{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T02:27:06Z","timestamp":1781058426991,"version":"3.54.1"},"update-to":[{"DOI":"10.1371\/journal.ppat.1012618","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000}}],"reference-count":84,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["ISF1984_2024"],"award-info":[{"award-number":["ISF1984_2024"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012213","name":"Rappaport Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012213","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["524590563"],"award-info":[{"award-number":["524590563"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006245","name":"Ministry of Science and Technology ISRAEL","doi-asserted-by":"crossref","award":["1020546"],"award-info":[{"award-number":["1020546"]}],"id":[{"id":"10.13039\/501100006245","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["1049\/24"],"award-info":[{"award-number":["1049\/24"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    Amebiasis, caused by\n                    <jats:italic>Entamoeba histolytica<\/jats:italic>\n                    , is a global health concern, affecting millions and causing significant mortality, particularly in areas with poor sanitation. Although recent studies have examined\n                    <jats:italic>E. histolytica<\/jats:italic>\n                    \u2019s interaction with human intestinal microbes, the impact of bacterial presence on the parasite\u2019s motility, mechanical forces, and their potential role in altering invasiveness have not been fully elucidated. In this study, we utilized a micropillar-array system combined with live imaging to investigate the effects of enteropathogenic\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    on\n                    <jats:italic>E. histolytica<\/jats:italic>\n                    \u2019s motility characteristics, F-actin spatial localization, and traction force exerted on fibronectin-coated substrates. Our findings indicate that co-incubation with live enteropathogenic\n                    <jats:italic>E. coli<\/jats:italic>\n                    significantly enhances the motility of\n                    <jats:italic>E. histolytica<\/jats:italic>\n                    , as evidenced by superdiffusive movement\u2014characterized by increased directionality and speed\u2014resulting in broader dispersal and more extensive tissue\/cell damage. This increased motility is accompanied by a reduction in F-actin-dependent traction forces and podosome-like structures on fibronectin-coated substrates, but with increased F-actin localization in the upper part of the cytoplasm. These findings highlight the role of physical interactions and cellular behaviors in modulating the parasite\u2019s virulence, providing new insights into the mechanistic basis of its pathogenicity.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1012618","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T13:57:37Z","timestamp":1748008657000},"page":"e1012618","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Enteropathogenic Escherichia coli induces Entamoeba histolytica superdiffusion movement on fibronectin by reducing traction forces"],"prefix":"10.1371","volume":"21","author":[{"given":"Yuanning","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Shemesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anas","family":"Odeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meirav","family":"Trebicz-Geffen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6892-7839","authenticated-orcid":true,"given":"Haguy","family":"Wolfenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8775-1557","authenticated-orcid":true,"given":"Serge","family":"Ankri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,5,23]]},"reference":[{"issue":"6","key":"ppat.1012618.ref001","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.pt.2011.02.006","article-title":"Tissue 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