{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:40:12Z","timestamp":1791362412325,"version":"4.3.1"},"update-to":[{"DOI":"10.1371\/journal.ppat.1011479","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T00:00:00Z","timestamp":1689811200000}}],"reference-count":60,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:00:00Z","timestamp":1688947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["Equipe FRM R20104NN"],"award-info":[{"award-number":["Equipe FRM R20104NN"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Labex IGO, ANR","award":["Program ANR-11-LABX-0016"],"award-info":[{"award-number":["Program ANR-11-LABX-0016"]}]},{"name":"Agence National de la Recherche ANR","award":["ANR JCJC"],"award-info":[{"award-number":["ANR JCJC"]}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>Buruli ulcer is a chronic infectious disease caused by <jats:italic>Mycobacterium ulcerans<\/jats:italic>. The pathogen persistence in host skin is associated with the development of ulcerative and necrotic lesions leading to permanent disabilities in most patients. However, few of diagnosed cases are thought to resolve through an unknown self-healing process. Using <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> mouse models and <jats:italic>M<\/jats:italic>. <jats:italic>ulcerans<\/jats:italic> purified vesicles and mycolactone, we showed that the development of an innate immune tolerance was only specific to macrophages from mice able to heal spontaneously. This tolerance mechanism depends on a type I interferon response and can be induced by interferon beta. A type I interferon signature was further detected during <jats:italic>in vivo<\/jats:italic> infection in mice as well as in skin samples from patients under antibiotics regiment. Our results indicate that type I interferon-related genes expressed in macrophages may promote tolerance and healing during infection with skin damaging pathogen.<\/jats:p>","DOI":"10.1371\/journal.ppat.1011479","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T17:57:33Z","timestamp":1689011853000},"page":"e1011479","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Type-I interferons promote innate immune tolerance in macrophages exposed to Mycobacterium ulcerans 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