{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T08:32:16Z","timestamp":1770280336677,"version":"3.49.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1012531","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000}}],"reference-count":75,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH,","award":["R01AI137062"],"award-info":[{"award-number":["R01AI137062"]}]},{"name":"BJC Investigator Program,"},{"DOI":"10.13039\/100011671","name":"G. Harold and Leila Y. Mathers Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011671","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH,","award":["T32 DK077653-29"],"award-info":[{"award-number":["T32 DK077653-29"]}]},{"DOI":"10.13039\/100011684","name":"Crohn's and Colitis Foundation","doi-asserted-by":"publisher","award":["Research Fellowship Award #935619"],"award-info":[{"award-number":["Research Fellowship Award #935619"]}],"id":[{"id":"10.13039\/100011684","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>Paramyxoviruses are significant human and animal pathogens that include mumps virus (MuV), Newcastle disease virus (NDV) and the murine parainfluenza virus Sendai (SeV). Despite their importance, few host factors implicated in paramyxovirus infection are known. Using a recombinant SeV expressing destabilized eGFP (rSeVC<jats:sup>dseGFP<\/jats:sup>) in a loss-of-function CRISPR screen, we identified the CMP-sialic acid transporter (CST) gene <jats:italic>SLC35A1<\/jats:italic> and the UDP-galactose transporter (UGT) gene <jats:italic>SLC35A2<\/jats:italic> as essential for paramyxovirus infection. As expected, <jats:italic>SLC35A1<\/jats:italic> knockout (KO) cells showed drastic reduction in infections with SeV, NDV and MuV due to the lack of cell surface sialic acids receptors. However, <jats:italic>SLC35A2<\/jats:italic> KO cells revealed unknown critical roles for this factor in virus-cell and cell-to-cell fusion events for the different paramyxoviruses. While UGT was essential for virus-cell fusion during SeV entry to the cell, it was not required for NDV or MuV entry. Importantly, UGT promoted the formation of syncytia during MuV infection, suggesting a role in cell-to-cell virus spread. Our findings demonstrate that paramyxoviruses can bind to or enter A549 cells in the absence of canonical galactose-bound sialic-acid decorations and show that UGT facilitates paramyxovirus fusion processes involved in entry and spread.<\/jats:p>","DOI":"10.1371\/journal.ppat.1012531","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T20:19:34Z","timestamp":1736540374000},"page":"e1012531","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["SLC35A2 gene product modulates paramyxovirus fusion events during infection"],"prefix":"10.1371","volume":"21","author":[{"given":"Yanling","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuchen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle 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