{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T06:39:19Z","timestamp":1785220759926,"version":"3.55.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1011807","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T00:00:00Z","timestamp":1702598400000}}],"reference-count":60,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T00:00:00Z","timestamp":1701734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["349355339"],"award-info":[{"award-number":["349355339"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004412","name":"Human Frontier Science Program","doi-asserted-by":"publisher","award":["CDA00013\/2018-C"],"award-info":[{"award-number":["CDA00013\/2018-C"]}],"id":[{"id":"10.13039\/100004412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002974","name":"Daimler und Benz Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002974","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012284","name":"Chica and Heinz Schaller Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012284","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    Malaria is caused by the rapid proliferation of\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    parasites in patients and disease severity correlates with the number of infected red blood cells in circulation. Parasite multiplication within red blood cells is called schizogony and occurs through an atypical multinucleated cell division mode. The mechanisms regulating the number of daughter cells produced by a single progenitor are poorly understood. We investigated underlying regulatory principles by quantifying nuclear multiplication dynamics in\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    and\n                    <jats:italic>knowlesi<\/jats:italic>\n                    using super-resolution time-lapse microscopy. This confirmed that the number of daughter cells was consistent with a model in which a counter mechanism regulates multiplication yet incompatible with a timer mechanism.\n                    <jats:italic>P<\/jats:italic>\n                    .\n                    <jats:italic>falciparum<\/jats:italic>\n                    cell volume at the start of nuclear division correlated with the final number of daughter cells. As schizogony progressed, the nucleocytoplasmic volume ratio, which has been found to be constant in all eukaryotes characterized so far, increased significantly, possibly to accommodate the exponentially multiplying nuclei. Depleting nutrients by dilution of culture medium caused parasites to produce fewer merozoites and reduced proliferation but did not affect cell volume or total nuclear volume at the end of schizogony. Our findings suggest that the counter mechanism implicated in malaria parasite proliferation integrates extracellular resource status to modify progeny number during blood stage infection.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1011807","type":"journal-article","created":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T13:31:56Z","timestamp":1701783116000},"page":"e1011807","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Progeny counter mechanism in malaria parasites is linked to extracellular resources"],"prefix":"10.1371","volume":"19","author":[{"given":"Vanessa S.","family":"St\u00fcrmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Stopper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Binder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Klemmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas P.","family":"Lichti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils B.","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8762-4259","authenticated-orcid":true,"given":"Julien","family":"Guizetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,12,5]]},"reference":[{"key":"ppat.1011807.ref001","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/s13071-018-2800-1","article-title":"Checks and balances? DNA replication and the cell cycle in Plasmodium","volume":"11","author":"H Matthews","year":"2018","journal-title":"Parasites and Vectors"},{"key":"ppat.1011807.ref002","volume-title":"WHO Global, World Malaria Report 2021. Word Malaria report Geneva","author":"WHO","year":"2021"},{"key":"ppat.1011807.ref003","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s11693-015-9167-9","article-title":"Visualization and quantification of Plasmodium falciparum intraerythrocytic merozoites","volume":"9","author":"S Garg","year":"2015","journal-title":"Systems and Synthetic Biology"},{"key":"ppat.1011807.ref004","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/j.ijpara.2007.05.003","article-title":"Quantitative dissection of clone-specific growth rates in cultured malaria parasites","volume":"37","author":"HB Reilly","year":"2007","journal-title":"International Journal for Parasitology"},{"key":"ppat.1011807.ref005","doi-asserted-by":"crossref","first-page":"658616","DOI":"10.3389\/fcimb.2021.658616","article-title":"How Many Is Enough?\u2014Challenges of Multinucleated Cell Division in Malaria Parasites","volume":"11","author":"CS Simon","year":"2021","journal-title":"Frontiers in Cellular and Infection Microbiology"},{"key":"ppat.1011807.ref006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms2539","article-title":"Sir2a regulates rDNA transcription and multiplication rate in the human malaria parasite Plasmodium falciparum","volume":"4","author":"L Mancio-Silva","year":"2013","journal-title":"Nature Communications"},{"key":"ppat.1011807.ref007","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ijpara.2010.07.012","article-title":"The progression of the intra-erythrocytic cell cycle of Plasmodium falciparum and the role of the centriolar plaques in asynchronous mitotic division during schizogony","volume":"41","author":"DE Arnot","year":"2011","journal-title":"Int J Parasitol"},{"key":"ppat.1011807.ref008","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/nrmicro3184","article-title":"Cell division in apicomplexan parasites","volume":"12","author":"ME Francia","year":"2014","journal-title":"Nat Rev Microbiol"},{"key":"ppat.1011807.ref009","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3389\/fcimb.2020.00269","article-title":"Fussing About Fission: Defining Variety Among Mainstream and Exotic Apicomplexan Cell Division Modes","volume":"5","author":"MJ Gubbels","year":"2020","journal-title":"Frontiers in Cellular and Infection Microbiology"},{"key":"ppat.1011807.ref010","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1128\/EC.00314-10","article-title":"Mitosis in the human malaria parasite plasmodium falciparum","volume":"10","author":"N Gerald","year":"2011","journal-title":"Eukaryotic Cell"},{"key":"ppat.1011807.ref011","doi-asserted-by":"crossref","first-page":"670049","DOI":"10.3389\/fcimb.2021.670049","article-title":"The Modular Circuitry of Apicomplexan Cell Division Plasticity","volume":"11","author":"MJ Gubbels","year":"2021","journal-title":"Frontiers in Cellular and Infection Microbiology"},{"key":"ppat.1011807.ref012","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1146\/annurev-micro-041320-010046","article-title":"Division and Transmission: Malaria Parasite Development in the Mosquito","volume":"76","author":"DS Guttery","year":"2022","journal-title":"Annual Review of Microbiology"},{"key":"ppat.1011807.ref013","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.pt.2018.07.006","article-title":"Apicomplexa Cell Cycles: Something Old, Borrowed, Lost, and New","volume":"34","author":"MW White","year":"2018","journal-title":"Trends in Parasitology"},{"key":"ppat.1011807.ref014","doi-asserted-by":"crossref","first-page":"11449","DOI":"10.1038\/ncomms11449","article-title":"An essential malaria protein defines the architecture of blood-stage and transmission-stage parasites","volume":"7","author":"S Absalon","year":"2016","journal-title":"Nature Communications"},{"key":"ppat.1011807.ref015","first-page":"16","article-title":"Three-dimensional ultrastructure of Plasmodium falciparum throughout cytokinesis","author":"RM Rudlaff","year":"2020","journal-title":"PLoS Pathogens"},{"key":"ppat.1011807.ref016","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1186\/1471-2164-11-577","article-title":"Quantitative trait loci mapping reveals candidate pathways regulating cell cycle duration in Plasmodium falciparum","volume":"11","author":"HB Reilly Ayala","year":"2010","journal-title":"BMC Genomics"},{"key":"ppat.1011807.ref017","doi-asserted-by":"crossref","first-page":"17017","DOI":"10.1038\/nmicrobiol.2017.17","article-title":"Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony","volume":"2","author":"M Ganter","year":"2017","journal-title":"Nature Microbiology"},{"key":"ppat.1011807.ref018","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.ppat.1010595","article-title":"DNA replication dynamics during erythrocytic schizogony in the malaria parasites Plasmodium falciparum and Plasmodium knowlesi","volume":"18","author":"J McDonald","year":"2022","journal-title":"PLoS Pathogens"},{"key":"ppat.1011807.ref019","first-page":"140","article-title":"Plasmodium knowlesi: the game changer for malaria eradication","author":"WC Lee","year":"2022","journal-title":"Malaria Journal. BioMed Central Ltd"},{"key":"ppat.1011807.ref020","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1073\/pnas.1216457110","article-title":"Adaptation of the genetically tractable malaria pathogen Plasmodium knowlesi to continuous culture in human erythrocytes","volume":"110","author":"RW Moon","year":"2013","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ppat.1011807.ref021","first-page":"1","article-title":"Rapid and iterative genome editing in the malaria parasite Plasmodium knowlesi provides new tools for P. vivax research","author":"F Mohring","year":"2019","journal-title":"eLife"},{"key":"ppat.1011807.ref022","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1128\/EC.00245-07","article-title":"Disruption of the PfPK7 gene impairs schizogony and sporogony in the human malaria parasite Plasmodium falciparum","volume":"7","author":"D Dorin-Semblat","year":"2008","journal-title":"Eukaryotic Cell"},{"key":"ppat.1011807.ref023","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2478\/kinome-2013-0001","article-title":"An atypical cyclin-dependent kinase controls Plasmodium falciparum proliferation rate","volume":"1","author":"D Dorin-Semblat","year":"2013","journal-title":"Kinome"},{"key":"ppat.1011807.ref024","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-020-01424-z","article-title":"Human Aurora kinase inhibitor Hesperadin reveals epistatic interaction between Plasmodium falciparum PfArk1 and PfNek1 kinases","volume":"3","author":"BJ Morahan","year":"2020","journal-title":"Communications Biology"},{"key":"ppat.1011807.ref025","doi-asserted-by":"crossref","first-page":"20386","DOI":"10.1074\/jbc.M114.561670","article-title":"Regulation of Plasmodium falciparum development by calcium-dependent protein kinase 7 (PfCDPK7)","volume":"289","author":"P Kumar","year":"2014","journal-title":"Journal of Biological Chemistry"},{"key":"ppat.1011807.ref026","doi-asserted-by":"crossref","first-page":"e00605","DOI":"10.1128\/mBio.00605-17","article-title":"The Malaria Parasite Cyclin H Homolog PfCyc1 Is Required for Efficient Cytokinesis in Blood-Stage Plasmodium falciparum","volume":"8","author":"JA Robbins","year":"2017","journal-title":"mBio"},{"key":"ppat.1011807.ref027","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nature23009","article-title":"Nutrient sensing modulates malaria parasite virulence","volume":"547","author":"L Mancio-Silva","year":"2017","journal-title":"Nature"},{"key":"ppat.1011807.ref028","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.tplants.2019.09.005","article-title":"Double or Nothing? Cell Division and Cell Size Control","volume":"24","author":"AR Jones","year":"2019","journal-title":"Trends in Plant Science"},{"key":"ppat.1011807.ref029","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.coisb.2017.08.010","article-title":"Controlling cell size through sizer mechanisms","volume":"5","author":"G Facchetti","year":"2017","journal-title":"Current Opinion in Systems Biology"},{"key":"ppat.1011807.ref030","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0960-9822(06)00060-1","article-title":"Oligodendrocyte precursor cells count time but not cell divisions before differentiation","volume":"7","author":"FB Gao","year":"1997","journal-title":"Current Biology"},{"key":"ppat.1011807.ref031","doi-asserted-by":"crossref","first-page":"e10767","DOI":"10.7554\/eLife.10767","article-title":"A new class of cyclin dependent kinase in chlamydomonas is required for coupling cell size to cell division","volume":"5","author":"Y Li","year":"2016","journal-title":"eLife"},{"key":"ppat.1011807.ref032","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1083\/jcb.200708054","article-title":"Nuclear size control in fission yeast","volume":"179","author":"FR Neumann","year":"2007","journal-title":"Journal of Cell Biology"},{"key":"ppat.1011807.ref033","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1016\/j.cub.2018.04.074","article-title":"Decoupling of Nuclear Division Cycles and Cell Size during the Coenocytic Growth of the Ichthyosporean Sphaeroforma arctica","volume":"28","author":"A Ondracka","year":"2018","journal-title":"Current Biology"},{"key":"ppat.1011807.ref034","doi-asserted-by":"crossref","first-page":"3275","DOI":"10.1038\/s41467-018-05393-0","article-title":"Size control in mammalian cells involves modulation of both growth rate and cell cycle duration","volume":"9","author":"C Cadart","year":"2018","journal-title":"Nature Communications"},{"key":"ppat.1011807.ref035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/sciadv.abj5362","article-title":"Asynchronous nuclear cycles in multinucleated Plasmodium falciparum facilitate rapid proliferation","volume":"8","author":"S Klaus","year":"2022","journal-title":"Science Advances"},{"key":"ppat.1011807.ref036","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1007\/s00294-019-00999-3","article-title":"Unravelling nuclear size control","volume":"65","author":"H Cantwell","year":"2019","journal-title":"Current Genetics"},{"key":"ppat.1011807.ref037","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1007\/BF02620943","article-title":"Analysis of the cytotoxic effects of light-exposed hepes-containing culture medium","volume":"21","author":"JS Zigler","year":"1985","journal-title":"In vitro Cellular and Developmental Biology"},{"key":"ppat.1011807.ref038","doi-asserted-by":"crossref","first-page":"e00130","DOI":"10.1128\/mBio.00130-18","article-title":"Calcium-dependent protein kinase 5 is required for release of egress-specific organelles in Plasmodium falciparum","volume":"9","author":"S Absalon","year":"2018","journal-title":"mBio"},{"key":"ppat.1011807.ref039","doi-asserted-by":"crossref","first-page":"e1011157","DOI":"10.1371\/journal.ppat.1011157","article-title":"Plasmodium schizogony, a chronology of the parasite\u2019s cell cycle in the blood stage","volume":"19","author":"Y Vo\u00df","year":"2023","journal-title":"PLOS Pathogens"},{"key":"ppat.1011807.ref040","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ceb.2018.02.009","article-title":"Subcellular scaling: does size matter for cell division?","volume":"52","author":"R Heald","year":"2018","journal-title":"Current Opinion in Cell Biology"},{"key":"ppat.1011807.ref041","doi-asserted-by":"crossref","first-page":"e12650","DOI":"10.1111\/cmi.12650","article-title":"Differential time-dependent volumetric and surface area changes and delayed induction of new permeation pathways in P. falciparum-infected hemoglobinopathic erythrocytes","volume":"19","author":"M Waldecker","year":"2017","journal-title":"Cellular Microbiology"},{"key":"ppat.1011807.ref042","first-page":"11","article-title":"The Homeostasis of Plasmodium falciparum-Infected Red Blood Cells","volume":"5","author":"JMA Mauritz","year":"2009","journal-title":"PLoS Computational Biology"},{"key":"ppat.1011807.ref043","doi-asserted-by":"crossref","first-page":"4189","DOI":"10.1182\/blood-2002-08-2654","article-title":"Excess hemoglobin digestion and the osmotic stability of Plasmodium falciparum\u2014Infected red blood cells","volume":"101","author":"VL Lew","year":"2003","journal-title":"Blood"},{"key":"ppat.1011807.ref044","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-28457-z","article-title":"Cellular dissection of malaria parasite invasion of human erythrocytes using viable Plasmodium knowlesi merozoites","volume":"8","author":"O Lyth","year":"2018","journal-title":"Scientific Reports"},{"key":"ppat.1011807.ref045","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1186\/s12936-019-2857-0","article-title":"Plasticity and genetic variation in traits underpinning asexual replication of the rodent malaria parasite, Plasmodium chabaudi","volume":"1","author":"PLG Birget","year":"2019","journal-title":"Malaria Journal"},{"key":"ppat.1011807.ref046","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/mmi.14652","article-title":"Linking nutrient sensing and gene expression in Plasmodium falciparum blood-stage parasites","volume":"115","author":"M Kumar","year":"2021","journal-title":"Molecular Microbiology"},{"key":"ppat.1011807.ref047","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/s42003-023-04566-y","article-title":"A non-canonical sensing pathway mediates Plasmodium adaptation to amino acid deficiency","volume":"6","author":"IM Marreiros","year":"2023","journal-title":"Communications Biology"},{"key":"ppat.1011807.ref048","doi-asserted-by":"crossref","first-page":"e02317","DOI":"10.1128\/mBio.02317-16","article-title":"Plasmodium falciparum Maf1 confers survival upon amino acid starvation","volume":"8","author":"KJ McLean","year":"2017","journal-title":"mBio"},{"key":"ppat.1011807.ref049","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.cub.2019.12.026","article-title":"A Single Light-Responsive Sizer Can Control Multiple-Fission Cycles in Chlamydomonas","volume":"30","author":"FS Heldt","year":"2020","journal-title":"Current Biology"},{"key":"ppat.1011807.ref050","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2018.12.001","article-title":"Importin \u03b1 Partitioning to the Plasma Membrane Regulates Intracellular Scaling","volume":"176","author":"C Brownlee","year":"2019","journal-title":"Cell"},{"key":"ppat.1011807.ref051","first-page":"49","article-title":"Ueber die Korrelation von Zell-und Kerngr\u00f6sse und ihre Bedeutung f\u00fcr die Geschlechtliche Differenzierung und die Teilung der Zelle","volume":"23","author":"R. Hertwig","year":"1903","journal-title":"Biol Centralbl"},{"key":"ppat.1011807.ref052","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1091\/mbc.E16-02-0129","article-title":"Clustered nuclei maintain autonomy and nucleocytoplasmic ratio control in a syncytium","volume":"27","author":"SER Dundon","year":"2016","journal-title":"Molecular Biology of the Cell"},{"key":"ppat.1011807.ref053","doi-asserted-by":"crossref","first-page":"660679","DOI":"10.3389\/fcimb.2021.660679","article-title":"Plasmodium Reproduction, Cell Size, and Transcription: How to Cope With Increasing DNA Content?","volume":"11","author":"M Machado","year":"2021","journal-title":"Frontiers in Cellular and Infection Microbiology."},{"key":"ppat.1011807.ref054","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.bpj.2014.05.024","article-title":"Membrane-wrapping contributions to malaria parasite invasion of the human erythrocyte","volume":"107","author":"S Dasgupta","year":"2014","journal-title":"Biophysical Journal"},{"key":"ppat.1011807.ref055","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1111\/cmi.12132","article-title":"Electron tomography of Plasmodium falciparum merozoites reveals core cellular events that underpin erythrocyte invasion","volume":"15","author":"E Hanssen","year":"2013","journal-title":"Cellular Microbiology"},{"key":"ppat.1011807.ref056","first-page":"18","article-title":"Live-cell fluorescence imaging of microgametogenesis in the human malaria parasite Plasmodium falciparum","author":"S Yahiya","year":"2022","journal-title":"PLoS Pathogens"},{"key":"ppat.1011807.ref057","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/ncomms1169","article-title":"Development and host cell modifications of Plasmodium falciparum blood stages in four dimensions","volume":"2","author":"C Gruring","year":"2011","journal-title":"Nat Commun"},{"key":"ppat.1011807.ref058","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nrmicro.2016.158","article-title":"Progress in imaging methods: insights gained into Plasmodium biology","volume":"15","author":"M De Niz","year":"2016","journal-title":"Nature Reviews Microbiology"},{"key":"ppat.1011807.ref059","doi-asserted-by":"crossref","first-page":"e202101199","DOI":"10.26508\/lsa.202101199","article-title":"An extended DNA-free intranuclear compartment organizes centrosome microtubules in malaria parasites","volume":"4","author":"CS Simon","year":"2021","journal-title":"Life Science Alliance"},{"key":"ppat.1011807.ref060","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.molbiopara.2019.02.007","article-title":"Immunofluorescence staining protocol for STED nanoscopy of Plasmodium-infected red blood cells","volume":"229","author":"AK Mehnert","year":"2019","journal-title":"Molecular and Biochemical Parasitology"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1011807","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T00:00:00Z","timestamp":1702598400000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1011807","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T13:47:37Z","timestamp":1702648057000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1011807"}},"subtitle":[],"editor":[{"given":"Kami","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,12,5]]},"references-count":60,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,12,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1011807","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.01.20.524890","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,5]]}}}