{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:03:28Z","timestamp":1787022208715,"version":"build-2736575974"},"update-to":[{"DOI":"10.1371\/journal.ppat.1011448","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000}}],"reference-count":74,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["R01 AI104956"],"award-info":[{"award-number":["R01 AI104956"]}]},{"name":"NIH","award":["R01 AI124165"],"award-info":[{"award-number":["R01 AI124165"]}]},{"name":"Howard Hughes Medical Institute and Bill and Melinda Gates Foundation","award":["OPP1158190"],"award-info":[{"award-number":["OPP1158190"]}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["PGSD3-488065-2016"],"award-info":[{"award-number":["PGSD3-488065-2016"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    Insecticide resistance is under strong selective pressure in\n                    <jats:italic>Anopheles<\/jats:italic>\n                    mosquitoes due to widespread usage of insecticides in vector control strategies. Resistance mechanisms likely cause changes that profoundly affect mosquito physiology, yet it remains poorly understood how selective pressures imposed by insecticides may alter the ability of the mosquito to host and transmit a\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    infection. From pyrethroid-resistant field-derived\n                    <jats:italic>Anopheles gambiae s<\/jats:italic>\n                    .\n                    <jats:italic>l<\/jats:italic>\n                    . mosquitoes, we established resistant (RES) and susceptible (SUS) colonies by either selection for, or loss of insecticide resistance. We show increased oocyst intensity and growth rate as well as increased sporozoite prevalence and intensity in RES compared to SUS females infected with\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    . The increase in infection intensity in RES females was not associated with the presence of the\n                    <jats:italic>kdr<\/jats:italic>\n                    L1014F mutation and was not impacted by inhibition of Cytochrome P450s. The lipid transporter lipophorin (Lp), which was upregulated in RES compared to SUS, was at least partly implicated in the increased intensity of\n                    <jats:italic>P<\/jats:italic>\n                    .\n                    <jats:italic>falciparum<\/jats:italic>\n                    but not directly involved in the insecticide resistance phenotype. Interestingly, we observed that although\n                    <jats:italic>P<\/jats:italic>\n                    .\n                    <jats:italic>falciparum<\/jats:italic>\n                    infections were not affected when RES females were exposed to permethrin, these females had decreased lipid abundance in the fat body following exposure, pointing to a possible role for lipid mobilization in response to damage caused by insecticide challenge. The finding that selection for insecticide resistance can increase\n                    <jats:italic>P<\/jats:italic>\n                    .\n                    <jats:italic>falciparum<\/jats:italic>\n                    infection intensities and growth rate reinforces the need to assess the overall impact on malaria transmission dynamics caused by selective pressures mosquitoes experience during repeated insecticide challenge.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1011448","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T13:28:16Z","timestamp":1687267696000},"page":"e1011448","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Selection for insecticide resistance can promote Plasmodium falciparum infection in Anopheles"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1184-8360","authenticated-orcid":true,"given":"Kelsey L.","family":"Adams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily K.","family":"Selland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bailey C.","family":"Willett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Carew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Vidoudez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naresh","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3295-6683","authenticated-orcid":true,"given":"Flaminia","family":"Catteruccia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,6,20]]},"reference":[{"key":"ppat.1011448.ref001","unstructured":"WHO. World malaria report 2021. 2021."},{"issue":"7572","key":"ppat.1011448.ref002","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature15535","article-title":"The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015","volume":"526","author":"S Bhatt","year":"2015","journal-title":"Nature"},{"key":"ppat.1011448.ref003","doi-asserted-by":"crossref","first-page":"100101","DOI":"10.1016\/j.crpvbd.2022.100101","article-title":"Understanding the current state-of-the-art of long-lasting insecticide nets and potential for sustainable alternatives","volume":"2","author":"S Brake","year":"2022","journal-title":"Current Research in Parasitology & Vector-Borne Diseases"},{"issue":"10","key":"ppat.1011448.ref004","first-page":"1691","article-title":"Increased pyrethroid resistance in malaria vectors and decreased bed net effectiveness, Burkina Faso","volume":"20","author":"KH Toe","year":"2014","journal-title":"Emerging infectious diseases"},{"issue":"7790","key":"ppat.1011448.ref005","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/s41586-019-1864-1","article-title":"A sensory appendage protein protects malaria vectors from pyrethroids","volume":"577","author":"VA Ingham","year":"2020","journal-title":"Nature"},{"issue":"33","key":"ppat.1011448.ref006","doi-asserted-by":"crossref","first-page":"9268","DOI":"10.1073\/pnas.1608295113","article-title":"Cytochrome P450 associated with insecticide resistance catalyzes cuticular hydrocarbon production in Anopheles gambiae","volume":"113","author":"V Balabanidou","year":"2016","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1907","key":"ppat.1011448.ref007","article-title":"Mosquitoes cloak their legs to resist insecticides","volume":"286","author":"V Balabanidou","year":"2019","journal-title":"Proc Biol Sci"},{"issue":"3","key":"ppat.1011448.ref008","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1080\/15216540701352042","article-title":"DDT, pyrethrins, pyrethroids and insect sodium channels","volume":"59","author":"TG Davies","year":"2007","journal-title":"IUBMB Life"},{"issue":"5","key":"ppat.1011448.ref009","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.pt.2009.02.007","article-title":"Does kdr genotype predict insecticide-resistance phenotype in mosquitoes?","volume":"25","author":"MJ Donnelly","year":"2009","journal-title":"Trends Parasitol"},{"issue":"2","key":"ppat.1011448.ref010","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1046\/j.1365-2583.1998.72062.x","article-title":"Molecular characterization of pyrethroid knockdown resistance (kdr) in the major malaria vector Anopheles gambiae s.s","volume":"7","author":"D Martinez-Torres","year":"1998","journal-title":"Insect Mol Biol"},{"issue":"5","key":"ppat.1011448.ref011","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1046\/j.1365-2583.2000.00209.x","article-title":"Identification of a point mutation in the voltage-gated sodium channel gene of Kenyan Anopheles gambiae associated with resistance to DDT and pyrethroids","volume":"9","author":"H Ranson","year":"2000","journal-title":"Insect Mol Biol"},{"issue":"11","key":"ppat.1011448.ref012","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000286","article-title":"Field-caught permethrin-resistant Anopheles gambiae overexpress CYP6P3, a P450 that metabolises pyrethroids","volume":"4","author":"P M\u00fcller","year":"2008","journal-title":"PLoS Genet"},{"issue":"3","key":"ppat.1011448.ref013","article-title":"CYP6 P450 enzymes and ACE-1 duplication produce extreme and multiple insecticide resistance in the malaria mosquito Anopheles gambiae","volume":"10","author":"CV Edi","year":"2014","journal-title":"PLoS Genet"},{"key":"ppat.1011448.ref014","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1186\/1475-2875-12-404","article-title":"Acetylcholinesterase (Ace-1) target site mutation 119S is strongly diagnostic of carbamate and organophosphate resistance in Anopheles gambiae s.s. and Anopheles coluzzii across southern Ghana","volume":"12","author":"J Essandoh","year":"2013","journal-title":"Malar J"},{"key":"ppat.1011448.ref015","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1146\/annurev-ento-010814-020828","article-title":"Insecticide resistance in mosquitoes: impact, mechanisms, and research directions","volume":"60","author":"N. Liu","year":"2015","journal-title":"Annu Rev Entomol"},{"key":"ppat.1011448.ref016","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cois.2018.03.001","article-title":"Insect cuticle: a critical determinant of insecticide resistance","volume":"27","author":"V Balabanidou","year":"2018","journal-title":"Current Opinion in Insect Science"},{"issue":"4","key":"ppat.1011448.ref017","doi-asserted-by":"crossref","first-page":"e60878","DOI":"10.1371\/journal.pone.0060878","article-title":"Assessing the effects of Aedes aegypti kdr mutations on pyrethroid resistance and its fitness cost","volume":"8","author":"LP Brito","year":"2013","journal-title":"PLoS One"},{"key":"ppat.1011448.ref018","article-title":"Investigation of the influence of a glutathione S-transferase metabolic resistance to pyrethroids\/DDT on mating competitiveness in males of the African malaria vector, Anopheles funestus","volume":"4","author":"M Tchouakui","year":"2019","journal-title":"Wellcome open research"},{"issue":"5","key":"ppat.1011448.ref019","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/s41437-020-0304-1","article-title":"Cytochrome P450 metabolic resistance (CYP6P9a) to pyrethroids imposes a fitness cost in the major African malaria vector Anopheles funestus","volume":"124","author":"M Tchouakui","year":"2020","journal-title":"Heredity"},{"issue":"4","key":"ppat.1011448.ref020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0009391","article-title":"Impact of deltamethrin-resistance in Aedes albopictus on its fitness cost and vector competence","volume":"15","author":"J Deng","year":"2021","journal-title":"PLoS Negl Trop Dis"},{"key":"ppat.1011448.ref021","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.cois.2019.12.001","article-title":"Effects of insecticide resistance and exposure on Plasmodium development in Anopheles mosquitoes","volume":"39","author":"C Minetti","year":"2020","journal-title":"Current Opinion in Insect Science"},{"key":"ppat.1011448.ref022","doi-asserted-by":"crossref","first-page":"29755","DOI":"10.1038\/srep29755","article-title":"Interactive cost of Plasmodium infection and insecticide resistance in the malaria vector Anopheles gambiae","volume":"6","author":"H Alout","year":"2016","journal-title":"Scientific reports"},{"issue":"1","key":"ppat.1011448.ref023","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1186\/1475-2875-13-340","article-title":"Effects of the kdr resistance mutation on the susceptibility of wild Anopheles gambiae populations to Plasmodium falciparum: a hindrance for vector control","volume":"13","author":"MO Ndiath","year":"2014","journal-title":"Malaria Journal"},{"issue":"5","key":"ppat.1011448.ref024","doi-asserted-by":"crossref","first-page":"e63849","DOI":"10.1371\/journal.pone.0063849","article-title":"Insecticide resistance alleles affect vector competence of Anopheles gambiae s.s. for Plasmodium falciparum field isolates","volume":"8","author":"H Alout","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"ppat.1011448.ref025","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1186\/s12936-015-0924-8","article-title":"The kdr-bearing haplotype and susceptibility to Plasmodium falciparum in Anopheles gambiae: genetic correlation and functional testing","volume":"14","author":"C Mitri","year":"2015","journal-title":"Malar J"},{"issue":"1","key":"ppat.1011448.ref026","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12936-019-2789-8","article-title":"Anopheline species composition and the 1014F-genotype in different ecological settings of Burkina Faso in relation to malaria transmission","volume":"18","author":"A Traor\u00e9","year":"2019","journal-title":"Malar J"},{"key":"ppat.1011448.ref027","article-title":"Exploring the impact of glutathione S-transferase (GST)-based metabolic resistance to insecticide on vector competence of Anopheles funestus for Plasmodium falciparum","volume":"4","author":"C Ndo","year":"2019","journal-title":"Wellcome open research"},{"issue":"1","key":"ppat.1011448.ref028","doi-asserted-by":"crossref","first-page":"5772","DOI":"10.1038\/s41598-019-42015-1","article-title":"A marker of glutathione S-transferase-mediated resistance to insecticides is associated with higher Plasmodium infection in the African malaria vector Anopheles funestus","volume":"9","author":"M Tchouakui","year":"2019","journal-title":"Scientific Reports"},{"key":"ppat.1011448.ref029","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s13071-016-1384-x","article-title":"Exposure to deltamethrin affects development of Plasmodium falciparum inside wild pyrethroid resistant Anopheles gambiae s","volume":"9","author":"M Kristan","year":"2016","journal-title":"s. mosquitoes in Uganda. Parasites & vectors"},{"issue":"1786","key":"ppat.1011448.ref030","article-title":"Insecticide exposure impacts vector-parasite interactions in insecticide-resistant malaria vectors","volume":"281","author":"H Alout","year":"2014","journal-title":"Proc Biol Sci"},{"key":"ppat.1011448.ref031","volume-title":"Effects of sublethal doses of pyrethroids on malaria vectors","author":"N. Hill","year":"2003"},{"key":"ppat.1011448.ref032","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1146\/annurev.ento.44.1.507","article-title":"Insect P450 enzymes","volume":"44","author":"R. Feyereisen","year":"1999","journal-title":"Annu Rev Entomol"},{"issue":"Pt 1","key":"ppat.1011448.ref033","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1042\/bj3570065","article-title":"Glutathione S-transferases as antioxidant defence agents confer pyrethroid resistance in Nilaparvata lugens","volume":"357","author":"JG Vontas","year":"2001","journal-title":"Biochem J"},{"issue":"Pt 2","key":"ppat.1011448.ref034","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1042\/bj3620329","article-title":"Purification, molecular cloning and heterologous expression of a glutathione S-transferase involved in insecticide resistance from the rice brown planthopper","volume":"362","author":"JG Vontas","year":"2002","journal-title":"Nilaparvata lugens. Biochem J"},{"issue":"24","key":"ppat.1011448.ref035","doi-asserted-by":"crossref","first-page":"14139","DOI":"10.1073\/pnas.2036262100","article-title":"The role of reactive oxygen species on Plasmodium melanotic encapsulation in Anopheles gambiae","volume":"100","author":"S Kumar","year":"2003","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"6","key":"ppat.1011448.ref036","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1074\/jbc.M705873200","article-title":"Reactive oxygen species modulate Anopheles gambiae immunity against bacteria and Plasmodium","volume":"283","author":"A Molina-Cruz","year":"2008","journal-title":"J Biol Chem"},{"issue":"2","key":"ppat.1011448.ref037","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1093\/jmedent\/47.2.188","article-title":"Differences in development, glycogen, and lipid content associated with cytochrome P450-mediated permethrin resistance in Culex pipiens quinquefasciatus (Diptera: Culicidae)","volume":"47","author":"MC Hardstone","year":"2010","journal-title":"Journal of medical entomology"},{"issue":"3","key":"ppat.1011448.ref038","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1603\/ME10121","article-title":"Energetic cost of insecticide resistance in Culex pipiens mosquitoes","volume":"48","author":"A Rivero","year":"2011","journal-title":"Journal of medical entomology"},{"key":"ppat.1011448.ref039","doi-asserted-by":"crossref","first-page":"e58019","DOI":"10.7554\/eLife.58019","article-title":"Isolation and transcriptomic analysis of Anopheles gambiae oenocytes enables the delineation of hydrocarbon biosynthesis","volume":"9","author":"L Grigoraki","year":"2020","journal-title":"eLife"},{"issue":"6175","key":"ppat.1011448.ref040","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1126\/science.1249998","article-title":"A single gene affects both ecological divergence and mate choice in Drosophila","volume":"343","author":"H Chung","year":"2014","journal-title":"Science (New York, NY)"},{"issue":"7","key":"ppat.1011448.ref041","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1002\/bies.201500014","article-title":"Wax, sex and the origin of species: Dual roles of insect cuticular hydrocarbons in adaptation and mating","volume":"37","author":"H Chung","year":"2015","journal-title":"Bioessays"},{"issue":"2","key":"ppat.1011448.ref042","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.cell.2019.02.036","article-title":"Steroid Hormone Function Controls Non-competitive Plasmodium Development in Anopheles","volume":"177","author":"K Werling","year":"2019","journal-title":"Cell"},{"issue":"1","key":"ppat.1011448.ref043","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.1038\/s41467-018-05893-z","article-title":"Non-competitive resource exploitation within mosquito shapes within-host malaria infectivity and virulence","volume":"9","author":"G Costa","year":"2018","journal-title":"Nat Commun"},{"issue":"2","key":"ppat.1011448.ref044","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.actatropica.2008.10.004","article-title":"The major insect lipoprotein is a lipid source to mosquito stages of malaria parasite","volume":"109","author":"GC Atella","year":"2009","journal-title":"Acta Trop"},{"key":"ppat.1011448.ref045","article-title":"Dissecting the mechanisms responsible for the multiple insecticide resistance phenotype in Anopheles gambiae s.s., M form, from Vall\u00e9e du Kou","volume":"519","author":"R Kwiatkowska","year":"2013","journal-title":"Burkina Faso. Gene"},{"issue":"4","key":"ppat.1011448.ref046","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/mve.12316","article-title":"Do bednets including piperonyl butoxide offer additional protection against populations of Anopheles gambiae s.l. that are highly resistant to pyrethroids? An experimental hut evaluation in Burkina Fasov","volume":"32","author":"KH Toe","year":"2018","journal-title":"Med Vet Entomol"},{"key":"ppat.1011448.ref047","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1186\/1471-2164-9-538","article-title":"Expression of the cytochrome P450s, CYP6P3 and CYP6M2 are significantly elevated in multiple pyrethroid resistant populations of Anopheles gambiae s.s. from Southern Benin and Nigeria","volume":"9","author":"RF Djouaka","year":"2008","journal-title":"BMC Genomics"},{"issue":"2","key":"ppat.1011448.ref048","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1365-2583.2007.00788.x","article-title":"Characterization of inhibitors and substrates of Anopheles gambiae CYP6Z2","volume":"17","author":"LA Mclaughlin","year":"2008","journal-title":"Insect Molecular Biology"},{"issue":"3","key":"ppat.1011448.ref049","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/hdy.2015.33","article-title":"Target-site resistance mutations (kdr and RDL), but not metabolic resistance, negatively impact male mating competiveness in the malaria vector Anopheles gambiae","volume":"115","author":"N Platt","year":"2015","journal-title":"Heredity (Edinb)"},{"issue":"1","key":"ppat.1011448.ref050","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/1475-2875-7-163","article-title":"Insertion polymorphisms of SINE200 retrotransposons within speciation islands of Anopheles gambiae molecular forms","volume":"7","author":"F Santolamazza","year":"2008","journal-title":"Malar J"},{"key":"ppat.1011448.ref051","volume-title":"Conditions for use of long-lasting insectividal nets treated with a pyrethroid and piperonyl butoxide","author":"WHO","year":"2015"},{"key":"ppat.1011448.ref052","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev-ento-031620-071754","article-title":"Chemical Ecology, Biochemistry, and Molecular Biology of Insect Hydrocarbons","volume":"66","author":"GJ Blomquist","year":"2021","journal-title":"Annual review of entomology"},{"issue":"7","key":"ppat.1011448.ref053","doi-asserted-by":"crossref","first-page":"e1000434","DOI":"10.1371\/journal.pbio.1000434","article-title":"The major yolk protein vitellogenin interferes with the anti-plasmodium response in the malaria mosquito Anopheles gambiae","volume":"8","author":"MK Rono","year":"2010","journal-title":"PLoS Biol"},{"issue":"13","key":"ppat.1011448.ref054","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.cub.2005.06.044","article-title":"Functional genomic analysis of midgut epithelial responses in Anopheles during Plasmodium invasion","volume":"15","author":"D Vlachou","year":"2005","journal-title":"Curr Biol"},{"key":"ppat.1011448.ref055","first-page":"250852","article-title":"Sub-lethal pyrethroid exposure and ageing lead to pronounced changes in gene expression in insecticide resistance Anopheles coluzzii","volume":"2020","author":"VA Ingham","year":"2020","journal-title":"bioRxiv"},{"issue":"9","key":"ppat.1011448.ref056","doi-asserted-by":"crossref","first-page":"863","DOI":"10.7150\/ijbs.6744","article-title":"Permethrin induction of multiple cytochrome P450 genes in insecticide resistant mosquitoes, Culex quinquefasciatus","volume":"9","author":"Y Gong","year":"2013","journal-title":"Int J Biol Sci"},{"issue":"8","key":"ppat.1011448.ref057","doi-asserted-by":"crossref","first-page":"e23403","DOI":"10.1371\/journal.pone.0023403","article-title":"Multiple Cytochrome P450 Genes: Their Constitutive Overexpression and Permethrin Induction in Insecticide Resistant Mosquitoes, Culex quinquefasciatus","volume":"6","author":"N Liu","year":"2011","journal-title":"PLOS ONE"},{"issue":"1","key":"ppat.1011448.ref058","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1365-2583.2005.00532.x","article-title":"Expression of Cyp6g1 and Cyp12d1 in DDT resistant and susceptible strains of Drosophila melanogaster","volume":"14","author":"RA Festucci-Buselli","year":"2005","journal-title":"Insect Mol Biol"},{"issue":"1","key":"ppat.1011448.ref059","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/s42003-021-02434-1","article-title":"Cuticular hydrocarbons are associated with mating success and insecticide resistance in malaria vectors","volume":"4","author":"KL Adams","year":"2021","journal-title":"Communications Biology"},{"issue":"1","key":"ppat.1011448.ref060","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1186\/s13071-021-05079-5","article-title":"Evaluation of the interaction between insecticide resistance-associated genes and malaria transmission in Anopheles gambiae sensu lato in central C\u00f4te d\u2019Ivoire","volume":"14","author":"RZ Wolie","year":"2021","journal-title":"Parasit Vectors"},{"issue":"10","key":"ppat.1011448.ref061","doi-asserted-by":"crossref","first-page":"5700","DOI":"10.1073\/pnas.95.10.5700","article-title":"The mosquito Anopheles stephensi limits malaria parasite development with inducible synthesis of nitric oxide","volume":"95","author":"S Luckhart","year":"1998","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ppat.1011448.ref062","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.envres.2016.05.003","article-title":"Permethrin-induced oxidative stress and toxicity and metabolism. A review","volume":"149","author":"X Wang","year":"2016","journal-title":"Environ Res"},{"issue":"13","key":"ppat.1011448.ref063","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.cub.2005.06.044","article-title":"Functional Genomic Analysis of Midgut Epithelial Responses in Anopheles during Plasmodium Invasion","volume":"15","author":"D Vlachou","year":"2005","journal-title":"Current Biology"},{"key":"ppat.1011448.ref064","unstructured":"WorldHealthOrganization. Test procedures for insecticide resistance monitoring in malaria vector mosquitoes (Second edition). 2016."},{"issue":"3","key":"ppat.1011448.ref065","doi-asserted-by":"crossref","first-page":"277","DOI":"10.4269\/ajtmh.1998.58.277","article-title":"Aedes aegypti survival and dispersal estimated by mark-release-recapture in northern Australia","volume":"58","author":"LE Muir","year":"1998","journal-title":"The American journal of tropical medicine and hygiene"},{"issue":"2","key":"ppat.1011448.ref066","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0166-6851(93)90077-B","article-title":"High sensitivity of detection of human malaria parasites by the use of nested polymerase chain reaction","volume":"61","author":"G Snounou","year":"1993","journal-title":"Mol Biochem Parasitol"},{"issue":"4254","key":"ppat.1011448.ref067","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1126\/science.781840","article-title":"Human malaria parasites in continuous culture","volume":"193","author":"W Trager","year":"1976","journal-title":"Science"},{"issue":"5839","key":"ppat.1011448.ref068","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/294364a0","article-title":"Complete in vitro maturation of Plasmodium falciparum gametocytes","volume":"294","author":"T Ifediba","year":"1981","journal-title":"Nature"},{"issue":"7","key":"ppat.1011448.ref069","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","volume":"9","author":"J Schindelin","year":"2012","journal-title":"Nat Methods"},{"key":"ppat.1011448.ref070","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1590\/S0074-02761996000400001","volume":"91","author":"J. Charlwood","year":"1996","journal-title":"Mem\u00f3rias do Instituto Oswaldo Cruz"},{"key":"ppat.1011448.ref071","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/1471-2105-13-134","article-title":"Primer-BLAST: a tool to design target-specific primers for polymerase chain reaction","volume":"13","author":"J Ye","year":"2012","journal-title":"BMC Bioinformatics"},{"issue":"10","key":"ppat.1011448.ref072","doi-asserted-by":"crossref","first-page":"e1001695","DOI":"10.1371\/journal.pbio.1001695","article-title":"The Interaction between a Sexually Transferred Steroid Hormone and a Female Protein Regulates Oogenesis in the Malaria Mosquito Anopheles gambiae","volume":"11","author":"F Baldini","year":"2013","journal-title":"PLoS Biol"},{"issue":"12","key":"ppat.1011448.ref073","doi-asserted-by":"crossref","first-page":"e1000272","DOI":"10.1371\/journal.pbio.1000272","article-title":"Transglutaminase-Mediated Semen Coagulation Controls Sperm Storage in the Malaria Mosquito","volume":"7","author":"DW Rogers","year":"2009","journal-title":"PLoS Biol"},{"issue":"7","key":"ppat.1011448.ref074","first-page":"940","volume":"5","author":"ER Miraldi","year":"2013","journal-title":"Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1011448","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1011448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T13:40:42Z","timestamp":1688132442000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1011448"}},"subtitle":[],"editor":[{"given":"Elizabeth A.","family":"McGraw","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,6,20]]},"references-count":74,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,6,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1011448","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,20]]}}}