>\n                    MTIP). Finally, we report a bare\n                    <jats:italic>Pf<\/jats:italic>\n                    Act1 filament structure at improved resolution.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1010408","type":"journal-article","created":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T13:31:11Z","timestamp":1649079071000},"page":"e1010408","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["High-resolution structures of malaria parasite actomyosin and actin filaments"],"prefix":"10.1371","volume":"18","author":[{"given":"Juha","family":"Vahokoski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5694-4033","authenticated-orcid":true,"given":"Lesley J.","family":"Calder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8956-3931","authenticated-orcid":true,"given":"Andrea J.","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8307-2450","authenticated-orcid":true,"given":"Justin E.","family":"Molloy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5236-7056","authenticated-orcid":true,"given":"Inari","family":"Kursula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0387-2862","authenticated-orcid":true,"given":"Peter B.","family":"Rosenthal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,4,4]]},"reference":[{"key":"ppat.1010408.ref001","unstructured":"WHO. 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