{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:02:37Z","timestamp":1793156557643,"version":"4.5.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1012147","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000}}],"reference-count":73,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170947"],"award-info":[{"award-number":["82170947"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170046"],"award-info":[{"award-number":["32170046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sichuan Science and Technology Program","award":["2022YFH0048"],"award-info":[{"award-number":["2022YFH0048"]}]},{"name":"Sichuan Science and Technology Program","award":["2023NSFSC1509"],"award-info":[{"award-number":["2023NSFSC1509"]}]},{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["23ZDYF2052"],"award-info":[{"award-number":["23ZDYF2052"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"name":"State Key Laboratory of Oral Diseases","award":["SKLOD2022OF03"],"award-info":[{"award-number":["SKLOD2022OF03"]}]},{"name":"Fundamental Research Funds for the Central Universities, Research and Develop Program, West China Hospital of Stomatology Sichuan University","award":["RD-02-202402"],"award-info":[{"award-number":["RD-02-202402"]}]},{"name":"Research Funding from West China School\/Hospital of Stomatology Sichuan University","award":["RCDWJS2023-10"],"award-info":[{"award-number":["RCDWJS2023-10"]}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>Post-transcriptional regulation by small RNAs and post-translational modifications (PTM) such as lysine acetylation play fundamental roles in physiological circuits, offering rapid responses to environmental signals with low energy consumption. Yet, the interplay between these regulatory systems remains underexplored. Here, we unveil the cross-talk between sRNAs and lysine acetylation in <jats:italic>Streptococcus mutans<\/jats:italic>, a primary cariogenic pathogen known for its potent acidogenic virulence. Through systematic overexpression of sRNAs in <jats:italic>S<\/jats:italic>. <jats:italic>mutans<\/jats:italic>, we identified sRNA SmsR1 as a critical player in modulating acidogenicity, a key cariogenic virulence feature in <jats:italic>S<\/jats:italic>. <jats:italic>mutans<\/jats:italic>. Furthermore, combined with the analysis of predicted target mRNA and transcriptome results, potential target genes were identified and experimentally verified. A direct interaction between SmsR1 and 5\u2019-UTR region of <jats:italic>pdhC<\/jats:italic> gene was determined by <jats:italic>in vitro<\/jats:italic> binding assays. Importantly, we found that overexpression of SmsR1 reduced the expression of <jats:italic>pdhC<\/jats:italic> mRNA and increased the intracellular concentration of acetyl-CoA, resulting in global changes in protein acetylation levels. This was verified by acetyl-proteomics in <jats:italic>S<\/jats:italic>. <jats:italic>mutans<\/jats:italic>, along with an increase in acetylation level and decreased activity of LDH. Our study unravels a novel regulatory paradigm where sRNA bridges post-transcriptional regulation with post-translational modification, underscoring bacterial adeptness in fine-tuning responses to environmental stress.<\/jats:p>","DOI":"10.1371\/journal.ppat.1012147","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T17:24:06Z","timestamp":1713201846000},"page":"e1012147","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Small RNA SmsR1 modulates acidogenicity and cariogenic virulence by affecting protein acetylation in Streptococcus mutans"],"prefix":"10.1371","volume":"20","author":[{"given":"Jing","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qizhao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongwang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3410-6300","authenticated-orcid":true,"given":"Yuqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,4,15]]},"reference":[{"issue":"8","key":"ppat.1012147.ref001","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.tim.2007.06.005","article-title":"Global 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with acid-tolerant catabolism and with ATP synthase activity","volume":"262","author":"J Sheng","year":"2006","journal-title":"FEMS Microbiol Lett"},{"issue":"6","key":"ppat.1012147.ref045","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1111\/omi.12110","article-title":"Transcriptional profile of glucose-shocked and acid-adapted strains of Streptococcus mutans.","volume":"30","author":"JL Baker","year":"2015","journal-title":"Mol Oral Microbiol"},{"issue":"6","key":"ppat.1012147.ref046","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/omi.12107","article-title":"Functional profiling in Streptococcus mutans: construction and examination of a genomic collection of gene deletion mutants","volume":"30","author":"RG Quivey","year":"2015","journal-title":"Mol Oral Microbiol"},{"issue":"1","key":"ppat.1012147.ref047","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1574-6968.2008.01351.x","article-title":"The involvement of the pyruvate dehydrogenase E1alpha subunit, in Streptococcus mutans acid tolerance","volume":"289","author":"B Korithoski","year":"2008","journal-title":"FEMS Microbiol Lett"},{"issue":"2","key":"ppat.1012147.ref048","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0378-1097(03)00693-1","article-title":"Effect of acid shock on protein expression by biofilm cells of Streptococcus mutans","volume":"227","author":"J Welin","year":"2003","journal-title":"FEMS Microbiol Lett"},{"key":"ppat.1012147.ref049","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1146\/annurev-biophys-070816-034058","article-title":"Integration of Bacterial Small RNAs in Regulatory Networks.","volume":"46","author":"M Nitzan","year":"2017","journal-title":"Annu Rev Biophys."},{"issue":"5","key":"ppat.1012147.ref050","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.tim.2018.03.002","article-title":"Mobilization of Bacteriocins during Competence in Streptococci","volume":"26","author":"CY Wang","year":"2018","journal-title":"Trends Microbiol"},{"issue":"1","key":"ppat.1012147.ref051","doi-asserted-by":"crossref","DOI":"10.1128\/mSystems.00102-16","article-title":"Transcriptional Profiling of the Oral Pathogen Streptococcus mutans in Response to Competence Signaling Peptide XIP.","volume":"2","author":"IB Wenderska","year":"2017","journal-title":"mSystems"},{"key":"ppat.1012147.ref052","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1146\/annurev-biochem-070611-102400","article-title":"Small proteins can no longer be ignored","volume":"83","author":"G Storz","year":"2014","journal-title":"Annu Rev Biochem"},{"issue":"51","key":"ppat.1012147.ref053","doi-asserted-by":"crossref","first-page":"20149","DOI":"10.1073\/pnas.0710634105","article-title":"Small RNAs making a small protein","volume":"104","author":"T Morita","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"ppat.1012147.ref054","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.1002\/j.1460-2075.1993.tb06074.x","article-title":"Synthesis of staphylococcal virulence factors is controlled by a regulatory RNA molecule","volume":"12","author":"RP Novick","year":"1993","journal-title":"EMBO J"},{"issue":"11","key":"ppat.1012147.ref055","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1101\/gad.423507","article-title":"Staphylococcus aureus RNAIII coordinately represses the synthesis of virulence factors and the transcription regulator Rot by an antisense mechanism","volume":"21","author":"S Boisset","year":"2007","journal-title":"Genes Dev"},{"issue":"1\u20132","key":"ppat.1012147.ref056","first-page":"155","article-title":"Translation of RNAIII, the Staphylococcus aureus agr regulatory RNA molecule, can be activated by a 3\u2019-end deletion","volume":"133","author":"N Balaban","year":"1995","journal-title":"FEMS Microbiol 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