{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:45:33Z","timestamp":1792086333568,"version":"4.4.0"},"reference-count":80,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32202767"],"award-info":[{"award-number":["32202767"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Modern Agriculture Development Special Fund of Yangzhou, Jiangsu Province, China;","award":["YZZY202303"],"award-info":[{"award-number":["YZZY202303"]}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>Lysosomes are acidic organelles that mediate the degradation and recycling of cellular waste materials. Damage to lysosomes can cause lysosomal membrane permeabilization (LMP) and trigger different types of cell death, including apoptosis. Newcastle disease virus (NDV) can naturally infect most birds. Additionally, it serves as a promising oncolytic virus known for its effective infection of tumor cells and induction of intensive apoptotic responses. However, the involvement of lysosomes in NDV-induced apoptosis remains poorly understood. Here, we demonstrate that NDV infection profoundly triggers LMP, leading to the translocation of cathepsin B and D and subsequent mitochondria-dependent apoptosis in various tumor and avian cells. Notably, the released cathepsin B and D exacerbate NDV-induced LMP by inducing the generation of reactive oxygen species. Additionally, we uncover that the viral Hemagglutinin neuraminidase (HN) protein induces the deglycosylation and degradation of lysosome-associated membrane protein 1 (LAMP1) and LAMP2 dependent on its sialidase activity, which finally contributes to NDV-induced LMP and cellular apoptosis. Overall, our findings elucidate the role of LMP in NDV-induced cell apoptosis and provide novel insights into the function of HN during NDV-induced LMP, which provide innovative approaches for the development of NDV-based oncolytic agents.<\/jats:p>","DOI":"10.1371\/journal.ppat.1011981","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T18:26:01Z","timestamp":1707935161000},"page":"e1011981","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":40,"title":["The HN protein of Newcastle disease virus induces cell apoptosis through the induction of lysosomal membrane permeabilization"],"prefix":"10.1371","volume":"20","author":[{"given":"Yu","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxing","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zenglei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoquan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruyi","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaituo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0216-2129","authenticated-orcid":true,"given":"Chan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunlin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9924-6646","authenticated-orcid":true,"given":"Xiufan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,2,14]]},"reference":[{"issue":"6","key":"ppat.1011981.ref001","doi-asserted-by":"crossref","first-page":"e202102001","DOI":"10.1083\/jcb.202102001","article-title":"Lysosome 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Yamashima","year":"2013","journal-title":"Progress in neurobiology"},{"issue":"8","key":"ppat.1011981.ref013","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1080\/15548627.2021.2002109","article-title":"Inhibition of PLA2G4E\/cPLA2 promotes survival of random skin flaps by alleviating Lysosomal membrane permeabilization-Induced necroptosis.","volume":"18","author":"J Lou","year":"2022","journal-title":"Autophagy."},{"issue":"5","key":"ppat.1011981.ref014","doi-asserted-by":"crossref","first-page":"e2110428119","DOI":"10.1073\/pnas.2110428119","article-title":"LCDR regulates the integrity of lysosomal membrane by hnRNP K-stabilized LAPTM5 transcript and promotes cell survival","volume":"119","author":"X Yang","year":"2022","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"ppat.1011981.ref015","doi-asserted-by":"crossref","first-page":"e1003328","DOI":"10.1371\/journal.ppat.1003328","article-title":"DRAM triggers lysosomal membrane permeabilization and cell 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Repnik","year":"2010","journal-title":"Mitochondrion"},{"issue":"1","key":"ppat.1011981.ref036","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/nyas.12953","article-title":"Targeting the lysosome in cancer","volume":"1371","author":"S Piao","year":"2016","journal-title":"Ann N Y Acad Sci"},{"issue":"3","key":"ppat.1011981.ref037","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/s41419-019-1407-6","article-title":"BCL-2 family isoforms in apoptosis and cancer","volume":"10","author":"CFA Warren","year":"2019","journal-title":"Cell Death Dis"},{"issue":"10","key":"ppat.1011981.ref038","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.3389\/fonc.2020.01156","article-title":"Targeting Lysosomes in Cancer as Promising Strategy to Overcome Chemoresistance-A Mini Review.","volume":"9","author":"F Geisslinger","year":"2020","journal-title":"Front 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Thirusangu","year":"2021","journal-title":"Cancers"},{"issue":"1","key":"ppat.1011981.ref067","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.rvsc.2021.07.028","article-title":"Evaluation of the oncolytic property of recombinant Newcastle disease virus strain R2B in 4T1 and B16-F10 cells in-vitro","volume":"139","author":"N Ramamurthy","year":"2021","journal-title":"Res Vet Sci"},{"issue":"7","key":"ppat.1011981.ref068","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1080\/15548627.2021.1990515","article-title":"Newcastle disease virus degrades SIRT3 via PINK1-PRKN-dependent mitophagy to reprogram energy metabolism in infected cells","volume":"18","author":"Y Gong","year":"2022","journal-title":"Autophagy"},{"issue":"1","key":"ppat.1011981.ref069","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.redox.2018.06.010","article-title":"ROS-mediated lysosomal membrane permeabilization is involved in bupivacaine-induced death of rabbit intervertebral disc cells","volume":"18","author":"X Cai","year":"2018","journal-title":"Redox biology"},{"issue":"3","key":"ppat.1011981.ref070","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jdermsci.2022.08.006","article-title":"Imiquimod-induced ROS production causes lysosomal membrane permeabilization and activates caspase-8-mediated apoptosis in skin cancer cells","volume":"107","author":"SH Chang","year":"2022","journal-title":"Journal of dermatological science"},{"issue":"9","key":"ppat.1011981.ref071","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1016\/j.freeradbiomed.2011.07.015","article-title":"Role of oxidative stress in lysosomal membrane permeabilization and apoptosis induced by gentamicin, an aminoglycoside antibiotic","volume":"51","author":"S Denamur","year":"2011","journal-title":"Free radical biology & 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Jiang","year":"2019","journal-title":"Toxicology"},{"issue":"19","key":"ppat.1011981.ref075","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1741-7007-10-62","article-title":"Crystal structure of the conserved domain of the DC lysosomal associated membrane protein: implications for the lysosomal glycocalyx.","volume":"10","author":"S Wilke","year":"2012","journal-title":"BMC biology"},{"issue":"4","key":"ppat.1011981.ref076","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1053\/j.seminoncol.2017.10.013","article-title":"LAMPs: Shedding light on cancer biology","volume":"44","author":"F Alessandrini","year":"2017","journal-title":"Semin Oncol"},{"issue":"12","key":"ppat.1011981.ref077","first-page":"e00050","article-title":"Lysosome-Associated Membrane Proteins Support the Furin-Mediated Processing of the Mumps Virus Fusion Protein","volume":"94","author":"A Ueo","year":"2020","journal-title":"J Virol"},{"issue":"20","key":"ppat.1011981.ref078","doi-asserted-by":"crossref","first-page":"10347","DOI":"10.1128\/JVI.01411-15","article-title":"Neuraminidase of Influenza A Virus Binds Lysosome-Associated Membrane Proteins Directly and Induces Lysosome Rupture","volume":"89","author":"X Ju","year":"2015","journal-title":"J Virol"},{"issue":"3","key":"ppat.1011981.ref079","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/oxfordjournals.aje.a118408","article-title":"A SIMPLE METHOD OF ESTIMATING FIFTY PER CENT ENDPOINTS12.","volume":"27","author":"LJ REED","year":"1938","journal-title":"American Journal of Epidemiology"},{"issue":"1","key":"ppat.1011981.ref080","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3389\/fnmol.2019.00014","article-title":"27-Hydroxycholesterol Contributes to Lysosomal Membrane Permeabilization-Mediated Pyroptosis in Co-cultured SH-SY5Y Cells and C6","volume":"12","author":"S Chen","year":"2019","journal-title":"Cells. 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