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Here, to investigate the role of PGD\n                    <jats:sub>2<\/jats:sub>\n                    and its cognate receptor DP2\n                    <jats:italic>in vivo<\/jats:italic>\n                    , impairment of PGD\n                    <jats:sub>2<\/jats:sub>\n                    synthesis by HQL-79 (an inhibitor of the H-PGD synthase) or DP2 receptor inhibition by CAY10471 (a selective DP2 antagonist) were used against the fibrotic response of hepatic eosinophilic granulomas of\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>mansoni<\/jats:italic>\n                    infection in mice. Although studies have postulated PGD\n                    <jats:sub>2<\/jats:sub>\n                    as a fibrogenic molecule, HQL-79 and CAY10471 amplified, rather than attenuated, the fibrotic response within schistosome hepatic granulomas. Both pharmacological strategies increased hepatic deposition of collagen fibers \u2014 an unexpected outcome accompanied by further elevation of hepatic levels of the pro-fibrotic cytokines TGF-\u03b2 and IL-13 in infected animals. In contrast, infection-induced enhanced LTC\n                    <jats:sub>4<\/jats:sub>\n                    synthesis in the schistosomal liver was reduced after HQL-79 and CAY10471 treatments, and therefore, inversely correlated with collagen production in granulomatous livers. Like PGD\n                    <jats:sub>2<\/jats:sub>\n                    -directed maneuvers, antagonism of cysteinyl leukotriene receptors CysLT1 by MK571 also promoted enhancement of TGF-\u03b2 and IL-13, indicating a key down-regulatory role for endogenous LTC\n                    <jats:sub>4<\/jats:sub>\n                    in schistosomiasis-induced liver fibrosis. An ample body of data supports the role of\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>mansoni<\/jats:italic>\n                    -driven DP2-mediated activation of eosinophils as the source of LTC\n                    <jats:sub>4<\/jats:sub>\n                    during infection, including: (i) HQL-79 and CAY10471 impaired systemic eosinophilia, drastically decreasing eosinophils within peritoneum and hepatic granulomas of infected animals in parallel to a reduction in cysteinyl leukotrienes levels; (ii) peritoneal eosinophils were identified as the only cells producing LTC\n                    <jats:sub>4<\/jats:sub>\n                    <jats:italic>in<\/jats:italic>\n                    PGD\n                    <jats:sub>2<\/jats:sub>\n                    -mediated\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>mansoni<\/jats:italic>\n                    -induced infection; (iii) the magnitude of hepatic granulomatous eosinophilia positively correlates with\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>mansoni<\/jats:italic>\n                    -elicited hepatic content of cysteinyl leukotrienes, and (iv) isolated eosinophils from\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>mansoni<\/jats:italic>\n                    -induced hepatic granuloma synthesize LTC\n                    <jats:sub>4<\/jats:sub>\n                    <jats:italic>in vitro<\/jats:italic>\n                    in a PGD\n                    <jats:sub>2<\/jats:sub>\n                    \/DP2 dependent manner. So, our findings uncover that granulomatous stellate cells-derived PGD\n                    <jats:sub>2<\/jats:sub>\n                    by activating DP2 receptors on eosinophils does stimulate production of anti-fibrogenic cysLTs, which endogenously down-regulates the hepatic fibrogenic process of\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>mansoni<\/jats:italic>\n                    granulomatous reaction \u2014 an\n                    <jats:italic>in vivo<\/jats:italic>\n                    protective function which demands caution in the future therapeutic attempts in targeting PGD\n                    <jats:sub>2<\/jats:sub>\n                    \/DP2 in schistosomiasis.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1011812","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T15:54:01Z","timestamp":1724342041000},"page":"e1011812","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Endogenous PGD2 acting on DP2 receptor counter regulates Schistosoma mansoni infection-driven hepatic granulomatous fibrosis"],"prefix":"10.1371","volume":"20","author":[{"given":"Giovanna N.","family":"Pezzella-Ferreira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila R. 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