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A large-scale screen to determine the diversity of double-stranded RNA (dsRNA) viruses in <jats:italic>S<\/jats:italic>. <jats:italic>cerevisiae<\/jats:italic> has identified multiple novel viruses from the family <jats:italic>Partitiviridae<\/jats:italic> that have been previously shown to infect plants, fungi, protozoans, and insects. Most <jats:italic>S<\/jats:italic>. <jats:italic>cerevisiae<\/jats:italic> partitiviruses (ScPVs) are associated with strains of yeasts isolated from coffee and cacao beans. The presence of partitiviruses was confirmed by sequencing the viral dsRNAs and purifying and visualizing isometric, non-enveloped viral particles. ScPVs have a typical bipartite genome encoding an RNA-dependent RNA polymerase (RdRP) and a coat protein (CP). Phylogenetic analysis of ScPVs identified three species of ScPV, which are most closely related to viruses of the genus <jats:italic>Cryspovirus<\/jats:italic> from the mammalian pathogenic protozoan <jats:italic>Cryptosporidium parvum<\/jats:italic>. Molecular modeling of the ScPV RdRP revealed a conserved tertiary structure and catalytic site organization when compared to the RdRPs of the <jats:italic>Picornaviridae<\/jats:italic>. The ScPV CP is the smallest so far identified in the <jats:italic>Partitiviridae<\/jats:italic> and has structural homology with the CP of other partitiviruses but likely lacks a protrusion domain that is a conspicuous feature of other partitivirus particles. ScPVs were stably maintained during laboratory growth and were successfully transferred to haploid progeny after sporulation, which provides future opportunities to study partitivirus-host interactions using the powerful genetic tools available for the model organism <jats:italic>S<\/jats:italic>. <jats:italic>cerevisiae<\/jats:italic>.<\/jats:p>","DOI":"10.1371\/journal.ppat.1011418","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T17:36:15Z","timestamp":1686159375000},"page":"e1011418","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["Novel viruses of the family Partitiviridae discovered in Saccharomyces cerevisiae"],"prefix":"10.1371","volume":"19","author":[{"given":"Nathan T.","family":"Taggart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M.","family":"Crabtree","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack W.","family":"Creagh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Bizarria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunji","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"de la Higuera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan E.","family":"Barnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mason A.","family":"Shipley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine M.","family":"Boyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth M.","family":"Stedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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