{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:07:30Z","timestamp":1787807250169,"version":"build-2784847793"},"update-to":[{"DOI":"10.1371\/journal.ppat.1012457","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000}}],"reference-count":61,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T00:00:00Z","timestamp":1724630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015084","name":"Lung Foundation Netherlands","doi-asserted-by":"publisher","award":["3.2.10.072"],"award-info":[{"award-number":["3.2.10.072"]}],"id":[{"id":"10.13039\/501100015084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015084","name":"Lung Foundation Netherlands","doi-asserted-by":"publisher","award":["5.1.15.015"],"award-info":[{"award-number":["5.1.15.015"]}],"id":[{"id":"10.13039\/501100015084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["91714352"],"award-info":[{"award-number":["91714352"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>Chronic infection with <jats:italic>Schistosoma mansoni<\/jats:italic> parasites is associated with reduced allergic sensitization in humans, while schistosome eggs protects against allergic airway inflammation (AAI) in mice. One of the main secretory\/excretory molecules from schistosome eggs is the glycosylated T2-RNAse Omega-1 (\u03c91). We hypothesized that \u03c91 induces protection against AAI during infection. Peritoneal administration of \u03c91 prior to sensitization with Ovalbumin (OVA) reduced airway eosinophilia and pathology, and OVA-specific Th2 responses upon challenge, independent from changes in regulatory T cells. \u03c91 was taken up by monocyte-derived dendritic cells, mannose receptor (CD206)-positive conventional type 2 dendritic cells (CD206<jats:sup>+<\/jats:sup> cDC2), and by recruited peritoneal macrophages. Additionally, \u03c91 impaired CCR7, F-actin, and costimulatory molecule expression on myeloid cells and cDC2 migration <jats:italic>in<\/jats:italic> and <jats:italic>ex vivo<\/jats:italic>, as evidenced by reduced OVA<jats:sup>+<\/jats:sup> CD206<jats:sup>+<\/jats:sup> cDC2 in the draining mediastinal lymph nodes (medLn) and retainment in the peritoneal cavity, while antigen processing and presentation in cDC2 were not affected by \u03c91 treatment. Importantly, RNAse mutant \u03c91 was unable to reduce AAI or affect DC migration, indicating that \u03c91 effects are dependent on its RNAse activity. Altogether, \u03c91 hampers migration of OVA<jats:sup>+<\/jats:sup> cDC2 to the draining medLn in mice, elucidating how \u03c91 prevents allergic airway inflammation in the OVA\/alum mouse model.<\/jats:p>","DOI":"10.1371\/journal.ppat.1012457","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T21:15:06Z","timestamp":1724706906000},"page":"e1012457","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["S. mansoni -derived omega-1 prevents OVA-specific allergic airway inflammation via hampering of cDC2 migration"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9333-869X","authenticated-orcid":true,"given":"Thiago A.","family":"Patente","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Gasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maaike","family":"Scheenstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arifa","family":"Ozir-Fazalalikhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Obieglo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sjoerd","family":"Schetters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stijn","family":"Verwaerde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Vergote","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Otto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruud H. P.","family":"Wilbers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eline","family":"van Bloois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda van","family":"Wijck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Taube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamida","family":"Hammad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjen","family":"Schots","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Everts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Yazdanbakhsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Guigas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelis H.","family":"Hokke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9279-2890","authenticated-orcid":true,"given":"Hermelijn H.","family":"Smits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,8,26]]},"reference":[{"key":"ppat.1012457.ref001","doi-asserted-by":"crossref","first-page":"04052","DOI":"10.7189\/jogh.12.04052","article-title":"Global, regional, and national prevalence of asthma in 2019: a systematic analysis and modelling study.","volume":"12","author":"P Song","year":"2022","journal-title":"J Glob Health"},{"key":"ppat.1012457.ref002","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1398-9995.2004.00526.x","article-title":"The global burden of asthma: executive summary of the GINA Dissemination Committee report","volume":"59","author":"Global Initiative for Asthma (GINA) Program","year":"2004","journal-title":"Allergy"},{"key":"ppat.1012457.ref003","article-title":"A historical overview of childhood asthma in southern Africa: Are we there yet?","volume":"27","author":"REM Mphahlele","year":"2021","journal-title":"Afr J Thorac Crit Care Med."},{"key":"ppat.1012457.ref004","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/j.1398-9995.2010.02512.x","article-title":"Atopy and current intestinal parasite infection: a systematic review and meta-analysis","volume":"66","author":"J Feary","year":"2011","journal-title":"Allergy"},{"key":"ppat.1012457.ref005","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/S0140-6736(20)31861-4","article-title":"Primary prevention of asthma: from risk and protective factors to targeted strategies for prevention","volume":"396","author":"E von Mutius","year":"2020","journal-title":"Lancet Lond Engl"},{"key":"ppat.1012457.ref006","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.jaci.2007.06.009","article-title":"Protective effect of Schistosoma mansoni infection on allergic airway inflammation depends on the intensity and chronicity of infection","volume":"120","author":"HH Smits","year":"2007","journal-title":"J Allergy Clin Immunol. 20070808th ed."},{"key":"ppat.1012457.ref007","doi-asserted-by":"crossref","first-page":"e2379","DOI":"10.1371\/journal.pntd.0002379","article-title":"Schistosoma mansoni-mediated suppression of allergic airway inflammation requires patency and Foxp3+ Treg cells.","volume":"7","author":"LE Layland","year":"2013","journal-title":"PLoS Negl Trop Dis."},{"key":"ppat.1012457.ref008","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1128\/IAI.00783-07","article-title":"Schistosoma mansoni Antigens Modulate Experimental Allergic Asthma in a Murine Model: a Major Role for CD4+ CD25+ Foxp3+ T Cells Independent of Interleukin-10","volume":"77","author":"LGG Pac\u00edfico","year":"2009","journal-title":"Infect Immun"},{"key":"ppat.1012457.ref009","doi-asserted-by":"crossref","first-page":"e12579","DOI":"10.1111\/pim.12579","article-title":"Isolated Schistosoma mansoni eggs prevent allergic airway inflammation","volume":"40","author":"K Obieglo","year":"2018","journal-title":"Parasite Immunol. 2018\/08\/15 ed."},{"key":"ppat.1012457.ref010","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.immuni.2018.10.016","article-title":"Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules","volume":"49","author":"RM Maizels","year":"2018","journal-title":"Immunity"},{"key":"ppat.1012457.ref011","doi-asserted-by":"crossref","first-page":"e1010064","DOI":"10.1371\/journal.ppat.1010064","article-title":"Schistosome immunomodulators.","volume":"17","author":"S Acharya","year":"2021","journal-title":"PLoS Pathog"},{"key":"ppat.1012457.ref012","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.molbiopara.2007.06.002","article-title":"Proteomic analysis of Schistosoma mansoni egg secretions","volume":"155","author":"CL Cass","year":"2007","journal-title":"Mol Biochem Parasitol. 20070619th ed"},{"key":"ppat.1012457.ref013","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.molbiopara.2005.08.003","article-title":"Molecular characterization of omega-1: a hepatotoxic ribonuclease from Schistosoma mansoni eggs","author":"CM Fitzsimmons","year":"2005","journal-title":"Mol Biochem Parasitol"},{"key":"ppat.1012457.ref014","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.chom.2020.10.002","article-title":"Schistosoma mansoni Eggs Modulate the Timing of Granuloma Formation to Promote Transmission","volume":"29","author":"KK Takaki","year":"2021","journal-title":"Cell Host Microbe"},{"key":"ppat.1012457.ref015","doi-asserted-by":"crossref","first-page":"5375","DOI":"10.1038\/ncomms6375","article-title":"Omega-1 knockdown in Schistosoma mansoni eggs by lentivirus transduction reduces granuloma size in vivo","volume":"5","author":"J Hagen","year":"2014","journal-title":"Nat Commun. 20141117th ed"},{"key":"ppat.1012457.ref016","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1084\/jem.20082460","article-title":"Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses","author":"B Everts","year":"2009","journal-title":"J Exp Med"},{"key":"ppat.1012457.ref017","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1084\/jem.20082462","article-title":"The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1).","volume":"206","author":"S Steinfelder","year":"2009","journal-title":"J Exp Med"},{"key":"ppat.1012457.ref018","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1084\/jem.20111381","article-title":"Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor","volume":"209","author":"B Everts","year":"2012","journal-title":"J Exp Med"},{"key":"ppat.1012457.ref019","doi-asserted-by":"crossref","first-page":"45910","DOI":"10.1038\/srep45910","article-title":"Production and glyco-engineering of immunomodulatory helminth glycoproteins in plants.","volume":"7","author":"RHP Wilbers","year":"2017","journal-title":"Sci Rep."},{"key":"ppat.1012457.ref020","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1002\/eji.201141429","article-title":"The S. mansoni glycoprotein \u03c9-1 induces Foxp3 expression in NOD mouse CD4+ T cells","volume":"41","author":"P Zaccone","year":"2011","journal-title":"Eur J Immunol"},{"issue":"Pt 2","key":"ppat.1012457.ref021","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1017\/S0031182000059503","article-title":"The purification, characterization, serological activity and hepatotoxic properties of two cationic glycoproteins (alpha 1 and omega 1) from Schistosoma mansoni eggs.","volume":"103","author":"DW Dunne","year":"1991","journal-title":"Parasitology. 1991\/10\/01 ed"},{"key":"ppat.1012457.ref022","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1084\/jem.20071087","article-title":"Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells","volume":"205","author":"M Kool","year":"2008","journal-title":"J Exp Med"},{"key":"ppat.1012457.ref023","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1600-065X.2008.00718.x","article-title":"Inflammatory signals in dendritic cell activation and the induction of adaptive immunity","volume":"227","author":"O Joffre","year":"2009","journal-title":"Immunol Rev"},{"key":"ppat.1012457.ref024","first-page":"2028","article-title":"Human NK Cells Lyse Th2-Polarizing Dendritic Cells via NKp30 and DNAM-1","volume":"201","author":"K Walwyn-Brown","year":"2018","journal-title":"J Immunol Baltim Md 1950."},{"key":"ppat.1012457.ref025","doi-asserted-by":"crossref","first-page":"18384","DOI":"10.1074\/jbc.M300497200","article-title":"Molecular characterization of an interleukin-4-inducing factor from Schistosoma mansoni eggs","volume":"278","author":"G Schramm","year":"2003","journal-title":"J Biol Chem"},{"key":"ppat.1012457.ref026","first-page":"771","article-title":"Studies on the host-parasite relationship in Schistosoma mansoni-infected mice: the immunological dependence of parasite egg excretion","volume":"35","author":"M Doenhoff","year":"1978","journal-title":"Immunology"},{"key":"ppat.1012457.ref027","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.02492","article-title":"Schistosoma \u201cEggs-Iting\u201d the Host: Granuloma Formation and Egg Excretion.","volume":"9","author":"C Schwartz","year":"2018","journal-title":"Front Immunol."},{"key":"ppat.1012457.ref028","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/icb.2015.114","article-title":"A central role for hepatic conventional dendritic cells in supporting Th2 responses during helminth infection","volume":"94","author":"RJ Lundie","year":"2016","journal-title":"Immunol Cell Biol"},{"key":"ppat.1012457.ref029","doi-asserted-by":"crossref","first-page":"15820","DOI":"10.1038\/ncomms15820","article-title":"Different populations of CD11b+ dendritic cells drive Th2 responses in the small intestine and colon.","volume":"8","author":"JU Mayer","year":"2017","journal-title":"Nat Commun"},{"key":"ppat.1012457.ref030","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1038\/s41467-023-37502-z","article-title":"Pulmonary inflammation promoted by type-2 dendritic cells is a feature of human and murine schistosomiasis.","volume":"14","author":"EL Houlder","year":"2023","journal-title":"Nat Commun."},{"key":"ppat.1012457.ref031","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nri2039","article-title":"Suppression of TH2-type allergic reactions by helminth infection","volume":"7","author":"PG Fallon","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"ppat.1012457.ref032","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/S1473-3099(14)70771-6","article-title":"Helminth therapy or elimination: epidemiological, immunological, and clinical considerations","volume":"14","author":"LJ Wammes","year":"2014","journal-title":"Lancet Infect Dis"},{"key":"ppat.1012457.ref033","doi-asserted-by":"crossref","first-page":"e12506","DOI":"10.1111\/pim.12506","article-title":"Schistosoma mansoni-specific immune responses and allergy in Uganda","volume":"40","author":"G Nkurunungi","year":"2018","journal-title":"Parasite Immunol"},{"key":"ppat.1012457.ref034","first-page":"e21331","article-title":"The helminth glycoprotein omega-1 improves metabolic homeostasis in obese mice through type 2 immunity-independent inhibition of food intake","volume":"35","author":"HJP van der Zande","year":"2021","journal-title":"FASEB J Off Publ Fed Am Soc Exp Biol"},{"key":"ppat.1012457.ref035","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1021\/pr100081c","article-title":"Structural characterization of glycans on omega-1, a major Schistosoma mansoni egg glycoprotein that drives Th2 responses","volume":"9","author":"MHJ Meevissen","year":"2010","journal-title":"J Proteome Res"},{"key":"ppat.1012457.ref036","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1146\/annurev.immunol.23.021704.115816","article-title":"Macrophage Receptors and Immune Recognition","volume":"23","author":"PR Taylor","year":"2005","journal-title":"Annu Rev Immunol"},{"key":"ppat.1012457.ref037","doi-asserted-by":"crossref","first-page":"765034","DOI":"10.3389\/fimmu.2021.765034","article-title":"The Mannose Receptor: From Endocytic Receptor and Biomarker to Regulator of (Meta)Inflammation.","volume":"12","author":"HJP van der Zande","year":"2021","journal-title":"Front Immunol."},{"key":"ppat.1012457.ref038","doi-asserted-by":"crossref","first-page":"ncomms11852","DOI":"10.1038\/ncomms11852","article-title":"Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities","volume":"7","author":"CC Bain","year":"2016","journal-title":"Nat Commun"},{"key":"ppat.1012457.ref039","first-page":"6770","article-title":"The mannose receptor mediates uptake of soluble but not of cell-associated antigen for cross-presentation","volume":"176","author":"S Burgdorf","year":"2006","journal-title":"J Immunol Baltim Md 1950."},{"key":"ppat.1012457.ref040","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.15252\/embj.201695345","article-title":"Type I interferon is required for T helper (Th) 2 induction by dendritic cells.","volume":"36","author":"LM Webb","year":"2017","journal-title":"EMBO J"},{"key":"ppat.1012457.ref041","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1038\/ni861","article-title":"Defective CCR7 expression on dendritic cells contributes to the development of visceral leishmaniasis","volume":"3","author":"M Ato","year":"2002","journal-title":"Nat Immunol"},{"key":"ppat.1012457.ref042","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/s41577-022-00707-2","article-title":"A guide to antigen processing and presentation","volume":"22","author":"N Pishesha","year":"2022","journal-title":"Nat Rev Immunol"},{"key":"ppat.1012457.ref043","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1242\/jcs.086934","article-title":"Cofilin cooperates with fascin to disassemble filopodial actin filaments","volume":"124","author":"D Breitsprecher","year":"2011","journal-title":"J Cell Sci"},{"key":"ppat.1012457.ref044","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1189\/jlb.2A0215-050RR","article-title":"WASp-dependent actin cytoskeleton stability at the dendritic cell immunological synapse is required for extensive, functional T cell contacts","volume":"99","author":"D Malinova","year":"2016","journal-title":"J Leukoc Biol"},{"key":"ppat.1012457.ref045","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.ijpara.2015.08.005","article-title":"The Schistosoma mansoni T2 ribonuclease omega-1 modulates inflammasome-dependent IL-1\u03b2 secretion in macrophages","volume":"45","author":"BJ Ferguson","year":"2015","journal-title":"Int J Parasitol"},{"key":"ppat.1012457.ref046","doi-asserted-by":"crossref","first-page":"20459","DOI":"10.1073\/pnas.1010337107","article-title":"Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses","volume":"107","author":"M Ritter","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ppat.1012457.ref047","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1172\/JCI28075","article-title":"MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals","volume":"116","author":"C-J Chen","year":"2006","journal-title":"J Clin Invest"},{"key":"ppat.1012457.ref048","first-page":"5271","article-title":"Aluminum hydroxide adjuvants activate caspase-1 and induce IL-1beta and IL-18 release","volume":"178","author":"H Li","year":"2007","journal-title":"J Immunol Baltim Md 1950."},{"key":"ppat.1012457.ref049","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1111\/j.1398-9995.2011.02586.x","article-title":"NLRP3 inflammasome is required in murine asthma in the absence of aluminum adjuvant","volume":"66","author":"A-G Besnard","year":"2011","journal-title":"Allergy"},{"issue":"Suppl 1","key":"ppat.1012457.ref050","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1590\/S0074-02762005000900024","article-title":"The role of interferon-gamma on immune and allergic responses","volume":"100","author":"LK Teixeira","year":"2005","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ppat.1012457.ref051","first-page":"209","article-title":"IFN-gamma attenuates antigen-induced overall immune response in the airway as a Th1-type immune regulatory cytokine","volume":"183","author":"K Nakagome","year":"2009","journal-title":"J Immunol Baltim Md 1950."},{"key":"ppat.1012457.ref052","first-page":"3554","article-title":"Modulation of the induction of lung and airway allergy in the offspring of IFN-gamma-treated mother mice","volume":"175","author":"C Lima","year":"2005","journal-title":"J Immunol Baltim Md 1950."},{"key":"ppat.1012457.ref053","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1038\/s41423-021-00726-4","article-title":"Dendritic cell migration in inflammation and immunity","volume":"18","author":"J Liu","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"ppat.1012457.ref054","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1182\/blood-2012-09-456483","article-title":"Neutrophil myeloperoxidase regulates T-cell-driven tissue inflammation in mice by inhibiting dendritic cell function","volume":"121","author":"D Odobasic","year":"2013","journal-title":"Blood"},{"key":"ppat.1012457.ref055","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.bcp.2011.12.021","article-title":"Orally bioavailable allosteric CCR8 antagonists inhibit dendritic cell, T cell and eosinophil migration","volume":"83","author":"S Connolly","year":"2012","journal-title":"Biochem Pharmacol"},{"key":"ppat.1012457.ref056","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.3892\/ijmm.2016.2743","article-title":"Baicalin attenuates inflammation in mice with OVA-induced asthma by inhibiting NF-\u03baB and suppressing CCR7\/CCL19\/CCL21","volume":"38","author":"J Liu","year":"2016","journal-title":"Int J Mol Med"},{"key":"ppat.1012457.ref057","first-page":"4126","article-title":"FTY720 Abrogates Collagen-Induced Arthritis by Hindering Dendritic Cell Migration to Local Lymph Nodes","volume":"195","author":"Y Han","year":"2015","journal-title":"J Immunol Baltim Md 1950."},{"key":"ppat.1012457.ref058","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/s41423-018-0056-5","article-title":"The chemokine receptor CCR7 is a promising target for rheumatoid arthritis therapy","volume":"16","author":"GL Moschovakis","year":"2019","journal-title":"Cell Mol Immunol"},{"key":"ppat.1012457.ref059","doi-asserted-by":"crossref","first-page":"1917484","DOI":"10.1080\/19420862.2021.1917484","article-title":"Targeting cancer homing into the lymph node with a novel anti-CCR7 therapeutic antibody: the paradigm of CLL.","volume":"13","author":"C Cuesta-Mateos","year":"2021","journal-title":"mAbs"},{"key":"ppat.1012457.ref060","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00262-021-03014-2","article-title":"Effect of ibrutinib on CCR7 expression and functionality in chronic lymphocytic leukemia and its implication for the activity of CAP-100, a novel therapeutic anti-CCR7 antibody","volume":"71","author":"T Mateu-Albero","year":"2022","journal-title":"Cancer Immunol Immunother CII"},{"key":"ppat.1012457.ref061","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1084\/jem.20061196","article-title":"Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells","volume":"204","author":"H Hammad","year":"2007","journal-title":"J Exp Med"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1012457","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1012457","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T18:31:56Z","timestamp":1725647516000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1012457"}},"subtitle":[],"editor":[{"given":"James J.","family":"Collins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,8,26]]},"references-count":61,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2024,8,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1012457","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.ppat.1012457","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,26]]}}}