{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:04:40Z","timestamp":1790298280279,"version":"4.1.0"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T00:00:00Z","timestamp":1728950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["ChromFunVir; P-32582-B08"],"award-info":[{"award-number":["ChromFunVir; P-32582-B08"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["FWF-SFB70-08"],"award-info":[{"award-number":["FWF-SFB70-08"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016234","name":"ASEAN-European Academic University Network","doi-asserted-by":"publisher","award":["Ernst Mach Grant 2021-2023"],"award-info":[{"award-number":["Ernst Mach Grant 2021-2023"]}],"id":[{"id":"10.13039\/100016234","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016234","name":"ASEAN-European Academic University Network","doi-asserted-by":"publisher","award":["Bernd Rode Award 2024"],"award-info":[{"award-number":["Bernd Rode Award 2024"]}],"id":[{"id":"10.13039\/100016234","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001704","name":"European Society of Clinical Microbiology and Infectious Diseases","doi-asserted-by":"publisher","award":["ESCMID Research Grant 2023"],"award-info":[{"award-number":["ESCMID Research Grant 2023"]}],"id":[{"id":"10.13039\/501100001704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["TissueHome; FWF-DOC32-B28"],"award-info":[{"award-number":["TissueHome; FWF-DOC32-B28"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>Intraspecies variations that affect pathogenicity and antifungal resistance traits pose a serious obstacle to efficient therapy of <jats:italic>Candida auris<\/jats:italic> infections. Recent reports indicate that mutations determine drug susceptibility and virulence. However, mutations alone cannot fully explain a bewildering variety of phenotypes in clinical isolates from known <jats:italic>C<\/jats:italic>. <jats:italic>auris<\/jats:italic> clades, suggesting an unprecedented complexity underlying virulence traits and antifungal resistance. Hence, we wish to discuss how phenotypic plasticity promotes morphogenetic switching and how that contributes to intraspecies variations in the human fungal pathogen <jats:italic>C<\/jats:italic>. <jats:italic>auris<\/jats:italic>. Further, we will also discuss how intraspecies variations and morphogenetic events can impact the progress in molecular mycology research that aims to find better treatments for <jats:italic>C<\/jats:italic>. <jats:italic>auris<\/jats:italic> infections. Finally, we will present our opinion as to the most relevant questions to be addressed when trying to better understand the pathophysiology of <jats:italic>C<\/jats:italic>. <jats:italic>auris<\/jats:italic>.<\/jats:p>","DOI":"10.1371\/journal.ppat.1012559","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T17:21:38Z","timestamp":1729012898000},"page":"e1012559","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Do morphogenetic switching and intraspecies variation enhance virulence of Candida auris?"],"prefix":"10.1371","volume":"20","author":[{"given":"Trinh","family":"Phan-Canh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2719-5955","authenticated-orcid":true,"given":"Karl","family":"Kuchler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,10,15]]},"reference":[{"key":"ppat.1012559.ref001","doi-asserted-by":"crossref","first-page":"e1010073","DOI":"10.1371\/journal.ppat.1010073","article-title":"Fungicide effects on human fungal pathogens: Cross-resistance to medical drugs and beyond","volume":"17","author":"RW Bastos","year":"2021","journal-title":"PLoS Pathog"},{"key":"ppat.1012559.ref002","doi-asserted-by":"crossref","first-page":"5554","DOI":"10.1073\/pnas.1505312112","article-title":"Ominous projections for global antibiotic use in food-animal production","volume":"112","author":"LB Price","year":"2015","journal-title":"Proc Natl Acad Sci"},{"key":"ppat.1012559.ref003","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.oneear.2022.03.010","article-title":"Permafrost as a potential pathogen reservoir","volume":"5","author":"R Wu","year":"2022","journal-title":"One Earth"},{"key":"ppat.1012559.ref004","article-title":"Global incidence and mortality of severe fungal disease","author":"DW Denning","year":"2024","journal-title":"The Lancet Infectious Diseases"},{"key":"ppat.1012559.ref005","unstructured":"World Health Organization. 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