{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:26:55Z","timestamp":1777354015198,"version":"3.51.4"},"update-to":[{"DOI":"10.1371\/journal.ppat.1012498","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000}}],"reference-count":80,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL107380"],"award-info":[{"award-number":["HL107380"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL164031"],"award-info":[{"award-number":["HL164031"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL159915"],"award-info":[{"award-number":["HL159915"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UPMC Children\u2019s Hospitalof Pittsburgh Research Advisory Committee"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>Influenza infections result in a significant number of severe illnesses annually, many of which are complicated by secondary bacterial super-infection. Primary influenza infection has been shown to increase susceptibility to secondary methicillin-resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA) infection by altering the host immune response, leading to significant immunopathology. Type III interferons (IFNs), or IFN\u03bbs, have gained traction as potential antiviral therapeutics due to their restriction of viral replication without damaging inflammation. The role of IFN\u03bb in regulating epithelial biology in super-infection has recently been established; however, the impact of IFN\u03bb on immune cells is less defined. In this study, we infected wild-type and IFNLR1<jats:sup>-\/-<\/jats:sup> mice with influenza A\/PR\/8\/34 followed by <jats:italic>S<\/jats:italic>. <jats:italic>aureus<\/jats:italic> USA300. We demonstrated that global IFNLR1<jats:sup>-\/-<\/jats:sup> mice have enhanced bacterial clearance through increased uptake by phagocytes, which was shown to be cell-intrinsic specifically in myeloid cells in mixed bone marrow chimeras. We also showed that depletion of IFNLR1 on CX<jats:sub>3<\/jats:sub>CR1 expressing myeloid immune cells, but not neutrophils, was sufficient to significantly reduce bacterial burden compared to mice with intact IFNLR1. These findings provide insight into how IFN\u03bb in an influenza-infected lung impedes bacterial clearance during super-infection and show a direct cell intrinsic role for IFN\u03bb signaling on myeloid cells.<\/jats:p>","DOI":"10.1371\/journal.ppat.1012498","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T18:12:43Z","timestamp":1724436763000},"page":"e1012498","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cell-intrinsic regulation of phagocyte function by interferon lambda during pulmonary viral, bacterial super-infection"],"prefix":"10.1371","volume":"20","author":[{"given":"Danielle","family":"Antos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia B.","family":"Parks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis M.","family":"Duray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nevil","family":"Abraham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua J.","family":"Michel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saran","family":"Kupul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemary","family":"Westcott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5997-7711","authenticated-orcid":true,"given":"John F.","family":"Alcorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,8,23]]},"reference":[{"key":"ppat.1012498.ref001","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/ni875","article-title":"IFN-\u03bbs mediate antiviral protection through a distinct class II cytokine receptor complex","volume":"4","author":"S V. 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Ardanuy","year":"2020","journal-title":"J Immunol"},{"key":"ppat.1012498.ref029","first-page":"1","article-title":"Interferon-Lambda 1 Inhibits Staphylococcus aureus Colonization in Human Primary Keratinocytes","volume":"12","author":"X Wu","year":"2021","journal-title":"Front Pharmacol"},{"key":"ppat.1012498.ref030","doi-asserted-by":"crossref","first-page":"3764","DOI":"10.1128\/IAI.00298-15","article-title":"Influenza and bacterial superinfection: Illuminating the immunologic mechanisms of disease","volume":"83","author":"A Rynda-Apple","year":"2015","journal-title":"Infect Immun"},{"key":"ppat.1012498.ref031","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1086\/591708","article-title":"Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: Implications for pandemic influenza preparedness","volume":"198","author":"DM Morens","year":"2008","journal-title":"J Infect 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Misharin","year":"2013","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ppat.1012498.ref056","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.cell.2004.10.010","article-title":"JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells","volume":"119","author":"E Passegu\u00e9","year":"2004","journal-title":"Cell"},{"key":"ppat.1012498.ref057","first-page":"89","author":"CL Abram","year":"2015","journal-title":"Myeloid Cre efficiencies"},{"key":"ppat.1012498.ref058","first-page":"1","article-title":"Macrophage cytokines: Involvement in immunity and infectious diseases","volume":"5","author":"GA Duque","year":"2014","journal-title":"Front Immunol"},{"key":"ppat.1012498.ref059","first-page":"1","article-title":"Macrophage Coordination of the Interferon Lambda Immune Response","volume":"10","author":"SA Read","year":"2019","journal-title":"Front 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Stegemann-Koniszewski","year":"2016","journal-title":"MBio"},{"key":"ppat.1012498.ref072","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.00863-23","article-title":"Antiviral epithelial-macrophage crosstalk permits secondary bacterial infections","volume":"14","author":"S Lane","year":"2023","journal-title":"MBio"},{"key":"ppat.1012498.ref073","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/s41587-020-0602-4","article-title":"COVID-19 severity correlates with airway epithelium\u2013immune cell interactions identified by single-cell analysis","volume":"38","author":"RL Chua","year":"2020","journal-title":"Nat Biotechnol"},{"key":"ppat.1012498.ref074","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1172\/JCI83931","article-title":"Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection","volume":"126","author":"C Peteranderl","year":"2016","journal-title":"J Clin 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