{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:57:41Z","timestamp":1783634261542,"version":"3.55.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1010846","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:00:00Z","timestamp":1664496000000}}],"reference-count":83,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["IRTG2290"],"award-info":[{"award-number":["IRTG2290"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SPP 1580; # IN 182\/1-1"],"award-info":[{"award-number":["SPP 1580; # IN 182\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01KI2104"],"award-info":[{"award-number":["01KI2104"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Collaborative Research Infrastructure Strategy"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    Protein export and host membrane remodeling are crucial for multiple\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    species to establish a niche in infected hosts. To better understand the contribution of these processes to successful parasite infection\n                    <jats:italic>in vivo<\/jats:italic>\n                    , we sought to find and characterize protein components of the intraerythrocytic\n                    <jats:italic>Plasmodium berghei<\/jats:italic>\n                    -induced membrane structures (IBIS) that form in the cytoplasm of infected erythrocytes. We identified proteins that immunoprecipitate with IBIS1, a signature member of the IBIS in\n                    <jats:italic>P<\/jats:italic>\n                    .\n                    <jats:italic>berghei<\/jats:italic>\n                    -infected erythrocytes. In parallel, we also report our data describing proteins that co-precipitate with the PTEX (\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    translocon of exported proteins) component EXP2. To validate our findings, we examined the location of three candidate IBIS1-interactors that are conserved across multiple\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    species, and we found they localized to IBIS in infected red blood cells and two further colocalized with IBIS1 in the liver-stage parasitophorous vacuole membrane. Successful gene deletion revealed that these two tryptophan-rich domain-containing proteins, termed here IPIS2 and IPIS3 (for intraerythrocytic\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    -induced membrane structures), are required for efficient blood-stage growth. Erythrocytes infected with IPIS2-deficient schizonts in particular fail to bind CD36 as efficiently as wild-type\n                    <jats:italic>P<\/jats:italic>\n                    .\n                    <jats:italic>berghei<\/jats:italic>\n                    -infected cells and therefore fail to effectively sequester out of the circulating blood. Our findings support the idea that intra-erythrocytic membrane compartments are required across species for alterations of the host erythrocyte that facilitate interactions of infected cells with host tissues.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1010846","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T14:00:58Z","timestamp":1663682458000},"page":"e1010846","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["A member of the tryptophan-rich protein family is required for efficient sequestration of Plasmodium berghei schizonts"],"prefix":"10.1371","volume":"18","author":[{"given":"Julie-Anne","family":"Gabelich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine","family":"Gr\u00fctzke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Kirscht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Popp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim M.","family":"Matz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Dittmar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Rug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3277-8162","authenticated-orcid":true,"given":"Alyssa","family":"Ingmundson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,9,20]]},"reference":[{"issue":"7249","key":"ppat.1010846.ref001","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1038\/nature08104","article-title":"A newly discovered protein export machine in malaria parasites","volume":"459","author":"TF de Koning-Ward","year":"2009","journal-title":"Nature"},{"issue":"7511","key":"ppat.1010846.ref002","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nature13574","article-title":"PTEX component HSP101 mediates export of diverse malaria effectors into host erythrocytes","volume":"511","author":"JR Beck","year":"2014","journal-title":"Nature"},{"issue":"7511","key":"ppat.1010846.ref003","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nature13555","article-title":"PTEX is an essential nexus for protein export in malaria parasites","volume":"511","author":"B Elsworth","year":"2014","journal-title":"Nature"},{"issue":"6","key":"ppat.1010846.ref004","doi-asserted-by":"crossref","first-page":"795","DOI":"10.4269\/ajtmh.1971.20.795","article-title":"The simian malarias: zoonoses, anthroponoses, or both?","volume":"20","author":"GR Coatney","year":"1971","journal-title":"Am J Trop Med Hyg"},{"issue":"2","key":"ppat.1010846.ref005","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/0014-4894(71)90094-4","article-title":"Parasitological review. 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A Morphological Study of the Erythroeytic Parasites.","volume":"24","author":"JW Field","year":"1956","journal-title":"Studies from the Institute for Medical Research, Federated Malay States."},{"issue":"9","key":"ppat.1010846.ref048","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1093\/infdis\/jiu018","article-title":"Paucity of Plasmodium vivax mature schizonts in peripheral blood is associated with their increased cytoadhesive potential","volume":"209","author":"SC Lopes","year":"2014","journal-title":"J Infect Dis"},{"issue":"1","key":"ppat.1010846.ref049","doi-asserted-by":"crossref","first-page":"e1004558","DOI":"10.1371\/journal.ppat.1004558","article-title":"Parasite biomass-related inflammation, endothelial activation, microvascular dysfunction and disease severity in vivax malaria.","volume":"11","author":"BE Barber","year":"2015","journal-title":"PLoS Pathog."},{"issue":"1","key":"ppat.1010846.ref050","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1186\/s12936-017-2008-4","article-title":"A model of Plasmodium vivax concealment based on Plasmodium cynomolgi infections in Macaca mulatta.","volume":"16","author":"LL Fonseca","year":"2017","journal-title":"Malar J"},{"issue":"3","key":"ppat.1010846.ref051","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00625-18","article-title":"Bone Marrow Is a Major Parasite Reservoir in Plasmodium vivax Infection.","volume":"9","author":"N Obaldia","year":"2018","journal-title":"mBio"},{"issue":"5","key":"ppat.1010846.ref052","doi-asserted-by":"crossref","first-page":"e1003632","DOI":"10.1371\/journal.pmed.1003632","article-title":"Evaluation of splenic accumulation and colocalization of immature reticulocytes and Plasmodium vivax in asymptomatic malaria: A prospective human splenectomy study.","volume":"18","author":"S Kho","year":"2021","journal-title":"PLoS 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by the Tryptophan-Rich Antigens of Monkey Malaria Parasite Plasmodium knowlesi.","volume":"10","author":"K Tyagi","year":"2015","journal-title":"PLoS One."},{"issue":"32","key":"ppat.1010846.ref065","doi-asserted-by":"crossref","first-page":"19496","DOI":"10.1074\/jbc.M114.588129","article-title":"A Sporozoite- and Liver Stage-expressed Tryptophan-rich Protein Plays an Auxiliary Role in Plasmodium Liver Stage Development and Is a Potential Vaccine Candidate","volume":"290","author":"DK Jaijyan","year":"2015","journal-title":"J Biol Chem"},{"issue":"2","key":"ppat.1010846.ref066","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/1873-3468.12053","article-title":"Host-parasite interaction: multiple sites in the Plasmodium vivax tryptophan-rich antigen PvTRAg38 interact with the erythrocyte receptor band 3","volume":"590","author":"MS Alam","year":"2016","journal-title":"FEBS 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Cunnington","year":"2013","journal-title":"J Infect."},{"issue":"12","key":"ppat.1010846.ref073","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1038\/s41591-020-1084-0","article-title":"Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season","volume":"26","author":"CM Andrade","year":"2020","journal-title":"Nat Med"},{"issue":"11","key":"ppat.1010846.ref074","doi-asserted-by":"crossref","first-page":"e1010114","DOI":"10.1371\/journal.ppat.1010114","article-title":"Skeleton binding protein-1-mediated parasite sequestration inhibits spontaneous resolution of malaria-associated acute respiratory distress syndrome.","volume":"17","author":"H Possemiers","year":"2021","journal-title":"PLoS Pathog"},{"issue":"1","key":"ppat.1010846.ref075","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.molbiopara.2005.09.007","article-title":"High efficiency transfection of Plasmodium berghei facilitates novel selection procedures","volume":"145","author":"CJ Janse","year":"2006","journal-title":"Mol Biochem Parasitol"},{"issue":"1","key":"ppat.1010846.ref076","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.molbiopara.2012.06.001","article-title":"Expansion of experimental genetics approaches for Plasmodium berghei with versatile transfection vectors","volume":"185","author":"TW Kooij","year":"2012","journal-title":"Mol Biochem Parasitol"},{"issue":"6","key":"ppat.1010846.ref077","doi-asserted-by":"crossref","first-page":"e1000086","DOI":"10.1371\/journal.ppat.1000086","article-title":"A sporozoite asparagine-rich protein controls initiation of Plasmodium liver stage development","volume":"4","author":"O Silvie","year":"2008","journal-title":"PLoS Pathog"},{"issue":"20","key":"ppat.1010846.ref078","doi-asserted-by":"crossref","first-page":"5965","DOI":"10.1007\/s00216-015-8595-4","article-title":"Differential proteomic analysis of mouse macrophages exposed to adsorbate-loaded heavy fuel oil derived combustion particles using an automated sample-preparation workflow","volume":"407","author":"T Kanashova","year":"2015","journal-title":"Anal Bioanal Chem"},{"issue":"3","key":"ppat.1010846.ref079","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1021\/ac026117i","article-title":"Stop and go extraction tips for matrix-assisted laser desorption\/ionization, nanoelectrospray, and LC\/MS sample pretreatment in proteomics","volume":"75","author":"J Rappsilber","year":"2003","journal-title":"Anal Chem"},{"issue":"12","key":"ppat.1010846.ref080","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"J Cox","year":"2008","journal-title":"Nat Biotechnol"},{"issue":"7","key":"ppat.1010846.ref081","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis.","volume":"9","author":"J Schindelin","year":"2012","journal-title":"Nat Methods"},{"issue":"1","key":"ppat.1010846.ref082","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/BF00932618","article-title":"Demonstration of heat-shock protein 70 in the sporozoite stage of malaria parasites","volume":"80","author":"M Tsuji","year":"1994","journal-title":"Parasitol Res"},{"issue":"5","key":"ppat.1010846.ref083","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1111\/cmi.12270","article-title":"Evidence of promiscuous endothelial binding by Plasmodium falciparum-infected erythrocytes","volume":"16","author":"C Esser","year":"2014","journal-title":"Cell Microbiol"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1010846","type":"new_version","label":"New 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