{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:22:52Z","timestamp":1777936972117,"version":"3.51.4"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CAMS Innovation Fund for Medical Science","award":["2021-I2M-1-059, 2017-I2M-1-017, 2021-I2M-1-001"],"award-info":[{"award-number":["2021-I2M-1-059, 2017-I2M-1-017, 2021-I2M-1-001"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173432"],"award-info":[{"award-number":["82173432"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103749"],"award-info":[{"award-number":["82103749"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>Dermal fibroblasts (dFBs) defend against deep bacterial skin infections by differentiating into preadipocytes (pAds) that produce the antimicrobial peptide cathelicidin; this differentiation is known as the dermal reactive adipogenesis response. However, the role of dFBs in fungal infection remains unknown. Here, we found that cathelicidin-producing pAds were present in high numbers in skin lesions from patients with cutaneous <jats:italic>Candida<\/jats:italic> granulomas. Second, we showed that dermal <jats:italic>Candida albicans<\/jats:italic> (<jats:italic>C<\/jats:italic>. <jats:italic>albicans<\/jats:italic>) infection in mice robustly triggered the dermal reactive adipogenesis response and induced cathelicidin expression, and inhibition of adipogenesis with pharmacological inhibitors of peroxisome proliferator\u2013activated receptor \u03b3 (PPAR\u03b3) impaired skin resistance to <jats:italic>C<\/jats:italic>. <jats:italic>albicans<\/jats:italic>. <jats:italic>In vitro<\/jats:italic>, <jats:italic>C<\/jats:italic>. <jats:italic>albicans<\/jats:italic> products induced cathelicidin expression in pAds, and differentiating pAds markedly suppressed the growth of <jats:italic>C<\/jats:italic>. <jats:italic>albicans<\/jats:italic> by producing cathelicidin. Finally, we showed that <jats:italic>C<\/jats:italic>. <jats:italic>albicans<\/jats:italic> induced an antimicrobial response in pAds through the FGFR-MEK-ERK pathway. Together, our data reveal a previously unknown role of dFBs in the defense against skin infection caused by <jats:italic>C<\/jats:italic>. <jats:italic>albicans<\/jats:italic>.<\/jats:p>","DOI":"10.1371\/journal.ppat.1011754","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T18:22:19Z","timestamp":1701368539000},"page":"e1011754","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Antimicrobial peptide-producing dermal preadipocytes defend against Candida albicans skin infection via the FGFR-MEK-ERK 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