{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:15:12Z","timestamp":1792714512773,"version":"4.5.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1010534","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000}}],"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T00:00:00Z","timestamp":1653436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773343"],"award-info":[{"award-number":["81773343"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51803128"],"award-info":[{"award-number":["51803128"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52073186"],"award-info":[{"award-number":["52073186"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803150"],"award-info":[{"award-number":["81803150"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["2020HXBH152"],"award-info":[{"award-number":["2020HXBH152"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["ZYJC18033"],"award-info":[{"award-number":["ZYJC18033"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["HXYS19003"],"award-info":[{"award-number":["HXYS19003"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    The emerging \"super fungus\"\n                    <jats:italic>Candida auris<\/jats:italic>\n                    has become an important threat to human health due to its pandrug resistance and high lethality. Therefore, the development of novel antimicrobial strategy is essential. Antimicrobial photodynamic therapy (aPDT) has excellent performance in clinical applications. However, the relevant study on antifungal activity and the mechanism involved against\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>auris<\/jats:italic>\n                    remains scarce. Herein, a recyclable and biodegradable polylactic acid-hypocrellin A (PLA-HA) nanofibrous membrane is newly developed.\n                    <jats:italic>In vitro<\/jats:italic>\n                    PLA-HA-aPDT could significantly reduce the survival rate of\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>auris<\/jats:italic>\n                    plankton and its biofilms, and the fungicidal effect of the membrane is still significant after four repeated uses. Simultaneously, PLA-HA exhibits good biocompatibility and low hemolysis.\n                    <jats:italic>In vivo<\/jats:italic>\n                    experiments show that PLA-HA-aPDT can promote\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>auris<\/jats:italic>\n                    -infected wound healing, reduce inflammatory response, and without obvious toxic side-effects. Further results reveal that PLA-HA-aPDT could increase endogenous reactive oxygen species (ROS) levels, leading to mitochondrial dysfunction, release of cytochrome C, activation of metacaspase, and nuclear fragmentation, thereby triggering apoptosis of\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>auris<\/jats:italic>\n                    . Compared with HA, PLA-HA shows stronger controllability and reusability, which can greatly improve the utilization efficiency of HA alone. Taken together, the efficacy, safety and antifungal activity make PLA-HA-aPDT a highly promising antifungal candidate for skin or mucous membrane\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>auris<\/jats:italic>\n                    infection.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1010534","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T13:44:16Z","timestamp":1653486256000},"page":"e1010534","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":36,"title":["A recyclable and light-triggered nanofibrous membrane against the emerging fungal pathogen Candida auris"],"prefix":"10.1371","volume":"18","author":[{"given":"Xinyao","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiwen","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muqiu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalin","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8440-5643","authenticated-orcid":true,"given":"Lin","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9382-0571","authenticated-orcid":true,"given":"Yuping","family":"Ran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,5,25]]},"reference":[{"issue":"165","key":"ppat.1010534.ref001","doi-asserted-by":"crossref","first-page":"165rv13","DOI":"10.1126\/scitranslmed.3004404","article-title":"Hidden killers: human fungal infections","volume":"4","author":"GD Brown","year":"2012","journal-title":"Sci Transl Med."},{"issue":"51","key":"ppat.1010534.ref002","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1439-0507.2008.01606.x","article-title":"Epidemiological trends in skin mycoses worldwide","author":"B Havlickova","year":"2008","journal-title":"Mycoses"},{"issue":"4","key":"ppat.1010534.ref003","first-page":"1","article-title":"Fungal cell wall: An underexploited target for antifungal therapies","volume":"17","author":"C Ibe","year":"2021","journal-title":"Plos Pathog"},{"issue":"1","key":"ppat.1010534.ref004","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1348-0421.2008.00083.x","article-title":"Candida auris sp. nov., a novel ascomycetous yeast isolated from the external ear canal of an inpatient in a Japanese hospital","volume":"53","author":"K Satoh","year":"2009","journal-title":"Microbiol Immunol"},{"issue":"4","key":"ppat.1010534.ref005","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1093\/jac\/dkx480","article-title":"A multicenter study of antifungal susceptibility patterns among 350 Candida auris isolates (2009\u201317) in India: role of the ERG11 and FKS1 genes in azole and echinocandin resistance","volume":"73","author":"A Chowdhary","year":"2018","journal-title":"J Antimicrob Chemoth"},{"issue":"10","key":"ppat.1010534.ref006","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.3389\/fmicb.2019.02788","article-title":"Review on antifungal resistance mechanisms in the emerging pathogen Candida auris","author":"F Chaabane","year":"2019","journal-title":"Front Microbiol."},{"issue":"3","key":"ppat.1010534.ref007","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1039\/C5TA08044D","article-title":"Visible-light-driven photocatalytic bacterial inactivation and the mechanism of zinc oxysulfide under LED light irradiation","volume":"4","author":"D Wu","year":"2016","journal-title":"J Mater Chem"},{"issue":"36","key":"ppat.1010534.ref008","first-page":"1","article-title":"Efficacy of antimicrobial photodynamic therapy (aPDT) for nonsurgical treatment of periodontal disease: a systematic review","author":"MG Moro","year":"2021","journal-title":"Laser Med Sci."},{"issue":"4","key":"ppat.1010534.ref009","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1021\/acsinfecdis.7b00004","article-title":"Potassium iodide potentiates broad-spectrum antimicrobial photodynamic inactivation using photofrin","volume":"3","author":"L Huang","year":"2017","journal-title":"ACS Infect Dis"},{"issue":"10","key":"ppat.1010534.ref010","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1166\/jbn.2019.2829","article-title":"Exploration of copper-cysteamine nanoparticles as a new type of agents for antimicrobial photodynamic inactivation","volume":"15","author":"L Huang","year":"2019","journal-title":"J Biomed Nanotechnol"},{"key":"ppat.1010534.ref011","doi-asserted-by":"crossref","first-page":"102092","DOI":"10.1016\/j.pdpdt.2020.102092","article-title":"Evaluation of antimicrobial photodynamic therapy on wounds infected by Staphylococcus aureus in animal models","volume":"33","author":"S Torabi","year":"2021","journal-title":"Photodiagn Photodyn"},{"issue":"33","key":"ppat.1010534.ref012","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.mib.2016.06.008","article-title":"Antimicrobial photodynamic inactivation: a bright new technique to kill resistant microbes","author":"MR Hamblin","year":"2016","journal-title":"Curr Opin Microbiol"},{"issue":"10","key":"ppat.1010534.ref013","doi-asserted-by":"crossref","first-page":"E380","DOI":"10.1111\/j.1469-0691.2012.03933.x","article-title":"Comparison of photodynamic therapy versus conventional antifungal therapy for the treatment of denture stomatitis: a randomized clinical trial","volume":"18","author":"EG Mima","year":"2012","journal-title":"Clin Microbiol Infec"},{"issue":"1","key":"ppat.1010534.ref014","first-page":"e00007","article-title":"Antimicrobial photodynamic inactivation of fungal biofilm using amino functionalized mesoporus silica-rose bengal nanoconjugate against Candida albicans","author":"P Paramanantham","year":"2018","journal-title":"Sci Afr."},{"issue":"10","key":"ppat.1010534.ref015","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1166\/jbn.2019.2829","article-title":"Exploration of copper-cysteamine nanoparticles as a new type of agents for antimicrobial photodynamic inactivation.","volume":"15","author":"L Huang","year":"2019","journal-title":"J Biomed Nanotechnol"},{"key":"ppat.1010534.ref016","first-page":"110","article-title":"A powerful combination of copper-cysteamine nanoparticles with potassium iodide for bacterial destruction","author":"X Zhen","year":"2020","journal-title":"Mater Sci Eng C"},{"issue":"3","key":"ppat.1010534.ref017","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1751-1097.1990.tb01807.x","article-title":"Hypocrellins and their use in photosensitization","volume":"52","author":"D Zhenjun","year":"1990","journal-title":"Photochem Photobiol"},{"issue":"6","key":"ppat.1010534.ref018","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/ja.2006.49","article-title":"Hypocrellin D, a cytotoxic fungal pigment from fruiting bodies of the ascomycete Shiraia bambusicola","volume":"59","author":"L-Z Fang","year":"2006","journal-title":"J Antibiot"},{"issue":"75","key":"ppat.1010534.ref019","doi-asserted-by":"crossref","first-page":"40085","DOI":"10.1039\/C4RA05796A","article-title":"Preparation and evaluation of hypocrellin A loaded poly(lactic-co-glycolic acid) nanoparticles for photodynamic therapy","volume":"4","author":"SS Qi","year":"2014","journal-title":"RSC Adv."},{"issue":"1","key":"ppat.1010534.ref020","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1751-1097.2011.01035.x","article-title":"Antitumor efficacy of photodynamic therapy using novel nanoformulations of hypocrellin photosensitizer SL052","volume":"88","author":"M Korbelik","year":"2012","journal-title":"Photochem Photobiol"},{"issue":"1","key":"ppat.1010534.ref021","first-page":"36","article-title":"Hypocrellin B-mediated photodynamic inactivation of gram-positive antibiotic-resistant bacteria: An in vitro study","volume":"38","author":"W Otieno","year":"2020","journal-title":"Photobiomod photomed."},{"issue":"10","key":"ppat.1010534.ref022","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.3389\/fmicb.2019.01810","article-title":"Photodynamic antifungal activity of hypocrellin A against Candida albicans","author":"Y Yang","year":"2019","journal-title":"Front Microbiol."},{"issue":"27","key":"ppat.1010534.ref023","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.pdpdt.2019.07.014","article-title":"In vitro photodynamic inactivation effects of hypocrellin B on azole-sensitive and resistant Candida albicans","author":"A Jan","year":"2019","journal-title":"Photodiagn Photodyn"},{"issue":"2","key":"ppat.1010534.ref024","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1111\/1751-7915.13601","article-title":"Antifungal activity of hypocrellin compounds and their synergistic effects with antimicrobial agents against Candida albicans","volume":"14","author":"S Song","year":"2021","journal-title":"Microb Biotechnol"},{"key":"ppat.1010534.ref025","doi-asserted-by":"crossref","first-page":"108574","DOI":"10.1016\/j.compscitech.2020.108574","article-title":"Fast-acting and highly rechargeable antibacterial composite nanofibrous membrane for protective applications","volume":"202","author":"X Yin","year":"2021","journal-title":"Compos Sci Technol"},{"issue":"89","key":"ppat.1010534.ref026","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.pmatsci.2017.06.003","article-title":"Application of materials as medical devices with localized drug delivery capabilities for enhanced wound repair","author":"EJ Lee","year":"2017","journal-title":"Prog Mater Sci"},{"key":"ppat.1010534.ref027","article-title":"Visible light active","author":"S Jiang"},{"issue":"194","key":"ppat.1010534.ref028","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.biomaterials.2018.12.012","article-title":"Chinese sesame stick-inspired nano-fibrous scaffolds for tumor therapy and skin tissue reconstruction","author":"Q Yu","year":"2019","journal-title":"Biomaterials"},{"issue":"70","key":"ppat.1010534.ref029","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.msec.2016.09.005","article-title":"Light-induced antibacterial activity of electrospun chitosan-based material containing photosensitizer","author":"AN Severyukhina","year":"2017","journal-title":"Mater Sci Eng C"},{"issue":"3","key":"ppat.1010534.ref030","doi-asserted-by":"crossref","first-page":"eaar5931","DOI":"10.1126\/sciadv.aar5931","article-title":"Daylight-driven rechargeable antibacterial and antiviral nanofibrous membranes for bioprotective applications","volume":"4","author":"Y Si","year":"2018","journal-title":"Sci Adv."},{"key":"ppat.1010534.ref031","doi-asserted-by":"crossref","first-page":"108238","DOI":"10.1016\/j.compositesb.2020.108238","article-title":"Current applications of poly(lactic acid) composites in tissue engineering and drug delivery","volume":"199","author":"S Liu","year":"2020","journal-title":"Compos Part B-Eng"},{"key":"ppat.1010534.ref032","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.matpr.2018.11.103","article-title":"PLA\/PCL-based foams as scaffolds for tissue engineering applications","volume":"7","author":"L Sartore","year":"2019","journal-title":"Mater Today Proc"},{"key":"ppat.1010534.ref033","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.addr.2016.06.012","article-title":"Physical and mechanical properties of PLA, and their functions in widespread applications\u2014a comprehensive review","volume":"107","author":"S Farah","year":"2016","journal-title":"Adv Drug Deliv Rev"},{"key":"ppat.1010534.ref034","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.polymdegradstab.2018.06.010","article-title":"Thermal properties, phase morphology and stability of biodegradable PLA\/PBSL\/HAp composites","volume":"154","author":"K Behera","year":"2018","journal-title":"Polym Degrad Stabil"},{"issue":"11","key":"ppat.1010534.ref035","doi-asserted-by":"crossref","first-page":"4875","DOI":"10.1007\/s00253-015-7222-9","article-title":"High-efficiency biosynthesis of hypocrellin A in Shiraia sp. using gamma-ray mutagenesis","volume":"100","author":"X Liu","year":"2016","journal-title":"Appl Microbiol Biot"},{"issue":"1\u20132","key":"ppat.1010534.ref036","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.ijpharm.2017.07.027","article-title":"Evaluation of three-layered doxycycline-collagen loaded nanofiber wound dressing","volume":"529","author":"S Tort","year":"2017","journal-title":"Int J Pharmaceut"},{"key":"ppat.1010534.ref037","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.ijbiomac.2018.10.115","article-title":"Wound dressing based on electrospun PVA\/chitosan\/starch nanofibrous mats: Fabrication, antibacterial and cytocompatibility evaluation and in vitro healing assay","volume":"122","author":"H Adeli","year":"2019","journal-title":"Int J Biol Macromol"},{"issue":"1","key":"ppat.1010534.ref038","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1600-0846.2008.00329.x","article-title":"Characterization of the mechanical properties of a dermal equivalent compared with human skin in vivo by indentation and static friction tests","volume":"15","author":"H Zahouani","year":"2009","journal-title":"Skin Res Technol"},{"key":"ppat.1010534.ref039","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.ijbiomac.2018.04.010","article-title":"Incorporation of ZnO nanoparticles into heparinised polyvinyl alcohol\/chitosan hydrogels for wound dressing application","volume":"114","author":"MT Khorasani","year":"2018","journal-title":"Int J Biol Macromol"},{"key":"ppat.1010534.ref040","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.carbpol.2017.06.096","article-title":"Pectinate nanofiber mat with high absorbency and antibacterial activity: A potential superior wound dressing to alginate and chitosan nanofiber mats","volume":"174","author":"S Chen","year":"2017","journal-title":"Carbohyd Polym"},{"issue":"1","key":"ppat.1010534.ref041","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41426-018-0095-0","article-title":"The first isolate of Candida auris in China: clinical and biological aspects","volume":"7","author":"X Wang","year":"2018","journal-title":"Emerg Microbes Infec"},{"key":"ppat.1010534.ref042","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.biomaterials.2016.05.024","article-title":"808 nm Light-triggered and hyaluronic acid-targeted dual-photosensitizers nanoplatform by fully utilizing Nd3+-sensitized upconversion emission with enhanced anti-tumor efficacy","volume":"101","author":"Z Hou","year":"2016","journal-title":"Biomaterials"},{"issue":"3","key":"ppat.1010534.ref043","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s11046-004-6987-7","article-title":"The use of new probes and stains for improved assessment of cell viability and extracellular polymeric substances in Candida albicans biofilms","volume":"159","author":"Y Jin","year":"2005","journal-title":"Mycopathologia"},{"issue":"14","key":"ppat.1010534.ref044","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202008720","article-title":"Copper clusters: An effective antibacterial for eradicating multidrug-resistant bacterial infection in vitro and in vivo","volume":"31","author":"XC Zhang","year":"2021","journal-title":"Adv Funct Mater"},{"issue":"1","key":"ppat.1010534.ref045","doi-asserted-by":"crossref","DOI":"10.1128\/mSphereDirect.00680-18","article-title":"Conserved role for biofilm matrix polysaccharides in Candida auris drug resistance","volume":"4","author":"EG Dominguez","year":"2019","journal-title":"MSphere"},{"key":"ppat.1010534.ref046","first-page":"7","article-title":"A prospective surveillance study of candidaemia: Epidemiology, risk factors, antifungal treatment and outcome in hospitalized patients","author":"R Rajendran","year":"2016","journal-title":"Front Microbiol."},{"issue":"3","key":"ppat.1010534.ref047","doi-asserted-by":"crossref","first-page":"346","DOI":"10.13181\/mji.ret.205057","article-title":"Retraction: Periodic acid-Schiff and alcian blue immunohistochemistry to detect mucin in mucinous breast carcinoma","volume":"29","author":"P Rustamadji","year":"2020","journal-title":"Med J Indones"},{"issue":"4","key":"ppat.1010534.ref048","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1083\/jcb.145.4.757","article-title":"Oxygen stress: a regulator of apoptosis in yeast","volume":"145","author":"F Madeo","year":"1999","journal-title":"J Cell Biol"},{"issue":"29","key":"ppat.1010534.ref049","doi-asserted-by":"crossref","first-page":"9846","DOI":"10.1002\/anie.201903981","article-title":"Specific generation of singlet oxygen through the russell mechanism in hypoxic tumors and GSH depletion by Cu-TCPP nanosheets for cancer therapy","volume":"58","author":"C Wang","year":"2019","journal-title":"Angew Chem Int Edit"},{"issue":"2","key":"ppat.1010534.ref050","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1007\/s10570-019-02852-9","article-title":"Photoinactivation of bacteria by hypocrellin-grafted bacterial cellulose","volume":"27","author":"T Wang","year":"2020","journal-title":"Cellulose"},{"issue":"8","key":"ppat.1010534.ref051","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3389\/fcimb.2018.00445","article-title":"Antifungal activity of coumarin against Candida albicans is related to apoptosis","author":"C Jia","year":"2019","journal-title":"Front Cell Infect Mi"},{"issue":"8","key":"ppat.1010534.ref052","doi-asserted-by":"crossref","first-page":"3335","DOI":"10.1007\/s00253-017-8146-3","article-title":"Calcium and oxidative stress mediate perillaldehyde-induced apoptosis in Candida albicans","volume":"101","author":"H Tian","year":"2017","journal-title":"Appl Microbiol Biot"},{"issue":"2","key":"ppat.1010534.ref053","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.bbrc.2009.02.117","article-title":"Caspase-dependent and caspase-independent cell death pathways in yeast","volume":"382","author":"F Madeo","year":"2009","journal-title":"Bioph Res Co"},{"issue":"24","key":"ppat.1010534.ref054","doi-asserted-by":"crossref","first-page":"14327","DOI":"10.1073\/pnas.2332326100","article-title":"Apoptosis induced by environmental stresses and amphotericin B in Candida albicans","volume":"100","author":"AJ Phillips","year":"2003","journal-title":"P Natl Acad Sci"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1010534","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1010534","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T13:48:42Z","timestamp":1654609722000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1010534"}},"subtitle":[],"editor":[{"given":"Alexander","family":"Idnurm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,5,25]]},"references-count":54,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,5,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1010534","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,25]]}}}