{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:32:59Z","timestamp":1791495179002,"version":"4.3.4"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE022550"],"award-info":[{"award-number":["DE022550"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI089443"],"award-info":[{"award-number":["AI089443"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>Oropharyngeal candidiasis (OPC) is the most common human fungal infection, arising typically from T cell immune impairments. IL-17 and IL-22 contribute individually to OPC responses, but here we demonstrate that the combined actions of both cytokines are essential for resistance to OPC. Mice lacking IL-17RA and IL-22RA1 exhibited high fungal loads in esophagus- and intestinal tract, severe weight loss, and symptoms of colitis. Ultimately, mice succumbed to infection. Dual loss of IL-17RA and IL-22RA impaired expression of small proline rich proteins (SPRRs), a class of antimicrobial effectors not previously linked to fungal immunity. Sprr2a1 exhibited direct candidacidal activity in vitro, and <jats:italic>Sprr1-3a<\/jats:italic><jats:sup><jats:italic>-\/-<\/jats:italic><\/jats:sup> mice were susceptible to OPC. Thus, cooperative actions of Type 17 cytokines mediate oral mucosal anti-<jats:italic>Candida<\/jats:italic> defenses and reveal a role for SPRRs.<\/jats:p>","DOI":"10.1371\/journal.ppat.1012302","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T17:21:36Z","timestamp":1719854496000},"page":"e1012302","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Combinatorial actions of IL-22 and IL-17 drive optimal immunity to oral candidiasis through SPRRs"],"prefix":"10.1371","volume":"20","author":[{"given":"Felix E. 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