{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:49:42Z","timestamp":1791557382238,"version":"4.3.4"},"reference-count":130,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["MO 846\/3, MO 846\/6, MO 846\/7"],"award-info":[{"award-number":["MO 846\/3, MO 846\/6, MO 846\/7"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>The yeast <jats:italic>Candida albicans<\/jats:italic> is usually a harmless member of the normal microbiota in healthy persons but is also a major fungal pathogen that can colonize and infect almost every human tissue. A successful adaptation to environmental changes encountered in different host niches requires an appropriate regulation of gene expression. The zinc cluster transcription factors are the largest family of transcriptional regulators in <jats:italic>C<\/jats:italic>. <jats:italic>albicans<\/jats:italic> and are involved in the control of virtually all aspects of its biology. Under certain circumstances, mutations in these transcription factors that alter their activity and the expression of their target genes confer a selective advantage, which results in the emergence of phenotypically altered variants that are better adapted to new environmental challenges. This review describes how gain-of-function mutations in different zinc cluster transcription factors enable <jats:italic>C<\/jats:italic>. <jats:italic>albicans<\/jats:italic> to overcome antifungal therapy and to successfully establish itself in specific host niches.<\/jats:p>","DOI":"10.1371\/journal.ppat.1012643","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T18:21:59Z","timestamp":1730744519000},"page":"e1012643","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Adaptation of Candida albicans to specific host environments by gain-of-function mutations in transcription factors"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4227-8687","authenticated-orcid":true,"given":"Joachim","family":"Morschh\u00e4user","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,11,4]]},"reference":[{"key":"ppat.1012643.ref001","volume-title":"Molecular biology of the cell","author":"B. 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