{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:14:51Z","timestamp":1790781291802,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1011156","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:00:00Z","timestamp":1676505600000}}],"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T00:00:00Z","timestamp":1675641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002661","name":"Fonds De La Recherche Scientifique - FNRS","doi-asserted-by":"publisher","award":["CDR 31270116"],"award-info":[{"award-number":["CDR 31270116"]}],"id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002661","name":"Fonds De La Recherche Scientifique - FNRS","doi-asserted-by":"publisher","award":["CDR 40007814"],"award-info":[{"award-number":["CDR 40007814"]}],"id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008136","name":"University of Namur","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008136","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003134","name":"Fonds pour la Formation \u00e0 la Recherche dans l\u2019Industrie et dans l\u2019Agriculture","doi-asserted-by":"publisher","award":["FRIA 31454280"],"award-info":[{"award-number":["FRIA 31454280"]}],"id":[{"id":"10.13039\/501100003134","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003134","name":"Fonds pour la Formation \u00e0 la Recherche dans l\u2019Industrie et dans l\u2019Agriculture","doi-asserted-by":"publisher","award":["FRIA 40008651"],"award-info":[{"award-number":["FRIA 40008651"]}],"id":[{"id":"10.13039\/501100003134","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002661","name":"Fonds De La Recherche Scientifique - FNRS","doi-asserted-by":"publisher","award":["PDR TLV 34972507"],"award-info":[{"award-number":["PDR TLV 34972507"]}],"id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Namur (Belgium) and University of Mons (Belgium)."},{"name":"Allocation de Recherche du Minist\u00e8re fran\u00e7ais de la Recherche"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>Human adenoviruses (HAdVs) are a large family of DNA viruses counting more than a hundred strains divided into seven species (A to G). HAdVs induce respiratory tract infections, gastroenteritis and conjunctivitis. APOBEC3B is a cytidine deaminase that restricts several DNA viruses. APOBEC3B is also implicated in numerous cancers where it is responsible for the introduction of clustered mutations into the cellular genome.<\/jats:p>\n<jats:p>In this study, we demonstrate that APOBEC3B is an adenovirus restriction factor acting through a deaminase-dependent mechanism. APOBEC3B introduces C-to-T clustered mutations into the adenovirus genome. APOBEC3B reduces the propagation of adenoviruses by limiting viral genome replication, progression to late phase, and production of infectious virions. APOBEC3B restriction efficiency varies between adenoviral strains, the A12 strain being more sensitive to APOBEC3B than the B3 or C2 strains. In A12-infected cells, APOBEC3B clusters in the viral replication centers. Importantly, we show that adenovirus infection leads to a reduction of the quantity and\/or enzymatic activity of the APOBEC3B protein depending on the strains. The A12 strain seems less able to resist APOBEC3B than the B3 or C2 strains, a characteristic which could explain the strong depletion of the APOBEC3-targeted motifs in the A12 genome.<\/jats:p>\n<jats:p>These findings suggest that adenoviruses evolved different mechanisms to antagonize APOBEC3B. Elucidating these mechanisms could benefit the design of cancer treatments. This study also identifies adenoviruses as triggers of the APOBEC3B-mediated innate response. The involvement of certain adenoviral strains in the genesis of the APOBEC3 mutational signature observed in tumors deserves further study.<\/jats:p>","DOI":"10.1371\/journal.ppat.1011156","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T18:46:57Z","timestamp":1675709217000},"page":"e1011156","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["The APOBEC3B cytidine deaminase is an adenovirus restriction factor"],"prefix":"10.1371","volume":"19","author":[{"given":"No\u00e9mie","family":"Lejeune","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Mathieu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Decloux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Poulain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zo\u00e9","family":"Blockx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle A.","family":"Raymond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e9vin","family":"Willemart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Vartanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolphe","family":"Susp\u00e8ne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9410-8738","authenticated-orcid":true,"given":"Nicolas A.","family":"Gillet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,2,6]]},"reference":[{"key":"ppat.1011156.ref001","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1128\/CMR.00116-13","article-title":"Adenovirus Infections in Immunocompetent and Immunocompromised Patients","volume":"27","author":"T. Lion","year":"2014","journal-title":"Clin Microbiol Rev"},{"key":"ppat.1011156.ref002","doi-asserted-by":"crossref","first-page":"5701","DOI":"10.1128\/JVI.00354-11","article-title":"Using the Whole-Genome Sequence To Characterize and Name Human Adenoviruses\u25bf","volume":"85","author":"D Seto","year":"2011","journal-title":"J Virol"},{"key":"ppat.1011156.ref003","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1055\/s-0036-1584923","article-title":"Adenovirus: Epidemiology, Global Spread of Novel Serotypes, and Advances in Treatment and Prevention","volume":"37","author":"J Lynch","year":"2016","journal-title":"Semin Respir Crit Care Med"},{"key":"ppat.1011156.ref004","first-page":"66","article-title":"Human Adenovirus Surveillance\u2014United States, 2003\u20132016","author":"AM Binder","year":"2017","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"ppat.1011156.ref005","article-title":"Functions and consequences of AID\/APOBEC-mediated DNA and RNA deamination","author":"R Pecori","year":"2022","journal-title":"Nat Rev Genet"},{"key":"ppat.1011156.ref006","first-page":"8","article-title":"The Role of APOBECs in Viral Replication","author":"WK Xu","year":"2020","journal-title":"Microorganisms"},{"key":"ppat.1011156.ref007","doi-asserted-by":"crossref","first-page":"JVI0117021","DOI":"10.1128\/JVI.01170-21","article-title":"APOBEC3B potently restricts HIV-2 but not HIV-1 in a Vif-dependent manner","author":"S Bandarra","year":"2021","journal-title":"J Virol"},{"key":"ppat.1011156.ref008","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.virol.2005.06.005","article-title":"Human APOBEC3B is a potent inhibitor of HIV-1 infectivity and is resistant to HIV-1 Vif","volume":"339","author":"BP Doehle","year":"2005","journal-title":"Virology"},{"key":"ppat.1011156.ref009","doi-asserted-by":"crossref","first-page":"6097","DOI":"10.1128\/JVI.06570-11","article-title":"APOBEC3A, APOBEC3B, and APOBEC3H haplotype 2 restrict human T-lymphotropic virus type 1","volume":"86","author":"M Ooms","year":"2012","journal-title":"J Virol"},{"key":"ppat.1011156.ref010","doi-asserted-by":"crossref","first-page":"8321","DOI":"10.1073\/pnas.0408223102","article-title":"Extensive editing of both hepatitis B virus DNA strands by APOBEC3 cytidine deaminases in vitro and in vivo","volume":"102","author":"R Susp\u00e8ne","year":"2005","journal-title":"Proc Natl Acad Sci"},{"key":"ppat.1011156.ref011","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/nar\/gkj416","article-title":"APOBEC3A and APOBEC3B are potent inhibitors of LTR-retrotransposon function in human cells","volume":"34","author":"HP Bogerd","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"ppat.1011156.ref012","doi-asserted-by":"crossref","first-page":"36427","DOI":"10.1074\/jbc.M111.251058","article-title":"Endogenous APOBEC3B restricts LINE-1 retrotransposition in transformed cells and human embryonic stem cells","volume":"286","author":"S Wissing","year":"2011","journal-title":"J Biol Chem"},{"key":"ppat.1011156.ref013","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41564-018-0284-6","article-title":"Epstein\u2013Barr virus BORF2 inhibits cellular APOBEC3B to preserve viral genome integrity","volume":"4","author":"AZ Cheng","year":"2019","journal-title":"Nat Microbiol"},{"key":"ppat.1011156.ref014","first-page":"e01539","article-title":"A Conserved Mechanism of APOBEC3 Relocalization by Herpesviral Ribonucleotide Reductase Large Subunits","volume":"93","author":"AZ Cheng","journal-title":"J Virol"},{"key":"ppat.1011156.ref015","first-page":"91","article-title":"Human Papillomavirus 16 E6 Upregulates APOBEC3B via the TEAD Transcription Factor","author":"S Mori","year":"2017","journal-title":"J Virol"},{"key":"ppat.1011156.ref016","first-page":"10","article-title":"Polyomavirus T Antigen Induces APOBEC3B Expression Using an LXCXE-Dependent and TP53-Independent Mechanism","author":"GJ Starrett","year":"2019","journal-title":"mBio"},{"key":"ppat.1011156.ref017","doi-asserted-by":"crossref","first-page":"6379","DOI":"10.1128\/JVI.00771-16","article-title":"Functional Upregulation of the DNA Cytosine Deaminase APOBEC3B by Polyomaviruses","volume":"90","author":"B Verhalen","year":"2016","journal-title":"J Virol"},{"key":"ppat.1011156.ref018","doi-asserted-by":"crossref","first-page":"e02234","DOI":"10.1128\/mBio.02234-14","article-title":"Human Papillomavirus E6 Triggers Upregulation of the Antiviral and Cancer Genomic DNA Deaminase APOBEC3B","volume":"5","author":"VC Vieira","year":"2014","journal-title":"mBio"},{"key":"ppat.1011156.ref019","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.chom.2018.04.005","article-title":"Characterization of BK Polyomaviruses from Kidney Transplant Recipients Suggests a Role for APOBEC3 in Driving In-Host Virus Evolution","volume":"23","author":"A Peretti","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ppat.1011156.ref020","first-page":"1","article-title":"Role of the host restriction factor APOBEC3 on papillomavirus evolution","author":"CJ Warren","year":"2015","journal-title":"Virus Evol"},{"key":"ppat.1011156.ref021","doi-asserted-by":"crossref","first-page":"e1008718","DOI":"10.1371\/journal.ppat.1008718","article-title":"Footprint of the host restriction factors APOBEC3 on the genome of human viruses","volume":"16","author":"F Poulain","year":"2020","journal-title":"PLOS Pathog"},{"key":"ppat.1011156.ref022","article-title":"Infection of bronchial epithelial cells by the human adenoviruses A12, B3 and C2 differently regulates the innate antiviral effector APOBEC3","author":"N Lejeune","year":"2021","journal-title":"B. J Virol"},{"key":"ppat.1011156.ref023","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1128\/jvi.33.1.423-437.1980","article-title":"Adenovirus type 12-induced rat tumor cells of neuroepithelial origin: persistence and expression of the viral genome","volume":"33","author":"H Ibelgaufts","year":"1980","journal-title":"J Virol"},{"key":"ppat.1011156.ref024","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/j.1460-2075.1982.tb01128.x","article-title":"Tumor induction by human adenovirus type 12 in hamsters: loss of the viral genome from adenovirus type 12-induced tumor cells is compatible with tumor formation","volume":"1","author":"I Kuhlmann","year":"1982","journal-title":"EMBO J"},{"key":"ppat.1011156.ref025","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/978-3-662-05599-1_7","volume-title":"Adenoviruses: Model and Vectors in Virus-Host Interactions","author":"U Hohlweg","year":"2004"},{"key":"ppat.1011156.ref026","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1128\/JVI.01890-10","article-title":"The E4orf6\/E1B55K E3 ubiquitin ligase complexes of human adenoviruses exhibit heterogeneity in composition and substrate specificity","volume":"85","author":"CY Cheng","year":"2011","journal-title":"J Virol"},{"key":"ppat.1011156.ref027","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.trsl.2021.05.002","article-title":"The von Hippel\u2013Lindau Cullin-RING E3 ubiquitin ligase regulates APOBEC3 cytidine deaminases","volume":"237","author":"GK Scholt\u00e9s","year":"2021","journal-title":"Transl Res."},{"key":"ppat.1011156.ref028","doi-asserted-by":"crossref","first-page":"8307","DOI":"10.1038\/s41598-019-44407-9","article-title":"Protein kinase A inhibits tumor mutator APOBEC3B through phosphorylation","volume":"9","author":"T Matsumoto","year":"2019","journal-title":"Sci Rep"},{"key":"ppat.1011156.ref029","doi-asserted-by":"crossref","first-page":"e1005621","DOI":"10.1371\/journal.ppat.1005621","article-title":"Functional and Structural Mimicry of Cellular Protein Kinase A Anchoring Proteins by a Viral Oncoprotein","volume":"12","author":"CR King","year":"2016","journal-title":"PLOS Pathog"},{"key":"ppat.1011156.ref030","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature12477","article-title":"Signatures of mutational processes in human cancer","volume":"500","author":"LB Alexandrov","year":"2013","journal-title":"Nature"},{"key":"ppat.1011156.ref031","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/nature11881","article-title":"APOBEC3B is an enzymatic source of mutation in breast cancer","volume":"494","author":"MB Burns","year":"2013","journal-title":"Nature"},{"key":"ppat.1011156.ref032","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/ng.2701","article-title":"Evidence for APOBEC3B mutagenesis in multiple human cancers","volume":"45","author":"MB Burns","year":"2013","journal-title":"Nat Genet"},{"key":"ppat.1011156.ref033","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1126\/science.1253462","article-title":"Spatial and temporal diversity in genomic instability processes defines lung cancer evolution","volume":"346","author":"EC de Bruin","year":"2014","journal-title":"Science"},{"key":"ppat.1011156.ref034","first-page":"2020.12.18.423280","article-title":"Targeted cancer therapy induces APOBEC fuelling the evolution of drug resistance","author":"MK Mayekar","year":"2020"},{"key":"ppat.1011156.ref035","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1158\/2159-8290.CD-20-0725","article-title":"Induction of APOBEC3 Exacerbates DNA Replication Stress and Chromosomal Instability in Early Breast and Lung Cancer Evolution.","volume":"11","author":"S Venkatesan","year":"2021","journal-title":"Cancer Discov"},{"key":"ppat.1011156.ref036","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.omto.2018.08.003","article-title":"APOBEC3 Mediates Resistance to Oncolytic Viral Therapy","volume":"11","author":"AL Huff","year":"2018","journal-title":"Mol Ther\u2014Oncolytics"},{"key":"ppat.1011156.ref037","doi-asserted-by":"crossref","first-page":"10402","DOI":"10.1128\/JVI.01223-10","article-title":"Human APOBEC3G-mediated editing can promote HIV-1 sequence diversification and accelerate adaptation to selective pressure","volume":"84","author":"E-Y Kim","year":"2010","journal-title":"J Virol"},{"key":"ppat.1011156.ref038","doi-asserted-by":"crossref","first-page":"e00534","DOI":"10.7554\/eLife.00534","article-title":"DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis","volume":"2","author":"BJ Taylor","year":"2013","journal-title":"eLife"},{"key":"ppat.1011156.ref039","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1016\/j.celrep.2014.05.012","article-title":"APOBEC-mediated cytosine deamination links PIK3CA helical domain mutations to human papillomavirus-driven tumor development","volume":"7","author":"S Henderson","year":"2014","journal-title":"Cell Rep"},{"key":"ppat.1011156.ref040","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41586-020-1943-3","article-title":"The repertoire of mutational signatures in human cancer","volume":"578","author":"LB Alexandrov","year":"2020","journal-title":"Nature"},{"key":"ppat.1011156.ref041","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/ng.3378","article-title":"An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers","volume":"47","author":"K Chan","year":"2015","journal-title":"Nat Genet"},{"key":"ppat.1011156.ref042","first-page":"217","article-title":"APOBEC3A catalyzes mutation and drives carcinogenesis in vivo","author":"EK Law","year":"2020","journal-title":"J Exp Med"},{"key":"ppat.1011156.ref043","doi-asserted-by":"crossref","first-page":"e1006717","DOI":"10.1371\/journal.ppat.1006717","article-title":"The curious case of APOBEC3 activation by cancer-associated human papillomaviruses","volume":"14","author":"NA Wallace","year":"2018","journal-title":"PLOS Pathog"},{"key":"ppat.1011156.ref044","article-title":"Induction of APOBEC3-mediated genomic damage in urothelium implicates BK polyomavirus (BKPyV) as a hit-and-run driver for bladder cancer","author":"SC Baker","year":"2022","journal-title":"Oncogene"},{"key":"ppat.1011156.ref045","doi-asserted-by":"crossref","first-page":"9027","DOI":"10.1158\/0008-5472.CAN-04-3703","article-title":"Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins","volume":"64","author":"RD Ramirez","year":"2004","journal-title":"Cancer Res"},{"key":"ppat.1011156.ref046","first-page":"2","article-title":"The DNA cytosine deaminase APOBEC3B promotes tamoxifen resistance in ER-positive breast cancer","author":"EK Law","year":"2016","journal-title":"Sci Adv"},{"key":"ppat.1011156.ref047","doi-asserted-by":"crossref","first-page":"e01090","DOI":"10.1128\/JVI.01090-17","article-title":"Highly Pathogenic New World Arenavirus Infection Activates the Pattern Recognition Receptor Protein Kinase R without Attenuating Virus Replication in Human Cells","volume":"91","author":"C Huang","year":"2017","journal-title":"J Virol"},{"key":"ppat.1011156.ref048","first-page":"8","article-title":"High-Incidence of Human Adenoviral Co-Infections in Taiwan","author":"S-L Wang","year":"2013","journal-title":"PLoS ONE"},{"key":"ppat.1011156.ref049","doi-asserted-by":"crossref","first-page":"4274","DOI":"10.1093\/nar\/gkq174","article-title":"Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction","volume":"38","author":"EW Refsland","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"ppat.1011156.ref050","doi-asserted-by":"crossref","first-page":"4538","DOI":"10.1158\/0008-5472.CAN-15-2171-T","article-title":"The PKC\/NF-\u03baB signaling pathway induces APOBEC3B expression in multiple human cancers","volume":"75","author":"B Leonard","year":"2015","journal-title":"Cancer Res"},{"key":"ppat.1011156.ref051","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"CA Schneider","year":"2012","journal-title":"Nat Methods"},{"key":"ppat.1011156.ref052","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1099\/vir.0.80426-0","article-title":"Recovery of APOBEC3-edited human immunodeficiency virus G->A hypermutants by differential DNA denaturation PCR","volume":"86","author":"R Susp\u00e8ne","year":"2005","journal-title":"J Gen Virol"},{"key":"ppat.1011156.ref053","doi-asserted-by":"crossref","first-page":"4858","DOI":"10.1073\/pnas.1009687108","article-title":"Somatic hypermutation of human mitochondrial and nuclear DNA by APOBEC3 cytidine deaminases, a pathway for DNA catabolism","volume":"108","author":"R Susp\u00e8ne","year":"2011","journal-title":"Proc Natl Acad Sci"},{"key":"ppat.1011156.ref054","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"J Schindelin","year":"2012","journal-title":"Nat Methods"},{"key":"ppat.1011156.ref055","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1365-2818.1993.tb03313.x","article-title":"Measurement of co-localization of objects in dual-colour confocal images","volume":"169","author":"EMM Manders","year":"1993","journal-title":"J Microsc"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1011156","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:00:00Z","timestamp":1676505600000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1011156","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T18:50:39Z","timestamp":1676573439000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1011156"}},"subtitle":[],"editor":[{"given":"Robert F.","family":"Kalejta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,2,6]]},"references-count":55,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1011156","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.ppat.1011156","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,6]]}}}