{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T23:41:39Z","timestamp":1779320499807,"version":"3.51.4"},"reference-count":56,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:00:00Z","timestamp":1697673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1R01AI177604"],"award-info":[{"award-number":["1R01AI177604"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p><jats:italic>Candida auris<\/jats:italic>, is an emerging fungal pathogen that can cause life-threatening infections in humans. Unlike many other <jats:italic>Candida<\/jats:italic> species that colonize the intestine, <jats:italic>C<\/jats:italic>. <jats:italic>auris<\/jats:italic> most efficiently colonizes the skin. Such colonization contaminates the patient\u2019s environment and can result in rapid nosocomial transmission. In addition, this transmission can lead to outbreaks of systemic infections that have mortality rates between 40% and 60%. <jats:italic>C<\/jats:italic>. <jats:italic>auris<\/jats:italic> isolates resistant to all known classes of antifungals have been identified and as such, understanding the underlying biochemical mechanisms of how skin colonization initiates and progresses is critical to developing better therapeutic options. With this review, we briefly summarize what is known about horizontal transmission and current tools used to identify, understand, and control <jats:italic>C<\/jats:italic>. <jats:italic>auris<\/jats:italic> infections.<\/jats:p>","DOI":"10.1371\/journal.ppat.1011698","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T17:21:43Z","timestamp":1697736103000},"page":"e1011698","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Tools and techniques to identify, study, and control Candida auris"],"prefix":"10.1371","volume":"19","author":[{"given":"James","family":"Carty","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anuradha","family":"Chowdhary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Bernstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0031-2392","authenticated-orcid":true,"given":"Shankar","family":"Thangamani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2023,10,19]]},"reference":[{"issue":"7","key":"ppat.1011698.ref001","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1097\/CCM.0000000000004371","article-title":"Key Takeaways From the U.S. CDC\u2019s 2019 Antibiotic Resistance Threats Report for Frontline Providers","volume":"48","author":"SS Kadri","year":"2020","journal-title":"Crit Care Med"},{"key":"ppat.1011698.ref002","unstructured":"WHO fungal priority pathogens list to guide research, development and public health action. Geneva: World Health Organization; 2022. Licence: CC BY-NC-SA 30 IGO. Available from: https:\/\/www.who.int\/publications\/i\/item\/9789240060241. WHO, 2022."},{"issue":"8","key":"ppat.1011698.ref003","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1038\/s41591-021-01383-w","article-title":"Integrated genomic, epidemiologic investigation of Candida auris skin colonization in a skilled nursing facility","volume":"27","author":"DM Proctor","year":"2021","journal-title":"Nat Med"},{"issue":"11","key":"ppat.1011698.ref004","doi-asserted-by":"crossref","first-page":"e753","DOI":"10.1093\/cid\/ciaa1462","article-title":"Factors Associated With Candida auris Colonization and Transmission in Skilled Nursing Facilities With Ventilator Units, New York, 2016\u20132018","volume":"72","author":"J Rossow","year":"2021","journal-title":"Clin Infect Dis"},{"issue":"9","key":"ppat.1011698.ref005","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/myc.12790","article-title":"Five-year profile of candidaemia at an Indian trauma centre: High rates of Candida auris blood stream infections","volume":"61","author":"P Mathur","year":"2018","journal-title":"Mycoses"},{"issue":"1","key":"ppat.1011698.ref006","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00910-19","article-title":"Candida auris Forms High-Burden Biofilms in Skin Niche Conditions and on Porcine Skin","volume":"5","author":"MV Horton","year":"2020","journal-title":"mSphere"},{"issue":"7","key":"ppat.1011698.ref007","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/myc.12781","article-title":"An outbreak due to Candida auris with prolonged colonisation and candidaemia in a tertiary care European hospital","volume":"61","author":"A Ruiz-Gaitan","year":"2018","journal-title":"Mycoses"},{"issue":"2","key":"ppat.1011698.ref008","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1093\/cid\/ciw691","article-title":"Simultaneous Emergence of Multidrug-Resistant Candida auris on 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological Analyses","volume":"64","author":"SR Lockhart","year":"2017","journal-title":"Clin Infect Dis"},{"issue":"6","key":"ppat.1011698.ref009","doi-asserted-by":"crossref","first-page":"432","DOI":"10.7326\/M19-2205","article-title":"Candida auris: An Emerging Antimicrobial Resistance Threat","volume":"171","author":"S Vallabhaneni","year":"2019","journal-title":"Ann Intern Med"},{"issue":"10","key":"ppat.1011698.ref010","doi-asserted-by":"crossref","first-page":"e1008921","DOI":"10.1371\/journal.ppat.1008921","article-title":"Candida auris: Epidemiology, biology, antifungal resistance, and virulence","volume":"16","author":"H Du","year":"2020","journal-title":"PLoS Pathog"},{"issue":"4","key":"ppat.1011698.ref011","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1093\/jac\/dkx480","article-title":"A multicentre study of antifungal susceptibility patterns among 350 Candida auris isolates (2009\u201317) in India: role of the ERG11 and FKS1 genes in azole and echinocandin resistance","volume":"73","author":"A Chowdhary","year":"2018","journal-title":"J Antimicrob Chemother"},{"issue":"2","key":"ppat.1011698.ref012","article-title":"Tracing the Evolutionary History and Global Expansion of Candida auris Using Population Genomic Analyses","volume":"11","author":"NA Chow","year":"2020","journal-title":"mBio"},{"issue":"1","key":"ppat.1011698.ref013","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1080\/22221751.2020.1771218","article-title":"Comparison of in vivo pathogenicity of four Candida auris clades in a neutropenic bloodstream infection murine model","volume":"9","author":"L Forgacs","year":"2020","journal-title":"Emerg Microbes Infect"},{"issue":"7","key":"ppat.1011698.ref014","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1093\/mmy\/myaa116","article-title":"Filamentous growth is a general feature of Candida auris clinical isolates","volume":"59","author":"S Fan","year":"2021","journal-title":"Med 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Available from: https:\/\/www.cdc.gov\/fungal\/candida-auris\/c-auris-infection-control.html."},{"issue":"10","key":"ppat.1011698.ref055","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1017\/ice.2017.162","article-title":"Effectiveness of Disinfectants Against Candida auris and Other Candida Species","volume":"38","author":"JL Cadnum","year":"2017","journal-title":"Infect Control Hosp Epidemiol"},{"issue":"10","key":"ppat.1011698.ref056","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1017\/ice.2020.278","article-title":"Evaluation of nine surface disinfectants against Candida auris using a quantitative disk carrier method: EPA SOP-MB-35","volume":"41","author":"DJ Sexton","year":"2020","journal-title":"Infect Control Hosp Epidemiol"}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1011698","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T17:22:15Z","timestamp":1697736135000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1011698"}},"subtitle":[],"editor":[{"given":"Mary Ann","family":"Jabra-Rizk","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2023,10,19]]},"references-count":56,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,10,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1011698","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,19]]}}}