{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T08:18:33Z","timestamp":1780561113940,"version":"3.54.1"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["R01AI127793, R01AI097312, R21 AI161302"],"award-info":[{"award-number":["R01AI127793, R01AI097312, R21 AI161302"]}]},{"DOI":"10.13039\/100008457","name":"University of Virginia","doi-asserted-by":"publisher","award":["Harrison Distinguished Teaching Professorship"],"award-info":[{"award-number":["Harrison Distinguished Teaching Professorship"]}],"id":[{"id":"10.13039\/100008457","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH","award":["T32AI007046, F31AI167563"],"award-info":[{"award-number":["T32AI007046, F31AI167563"]}]},{"name":"NIH","award":["T32AI055432, T32GM007267"],"award-info":[{"award-number":["T32AI055432, T32GM007267"]}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1011091","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T18:25:55Z","timestamp":1675362355000},"page":"e1011091","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Metal piracy by Neisseria gonorrhoeae to overcome human nutritional immunity"],"prefix":"10.1371","volume":"19","author":[{"given":"Ian K.","family":"Liyayi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy L.","family":"Forehand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn C.","family":"Ray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7738-3757","authenticated-orcid":true,"given":"Alison K.","family":"Criss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,2,2]]},"reference":[{"issue":"9","key":"ppat.1011091.ref001","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.tim.2022.01.017","article-title":"Targeting bacterial transferrin and lactoferrin receptors for vaccines","volume":"30","author":"AB Schryvers","year":"2022","journal-title":"Trends Microbiol"},{"issue":"11","key":"ppat.1011091.ref002","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41579-022-00745-6","article-title":"Nutritional immunity: the battle for nutrient metals at the host-pathogen interface","volume":"20","author":"CC Murdoch","year":"2022","journal-title":"Nat Rev Microbiol"},{"issue":"7","key":"ppat.1011091.ref003","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.tim.2021.12.006","article-title":"Metal sequestration by S100 proteins in chemically diverse environments","volume":"30","author":"T Rosen","year":"2022","journal-title":"Trends Microbiol"},{"key":"ppat.1011091.ref004","doi-asserted-by":"crossref","first-page":"909888","DOI":"10.3389\/fcimb.2022.909888","article-title":"Acclimation to Nutritional Immunity and Metal Intoxication Requires Zinc, Manganese, and Copper Homeostasis in the Pathogenic Neisseriae.","volume":"12","author":"AH Branch","year":"2022","journal-title":"Front Cell Infect Microbiol."},{"key":"ppat.1011091.ref005","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1477-5956-7-17","article-title":"Comprehensive proteomic analysis of human cervical-vaginal fluid using colposcopy samples.","volume":"7","author":"G Zegels","year":"2009","journal-title":"Proteome Sci."},{"issue":"10","key":"ppat.1011091.ref006","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/nchembio.1891","article-title":"Human calprotectin is an iron-sequestering host-defense protein","volume":"11","author":"TG Nakashige","year":"2015","journal-title":"Nat Chem Biol"},{"issue":"12","key":"ppat.1011091.ref007","doi-asserted-by":"crossref","first-page":"7706","DOI":"10.1016\/S0021-9258(20)89506-4","article-title":"Identification of p8,14 as a highly abundant heterodimeric calcium binding protein complex of myeloid cells","volume":"266","author":"J Edgeworth","year":"1991","journal-title":"J Biol Chem"},{"issue":"3","key":"ppat.1011091.ref008","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1084\/jem.130.3.643","article-title":"Lactoferrin, an iron-binding protein in neutrophilic leukocytes","volume":"130","author":"PL Masson","year":"1969","journal-title":"J Exp Med"},{"issue":"5","key":"ppat.1011091.ref009","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S1097-2765(02)00708-6","article-title":"The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition","volume":"10","author":"DH Goetz","year":"2002","journal-title":"Mol Cell"},{"issue":"10","key":"ppat.1011091.ref010","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1128\/IAI.00319-16","article-title":"Neisseria gonorrhoeae Evades Calprotectin-Mediated Nutritional Immunity and Survives Neutrophil Extracellular Traps by Production of TdfH","volume":"84","author":"S Jean","year":"2016","journal-title":"Infect Immun"},{"issue":"1","key":"ppat.1011091.ref011","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1001\/jama.1975.03240130021018","article-title":"Nutritional immunity. Host\u2019s attempt to withold iron from microbial invaders","volume":"231","author":"ED Weinberg","year":"1975","journal-title":"JAMA"},{"issue":"4","key":"ppat.1011091.ref012","doi-asserted-by":"crossref","first-page":"459","DOI":"10.2164\/jandrol.04104","article-title":"A review of the physical and chemical properties of human semen and the formulation of a semen simulant","volume":"26","author":"DH Owen","year":"2005","journal-title":"J Androl"},{"issue":"1","key":"ppat.1011091.ref013","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1128\/JB.00741-09","article-title":"Transcriptional and functional analysis of the Neisseria gonorrhoeae Fur regulon","volume":"192","author":"LA Jackson","year":"2010","journal-title":"J Bacteriol"},{"issue":"23","key":"ppat.1011091.ref014","doi-asserted-by":"crossref","first-page":"6594","DOI":"10.1128\/JB.01091-12","article-title":"The zinc-responsive regulon of Neisseria meningitidis comprises 17 genes under control of a Zur element","volume":"194","author":"MC Pawlik","year":"2012","journal-title":"J Bacteriol"},{"issue":"7","key":"ppat.1011091.ref015","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1128\/JB.06176-11","article-title":"Fur-mediated activation of gene transcription in the human pathogen Neisseria gonorrhoeae","volume":"194","author":"C Yu","year":"2012","journal-title":"J Bacteriol"},{"issue":"2","key":"ppat.1011091.ref016","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1365-2958.1993.tb01957.x","article-title":"The ferric iron-binding protein of pathogenic Neisseria spp. functions as a periplasmic transport protein in iron acquisition from human transferrin","volume":"10","author":"CY Chen","year":"1993","journal-title":"Mol Microbiol"},{"issue":"1","key":"ppat.1011091.ref017","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1574-6968.2001.tb10781.x","article-title":"Identification and characterization of a high-affinity zinc uptake system in Neisseria gonorrhoeae","volume":"202","author":"CY Chen","year":"2001","journal-title":"FEMS Microbiol Lett"},{"issue":"8","key":"ppat.1011091.ref018","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1128\/IAI.01725-07","article-title":"Metal binding specificity of the MntABC permease of Neisseria gonorrhoeae and its influence on bacterial growth and interaction with cervical epithelial cells","volume":"76","author":"KH Lim","year":"2008","journal-title":"Infect Immun"},{"issue":"7387","key":"ppat.1011091.ref019","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nature10823","article-title":"Structural basis for iron piracy by pathogenic Neisseria","volume":"483","author":"N Noinaj","year":"2012","journal-title":"Nature"},{"issue":"11","key":"ppat.1011091.ref020","doi-asserted-by":"crossref","first-page":"e0041422","DOI":"10.1128\/iai.00414-22","article-title":"Point Mutations in TbpA Abrogate Human Transferrin Binding in Neisseria gonorrhoeae","volume":"90","author":"AN Greenawalt","year":"2022","journal-title":"Infect Immun"},{"issue":"1","key":"ppat.1011091.ref021","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1128\/IAI.67.1.455-459.1999","article-title":"Identification and functional characterization of the Neisseria gonorrhoeae lbpB gene product","volume":"67","author":"GD Biswas","year":"1999","journal-title":"Infect Immun"},{"issue":"3","key":"ppat.1011091.ref022","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1128\/IAI.66.3.987-993.1998","article-title":"Phase variation of hemoglobin utilization in Neisseria gonorrhoeae","volume":"66","author":"CJ Chen","year":"1998","journal-title":"Infect Immun"},{"issue":"8","key":"ppat.1011091.ref023","doi-asserted-by":"crossref","first-page":"e1007937","DOI":"10.1371\/journal.ppat.1007937","article-title":"The novel interaction between Neisseria gonorrhoeae TdfJ and human S100A7 allows gonococci to subvert host zinc restriction.","volume":"15","author":"S Maurakis","year":"2019","journal-title":"PLoS Pathog."},{"issue":"3","key":"ppat.1011091.ref024","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00949-20","article-title":"Molecular Insight into TdfH-Mediated Zinc Piracy from Human Calprotectin by Neisseria gonorrhoeae.","volume":"11","author":"MT Kammerman","year":"2020","journal-title":"mBio"},{"issue":"1","key":"ppat.1011091.ref025","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/s42003-022-03039-y","article-title":"TdfH selectively binds metal-loaded tetrameric calprotectin for zinc import.","volume":"5","author":"AK Bera","year":"2022","journal-title":"Commun Biol."},{"issue":"3","key":"ppat.1011091.ref026","doi-asserted-by":"crossref","first-page":"e0000922","DOI":"10.1128\/iai.00009-22","article-title":"Adherence Enables Neisseria gonorrhoeae to Overcome Zinc Limitation Imposed by Nutritional Immunity Proteins","volume":"90","author":"JC Ray","year":"2022","journal-title":"Infect Immun"},{"issue":"9","key":"ppat.1011091.ref027","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1128\/JB.181.9.2895-2901.1999","article-title":"Ferric enterobactin binding and utilization by Neisseria gonorrhoeae","volume":"181","author":"SD Carson","year":"1999","journal-title":"J Bacteriol"},{"issue":"4","key":"ppat.1011091.ref028","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1111\/j.1365-2958.2006.05429.x","article-title":"Neisseria gonorrhoeae requires expression of TonB and the putative transporter TdfF to replicate within cervical epithelial cells","volume":"62","author":"TA Hagen","year":"2006","journal-title":"Mol Microbiol"},{"issue":"1","key":"ppat.1011091.ref029","doi-asserted-by":"crossref","DOI":"10.1128\/mSystems.00729-19","article-title":"Global Network Analysis of Neisseria gonorrhoeae Identifies Coordination between Pathways, Processes, and Regulators Expressed during Human Infection.","volume":"5","author":"R McClure","year":"2020","journal-title":"mSystems"},{"issue":"3","key":"ppat.1011091.ref030","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1046\/j.1365-2958.1998.00710.x","article-title":"The transferrin receptor expressed by gonococcal strain FA1090 is required for the experimental infection of human male volunteers","volume":"27","author":"CN Cornelissen","year":"1998","journal-title":"Mol Microbiol"},{"issue":"2","key":"ppat.1011091.ref031","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1365-2958.2006.05079.x","article-title":"PerR controls Mn-dependent resistance to oxidative stress in Neisseria gonorrhoeae","volume":"60","author":"HJ Wu","year":"2006","journal-title":"Mol Microbiol"}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1011091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T18:26:18Z","timestamp":1675362378000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1011091"}},"subtitle":[],"editor":[{"given":"Jorn","family":"Coers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,2,2]]},"references-count":31,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1011091","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,2]]}}}