{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T20:44:02Z","timestamp":1772311442003,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.ppat.1012555","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:00:00Z","timestamp":1727308800000}}],"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["DEQ. 20180339200"],"award-info":[{"award-number":["DEQ. 20180339200"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-22-CE15-0044"],"award-info":[{"award-number":["ANR-22-CE15-0044"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>Manipulation of immune cell functions, independently of direct infection of these cells, emerges as a key process in viral pathophysiology. Chronic infection by Human T-cell Leukemia Virus type 1 (HTLV-1) is associated with immune dysfunctions, including misdirected responses of dendritic cells (DCs). Here, we interrogate the ability of transformed HTLV-1-infected T cells to manipulate human DC functions. We show that exposure to transformed HTLV-1-infected T cells induces a biased and peculiar transcriptional signature in monocyte-derived DCs, associated with an inefficient maturation and a poor responsiveness to subsequent stimulation by a TLR4 agonist. This poor responsiveness is also associated with a unique transcriptional landscape characterized by a set of genes whose expression is either conferred, impaired or abolished by HTLV-1 pre-exposure. Induction of this functional impairment requires several hours of coculture with transformed HTLV-1-infected cells, and associated mechanisms driven by viral capture, cell-cell contacts, and soluble mediators. Altogether, this cross-talk between infected T cells and DCs illustrate how HTLV-1 might co-opt communications between cells to induce a unique local tolerogenic immune microenvironment suitable for its own persistence.<\/jats:p>","DOI":"10.1371\/journal.ppat.1012555","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T13:58:41Z","timestamp":1726495121000},"page":"e1012555","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Peculiar transcriptional reprogramming with functional impairment of dendritic cells upon exposure to transformed HTLV-1-infected cells"],"prefix":"10.1371","volume":"20","author":[{"given":"Auriane","family":"Carcone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franck","family":"Mortreux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Alais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyrille","family":"Mathieu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chlo\u00e9","family":"Journo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2682-4302","authenticated-orcid":true,"given":"H\u00e9l\u00e8ne","family":"Dutartre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,9,16]]},"reference":[{"key":"ppat.1012555.ref001","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1146\/annurev-immunol-042617-053222","article-title":"Human T Cell Leukemia Virus Type 1: Persistence and Pathogenesis","volume":"36","author":"CRM Bangham","year":"2018","journal-title":"Annu Rev Immunol"},{"key":"ppat.1012555.ref002","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/bs.apar.2020.11.002","article-title":"HTLV-I and Strongyloides in Australia: The worm lurking beneath.","volume":"111","author":"CA Gordon","year":"2021","journal-title":"Adv Parasitol."},{"key":"ppat.1012555.ref003","doi-asserted-by":"crossref","first-page":"e0006967","DOI":"10.1371\/journal.pntd.0006967","article-title":"Detection of clinical and neurological signs in apparently asymptomatic HTLV-1 infected carriers: Association with high proviral load.","volume":"13","author":"ME Haziot","year":"2019","journal-title":"PLoS Negl Trop Dis"},{"key":"ppat.1012555.ref004","doi-asserted-by":"crossref","first-page":"e1006861","DOI":"10.1371\/journal.ppat.1006861","article-title":"Switching and loss of cellular cytokine producing capacity characterize in vivo viral infection and malignant transformation in human T- lymphotropic virus type 1 infection.","volume":"14","author":"H Kagdi","year":"2018","journal-title":"PLoS Pathog."},{"key":"ppat.1012555.ref005","doi-asserted-by":"crossref","first-page":"e0175345","DOI":"10.1371\/journal.pone.0175345","article-title":"MAIT cells are reduced in frequency and functionally impaired in human T lymphotropic virus type 1 infection: Potential clinical implications.","volume":"12","author":"D Paquin-Proulx","year":"2017","journal-title":"PloS One"},{"key":"ppat.1012555.ref006","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1128\/JVI.02735-15","article-title":"Human T Cell Leukemia Virus Type 1 Infection of the Three Monocyte Subsets Contributes to Viral Burden in Humans","volume":"90","author":"MF de Castro-Amarante","year":"2015","journal-title":"J Virol"},{"key":"ppat.1012555.ref007","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3389\/fmicb.2012.00323","article-title":"The roles of acquired and innate immunity in human T-cell leukemia virus type 1-mediated diseases.","volume":"3","author":"M Kannagi","year":"2012","journal-title":"Front Microbiol."},{"key":"ppat.1012555.ref008","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1002\/embj.201488027","article-title":"Dendritic cell maturation: functional specialization through signaling specificity and transcriptional programming","volume":"33","author":"M Dalod","year":"2014","journal-title":"EMBO J"},{"key":"ppat.1012555.ref009","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.smim.2015.03.012","article-title":"Dendritic cell functions: Learning from microbial evasion strategies","volume":"27","author":"M. 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Bhat","year":"1993","journal-title":"Virology"},{"key":"ppat.1012555.ref023","doi-asserted-by":"crossref","first-page":"112193","DOI":"10.1016\/j.celrep.2023.112193","article-title":"Aryl hydrocarbon receptor activity downstream of IL-10 signaling is required to promote regulatory functions in human dendritic cells.","volume":"42","author":"D Avancini","year":"2023","journal-title":"Cell Rep"},{"key":"ppat.1012555.ref024","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12977-021-00550-8","article-title":"Extracellular vesicles from HTLV-1 infected cells modulate target cells and viral spread.","volume":"18","author":"DO Pinto","year":"2021","journal-title":"Retrovirology."},{"key":"ppat.1012555.ref025","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nm.2065","article-title":"Biofilm-like extracellular viral assemblies mediate HTLV-1 cell-to-cell transmission at virological synapses","volume":"16","author":"A-M 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Microbiol."},{"key":"ppat.1012555.ref032","doi-asserted-by":"crossref","first-page":"22284","DOI":"10.1074\/jbc.M114.549659","article-title":"Human T-lymphotropic Virus Type 1-infected Cells Secrete Exosomes That Contain Tax Protein","volume":"289","author":"E Jaworski","year":"2014","journal-title":"J Biol Chem"},{"key":"ppat.1012555.ref033","doi-asserted-by":"crossref","first-page":"781","DOI":"10.3390\/cells10040781","article-title":"Extracellular Vesicles from Infected Cells Are Released Prior to Virion Release.","volume":"10","author":"Y Kim","year":"2021","journal-title":"Cells."},{"key":"ppat.1012555.ref034","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.3390\/microorganisms8111776","article-title":"Exosomes of Epstein-Barr Virus-Associated Gastric Carcinoma Suppress Dendritic Cell Maturation.","volume":"8","author":"M Hinata","year":"2020","journal-title":"Microorganisms"},{"key":"ppat.1012555.ref035","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1128\/JVI.01788-13","article-title":"Human T-cell leukemia\/lymphoma virus type 1 p30, but not p12\/p8, counteracts toll-like receptor 3 (TLR3) and TLR4 signaling in human monocytes and dendritic cells.","volume":"88","author":"C Fenizia","year":"2014","journal-title":"J Virol"},{"key":"ppat.1012555.ref036","doi-asserted-by":"crossref","first-page":"6208","DOI":"10.1074\/jbc.M806390200","article-title":"HTLV-1 Tax Is a Critical Lipid Raft Modulator That Hijacks I\u03baB Kinases to the Microdomains for Persistent Activation of NF-\u03baB *","volume":"284","author":"J Huang","year":"2009","journal-title":"J Biol Chem"},{"key":"ppat.1012555.ref037","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1182\/blood-2008-06-161729","article-title":"Human T-cell leukemia virus type 1 bZIP factor selectively suppresses the classical pathway of 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Tattermusch","year":"2012","journal-title":"PLoS Pathog."},{"key":"ppat.1012555.ref047","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1089\/aid.2013.0109","article-title":"Genes related to antiviral activity, cell migration, and lysis are differentially expressed in CD4(+) T cells in human t cell leukemia virus type 1-associated myelopathy\/tropical spastic paraparesis patients","volume":"30","author":"MT Pinto","year":"2014","journal-title":"AIDS Res Hum Retroviruses"},{"key":"ppat.1012555.ref048","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1089\/aid.2012.0205","article-title":"Altered expression of degranulation-related genes in CD8+ T cells in human T lymphotropic virus type I infection","volume":"29","author":"TM Malta","year":"2013","journal-title":"AIDS Res Hum Retroviruses"},{"key":"ppat.1012555.ref049","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/1743-422X-9-171","article-title":"Simultaneous RNA quantification of human and retroviral genomes reveals intact interferon signaling in HTLV-1-infected CD4+ T cell lines.","volume":"9","author":"B Moens","year":"2012","journal-title":"Virol J."},{"key":"ppat.1012555.ref050","doi-asserted-by":"crossref","first-page":"e1426423","DOI":"10.1080\/2162402X.2018.1426423","article-title":"A genetic IFN\/STAT1\/FAS axis determines CD4 T stem cell memory levels and apoptosis in healthy controls and Adult T-cell Leukemia patients","volume":"7","author":"R Khouri","year":"2018","journal-title":"Oncoimmunology"},{"key":"ppat.1012555.ref051","article-title":"Comprehensive Antiretroviral Restriction Factor Profiling Reveals the Evolutionary Imprint of the ex Vivo and in Vivo IFN-\u03b2 Response in HTLV-1-Associated Neuroinflammation.","volume":"9","author":"FE Leal","year":"2018","journal-title":"Front Microbiol."},{"key":"ppat.1012555.ref052","article-title":"Systemic cytokines and GlycA discriminate inflammaging, disease progression and corticosteroid response in 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Morozov","year":"1999","journal-title":"Virology"},{"key":"ppat.1012555.ref056","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/jcb.240630503","article-title":"T-cell lymphoma cell lines (HUT102 and HUT78) established at the National Cancer Institute: history and importance to understanding the biology, clinical features, and therapy of cutaneous T-cell lymphomas (CTCL) and adult T-cell leukemia-lymphomas (ATLL).","volume":"24","author":"PA Bunn","year":"1996","journal-title":"J Cell Biochem Suppl"},{"key":"ppat.1012555.ref057","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1006\/jmbi.1994.1651","article-title":"Domains of interaction between alpha interferon and its receptor components","volume":"243","author":"G Uz\u00e9","year":"1994","journal-title":"J Mol Biol"},{"key":"ppat.1012555.ref058","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3390\/v15010229","article-title":"Early Permissiveness of Central Nervous System Cells to Measles Virus 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