{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T20:14:57Z","timestamp":1780344897930,"version":"3.54.1"},"update-to":[{"DOI":"10.1371\/journal.ppat.1011693","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T00:00:00Z","timestamp":1696377600000}}],"reference-count":105,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["1RO1EY029160"],"award-info":[{"award-number":["1RO1EY029160"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["1RO1EY013615"],"award-info":[{"award-number":["1RO1EY013615"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["RO1EY026944"],"award-info":[{"award-number":["RO1EY026944"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>Previously we reported that the HSV-1 latency associated transcript (LAT) specifically upregulates the cellular herpesvirus entry mediator (HVEM) but no other known HSV-1 receptors. HSV-1 glycoprotein D (gD) binds to HVEM but the effect of this interaction on latency-reactivation is not known. We found that the levels of latent viral genomes were not affected by the absence of gD binding to HVEM. However, reactivation of latent virus in trigeminal ganglia explant cultures was blocked in the absence of gD binding to HVEM. Neither differential HSV-1 replication and spread in the eye nor levels of latency influenced reactivation. Despite similar levels of latency, reactivation in the absence of gD binding to HVEM correlated with reduced T cell exhaustion. Our results indicate that HVEM-gD signaling plays a significant role in HSV-1 reactivation but not in ocular virus replication or levels of latency. The results presented here identify gD binding to HVEM as an important target that influences reactivation and survival of ganglion resident T cells but not levels of latency. This concept may also apply to other herpesviruses that engages HVEM.<\/jats:p>","DOI":"10.1371\/journal.ppat.1011693","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T17:27:26Z","timestamp":1695403646000},"page":"e1011693","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Binding of herpesvirus entry mediator (HVEM) and HSV-1 gD affect reactivation but not latency levels"],"prefix":"10.1371","volume":"19","author":[{"given":"Ujjaldeep","family":"Jaggi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin R.","family":"Mott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3291-1995","authenticated-orcid":true,"given":"Homayon","family":"Ghiasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,9,22]]},"reference":[{"issue":"3","key":"ppat.1011693.ref001","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1128\/mr.53.3.318-332.1989","article-title":"Human herpesviruses: a consideration of the latent state","volume":"53","author":"JG Stevens","year":"1989","journal-title":"Microbiol Rev"},{"issue":"Pt 12","key":"ppat.1011693.ref002","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1099\/0022-1317-69-12-3101","article-title":"Fine mapping of the major latency-related RNA of herpes simplex virus type 1 in humans","volume":"69","author":"SL Wechsler","year":"1988","journal-title":"J Gen Virol"},{"issue":"2","key":"ppat.1011693.ref003","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1006\/mpat.1993.1059","article-title":"Viral, neuronal and immune factors which may influence herpes simplex virus (HSV) latency and reactivation","volume":"15","author":"NW Fraser","year":"1993","journal-title":"Microb Pathog"},{"key":"ppat.1011693.ref004","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/978-1-4684-5853-4_21","article-title":"Pathogenesis and latency of herpes simplex virus type 1 (HSV-1): an ophthalmologist\u2019s view of the eye as a model for the study of the virus- host relationship","volume":"278","author":"YJ Gordon","year":"1990","journal-title":"Adv Exp Med Biol"},{"key":"ppat.1011693.ref005","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1600-065X.1996.tb00915.x","article-title":"Human herpes viruses latent infection in the nervous system","volume":"152","author":"I. 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