{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T07:30:22Z","timestamp":1787988622931,"version":"build-2784847793"},"update-to":[{"DOI":"10.1371\/journal.ppat.1012205","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000}}],"reference-count":83,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:00:00Z","timestamp":1714694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015691","name":"Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U01 AI166309"],"award-info":[{"award-number":["U01 AI166309"]}],"id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015691","name":"Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI51242"],"award-info":[{"award-number":["R01 AI51242"]}],"id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    (Mtb) infects lung myeloid cells, but the specific Mtb-permissive cells and host mechanisms supporting Mtb persistence during chronic infection are incompletely characterized. We report that after the development of T cell responses, CD11c\n                    <jats:sup>lo<\/jats:sup>\n                    monocyte-derived cells harbor more live Mtb than alveolar macrophages (AM), neutrophils, and CD11c\n                    <jats:sup>hi<\/jats:sup>\n                    monocyte-derived cells. Transcriptomic and functional studies revealed that the lysosome pathway is underexpressed in this highly permissive subset, characterized by less lysosome content, acidification, and proteolytic activity than AM, along with less nuclear TFEB, a regulator of lysosome biogenesis. Mtb infection does not drive lysosome deficiency in CD11c\n                    <jats:sup>lo<\/jats:sup>\n                    monocyte-derived cells but promotes recruitment of monocytes that develop into permissive lung cells, mediated by the Mtb ESX-1 secretion system. The c-Abl tyrosine kinase inhibitor nilotinib activates TFEB and enhances lysosome functions of macrophages in vitro and in vivo, improving control of Mtb infection. Our results suggest that Mtb exploits lysosome-poor lung cells for persistence and targeting lysosome biogenesis is a potential host-directed therapy for tuberculosis.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1012205","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T13:29:57Z","timestamp":1714742997000},"page":"e1012205","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":38,"title":["Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection"],"prefix":"10.1371","volume":"20","author":[{"given":"Weihao","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Chang","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Limberis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Budzik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth Shoshana","family":"Zha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Howard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9951-6207","authenticated-orcid":true,"given":"Joel D.","family":"Ernst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,5,3]]},"reference":[{"issue":"1","key":"ppat.1012205.ref001","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.chom.2018.06.004","article-title":"Mechanisms of M. tuberculosis Immune Evasion as Challenges to TB Vaccine Design","volume":"24","author":"JD Ernst","year":"2018","journal-title":"Cell Host Microbe"},{"issue":"4","key":"ppat.1012205.ref002","doi-asserted-by":"crossref","DOI":"10.1093\/femspd\/fty037","article-title":"Tuberculosis and the art of macrophage manipulation","volume":"76","author":"S Upadhyay","year":"2018","journal-title":"Pathogens and disease"},{"issue":"suppl_6","key":"ppat.1012205.ref003","doi-asserted-by":"crossref","first-page":"S629","DOI":"10.1093\/infdis\/jix362","article-title":"What We Know About Tuberculosis Transmission: An Overview","volume":"216","author":"G Churchyard","year":"2017","journal-title":"J Infect Dis"},{"issue":"3","key":"ppat.1012205.ref004","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.immuni.2017.08.003","article-title":"Phenolic Glycolipid Facilitates Mycobacterial Escape from Microbicidal Tissue-Resident Macrophages.","volume":"47","author":"CJ Cambier","year":"2017","journal-title":"Immunity"},{"issue":"3","key":"ppat.1012205.ref005","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.chom.2018.08.001","article-title":"Alveolar Macrophages Provide an Early Mycobacterium tuberculosis Niche and Initiate Dissemination","volume":"24","author":"SB Cohen","year":"2018","journal-title":"Cell Host Microbe"},{"issue":"1","key":"ppat.1012205.ref006","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cell.2008.11.014","article-title":"The role of the granuloma in expansion and dissemination of early tuberculous infection","volume":"136","author":"JM Davis","year":"2009","journal-title":"Cell"},{"issue":"4","key":"ppat.1012205.ref007","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1084\/jem.20172020","article-title":"Growth of Mycobacterium tuberculosis in vivo segregates with host macrophage metabolism and ontogeny","volume":"215","author":"L Huang","year":"2018","journal-title":"The Journal of experimental medicine"},{"issue":"6","key":"ppat.1012205.ref008","doi-asserted-by":"crossref","first-page":"e1008621","DOI":"10.1371\/journal.ppat.1008621","article-title":"CD11cHi monocyte-derived macrophages are a major cellular compartment infected by Mycobacterium tuberculosis","volume":"16","author":"J Lee","year":"2020","journal-title":"PLoS Pathog"},{"issue":"10","key":"ppat.1012205.ref009","doi-asserted-by":"crossref","first-page":"e1007154","DOI":"10.1371\/journal.ppat.1007154","article-title":"Mononuclear cell dynamics in M. tuberculosis infection provide opportunities for therapeutic intervention","volume":"14","author":"BA Norris","year":"2018","journal-title":"PLoS Pathog"},{"issue":"37","key":"ppat.1012205.ref010","first-page":"4","article-title":"Alveolar macrophages generate a noncanonical NRF2-driven transcriptional response to Mycobacterium tuberculosis in vivo","author":"AC Rothchild","year":"2019","journal-title":"Sci Immunol"},{"issue":"4","key":"ppat.1012205.ref011","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1084\/jem.46.4.627","article-title":"THE RELATION OF MONOCYTES AND CLASMATOCYTES TO EARLY INFECTION IN RABBITS WITH BOVINE TUBERCLE BACILLI","volume":"46","author":"FR Sabin","year":"1927","journal-title":"The Journal of experimental medicine"},{"issue":"4","key":"ppat.1012205.ref012","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.4049\/jimmunol.179.4.2509","article-title":"Mycobacterium tuberculosis infects dendritic cells with high frequency and impairs their function in vivo","volume":"179","author":"AJ Wolf","year":"2007","journal-title":"J Immunol"},{"issue":"3","key":"ppat.1012205.ref013","first-page":"e0133222","article-title":"Bacterial Strain-Dependent Dissociation of Cell Recruitment and Cell-to-Cell Spread in Early M.","volume":"13","author":"BS Zha","year":"2022","journal-title":"tuberculosis Infection. mBio"},{"issue":"14","key":"ppat.1012205.ref014","doi-asserted-by":"crossref","first-page":"7958","DOI":"10.1073\/pnas.131207398","article-title":"Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis.","volume":"98","author":"W Peters","year":"2001","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"9","key":"ppat.1012205.ref015","doi-asserted-by":"crossref","first-page":"6349","DOI":"10.4049\/jimmunol.181.9.6349","article-title":"Tuberculosis triggers a tissue-dependent program of differentiation and acquisition of effector functions by circulating monocytes","volume":"181","author":"M Skold","year":"2008","journal-title":"J Immunol"},{"issue":"5","key":"ppat.1012205.ref016","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.immuni.2017.10.021","article-title":"Granulocyte-Monocyte Progenitors and Monocyte-Dendritic Cell Progenitors Independently Produce Functionally Distinct Monocytes","volume":"47","author":"A Yanez","year":"2017","journal-title":"Immunity"},{"issue":"3","key":"ppat.1012205.ref017","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/ni1309","article-title":"Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2","volume":"7","author":"NV Serbina","year":"2006","journal-title":"Nat Immunol"},{"issue":"1","key":"ppat.1012205.ref018","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1084\/jem.20071367","article-title":"Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungs","volume":"205","author":"AJ Wolf","year":"2008","journal-title":"The Journal of experimental medicine"},{"issue":"6","key":"ppat.1012205.ref019","doi-asserted-by":"crossref","first-page":"3128","DOI":"10.4049\/jimmunol.171.6.3128","article-title":"Dynamics of macrophage cell populations during murine pulmonary tuberculosis","volume":"171","author":"M Gonzalez-Juarrero","year":"2003","journal-title":"J Immunol"},{"key":"ppat.1012205.ref020","doi-asserted-by":"crossref","first-page":"e01086","DOI":"10.7554\/eLife.01086","article-title":"Essential yet limited role for CCR2(+) inflammatory monocytes during Mycobacterium tuberculosis-specific T cell priming.","volume":"2","author":"M Samstein","year":"2013","journal-title":"Elife"},{"issue":"6","key":"ppat.1012205.ref021","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.chom.2014.05.007","article-title":"Cell-to-cell transfer of M. tuberculosis antigens optimizes CD4 T cell priming","volume":"15","author":"S Srivastava","year":"2014","journal-title":"Cell Host Microbe."},{"issue":"12","key":"ppat.1012205.ref022","doi-asserted-by":"crossref","first-page":"7110","DOI":"10.4049\/jimmunol.1100001","article-title":"Lung neutrophils facilitate activation of naive antigen-specific CD4+ T cells during Mycobacterium tuberculosis infection","volume":"186","author":"R Blomgran","year":"2011","journal-title":"J Immunol"},{"issue":"9","key":"ppat.1012205.ref023","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20210615","article-title":"Single cell analysis of M. tuberculosis phenotype and macrophage lineages in the infected lung","volume":"218","author":"D Pisu","year":"2021","journal-title":"The Journal of experimental medicine"},{"issue":"11","key":"ppat.1012205.ref024","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/ni.2419","article-title":"Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages","volume":"13","author":"EL Gautier","year":"2012","journal-title":"Nat Immunol"},{"issue":"1","key":"ppat.1012205.ref025","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1165\/rcmb.2016-0361OC","article-title":"Three Unique Interstitial Macrophages in the Murine Lung at Steady State","volume":"57","author":"SL Gibbings","year":"2017","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"3","key":"ppat.1012205.ref026","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.chom.2012.06.010","article-title":"Efferocytosis Is an Innate Antibacterial Mechanism.","volume":"12","author":"CJ Martin","year":"2012","journal-title":"Cell Host & Microbe."},{"issue":"8","key":"ppat.1012205.ref027","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1002\/eji.201344383","article-title":"Lysosomal phospholipase A2: a novel player in host immunity to Mycobacterium tuberculosis","volume":"44","author":"BE Schneider","year":"2014","journal-title":"Eur J Immunol"},{"issue":"2","key":"ppat.1012205.ref028","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1073\/pnas.0708110105","article-title":"Role for lysosomal enzyme beta-hexosaminidase in the control of mycobacteria infection","volume":"105","author":"IC Koo","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ppat.1012205.ref029","doi-asserted-by":"crossref","first-page":"32247","DOI":"10.1038\/srep32247","article-title":"Role of Cathepsins in Mycobacterium tuberculosis Survival in Human Macrophages.","volume":"6","author":"D Pires","year":"2016","journal-title":"Sci Rep"},{"key":"ppat.1012205.ref030","doi-asserted-by":"crossref","first-page":"16320","DOI":"10.1038\/srep16320","article-title":"Mycobacterium tuberculosis Inhibits RAB7 Recruitment to Selectively Modulate Autophagy Flux in Macrophages.","volume":"5","author":"P Chandra","year":"2015","journal-title":"Sci Rep."},{"issue":"9","key":"ppat.1012205.ref031","doi-asserted-by":"crossref","first-page":"16133","DOI":"10.1038\/nmicrobiol.2016.133","article-title":"Suppression of autophagy and antigen presentation by Mycobacterium tuberculosis PE_PGRS47.","volume":"1","author":"NK Saini","year":"2016","journal-title":"Nat Microbiol."},{"issue":"12","key":"ppat.1012205.ref032","doi-asserted-by":"crossref","first-page":"e1001230","DOI":"10.1371\/journal.ppat.1001230","article-title":"Mycobacterium tuberculosis eis regulates autophagy, inflammation, and cell death through redox-dependent signaling.","volume":"6","author":"DM Shin","year":"2010","journal-title":"PLoS Pathog."},{"issue":"4","key":"ppat.1012205.ref033","doi-asserted-by":"crossref","first-page":"e0054921","DOI":"10.1128\/mSphere.00549-21","article-title":"Mycobacterium tuberculosis PE_PGRS20 and PE_PGRS47 Proteins Inhibit Autophagy by Interaction with Rab1A.","volume":"6","author":"EJ Strong","year":"2021","journal-title":"mSphere"},{"issue":"12","key":"ppat.1012205.ref034","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1177\/002215540104901201","article-title":"Enzyme cytochemical techniques for metabolic mapping in living cells, with special reference to proteolysis","volume":"49","author":"E Boonacker","year":"2001","journal-title":"J Histochem Cytochem"},{"issue":"26","key":"ppat.1012205.ref035","doi-asserted-by":"crossref","first-page":"17707","DOI":"10.1016\/S0021-9258(19)47429-2","article-title":"Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells.","volume":"266","author":"T Yoshimori","year":"1991","journal-title":"J Biol Chem"},{"issue":"10","key":"ppat.1012205.ref036","doi-asserted-by":"crossref","first-page":"e106188","DOI":"10.15252\/embj.2020106188","article-title":"TPL-2 kinase induces phagosome acidification to promote macrophage killing of bacteria","volume":"40","author":"F Breyer","year":"2021","journal-title":"Embo j"},{"issue":"40","key":"ppat.1012205.ref037","doi-asserted-by":"crossref","first-page":"28436","DOI":"10.1074\/jbc.274.40.28436","article-title":"Phagosomal maturation, acidification, and inhibition of bacterial growth in nonphagocytic cells transfected with FcgammaRIIA receptors","volume":"274","author":"GP Downey","year":"1999","journal-title":"J Biol Chem"},{"issue":"11","key":"ppat.1012205.ref038","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nrm2272","article-title":"Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology","volume":"8","author":"M. Forgac","year":"2007","journal-title":"Nature Reviews Molecular Cell Biology"},{"issue":"12","key":"ppat.1012205.ref039","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1111\/tra.12447","article-title":"Cresyl violet: a superior fluorescent lysosomal marker","volume":"17","author":"PP Ostrowski","year":"2016","journal-title":"Traffic"},{"issue":"5939","key":"ppat.1012205.ref040","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1126\/science.1174447","article-title":"A Gene Network Regulating Lysosomal Biogenesis and Function","volume":"325","author":"M Sardiello","year":"2009","journal-title":"Science"},{"issue":"6036","key":"ppat.1012205.ref041","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1126\/science.1204592","article-title":"TFEB links autophagy to lysosomal biogenesis","volume":"332","author":"C Settembre","year":"2011","journal-title":"Science"},{"issue":"19","key":"ppat.1012205.ref042","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1093\/hmg\/ddr306","article-title":"Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways","volume":"20","author":"M Palmieri","year":"2011","journal-title":"Human Molecular Genetics"},{"issue":"228","key":"ppat.1012205.ref043","doi-asserted-by":"crossref","first-page":"ra42","DOI":"10.1126\/scisignal.2002790","article-title":"The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis","volume":"5","author":"A Roczniak-Ferguson","year":"2012","journal-title":"Science signaling"},{"issue":"63","key":"ppat.1012205.ref044","doi-asserted-by":"crossref","first-page":"eabc2934","DOI":"10.1126\/sciimmunol.abc2934","article-title":"Pulmonary BCG induces lung-resident macrophage activation and confers long-term protection against tuberculosis","volume":"6","author":"E Mata","year":"2021","journal-title":"Sci Immunol"},{"issue":"6","key":"ppat.1012205.ref045","doi-asserted-by":"crossref","first-page":"e1008567","DOI":"10.1371\/journal.ppat.1008567","article-title":"Potentiation of rifampin activity in a mouse model of tuberculosis by activation of host transcription factor EB","volume":"16","author":"R Bryk","year":"2020","journal-title":"PLoS Pathog"},{"issue":"8","key":"ppat.1012205.ref046","doi-asserted-by":"crossref","first-page":"4069","DOI":"10.4049\/jimmunol.1201538","article-title":"Abelson tyrosine kinase controls phagosomal acidification required for killing of Mycobacterium tuberculosis in human macrophages","volume":"189","author":"H Bruns","year":"2012","journal-title":"J Immunol"},{"key":"ppat.1012205.ref047","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3389\/fimmu.2018.00085","article-title":"c-Abl-TWIST1 Epigenetically Dysregulate Inflammatory Responses during Mycobacterial Infection by Co-Regulating Bone Morphogenesis Protein and miR27a.","volume":"9","author":"K Mahadik","year":"2018","journal-title":"Front Immunol."},{"issue":"5","key":"ppat.1012205.ref048","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.chom.2011.09.010","article-title":"Imatinib-sensitive tyrosine kinases regulate mycobacterial pathogenesis and represent therapeutic targets against tuberculosis","volume":"10","author":"RJ Napier","year":"2011","journal-title":"Cell Host Microbe"},{"issue":"8","key":"ppat.1012205.ref049","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1080\/15548627.2016.1179405","article-title":"TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages.","volume":"12","author":"N Pastore","year":"2016","journal-title":"Autophagy."},{"issue":"2","key":"ppat.1012205.ref050","doi-asserted-by":"crossref","first-page":"e1003946","DOI":"10.1371\/journal.ppat.1003946","article-title":"Identification of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growth","volume":"10","author":"SA Stanley","year":"2014","journal-title":"PLoS Pathog"},{"key":"ppat.1012205.ref051","first-page":"9","article-title":"The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection.","author":"A Giraud-Gatineau","year":"2020","journal-title":"Elife"},{"issue":"8","key":"ppat.1012205.ref052","doi-asserted-by":"crossref","first-page":"3283","DOI":"10.4049\/jimmunol.1601920","article-title":"PPAR-alpha Activation Mediates Innate Host Defense through Induction of TFEB and Lipid Catabolism","volume":"198","author":"YS Kim","year":"2017","journal-title":"J Immunol"},{"issue":"6","key":"ppat.1012205.ref053","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/ni.3434","article-title":"Mycobacterium tuberculosis induces the miR-33 locus to reprogram autophagy and host lipid metabolism","volume":"17","author":"M Ouimet","year":"2016","journal-title":"Nat Immunol"},{"issue":"6","key":"ppat.1012205.ref054","first-page":"972","article-title":"Antimycobacterial effect of IFNG (interferon gamma)-induced autophagy depends on HMOX1 (heme oxygenase 1)-mediated increase in intracellular calcium levels and modulation of PPP3\/calcineurin-TFEB (transcription factor EB) axis.","volume":"14","author":"N Singh","year":"2018","journal-title":"Autophagy"},{"issue":"8","key":"ppat.1012205.ref055","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1021\/acsinfecdis.7b00046","article-title":"The Tyrosine Kinase Inhibitor Gefitinib Restricts Mycobacterium tuberculosis Growth through Increased Lysosomal Biogenesis and Modulation of Cytokine Signaling","volume":"3","author":"KM Sogi","year":"2017","journal-title":"ACS Infect Dis"},{"issue":"2","key":"ppat.1012205.ref056","doi-asserted-by":"crossref","first-page":"846","DOI":"10.4049\/jimmunol.1501595","article-title":"Activator of G-Protein Signaling 3-Induced Lysosomal Biogenesis Limits Macrophage Intracellular Bacterial Infection","volume":"196","author":"A Vural","year":"2016","journal-title":"J Immunol"},{"issue":"7","key":"ppat.1012205.ref057","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.4049\/jimmunol.1700654","article-title":"T Cells Identified by Activation-Induced Expression of CD154","volume":"199","author":"S Kunnath-Velayudhan","year":"2017","journal-title":"J Immunol"},{"issue":"30","key":"ppat.1012205.ref058","doi-asserted-by":"crossref","first-page":"12434","DOI":"10.1073\/pnas.0703510104","article-title":"Poor correlation between BCG vaccination-induced T cell responses and protection against tuberculosis","volume":"104","author":"HW Mittrucker","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"11","key":"ppat.1012205.ref059","doi-asserted-by":"crossref","first-page":"e22009","DOI":"10.1096\/fj.202100614R","article-title":"HDAC6 contributes to human resistance against Mycobacterium tuberculosis infection via mediating innate immune responses","volume":"35","author":"F Zhang","year":"2021","journal-title":"FASEB J"},{"key":"ppat.1012205.ref060","article-title":"Immune evasion and provocation by Mycobacterium tuberculosis","author":"P Chandra","year":"2022","journal-title":"Nat Rev Microbiol"},{"issue":"1","key":"ppat.1012205.ref061","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.chom.2016.11.002","article-title":"The Ubiquitin Ligase Smurf1 Functions in Selective Autophagy of Mycobacterium tuberculosis and Anti-tuberculous Host Defense","volume":"21","author":"LH Franco","year":"2017","journal-title":"Cell Host Microbe"},{"issue":"1","key":"ppat.1012205.ref062","doi-asserted-by":"crossref","first-page":"4295","DOI":"10.1038\/s41467-018-06836-4","article-title":"MicroRNA-27a controls the intracellular survival of Mycobacterium tuberculosis by regulating calcium-associated autophagy","volume":"9","author":"F Liu","year":"2018","journal-title":"Nat Commun"},{"issue":"7468","key":"ppat.1012205.ref063","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/nature12566","article-title":"The ubiquitin ligase parkin mediates resistance to intracellular pathogens","volume":"501","author":"PS Manzanillo","year":"2013","journal-title":"Nature"},{"issue":"7","key":"ppat.1012205.ref064","doi-asserted-by":"crossref","first-page":"e1005076","DOI":"10.1371\/journal.ppat.1005076","article-title":"Ubiquilin 1 Promotes IFN-gamma-Induced Xenophagy of Mycobacterium tuberculosis","volume":"11","author":"ET Sakowski","year":"2015","journal-title":"PLoS Pathog"},{"issue":"4","key":"ppat.1012205.ref065","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.cell.2012.06.040","article-title":"Extracellular M. tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing pathway","volume":"150","author":"RO Watson","year":"2012","journal-title":"Cell"},{"issue":"11","key":"ppat.1012205.ref066","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1080\/15548627.2015.1091140","article-title":"NR1D1 ameliorates Mycobacterium tuberculosis clearance through regulation of autophagy","volume":"11","author":"V Chandra","year":"2015","journal-title":"Autophagy"},{"issue":"2","key":"ppat.1012205.ref067","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1080\/15548627.2020.1725374","article-title":"Trehalose limits opportunistic mycobacterial survival during HIV co-infection by reversing HIV-mediated autophagy block.","volume":"17","author":"V Sharma","year":"2021","journal-title":"Autophagy"},{"issue":"5","key":"ppat.1012205.ref068","doi-asserted-by":"crossref","DOI":"10.3390\/cells8050506","article-title":"Nilotinib: A Tyrosine Kinase Inhibitor Mediates Resistance to Intracellular Mycobacterium Via Regulating Autophagy.","volume":"8","author":"T Hussain","year":"2019","journal-title":"Cells"},{"issue":"1","key":"ppat.1012205.ref069","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.cell.2016.02.034","article-title":"Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration","volume":"165","author":"RD Berg","year":"2016","journal-title":"Cell"},{"issue":"2","key":"ppat.1012205.ref070","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1189\/jlb.0810457","article-title":"Phagosome dynamics during phagocytosis by neutrophils","volume":"90","author":"P Nordenfelt","year":"2011","journal-title":"J Leukoc Biol"},{"issue":"3","key":"ppat.1012205.ref071","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1182\/blood.V91.3.1044","article-title":"Azurophilic granules of human neutrophilic leukocytes are deficient in lysosome-associated membrane proteins but retain the mannose 6-phosphate recognition marker","volume":"91","author":"AM Cieutat","year":"1998","journal-title":"Blood"},{"issue":"1","key":"ppat.1012205.ref072","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.chom.2015.12.003","article-title":"Antigen Export Reduces Antigen Presentation and Limits T Cell Control of M. tuberculosis","volume":"19","author":"S Srivastava","year":"2016","journal-title":"Cell Host Microbe"},{"issue":"5","key":"ppat.1012205.ref073","doi-asserted-by":"crossref","first-page":"e1002063","DOI":"10.1371\/journal.ppat.1002063","article-title":"Suboptimal activation of antigen-specific CD4+ effector cells enables persistence of M. tuberculosis in vivo","volume":"7","author":"TD Bold","year":"2011","journal-title":"PLoS Pathog"},{"issue":"6","key":"ppat.1012205.ref074","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1093\/infdis\/jir883","article-title":"Impaired fitness of Mycobacterium africanum despite secretion of ESAT-6","volume":"205","author":"TD Bold","year":"2012","journal-title":"J Infect Dis"},{"issue":"5","key":"ppat.1012205.ref075","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.4049\/jimmunol.1200994","article-title":"CD4+ T cell-dependent IFN-gamma production by CD8+ effector T cells in Mycobacterium tuberculosis infection","volume":"189","author":"TD Bold","year":"2012","journal-title":"J Immunol"},{"issue":"12","key":"ppat.1012205.ref076","doi-asserted-by":"crossref","first-page":"6205","DOI":"10.4049\/jimmunol.1200255","article-title":"Dynamic roles of type I and type II IFNs in early infection with Mycobacterium tuberculosis","volume":"188","author":"L Desvignes","year":"2012","journal-title":"J Immunol"},{"issue":"10","key":"ppat.1012205.ref077","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1093\/infdis\/jiy142","article-title":"Limited Antimycobacterial Efficacy of Epitope Peptide Administration Despite Enhanced Antigen-Specific CD4 T-Cell Activation","volume":"218","author":"JD Ernst","year":"2018","journal-title":"J Infect Dis"},{"issue":"1","key":"ppat.1012205.ref078","doi-asserted-by":"crossref","first-page":"357","DOI":"10.4049\/jimmunol.1501494","article-title":"Suboptimal Antigen Presentation Contributes to Virulence of Mycobacterium tuberculosis In Vivo","volume":"196","author":"PS Grace","year":"2016","journal-title":"J Immunol"},{"issue":"2","key":"ppat.1012205.ref079","doi-asserted-by":"crossref","first-page":"895","DOI":"10.4049\/jimmunol.0901230","article-title":"Ectopic activation of Mycobacterium tuberculosis-specific CD4+ T cells in lungs of CCR7-\/- mice","volume":"184","author":"S Olmos","year":"2010","journal-title":"J Immunol"},{"issue":"12","key":"ppat.1012205.ref080","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1093\/infdis\/jiw519","article-title":"Type I Interferon is Pathogenic During Chronic Mycobacterium africanum Infection","volume":"214","author":"KE Wiens","year":"2016","journal-title":"J Infect Dis"},{"issue":"1","key":"ppat.1012205.ref081","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.chom.2011.11.012","article-title":"Mycobacterium tuberculosis inhibits neutrophil apoptosis, leading to delayed activation of naive CD4 T cells.","volume":"11","author":"R Blomgran","year":"2012","journal-title":"Cell Host Microbe."},{"issue":"6","key":"ppat.1012205.ref082","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.immuni.2009.10.007","article-title":"Interferon-gamma-responsive nonhematopoietic cells regulate the immune response to Mycobacterium tuberculosis","volume":"31","author":"L Desvignes","year":"2009","journal-title":"Immunity"},{"issue":"3","key":"ppat.1012205.ref083","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.4049\/jimmunol.1301236","article-title":"Cutting edge: Direct recognition of infected cells by CD4 T cells is required for control of intracellular Mycobacterium tuberculosis in vivo","volume":"191","author":"S Srivastava","year":"2013","journal-title":"J Immunol"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1012205","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1012205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T13:51:59Z","timestamp":1715781119000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1012205"}},"subtitle":[],"editor":[{"given":"Helena Ingrid","family":"Boshoff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,5,3]]},"references-count":83,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,5,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1012205","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3049913\/v1","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,3]]}}}