{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:09:50Z","timestamp":1790662190315,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1011616","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T00:00:00Z","timestamp":1694131200000}}],"reference-count":69,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007258","name":"State University of New York","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007258","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>Dengue represents a growing public health burden worldwide, accounting for approximately 100 million symptomatic cases and tens of thousands of fatalities yearly. Prior infection with one serotype of dengue virus (DENV) is the greatest known risk factor for severe disease upon secondary infection with a heterologous serotype, a risk which increases as serotypes co-circulate in endemic regions. This disease risk is thought to be mediated by IgG-isotype antibodies raised during a primary infection, which poorly neutralize heterologous DENV serotypes and instead opsonize virions for uptake by Fc\u03b3R-bearing cells. This antibody-dependent enhancement (ADE) of infection leads to a larger proportion of susceptible cells infected, higher viremia and greater immunopathology. We have previously characterized the induction of a serum IgA response, along with the typical IgM and IgG responses, during dengue infection, and have shown that DENV-reactive IgA can neutralize DENV and competitively antagonize IgG-mediated ADE. Here, we evaluate the potential for IgA itself to cause ADE. We show that IgG, but not IgA, mediated ADE of infection in cells expressing both Fc\u03b1R and Fc\u03b3Rs. IgG-mediated ADE stimulated significantly higher pro-inflammatory cytokine production by primary human macrophages, while IgA did not affect, or slightly suppressed, this production. Mechanistically, we show that DENV\/IgG immune complexes bind susceptible cells significantly more efficiently than DENV\/IgA complexes or virus alone. Finally, we show that over the course of primary dengue infection, the expression of Fc\u03b3RI (CD64) increases during the period of acute viremia, while Fc\u03b3RIIa (CD32) and Fc\u03b1R (CD89) expression decreases, thereby further limiting the ability of IgA to facilitate ADE in the presence of DENV. Overall, these data illustrate the distinct protective role of IgA during ADE of dengue infection and highlight the potential therapeutic and prognostic value of DENV-specific IgA.<\/jats:p>","DOI":"10.1371\/journal.ppat.1011616","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T13:32:21Z","timestamp":1693229541000},"page":"e1011616","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":25,"title":["DENV-specific IgA contributes protective and non-pathologic function during antibody-dependent enhancement of DENV infection"],"prefix":"10.1371","volume":"19","author":[{"given":"Adam D.","family":"Wegman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell J.","family":"Waldran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren E.","family":"Bahr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph Q.","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen E.","family":"Baxter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4536-6714","authenticated-orcid":true,"given":"Adam T.","family":"Waickman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,8,28]]},"reference":[{"issue":"10","key":"ppat.1011616.ref001","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1146\/annurev-immunol-042617-053142","article-title":"Immune Response to Dengue and Zika","volume":"36","author":"AE Ngono","year":"2018","journal-title":"Annu Rev Immunol"},{"issue":"7446","key":"ppat.1011616.ref002","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"S Bhatt","year":"2013","journal-title":"Nature"},{"issue":"10","key":"ppat.1011616.ref003","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1080\/21645515.2019.1658503","article-title":"A review of Dengvaxia(R): development to deployment","volume":"15","author":"SJ Thomas","year":"2019","journal-title":"Hum Vaccin Immunother"},{"issue":"4","key":"ppat.1011616.ref004","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1128\/CMR.00035-09","article-title":"Dengue virus pathogenesis: an integrated view","volume":"22","author":"BE Martina","year":"2009","journal-title":"Clin Microbiol Rev"},{"issue":"11","key":"ppat.1011616.ref005","doi-asserted-by":"crossref","first-page":"e50387","DOI":"10.1371\/journal.pone.0050387","article-title":"Cellular and cytokine correlates of severe dengue infection","volume":"7","author":"GN Malavige","year":"2012","journal-title":"PLoS One"},{"key":"ppat.1011616.ref006","unstructured":"Clinical Presentation | Dengue | CDC."},{"issue":"e3589","key":"ppat.1011616.ref007","first-page":"e3589","article-title":"Meta-analysis of biomarkers for severe dengue infections","volume":"5","author":"KM Soo","year":"2017","journal-title":"PeerJ"},{"issue":"5","key":"ppat.1011616.ref008","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00281-017-0625-1","article-title":"Immune-mediated cytokine storm and its role in severe dengue","volume":"39","author":"A Srikiatkhachorn","year":"2017","journal-title":"Semin Immunopathol"},{"issue":"1","key":"ppat.1011616.ref009","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12941-019-0309-x","article-title":"Plasma cell-free DNA: a potential biomarker for early prediction of severe dengue","volume":"18","author":"NTN Phuong","year":"2019","journal-title":"Ann Clin Microbiol Antimicrob"},{"issue":"Pt 1","key":"ppat.1011616.ref010","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1099\/0022-1317-70-1-37","article-title":"Antigenic relationships between flaviviruses as determined by cross-neutralization tests with polyclonal antisera","volume":"70","author":"CH Calisher","year":"1989","journal-title":"J Gen Virol"},{"issue":"2","key":"ppat.1011616.ref011","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/0042-6822(90)90102-W","article-title":"Molecular evolution and distribution of dengue viruses type 1 and 2 in nature","volume":"174","author":"R. 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