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We found that <jats:italic>C<\/jats:italic>. <jats:italic>albicans<\/jats:italic> infection of oral epithelial cells induces c-Met to form a multi-protein complex with E-cadherin and the epidermal growth factor receptor (EGFR). E-cadherin is necessary for <jats:italic>C<\/jats:italic>. <jats:italic>albicans<\/jats:italic> to activate both c-Met and EGFR and to induce the endocytosis of <jats:italic>C<\/jats:italic>. <jats:italic>albicans<\/jats:italic>. Proteomics analysis revealed that c-Met interacts with <jats:italic>C<\/jats:italic>. <jats:italic>albicans<\/jats:italic> Hyr1, Als3 and Ssa1. Both Hyr1 and Als3 are required for <jats:italic>C<\/jats:italic>. <jats:italic>albicans<\/jats:italic> to stimulate c-Met and EGFR in oral epithelial cells in vitro and for full virulence during OPC in mice. Treating mice with small molecule inhibitors of c-Met and EGFR ameliorates OPC, demonstrating the potential therapeutic efficacy of blocking these host receptors for <jats:italic>C<\/jats:italic>. <jats:italic>albicans<\/jats:italic>.<\/jats:p>","DOI":"10.1371\/journal.ppat.1011579","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T17:32:30Z","timestamp":1692811950000},"page":"e1011579","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":27,"title":["Candida albicans stimulates formation of a multi-receptor complex that mediates epithelial cell invasion during oropharyngeal infection"],"prefix":"10.1371","volume":"19","author":[{"given":"Quynh T.","family":"Phan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma 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