{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:42:22Z","timestamp":1792633342455,"version":"4.5.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1012614","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T00:00:00Z","timestamp":1731628800000}}],"reference-count":67,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371790"],"award-info":[{"award-number":["82371790"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2022JJ20034"],"award-info":[{"award-number":["2022JJ20034"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2022JJ50165"],"award-info":[{"award-number":["2022JJ50165"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Foundation of Education Bureau of Hunan Province","award":["22B0412"],"award-info":[{"award-number":["22B0412"]}]},{"DOI":"10.13039\/100017695","name":"Health Commission of Hunan Province","doi-asserted-by":"publisher","award":["202202074638"],"award-info":[{"award-number":["202202074638"]}],"id":[{"id":"10.13039\/100017695","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    <jats:italic>Mycoplasma pneumoniae<\/jats:italic>\n                    is a common cause of community-acquired pneumonia in which neutrophils play a critical role. Immune-responsive gene 1 (IRG1), responsible for itaconate production, has emerged as an important regulator of inflammation and infection, but its role during\n                    <jats:italic>M<\/jats:italic>\n                    .\n                    <jats:italic>pneumoniae<\/jats:italic>\n                    infection remains unknown. Here, we reveal that itaconate is an endogenous pro-inflammatory metabolite during\n                    <jats:italic>M<\/jats:italic>\n                    .\n                    <jats:italic>pneumoniae<\/jats:italic>\n                    infection.\n                    <jats:italic>Irg1<\/jats:italic>\n                    knockout (KO) mice had lower levels of bacterial burden, lactate dehydrogenase (LDH), and pro-inflammatory cytokines compared with wild-type (WT) controls after\n                    <jats:italic>M<\/jats:italic>\n                    .\n                    <jats:italic>pneumoniae<\/jats:italic>\n                    infection. Neutrophils were the major cells producing itaconate during\n                    <jats:italic>M<\/jats:italic>\n                    .\n                    <jats:italic>pneumoniae<\/jats:italic>\n                    infection in mice. Neutrophil counts were positively correlated with itaconate concentrations in bronchoalveolar lavage fluid (BALF) of patients with severe\n                    <jats:italic>M<\/jats:italic>\n                    .\n                    <jats:italic>pneumoniae<\/jats:italic>\n                    pneumonia. Adoptive transfer of\n                    <jats:italic>Irg1<\/jats:italic>\n                    KO neutrophils, or administration of \u03b2-glucan (an inhibitor of\n                    <jats:italic>Irg1<\/jats:italic>\n                    expression), significantly attenuated\n                    <jats:italic>M<\/jats:italic>\n                    .\n                    <jats:italic>pneumoniae<\/jats:italic>\n                    pneumonia in mice. Mechanistically, itaconate impaired neutrophil bacterial killing and suppressed neutrophil apoptosis via inhibiting mitochondrial ROS. Moreover,\n                    <jats:italic>M<\/jats:italic>\n                    .\n                    <jats:italic>pneumoniae<\/jats:italic>\n                    induced\n                    <jats:italic>Irg1<\/jats:italic>\n                    expression by activating NF-\u03baB and STAT1 pathways involving TLR2. Our data thus identify\n                    <jats:italic>Irg1<\/jats:italic>\n                    \/itaconate pathway as a potential therapeutic target for the treatment of\n                    <jats:italic>M<\/jats:italic>\n                    .\n                    <jats:italic>pneumoniae<\/jats:italic>\n                    pneumonia.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1012614","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T13:34:18Z","timestamp":1730813658000},"page":"e1012614","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":39,"title":["Suppressing neutrophil itaconate production attenuates Mycoplasma pneumoniae pneumonia"],"prefix":"10.1371","volume":"20","author":[{"given":"Cui","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijun","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhande","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenkui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiming","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimou","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1498-5520","authenticated-orcid":true,"given":"Aihua","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,11,5]]},"reference":[{"key":"ppat.1012614.ref001","article-title":"Pneumonia 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