{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T11:04:44Z","timestamp":1767179084248,"version":"build-2238731810"},"update-to":[{"DOI":"10.1371\/journal.ppat.1012027","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000}}],"reference-count":63,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32202767"],"award-info":[{"award-number":["32202767"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013909","name":"State Key Laboratory of Veterinary Biotechnology","doi-asserted-by":"publisher","award":["SKLVBF202205"],"award-info":[{"award-number":["SKLVBF202205"]}],"id":[{"id":"10.13039\/501100013909","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20210077"],"award-info":[{"award-number":["BK20210077"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31702243"],"award-info":[{"award-number":["31702243"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>Newcastle disease virus (NDV) has been extensively studied as a promising oncolytic virus for killing tumor cells in vitro and in vivo in clinical trials. However, the viral components that regulate the oncolytic activity of NDV remain incompletely understood. In this study, we systematically compared the replication ability of different NDV genotypes in various tumor cells and identified NP protein determines the oncolytic activity of NDV. On the one hand, NDV strains with phenylalanine (F) at the 450th amino acid position of the NP protein (450th-F-NP) exhibit a loss of oncolytic activity. This phenotype is predominantly associated with genotype VII NDVs. In contrast, the NP protein with a leucine amino acid at this site in other genotypes (450th-L-NP) can facilitate the loading of viral mRNA onto ribosomes more effectively than 450th-F-NP. On the other hand, the NP protein from NDV strains that exhibit strong oncogenicity interacts with eIF4A1 within its 366\u2013489 amino acid region, leading to the inhibition of cellular mRNA translation with a complex 5\u2019 UTR structure. Our study provide mechanistic insights into how highly oncolytic NDV strains selectively promote the translation of viral mRNA and will also facilitate the screening of oncolytic strains for oncolytic therapy.<\/jats:p>","DOI":"10.1371\/journal.ppat.1012027","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T13:32:37Z","timestamp":1708435957000},"page":"e1012027","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["The NP protein of Newcastle disease virus dictates its oncolytic activity by regulating viral mRNA translation efficiency"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6705-3788","authenticated-orcid":true,"given":"Tianxing","family":"Liao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiansong","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haixu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zenglei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoquan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunlin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiufan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"issue":"1","key":"ppat.1012027.ref001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1386-6532(99)00072-4","article-title":"Newcastle disease virus (NDV): Brief history of its oncolytic strains","volume":"16","author":"JG Sinkovics","year":"2000","journal-title":"J Clin Virol"},{"issue":"5","key":"ppat.1012027.ref002","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/0022-4804(92)90310-V","article-title":"Newcastle disease virus selectively kills human tumor cells","volume":"52","author":"KW Reichard","year":"1992","journal-title":"J Surg Res"},{"key":"ppat.1012027.ref003","doi-asserted-by":"crossref","first-page":"889403","DOI":"10.3389\/fmolb.2022.889403","article-title":"Development of molecular mechanisms and their application on oncolytic Newcastle disease virus in cancer therapy","volume":"9","author":"F Huang","year":"2022","journal-title":"Front Mol Biosci"},{"issue":"3","key":"ppat.1012027.ref004","doi-asserted-by":"crossref","first-page":"347","DOI":"10.2217\/fmb.12.4","article-title":"Oncolytic Newcastle disease virus for cancer therapy: Old challenges and new directions","volume":"7","author":"D Zamarin","year":"2012","journal-title":"Future Microbiology"},{"issue":"2","key":"ppat.1012027.ref005","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.virusres.2003.11.007","article-title":"The c-terminal domain of Measles virus nucleoprotein belongs to the class of intrinsically disordered proteins that fold upon binding to their physiological partner","volume":"99","author":"JM Bourhis","year":"2004","journal-title":"Virus Res"},{"issue":"10","key":"ppat.1012027.ref006","doi-asserted-by":"crossref","first-page":"5803","DOI":"10.1128\/jvi.67.10.5803-5812.1993","article-title":"The conserved n-terminal region of Sendai virus nucleocapsid protein np is required for nucleocapsid assembly","volume":"67","author":"CJ Buchholz","year":"1993","journal-title":"J Virol"},{"issue":"Pt 8","key":"ppat.1012027.ref007","first-page":"2163","article-title":"Newcastle disease virus nucleocapsid protein: Self-assembly and length-determination domains","volume":"84","author":"CL Kho","year":"2003","journal-title":"J Gen Virol"},{"issue":"1\u20132","key":"ppat.1012027.ref008","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0168-1702(01)00427-0","article-title":"Nucleotide sequence analysis of the Newcastle disease virus nucleocapsid protein gene and phylogenetic relationships among the paramyxoviridae","volume":"83","author":"BS Seal","year":"2002","journal-title":"Virus Res"},{"issue":"22","key":"ppat.1012027.ref009","doi-asserted-by":"crossref","first-page":"12457","DOI":"10.1128\/JVI.01565-13","article-title":"An amino acid of human parainfluenza virus type 3 nucleoprotein is critical for template function and cytoplasmic inclusion body formation","volume":"87","author":"S Zhang","year":"2013","journal-title":"J Virol"},{"issue":"7","key":"ppat.1012027.ref010","doi-asserted-by":"crossref","first-page":"4358","DOI":"10.1128\/jvi.67.7.4358-4364.1993","article-title":"The hypervariable c-terminal tail of the sendai paramyxovirus nucleocapsid protein is required for template function but not for rna encapsidation","volume":"67","author":"J Curran","year":"1993","journal-title":"J Virol"},{"issue":"21","key":"ppat.1012027.ref011","doi-asserted-by":"crossref","first-page":"11569","DOI":"10.1128\/JVI.00570-07","article-title":"Measles virus n protein inhibits host translation by binding to eif3-p40","volume":"81","author":"H Sato","year":"2007","journal-title":"Journal of Virology"},{"issue":"6","key":"ppat.1012027.ref012","doi-asserted-by":"crossref","first-page":"e1008610","DOI":"10.1371\/journal.ppat.1008610","article-title":"Newcastle disease virus infection activates pi3k\/akt\/mtor and p38 mapk\/mnk1 pathways to benefit viral mRNA translation via interaction of the viral np protein and host eif4e","volume":"16","author":"Y Zhan","year":"2020","journal-title":"PLoS Pathog"},{"issue":"2","key":"ppat.1012027.ref013","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1128\/MMBR.64.2.239-280.2000","article-title":"Translational control of viral gene expression in eukaryotes","volume":"64","author":"M Gale","year":"2000","journal-title":"Microbiol Mol Biol R"},{"issue":"1","key":"ppat.1012027.ref014","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.pep.2012.10.001","article-title":"Reconstitution of eukaryotic translation initiation factor 3 by co-expression of the subunits in a human cell-derived in vitro protein synthesis system","volume":"87","author":"M Masutani","year":"2013","journal-title":"Protein Expres Purif"},{"issue":"2","key":"ppat.1012027.ref015","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/wrna.52","article-title":"Cap and cap-binding proteins in the control of gene expression","volume":"2","author":"I Topisirovic","year":"2011","journal-title":"Wiley Interdisciplinary Reviews-RNA"},{"issue":"40","key":"ppat.1012027.ref016","doi-asserted-by":"crossref","first-page":"24091","DOI":"10.1074\/jbc.R115.675280","article-title":"Eif4f: A retrospective","volume":"290","author":"WC Merrick","year":"2015","journal-title":"Journal of Biological Chemistry"},{"issue":"2","key":"ppat.1012027.ref017","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nrm2838","article-title":"The mechanism of eukaryotic translation initiation and principles of its regulation","volume":"11","author":"RJ Jackson","year":"2010","journal-title":"Nat Rev Mol Cell Bio"},{"key":"ppat.1012027.ref018","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1042\/BST20150126","article-title":"Signalling to eIF4E in cancer","volume":"43","author":"N Siddiqui","year":"2015","journal-title":"Biochemical Society Transactions"},{"issue":"1","key":"ppat.1012027.ref019","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1158\/1078-0432.CCR-14-2362","article-title":"Molecular pathways: The eIF4F translation initiation complex-new opportunities for cancer treatment","volume":"23","author":"H Malka-Mahieu","year":"2017","journal-title":"Clinical Cancer Research"},{"issue":"22","key":"ppat.1012027.ref020","doi-asserted-by":"crossref","first-page":"12427","DOI":"10.1128\/JVI.01105-07","article-title":"Influenza virus mrna translation revisited: Is the eIF4E cap-binding factor required for viral mrna translation?","volume":"81","author":"I Burgui","year":"2007","journal-title":"Journal of Virology"},{"issue":"12","key":"ppat.1012027.ref021","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nrmicro2655","article-title":"Viral subversion of the host protein synthesis machinery","volume":"9","author":"D Walsh","year":"2011","journal-title":"Nat Rev Microbiol"},{"issue":"20","key":"ppat.1012027.ref022","doi-asserted-by":"crossref","first-page":"10177","DOI":"10.1128\/JVI.76.20.10177-10187.2002","article-title":"Vesicular stomatitis virus infection alters the eIF4F translation initiation complex and causes dephosphorylation of the eif4e binding protein 4e-bp1","volume":"76","author":"JH Connor","year":"2002","journal-title":"J Virol"},{"issue":"6","key":"ppat.1012027.ref023","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1128\/jvi.67.6.3027-3035.1993","article-title":"Modification of eukaryotic initiation factor 4f during infection by influenza virus","volume":"67","author":"D Feigenblum","year":"1993","journal-title":"J Virol"},{"issue":"16","key":"ppat.1012027.ref024","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1101\/gad.1212504","article-title":"Tethering of eIF4G to adenoviral mrnas by viral 100k protein drives ribosome shunting","volume":"18","author":"Q Xi","year":"2004","journal-title":"Genes Dev"},{"key":"ppat.1012027.ref025","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/1743-422X-9-208","article-title":"Strong innate immune response and cell death in chicken splenocytes infected with genotype viid Newcastle disease virus","volume":"9","author":"Z Hu","year":"2012","journal-title":"Virol J"},{"issue":"3","key":"ppat.1012027.ref026","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s00705-014-2301-2","article-title":"High levels of virus replication and an intense inflammatory response contribute to the severe pathology in lymphoid tissues caused by Newcastle disease virus genotype viid","volume":"160","author":"ZL Hu","year":"2015","journal-title":"Archives of Virology"},{"key":"ppat.1012027.ref027","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s12985-015-0366-5","article-title":"The M, F and HN genes of genotype VIId Newcastle disease virus are associated with the severe pathological changes in the spleen of chickens","volume":"12","author":"Y Kai","year":"2015","journal-title":"Virol J"},{"issue":"5","key":"ppat.1012027.ref028","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/s41419-021-03744-2","article-title":"Inhibition of the sonic hedgehog pathway activates tgf-beta-activated kinase (TAK1) to induce autophagy and suppress apoptosis in thyroid tumor cells","volume":"12","author":"S Li","year":"2021","journal-title":"Cell Death Dis"},{"issue":"7","key":"ppat.1012027.ref029","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.02087-20","article-title":"Mechanisms and consequences of Newcastle disease virus w protein subcellular localization in the nucleus or mitochondria","volume":"95","author":"Y Yang","year":"2021","journal-title":"J Virol"},{"issue":"8","key":"ppat.1012027.ref030","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1007\/s00705-016-2884-x","article-title":"Identification and functional analysis of phosphorylation in Newcastle disease virus phosphoprotein","volume":"161","author":"X Qiu","year":"2016","journal-title":"Arch Virol"},{"issue":"3","key":"ppat.1012027.ref031","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1637\/9633-122410-Reg.1","article-title":"Generation of a genotype VII Newcastle disease virus vaccine candidate with high yield in embryonated chicken eggs","volume":"55","author":"Z Hu","year":"2011","journal-title":"Avian Dis"},{"issue":"1","key":"ppat.1012027.ref032","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1128\/jvi.37.1.317-327.1981","article-title":"Noncytopathic mutants of Newcastle disease virus are defective in virus-specific rna synthesis","volume":"37","author":"CH Madansky","year":"1981","journal-title":"J Virol"},{"issue":"3","key":"ppat.1012027.ref033","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1093\/glycob\/cwr146","article-title":"Hybrid- and complex-type n-glycans are not essential for Newcastle disease virus infection and fusion of host cells","volume":"22","author":"Q Sun","year":"2012","journal-title":"Glycobiology"},{"issue":"1","key":"ppat.1012027.ref034","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13567-019-0640-4","article-title":"Nuclear localization of Newcastle disease virus matrix protein promotes virus replication by affecting viral rna synthesis and transcription and inhibiting host cell transcription","volume":"50","author":"Z Duan","year":"2019","journal-title":"Vet Res"},{"key":"ppat.1012027.ref035","first-page":"934851","article-title":"Development of strand-specific real-time rt-PCR to distinguish viral RNAs during Newcastle disease virus infection","volume":"2014","author":"X Qiu","year":"2014","journal-title":"ScientificWorldJournal"},{"issue":"5","key":"ppat.1012027.ref036","doi-asserted-by":"crossref","first-page":"e01463","DOI":"10.1128\/mBio.01463-14","article-title":"Virus-mediated compartmentalization of the host translational machinery","volume":"5","author":"EA Desmet","year":"2014","journal-title":"mBio"},{"issue":"4","key":"ppat.1012027.ref037","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22042222","article-title":"Kras(g12c) can either promote or impair cap-dependent translation in two different lung adenocarcinoma cell lines","volume":"22","author":"G Kyriakopoulos","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"5","key":"ppat.1012027.ref038","doi-asserted-by":"crossref","first-page":"110767","DOI":"10.1016\/j.celrep.2022.110767","article-title":"An eif3d-dependent switch regulates hcmv replication by remodeling the infected cell translation landscape to mimic chronic er stress","volume":"39","author":"L Thompson","year":"2022","journal-title":"Cell Rep"},{"issue":"8","key":"ppat.1012027.ref039","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nmeth.3047","article-title":"Improved vectors and genome-wide libraries for crispr screening","volume":"11","author":"NE Sanjana","year":"2014","journal-title":"Nat Methods"},{"key":"ppat.1012027.ref040","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.virusres.2014.07.025","article-title":"Porcine reproductive and respiratory syndrome virus counteracts the porcine intrinsic virus restriction factors-ifitm1 and tetherin in marc-145 cells","volume":"191","author":"X Wang","year":"2014","journal-title":"Virus Res"},{"issue":"1","key":"ppat.1012027.ref041","doi-asserted-by":"crossref","first-page":"17471","DOI":"10.1038\/s41598-017-17803-2","article-title":"The glutamic residue at position 402 in the c-terminus of Newcastle disease virus nucleoprotein is critical for the virus","volume":"7","author":"X Yu","year":"2017","journal-title":"Sci Rep"},{"issue":"1","key":"ppat.1012027.ref042","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3181\/00379727-90-21945","article-title":"Propagation of Newcastle disease virus in ehrlich ascites cells in vitro and in vivo","volume":"90","author":"AD Flanagan","year":"1955","journal-title":"Proc Soc Exp Biol Med"},{"issue":"3","key":"ppat.1012027.ref043","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1006\/mpat.1995.0055","article-title":"Apoptosis as a cause of death in chicken embryos inoculated with Newcastle disease virus","volume":"19","author":"KM Lam","year":"1995","journal-title":"Microb Pathog"},{"issue":"1\u20132","key":"ppat.1012027.ref044","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.virusres.2009.05.012","article-title":"Time course of Newcastle disease virus-induced apoptotic pathways","volume":"144","author":"PV Ravindra","year":"2009","journal-title":"Virus Res"},{"issue":"2","key":"ppat.1012027.ref045","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.virusres.2008.01.010","article-title":"Induction of apoptosis in vero cells by Newcastle disease virus requires viral replication, de-novo protein synthesis and caspase activation","volume":"133","author":"PV Ravindra","year":"2008","journal-title":"Virus Res"},{"issue":"10","key":"ppat.1012027.ref046","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1007\/s00705-019-04339-1","article-title":"Np protein and f protein of pigeon paramyxovirus type 1 are associated with its low pathogenicity in chickens","volume":"164","author":"Y Song","year":"2019","journal-title":"Arch Virol"},{"issue":"19","key":"ppat.1012027.ref047","doi-asserted-by":"crossref","first-page":"10113","DOI":"10.1128\/JVI.00097-10","article-title":"The viral replication complex is associated with the virulence of Newcastle disease virus","volume":"84","author":"Rottier PJM Dortmans JCFM","year":"2010","journal-title":"Journal of Virology"},{"issue":"16","key":"ppat.1012027.ref048","doi-asserted-by":"crossref","first-page":"7828","DOI":"10.1128\/JVI.00578-08","article-title":"The large polymerase protein is associated with the virulence of Newcastle disease virus","volume":"82","author":"SN Rout","year":"2008","journal-title":"Journal of Virology"},{"issue":"22","key":"ppat.1012027.ref049","doi-asserted-by":"crossref","first-page":"12079","DOI":"10.1128\/JVI.05679-11","article-title":"Role of the two sialic acid binding sites on the Newcastle disease virus hn protein in triggering the interaction with the f protein required for the promotion of fusion","volume":"85","author":"PJ Mahon","year":"2011","journal-title":"J Virol"},{"issue":"Pt 11","key":"ppat.1012027.ref050","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1099\/vir.0.19416-0","article-title":"Contribution of the length of the hn protein and the sequence of the f protein cleavage site to Newcastle disease virus pathogenicity","volume":"84","author":"A Romer-Oberdorfer","year":"2003","journal-title":"J Gen Virol"},{"issue":"1","key":"ppat.1012027.ref051","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1039\/C1MB05204G","article-title":"Structural disorder within paramyxovirus nucleoproteins and phosphoproteins","volume":"8","author":"J Habchi","year":"2012","journal-title":"Mol Biosyst"},{"issue":"19","key":"ppat.1012027.ref052","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1016\/j.febslet.2015.05.055","article-title":"Structural disorder within paramyxoviral nucleoproteins","volume":"589","author":"S. Longhi","year":"2015","journal-title":"Febs Lett"},{"issue":"5561","key":"ppat.1012027.ref053","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/261611a0","article-title":"Newcastle disease virus mRNA lacks 2\u2019-o-methylated nucleotides","volume":"261","author":"RJ Colonno","year":"1976","journal-title":"Nature"},{"issue":"2","key":"ppat.1012027.ref054","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1128\/mr.44.2.175-205.1980","article-title":"5\u2019-terminal cap structure in eucaryotic messenger ribonucleic acids","volume":"44","author":"AK Banerjee","year":"1980","journal-title":"Microbiol Rev"},{"issue":"3","key":"ppat.1012027.ref055","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1073\/pnas.72.3.1189","article-title":"Methylation-dependent translation of viral messenger RNAs in vitro","volume":"72","author":"GW Both","year":"1975","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"ppat.1012027.ref056","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.molcel.2004.11.023","article-title":"VSV disrupts the rae1\/mrnp41 mRNA nuclear export pathway","volume":"17","author":"PA Faria","year":"2005","journal-title":"Mol Cell"},{"issue":"4","key":"ppat.1012027.ref057","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1089\/vim.2012.0020","article-title":"Cell-type-specific innate immune response to oncolytic Newcastle disease virus","volume":"25","author":"M Biswas","year":"2012","journal-title":"Viral Immunol"},{"issue":"4","key":"ppat.1012027.ref058","first-page":"971","article-title":"Expression of RIG-I IRF3, IFN-beta and IRF7 determines resistance or susceptibility of cells to infection by Newcastle disease virus","volume":"34","author":"H Wilden","year":"2009","journal-title":"Int J Oncol"},{"key":"ppat.1012027.ref059","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1743-422X-11-62","article-title":"Activation of the PKR\/eIF2alpha signaling cascade inhibits replication of newcastle disease virus","volume":"11","author":"S Zhang","year":"2014","journal-title":"Virol J"},{"issue":"18","key":"ppat.1012027.ref060","article-title":"Newcastle disease virus V protein degrades mitochondrial antiviral signaling protein to inhibit host type I interferon production via E3 ubiquitin ligase RNF5","volume":"93","author":"YJ Sun","year":"2019","journal-title":"Journal of Virology"},{"key":"ppat.1012027.ref061","doi-asserted-by":"crossref","first-page":"109851","DOI":"10.1016\/j.vetmic.2023.109851","article-title":"Newcastle disease virus nucleocapsid protein mediates the degradation of 14-3-3epsilon to antagonize the interferon response and promote viral replication","volume":"284","author":"Q Xu","year":"2023","journal-title":"Vet Microbiol"},{"issue":"1","key":"ppat.1012027.ref062","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1128\/JVI.01520-07","article-title":"Akt plays a critical role in replication of nonsegmented negative-stranded rna viruses","volume":"82","author":"M Sun","year":"2008","journal-title":"Journal of Virology"},{"issue":"2","key":"ppat.1012027.ref063","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1158\/0008-5472.CAN-14-2789","article-title":"Targeting the eIF4F translation initiation complex: A critical nexus for cancer development","volume":"75","author":"J Pelletier","year":"2015","journal-title":"Cancer Research"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1012027","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1012027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T13:48:51Z","timestamp":1709300931000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1012027"}},"subtitle":[],"editor":[{"given":"Michael D.","family":"Robek","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,2,20]]},"references-count":63,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,2,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1012027","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,20]]}}}