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Translocation across the intestinal barrier into the bloodstream by intestine-colonizing\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>albicans<\/jats:italic>\n                    cells serves as the main source of disseminated candidiasis. However, the host and microbial mechanisms behind this process remain unclear. In this study we identified fungal and host factors specifically involved in infection of intestinal epithelial cells (IECs) using dual-RNA sequencing. Our data suggest that host-cell damage mediated by the peptide toxin candidalysin-encoding gene\n                    <jats:italic>ECE1<\/jats:italic>\n                    facilitates fungal zinc acquisition. This in turn is crucial for the full virulence potential of\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>albicans<\/jats:italic>\n                    during infection. IECs in turn exhibit a filamentation- and damage-specific response to\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>albicans<\/jats:italic>\n                    infection, including NF\u03baB, MAPK, and TNF signaling. NF\u03baB activation by IECs limits candidalysin-mediated host-cell damage and mediates maintenance of the intestinal barrier and cell-cell junctions to further restrict fungal translocation. This is the first study to show that candidalysin-mediated damage is necessary for\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>albicans<\/jats:italic>\n                    nutrient acquisition during infection and to explain how IECs counteract damage and limit fungal translocation via NF\u03baB-mediated maintenance of the intestinal barrier.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1012031","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T16:04:46Z","timestamp":1709309086000},"page":"e1012031","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":39,"title":["Candida albicans translocation through the intestinal epithelial barrier is promoted by fungal zinc acquisition and limited by NF\u03baB-mediated barrier protection"],"prefix":"10.1371","volume":"20","author":[{"given":"Jakob L.","family":"Sprague","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim B.","family":"Schille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Allert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Tr\u00fcmper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Lier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Gro\u00dfmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily 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