{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:55:44Z","timestamp":1790826944297,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1010785","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T00:00:00Z","timestamp":1721260800000}}],"reference-count":90,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-19-CE18-0024-02"],"award-info":[{"award-number":["ANR-19-CE18-0024-02"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche Medicale","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>The involvement of \u03b3\u03b4 TCR-bearing lymphocytes in immunological memory has gained increasing interest due to their functional duality between adaptive and innate immunity. \u03b3\u03b4 T effector memory (TEM) and central memory (TCM) subsets have been identified, but their respective roles in memory responses are poorly understood. In the present study, we used subsequent mouse cytomegalovirus (MCMV) infections of \u03b1\u03b2 T cell deficient mice in order to analyze the memory potential of \u03b3\u03b4 T cells. As for CMV-specific \u03b1\u03b2 T cells, MCMV induced the accumulation of cytolytic, KLRG1+CX3CR1+ \u03b3\u03b4 TEM that principally localized in infected organ vasculature. Typifying T cell memory, \u03b3\u03b4 T cell expansion in organs and blood was higher after secondary viral challenge than after primary infection. Viral control upon MCMV reinfection was prevented when masking \u03b3\u03b4 T-cell receptor, and was associated with a preferential amplification of private and unfocused TCR \u03b4 chain repertoire composed of a combination of clonotypes expanded post-primary infection and, more unexpectedly, of novel expanded clonotypes. Finally, long-term-primed \u03b3\u03b4 TCM cells, but not \u03b3\u03b4 TEM cells, protected T cell-deficient hosts against MCMV-induced death upon adoptive transfer, probably through their ability to survive and to generate TEM in the recipient host. This better survival potential of TCM cells was confirmed by a detailed scRNASeq analysis of the two \u03b3\u03b4 T cell memory subsets which also revealed their similarity to classically adaptive \u03b1\u03b2 CD8 T cells. Overall, our study uncovered memory properties of long-lived TCM \u03b3\u03b4 T cells that confer protection in a chronic infection, highlighting the interest of this T cell subset in vaccination approaches.<\/jats:p>","DOI":"10.1371\/journal.ppat.1010785","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T19:06:56Z","timestamp":1720465616000},"page":"e1010785","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Long-lived central memory \u03b3\u03b4 T cells confer protection against murine cytomegalovirus reinfection"],"prefix":"10.1371","volume":"20","author":[{"given":"Nathalie","family":"Yared","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3006-1993","authenticated-orcid":true,"given":"Maria","family":"Papadopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Barennes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang-Phuong","family":"Pham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin","family":"Quiniou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Netzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Kaminski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Burguet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandine","family":"Demeste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pac\u00f4me","family":"Colas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Mora-Charrot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Rousseau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Izotte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atika","family":"Zouine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Gauthereau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Vermijlen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"D\u00e9chanet-Merville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6419-9253","authenticated-orcid":true,"given":"Myriam","family":"Capone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,7,8]]},"reference":[{"issue":"2","key":"ppat.1010785.ref001","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/nri.2016.13","article-title":"Immunological memory: lessons from the past and a look to the future","volume":"16","author":"DL Farber","year":"2016","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"ppat.1010785.ref002","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/imr.12652","article-title":"Immunological memory: What\u2019s in a name?","volume":"283","author":"T Pradeu","year":"2018","journal-title":"Immunol Rev"},{"issue":"1","key":"ppat.1010785.ref003","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.chom.2018.12.006","article-title":"Innate and Adaptive Immune Memory: an Evolutionary Continuum in the Host\u2019s Response to Pathogens","volume":"25","author":"MG Netea","year":"2019","journal-title":"Cell Host Microbe"},{"key":"ppat.1010785.ref004","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.3389\/fimmu.2018.02692","article-title":"Defining Memory CD8","volume":"9","author":"MD Martin","year":"2018","journal-title":"T Cell. 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single-cycle cytomegalovirus","volume":"7","author":"CM Snyder","year":"2011","journal-title":"PLoS Pathog"},{"issue":"3","key":"ppat.1010785.ref066","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.celrep.2018.03.074","article-title":"Induction and Maintenance of CX3CR1-Intermediate Peripheral Memory CD8(+) T Cells by Persistent Viruses and Vaccines.","volume":"23","author":"CL Gordon","year":"2018","journal-title":"Cell Rep"},{"issue":"4","key":"ppat.1010785.ref067","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1002\/eji.201343946","article-title":"Viral inoculum dose impacts memory T-cell inflation","volume":"44","author":"A Redeker","year":"2014","journal-title":"Eur J Immunol"},{"issue":"3","key":"ppat.1010785.ref068","article-title":"Revisiting CD8 T-cell \u2019Memory Inflation\u2019: New Insights with Implications for Cytomegaloviruses as Vaccine Vectors.","volume":"8","author":"R Holtappels","year":"2020","journal-title":"Vaccines (Basel)."},{"issue":"3","key":"ppat.1010785.ref069","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/s41385-020-00373-4","article-title":"Influenza- and MCMV-induced memory CD8 T cells control respiratory vaccinia virus infection despite residence in distinct anatomical niches.","volume":"14","author":"SPM Welten","year":"2021","journal-title":"Mucosal Immunol.PubMed Central PMCID"},{"issue":"1","key":"ppat.1010785.ref070","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.immuni.2010.06.014","article-title":"Repetitive antigen stimulation induces stepwise transcriptome diversification but preserves a core signature of memory CD8(+) T cell differentiation.","volume":"33","author":"TC Wirth","year":"2010","journal-title":"Immunity"},{"issue":"2","key":"ppat.1010785.ref071","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.4049\/jimmunol.161.2.1045","article-title":"Bacille Calmette-Guerin vaccination enhances human gamma delta T cell responsiveness to mycobacteria suggestive of a memory-like phenotype","volume":"161","author":"DF Hoft","year":"1998","journal-title":"J Immunol"},{"issue":"2","key":"ppat.1010785.ref072","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1046\/j.1365-2249.2003.02209.x","article-title":"Immune biology of macaque lymphocyte populations during mycobacterial infection","volume":"133","author":"X Lai","year":"2003","journal-title":"Clin Exp Immunol"},{"issue":"3","key":"ppat.1010785.ref073","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.4049\/jimmunol.1200641","article-title":"Multieffector-functional immune responses of HMBPP-specific Vgamma2Vdelta2 T cells in nonhuman primates inoculated with Listeria monocytogenes DeltaactA prfA*","volume":"189","author":"B Ryan-Payseur","year":"2012","journal-title":"J Immunol"},{"issue":"1","key":"ppat.1010785.ref074","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.immuni.2013.06.015","article-title":"gammadelta T cells exhibit 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Tieppo","year":"2020","journal-title":"J Exp Med"},{"issue":"9","key":"ppat.1010785.ref078","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1086\/644509","article-title":"Common features of gammadelta T cells and CD8(+) alphabeta T cells responding to human cytomegalovirus infection in kidney transplant recipients.","volume":"200","author":"L Couzi","year":"2009","journal-title":"J Infect Dis"},{"issue":"10","key":"ppat.1010785.ref079","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1172\/JCI5409","article-title":"Implication of gammadelta T cells in the human immune response to cytomegalovirus","volume":"103","author":"J Dechanet","year":"1999","journal-title":"J Clin Invest"},{"key":"ppat.1010785.ref080","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1146\/annurev-immunol-102819-023144","article-title":"The Innate Biologies of Adaptive Antigen Receptors","volume":"38","author":"AC Hayday","year":"2020","journal-title":"Annu Rev Immunol"},{"issue":"12","key":"ppat.1010785.ref081","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1038\/s41590-020-00807-y","article-title":"Early emergence of T central memory precursors programs clonal dominance during chronic viral infection","volume":"21","author":"S Grassmann","year":"2020","journal-title":"Nat Immunol"},{"issue":"10","key":"ppat.1010785.ref082","doi-asserted-by":"crossref","first-page":"e1002313","DOI":"10.1371\/journal.ppat.1002313","article-title":"Non-hematopoietic cells in lymph nodes drive memory CD8 T cell inflation during murine cytomegalovirus infection","volume":"7","author":"N Torti","year":"2011","journal-title":"PLoS Pathog"},{"issue":"4","key":"ppat.1010785.ref083","doi-asserted-by":"crossref","first-page":"e1006993","DOI":"10.1371\/journal.ppat.1006993","article-title":"Tissue maintenance of CMV-specific inflationary memory T cells by IL-15.","volume":"14","author":"NS Baumann","year":"2018","journal-title":"PLoS PathogPubMed Central 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Philpott","year":"1992","journal-title":"Science"},{"issue":"1","key":"ppat.1010785.ref087","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nprot.2014.005","article-title":"Intravascular staining for discrimination of vascular and tissue leukocytes.","volume":"9","author":"KG Anderson","year":"2014","journal-title":"Nat Protoc.PubMed Central PMCID"},{"issue":"5","key":"ppat.1010785.ref088","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nmeth.3364","article-title":"MiXCR: software for comprehensive adaptive immunity profiling","volume":"12","author":"DA Bolotin","year":"2015","journal-title":"Nat Methods"},{"issue":"11","key":"ppat.1010785.ref089","doi-asserted-by":"crossref","first-page":"e1004503","DOI":"10.1371\/journal.pcbi.1004503","article-title":"VDJtools: Unifying Post-analysis of T Cell Receptor Repertoires","volume":"11","author":"M Shugay","year":"2015","journal-title":"PLoS Comput 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