{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:46:41Z","timestamp":1790725601546,"version":"4.1.0"},"reference-count":97,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:00:00Z","timestamp":1703116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["R01AI145939"],"award-info":[{"award-number":["R01AI145939"]}]},{"name":"NIH","award":["R21AI159583"],"award-info":[{"award-number":["R21AI159583"]}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p><jats:italic>Candida auris<\/jats:italic> recently emerged as an urgent public health threat, causing outbreaks of invasive infections in healthcare settings throughout the world. This fungal pathogen persists on the skin of patients and on abiotic surfaces despite antiseptic and decolonization attempts. The heightened capacity for skin colonization and environmental persistence promotes rapid nosocomial spread. Following skin colonization, <jats:italic>C<\/jats:italic>. <jats:italic>auris<\/jats:italic> can gain entrance to the bloodstream and deeper tissues, often through a wound or an inserted medical device, such as a catheter. <jats:italic>C<\/jats:italic>. <jats:italic>auris<\/jats:italic> possesses a variety of virulence traits, including the capacity for biofilm formation, production of adhesins and proteases, and evasion of innate immune responses. In this review, we highlight the interactions of <jats:italic>C<\/jats:italic>. <jats:italic>auris<\/jats:italic> with the host, emphasizing the intersection of laboratory studies and clinical observations.<\/jats:p>","DOI":"10.1371\/journal.ppat.1011843","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T18:21:44Z","timestamp":1703182904000},"page":"e1011843","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":77,"title":["Mechanisms of pathogenicity for the emerging fungus Candida auris"],"prefix":"10.1371","volume":"19","author":[{"given":"Mark V.","family":"Horton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley M.","family":"Holt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8587-6244","authenticated-orcid":true,"given":"Jeniel E.","family":"Nett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,12,21]]},"reference":[{"issue":"7","key":"ppat.1011843.ref001","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.3201\/eid2007.131765","article-title":"Candida auris-associated candidemia, South Africa","volume":"20","author":"RE Magobo","year":"2014","journal-title":"Emerg Infect Dis"},{"issue":"2","key":"ppat.1011843.ref002","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1093\/cid\/ciw691","article-title":"Simultaneous Emergence of Multidrug-Resistant Candida auris on 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological Analyses","volume":"64","author":"SR Lockhart","year":"2017","journal-title":"Clin Infect Dis"},{"issue":"4","key":"ppat.1011843.ref003","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jinf.2016.07.008","article-title":"First report of Candida 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