{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:47:04Z","timestamp":1761864424100,"version":"3.37.3"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T00:00:00Z","timestamp":1652745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310030B_201273"],"award-info":[{"award-number":["310030B_201273"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hans Buss Stiftung"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>Vertical transmission of<jats:italic>Bartonella<\/jats:italic>infection has been reported for several mammalian species including mice and humans. Accordingly, it is commonly held that acquired immunological tolerance contributes critically to the high prevalence of Bartonellae in wild-ranging rodent populations. Here we studied an experimental model of<jats:italic>Bartonella<\/jats:italic>infection in mice to assess the impact of maternal and newborn immune defense on vertical transmission and bacterial persistence in the offspring, respectively. Congenital infection was frequently observed in B cell-deficient mothers but not in immunocompetent dams, which correlated with a rapid onset of an antibacterial antibody response in infected WT animals. Intriguingly, B cell-deficient offspring with congenital infection exhibited long-term bacteremia whereas B cell-sufficient offspring cleared bacteremia within a few weeks after birth. Clearance of congenital<jats:italic>Bartonella<\/jats:italic>infection resulted in immunity against bacterial rechallenge, with the animals mounting<jats:italic>Bartonella<\/jats:italic>-neutralizing antibody responses of normal magnitude. These observations reveal a key role for humoral immune defense by the mother and offspring in preventing and eliminating vertical transmission. Moreover, congenital<jats:italic>Bartonella<\/jats:italic>infection does not induce humoral immune tolerance but results in anti-bacterial immunity, questioning the contribution of neonatal tolerance to<jats:italic>Bartonella<\/jats:italic>prevalence in wild-ranging rodents.<\/jats:p>","DOI":"10.1371\/journal.ppat.1010489","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T17:55:55Z","timestamp":1652810155000},"page":"e1010489","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Adaptive immune defense prevents Bartonella persistence upon trans-placental transmission"],"prefix":"10.1371","volume":"18","author":[{"given":"Lena K.","family":"Siewert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Dehio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1594-3189","authenticated-orcid":true,"given":"Daniel D.","family":"Pinschewer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2022,5,17]]},"reference":[{"key":"ppat.1010489.ref001","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1128\/CMR.05009-11","article-title":"Intruders below the Radar: Molecular Pathogenesis of Bartonella spp.","volume":"25","author":"A Harms","year":"2012","journal-title":"Clin Microbiol Rev"},{"key":"ppat.1010489.ref002","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1051\/vetres\/2009011","article-title":"Ecological fitness and strategies of adaptation of Bartonella species to their hosts and vectors","volume":"40","author":"BB Chomel","year":"2009","journal-title":"Vet Res"},{"key":"ppat.1010489.ref003","doi-asserted-by":"crossref","first-page":"e13004","DOI":"10.1111\/cmi.13004","article-title":"Role of distinct type-IV-secretion systems and secreted effector sets in host adaptation by pathogenic Bartonella species","volume":"21","author":"A Wagner","year":"2019","journal-title":"Cell Microbiol"},{"key":"ppat.1010489.ref004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0891-5520(05)70215-4","article-title":"Bartonellosis. New and old.","volume":"14","author":"C Magui\u00f1a","year":"2000","journal-title":"Infect Dis Clin North Am"},{"key":"ppat.1010489.ref005","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.clindermatol.2008.10.006","article-title":"Bartonellosis.","volume":"27","author":"C Magui\u00f1a","year":"2009","journal-title":"Clin Dermatol"},{"volume-title":"Bartonellosis. 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