{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T20:54:17Z","timestamp":1779224057382,"version":"3.51.4"},"reference-count":84,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Calgary: Eyes High Doctoral Scholarship"},{"name":"Maria Fotaki Scholarship for International students"},{"name":"Alberta Graduate Excellence Scholarship"},{"name":"Henry Koopman's Memorial Award"},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases","award":["Beverly Philip's scholarship"],"award-info":[{"award-number":["Beverly Philip's scholarship"]}]},{"name":"Henry Koopman's Memorial Award"},{"name":"University of Calgary: Eyes High Doctoral Recruitment Scholarship"},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2017-03826"],"award-info":[{"award-number":["RGPIN-2017-03826"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>Recognizing that enteric tuft cells can signal the presence of nematode parasites, we investigated whether tuft cells are required for the expulsion of the cestode, <jats:italic>Hymenolepis diminuta<\/jats:italic>, from the non-permissive mouse host, and in concomitant anti-helminthic responses. BALB\/c and C57BL\/6 mice infected with <jats:italic>H<\/jats:italic>. <jats:italic>diminuta<\/jats:italic> expelled the worms by 11 days post-infection (dpi) and displayed DCLK1<jats:sup>+<\/jats:sup> (doublecortin-like kinase 1) tuft cell hyperplasia in the small intestine (not the colon) at 11 dpi. This tuft cell hyperplasia was dependent on IL-4R<jats:italic>\u03b1<\/jats:italic> signalling and adaptive immunity, but not the microbiota. Expulsion of <jats:italic>H<\/jats:italic>. <jats:italic>diminuta<\/jats:italic> was slowed until at least 14 dpi, but not negated, in tuft cell-deficient <jats:italic>Pou2f3<\/jats:italic><jats:sup><jats:italic>-\/-<\/jats:italic><\/jats:sup> mice and was accompanied by delayed goblet cell hyperplasia and slowed small bowel transit. Worm antigen and mitogen evoked production of IL-4 and IL-10 by splenocytes from wild-type and <jats:italic>Pou2f3<\/jats:italic><jats:sup><jats:italic>-\/-<\/jats:italic><\/jats:sup> mice was not appreciably different, suggesting similar systemic immune reactivity to infection with <jats:italic>H<\/jats:italic>. <jats:italic>diminuta<\/jats:italic>. Wild-type and <jats:italic>Pou2f3<\/jats:italic><jats:sup><jats:italic>-\/-<\/jats:italic><\/jats:sup> mice infected with <jats:italic>H<\/jats:italic>. <jats:italic>diminuta<\/jats:italic> displayed partial protection against subsequent infection with the nematode <jats:italic>Heligmosomoides bakeri<\/jats:italic>. We speculate that, with respect to <jats:italic>H<\/jats:italic>. <jats:italic>diminuta<\/jats:italic>, enteric tuft cells are important for local immune events driving the rapidity of <jats:italic>H<\/jats:italic>. <jats:italic>diminuta<\/jats:italic> expulsion but are not critical in initiating or sustaining systemic Th2 responses that provide concomitant immunity against secondary infection with <jats:italic>H<\/jats:italic>. <jats:italic>bakeri<\/jats:italic>.<\/jats:p>","DOI":"10.1371\/journal.ppat.1012381","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T22:48:36Z","timestamp":1722552516000},"page":"e1012381","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Enteric tuft cells coordinate timely expulsion of the tapeworm Hymenolepis diminuta from the murine host by coordinating local but not systemic immunity"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5735-7479","authenticated-orcid":true,"given":"Sruthi","family":"Rajeev","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ShuHua","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aralia","family":"Leon-Coria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"Kraemer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan Joanne","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annaliese","family":"Boim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle","family":"Flannigan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Shute","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiane H.","family":"Baggio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca E.","family":"Callejas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wallace K.","family":"MacNaughton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constance A. M.","family":"Finney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0557-8210","authenticated-orcid":true,"given":"Derek M.","family":"McKay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,7,31]]},"reference":[{"key":"ppat.1012381.ref001","first-page":"1","article-title":"Host\u2014parasite interactions promote disease tolerance to intestinal helminth infection","volume":"9","author":"IL King","year":"2018","journal-title":"Front. Immunol"},{"key":"ppat.1012381.ref002","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.smim.2014.06.003","article-title":"Host protective roles of type 2 immunity: Parasite killing and tissue repair, flip sides of the same coin","volume":"26","author":"JE Allen","year":"2014","journal-title":"Semin. 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