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Although <jats:italic>Candida albicans<\/jats:italic>, which forms hyphae, readily invades endothelial cells, other medically important species of <jats:italic>Candida<\/jats:italic> are poorly invasive in standard in vitro assays and have low virulence in immunocompetent mouse models of disseminated infection. Here, we show that <jats:italic>Candida glabrata<\/jats:italic>, <jats:italic>Candida tropicalis<\/jats:italic>, <jats:italic>Candida parapsilosis<\/jats:italic>, and <jats:italic>Candida krusei<\/jats:italic> can bind to vitronectin and high molecular weight kininogen present in human serum. Acting as bridging molecules, vitronectin and kininogen bind to \u03b1v integrins and the globular C1q receptor (gC1qR), inducing human endothelial cells to endocytose the fungus. This mechanism of endothelial cell invasion is poorly supported by mouse endothelial cells but can be restored when mouse endothelial cells are engineered to express human gC1qR or \u03b1v integrin. Overall, these data indicate that bridging molecule-mediated endocytosis is a common pathogenic strategy used by many medically important <jats:italic>Candida spp<\/jats:italic>. to invade human vascular endothelial cells.<\/jats:p>","DOI":"10.1371\/journal.ppat.1010681","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T17:42:47Z","timestamp":1657215767000},"page":"e1010681","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Serum bridging molecules drive candidal invasion of human but not mouse endothelial cells"],"prefix":"10.1371","volume":"18","author":[{"given":"Quynh T.","family":"Phan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma 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Ghebrehiwet","year":"1996","journal-title":"Hybridoma"},{"issue":"Pt 11","key":"ppat.1010681.ref026","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1099\/00221287-147-11-3159","article-title":"Antibodies to alpha5beta1 and alpha(v)beta3 integrins react with Candida albicans alcohol dehydrogenase","volume":"147","author":"SA Klotz","year":"2001","journal-title":"Microbiology"},{"issue":"1","key":"ppat.1010681.ref027","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1086\/314822","article-title":"Evidence for alphavbeta3 and alphavbeta5 integrin-like vitronectin (VN) receptors in Candida albicans and their involvement in yeast cell adhesion to VN","volume":"180","author":"E Spreghini","year":"1999","journal-title":"J Infect Dis"},{"issue":"11","key":"ppat.1010681.ref028","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1016\/j.biochi.2010.03.011","article-title":"Kininogens: More than cysteine protease inhibitors and kinin 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Sanchez","year":"2004","journal-title":"Infect Immun"},{"issue":"148","key":"ppat.1010681.ref032","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0018-2018","article-title":"How bacteria hack the matrix and dodge the bullets of immunity","volume":"27","author":"M Paulsson","year":"2018","journal-title":"Eur Respir Rev"},{"issue":"1\u20132","key":"ppat.1010681.ref033","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0014-5793(98)00144-6","article-title":"Vitronectin-dependent invasion of epithelial cells by Neisseria gonorrhoeae involves alpha(v) integrin receptors","volume":"424","author":"M Dehio","year":"1998","journal-title":"FEBS Lett"},{"key":"ppat.1010681.ref034","doi-asserted-by":"crossref","first-page":"408","DOI":"10.2741\/4215","article-title":"AlphaVBeta5 integrins mediates Pseudomonas fluorescens interaction with A549 cells","volume":"19","author":"E Buommino","year":"2014","journal-title":"Front Biosci (Landmark 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